%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 128 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/Pattern<>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 102.80000305 386.1499939 cm q 0.70710677 -0.70710677 0.70710677 0.70710677 30.64698792 143.58837891 cm q 377.30001831 0 0 -69.59999847 0 69.59999847 cm /X1 Do Q Q Q EMC /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 12.98600006 l -90 12.98600006 l h W n Q EMC /Artifact <> BDC q 1 0 0 1 90 781.31402588 cm -90 0 m 505.29998779 0 l 505.29998779 10.98600006 l -90 10.98600006 l h W n Q EMC /Artifact <> BDC q 1 0 0 1 -13.75 -22.5 cm q 1 0 0 1 348.13919067 52.52742767 cm q 0 0.6901961 0.3137255 rg -348.15930176 -3.4615972 m 349.0982666 -3.4615972 l 349.0982666 -3.4615972 l 349.0982666 3.47312713 l 349.0982666 3.47312713 l -348.15930176 3.47312713 l h f* Q q 0 0 1 RG -348.15930176 -3.4615972 m 349.0982666 -3.4615972 l 349.0982666 -3.4615972 l 349.0982666 3.47312713 l 349.0982666 3.47312713 l -348.15930176 3.47312713 l h s Q Q q 1 0 0 1 620.03027344 29.03481674 cm q 0 g -41.67387772 -20.39015198 m 76.66989136 -20.43765068 l 76.66989136 -20.43765068 l 76.66989136 20.50552368 l 76.66989136 20.50552368 l -76.46366882 20.50552368 l -76.46366882 20.50552368 l -41.67387772 -20.39015198 l h f* Q Q q 1 0 0 1 628.92266846 26.27020454 cm q 0.67058825 0.84313726 0.54901963 rg -33.4988327 -26.27020454 m 68.64868164 -25.84272385 l 68.64868164 -25.84272385 l 68.64868164 26.35744858 l 68.64868164 26.35744858 l -68.46403503 26.35744858 l -68.46403503 26.35744858 l -33.4988327 -26.27020454 l h f* Q Q Q EMC /Artifact <> BDC q 1 0 0 1 -27.5 1.25000072 cm q 1 0 0 1 278.78527832 14.34909439 cm q 1 0 0 1 -278.78527832 -14.34909439 cm 0 3.60000014 m 558.45001221 3.60000014 l 558.45001221 25.19307137 l 0 25.19307137 l h W n q 1 0 0 1 7.45000029 3.85000014 cm q 19.54800034 0 0 -21.1875 92.25 23.06100082 cm /X2 Do Q BT /FAAAAJ 12 Tf 1 0 0 -1 96 15.93600082 Tm 2 Tr 0.28235295 0.45490196 0.79607844 rg 0.34285715 w 0.28235295 0.45490196 0.79607844 RG [<0003>] TJ ET q 19.54800034 0 0 -21.1875 112.23400879 23.06100082 cm /X3 Do Q BT 1 0 0 -1 115.98400879 15.93600082 Tm [<0004>] TJ ET q 19.54800034 0 0 -21.1875 132.21800232 23.06100082 cm /X4 Do Q BT 1 0 0 -1 135.96800232 15.93600082 Tm [<0005>] TJ ET q 19.54800034 0 0 -21.1875 152.20199585 23.06100082 cm /X5 Do Q BT 1 0 0 -1 155.95199585 15.93600082 Tm [<0006>] TJ /FAAABG 12 Tf [-4( )] TJ /FAAABG 10.5 Tf 0.30000001 w [( )-4( )-4( )-4( )] TJ ET q 1 0 0 1 0.30197144 0.30197668 cm q 13.54800129 0 0 -15.1875 194.25 20.06100082 cm /X6 Do Q Q BT /FAAAAJ 12 Tf 1 0 0 -1 195 15.93600082 Tm 0 g 0.34285715 w 0 G [<0007>] TJ ET q 1 0 0 1 0.30197144 0.30197668 cm q 13.54800129 0 0 -15.1875 224.91101074 20.06100082 cm /X7 Do Q Q BT 1 0 0 -1 225.66101074 15.93600082 Tm [<0008>] TJ ET q 1 0 0 1 0.30197144 0.30197668 cm q 13.54800129 0 0 -15.1875 255.57203674 20.06100082 cm /X8 Do Q Q BT 1 0 0 -1 256.32202148 15.93600082 Tm [<0009>] TJ ET q 1 0 0 1 0.30197144 0.30197668 cm q 13.54800129 0 0 -15.1875 286.23303223 20.06100082 cm /X9 Do Q Q BT 1 0 0 -1 286.98303223 15.93600082 Tm [<000A>] TJ ET q 1 0 0 1 0.30197144 0.30197668 cm q 13.54800129 0 0 -15.1875 316.89404297 20.06100082 cm /X10 Do Q Q BT 1 0 0 -1 317.64404297 15.93600082 Tm [<000B>] TJ ET q 1 0 0 1 0.30197144 0.30197668 cm q 13.54800129 0 0 -15.1875 347.55505371 20.06100082 cm /X11 Do Q Q BT 1 0 0 -1 348.30505371 15.93600082 Tm [<000C>] TJ ET q 1 0 0 1 0.30197144 0.30197668 cm q 13.54800129 0 0 -15.1875 378.21606445 20.06100082 cm /X12 Do Q Q BT 1 0 0 -1 378.96606445 15.93600082 Tm [<000D>] TJ ET q 1 0 0 1 0.30197144 0.30197668 cm q 13.54800129 0 0 -15.1875 408.87710571 20.06100082 cm /X13 Do Q Q BT 1 0 0 -1 409.62710571 15.93600082 Tm [<000E>] TJ ET q 1 0 0 1 0.30197144 0.30197668 cm q 13.54800129 0 0 -15.1875 439.53808594 20.06100082 cm /X14 Do Q Q BT 1 0 0 -1 440.28808594 15.93600082 Tm [<000F>] TJ ET q 1 0 0 1 0.30197144 0.30197668 cm q 13.54800129 0 0 -15.1875 470.19903564 20.06100082 cm /X15 Do Q Q BT 1 0 0 -1 470.94903564 15.93600082 Tm [<0010>] TJ ET Q Q Q q 1 0 0 1 30.47141838 21.49246407 cm q 0 g -2.97031498 -3.92962766 m 2.97968507 -3.92962766 l 2.97968507 -3.92962766 l 2.97968507 3.95564818 l 2.97968507 3.95564818 l -2.97031498 3.95564818 l h f* Q Q Q EMC /Artifact <> BDC q 1 0 0 1 -18.39999962 816.76397705 cm q 0 3.60000014 m 617.5 3.60000014 l 617.5 21.70000076 l 0 21.70000076 l h W n q 1 0 0 1 7.45000029 3.85000014 cm BT /FAAACJ 12 Tf 1 0 0 -1 16.29999924 11.42500019 Tm 0 g [( )-1( )-1( )-1( )-1( )-1( )-19997(w)-445(w)-445(w)-446(.)-445(m)-445(l)-445(b)-445(i)-444(o)-445(.)-445(c)-446(n)] TJ ET q 0 G 0.78515625 w 454.30001831 13.17695427 m 586.30004883 13.17695427 l S Q Q Q Q EMC /Artifact <> BDC q 1 0 0 1 -5 837.26397705 cm q /Pattern cs /P1 scn 0 0 m 612.45001221 0 l 612.45001221 0 l 612.45001221 9.40000057 l 612.45001221 9.40000057 l 0 9.40000057 l h f* Q Q EMC q 1 0 0 1 90 72 cm /P <> BDC BT /FAAADE 18 Tf 1 0 0 -1 29.03899956 23.44400024 Tm 0 g [<00030004000500060007>] TJ ET EMC /P <> BDC BT /FAAADI 18 Tf 1 0 0 -1 119.03900146 23.44400024 Tm [(\(MS\))] TJ ET EMC /P <> BDC BT /FAAADE 18 Tf 1 0 0 -1 162.40400696 23.44400024 Tm [<000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.40400696 23.44400024 Tm [<000E000F001000110012>] TJ ET EMC /P <> BDC BT /FAAADI 18 Tf 1 0 0 -1 288.4039917 23.44400024 Tm [(-)] TJ ET EMC /P <> BDC BT /FAAADE 18 Tf 1 0 0 -1 296.26098633 23.44400024 Tm [<00140015001600170018>] TJ ET EMC /P <> BDC BT /FAAADI 22 Tf 1 0 0 -1 386.26098633 23.44400024 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 221.19999695 31.20000076 cm /P <> BDC BT /FAAADE 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0 0.6901961 0.3137255 rg [<0019>-1010<001A>-1011<0018>] TJ ET EMC /P <> BDC BT /FAAADI 10.5 Tf 1 0 0 -1 68.60199738 20.17499924 Tm [(4)-1010(8)] TJ ET EMC /P <> BDC BT /FAAADE 10.5 Tf 1 0 0 -1 108.04599762 20.17499924 Tm [<001D>] TJ ET EMC /P <> BDC BT /FAAAED 12 Tf 1 0 0 -1 118.55000305 20.17499924 Tm 1 Tr 0.34285715 w /GS3 gs 0 G [<0001>] TJ ET EMC Q q 1 0 0 1 0 62.40000153 cm /P <> BDC BT /FAAADI 14 Tf 1 0 0 -1 0 21.70100021 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAAED 12 Tf 1 0 0 -1 0 20.63999939 Tm 2 Tr /GS2 gs 0 0.6901961 0.3137255 rg 0.34285715 w 0 0.6901961 0.3137255 RG [<2761>-611<3177>-611<768D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.99900055 20.63999939 Tm [<279D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 70 20.63999939 Tm [<001B>] TJ ET EMC /P <> BDC q 0.60000002 w 0 24.07499886 m 70 24.07499886 l S Q EMC /P <> BDC BT /FAAADI 14 Tf 1 0 0 -1 72.77200317 20.63999939 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAAEJ 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0 g [<0003>-12<0004>-12<0005>-11<0006>-12<0007>-12<0008>] TJ ET EMC /P <> BDC BT /FAAAFD 10.5 Tf 1 0 0 -1 63.74399948 51.375 Tm [(MS)] TJ ET EMC /P <> BDC BT /FAAAEJ 10.5 Tf 1 0 0 -1 80.18699646 51.375 Tm [<000B>] TJ ET EMC /P <> BDC BT /FAAAFD 10.5 Tf 1 0 0 -1 90.81099701 51.375 Tm [(EC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.60800171 51.375 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.83899689 51.375 Tm [(2.3)-1(.)1(3)-1(.)1(9)] TJ ET EMC /P <> BDC BT /FAAAEJ 10.5 Tf 1 0 0 -1 139.17599487 51.375 Tm [<0012>-12<0013>-12<0014>-11<0015>-12<0005>-12<0016>-12<0017>-12<0018>-11<0019>-12<001A>-12<0007>-12<001B>-12<001C>-12<000B>-11<001D>-12<001E>-12<001F>-12<0020>-12<0021>-11<001F>-12<0020>-12<0022>-12<0023>-12<0024>-11<0025>-12<0026>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 82.57499695 Tm [<0027002800290018002A0025002B002C002D002E002F002900300031>] TJ ET EMC /P <> BDC BT /FAAAFD 10.5 Tf 1 0 0 -1 147 82.57499695 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 187.19999695 cm /P <> BDC BT /FAAAEJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0 g [<00030004000500060007>] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.5320015 20.17499924 Tm [<0008>] TJ ET EMC /P <> BDC BT /FAAAFD 10.5 Tf 1 0 0 -1 62.0320015 20.17499924 Tm [(MS)] TJ ET EMC /P <> BDC BT /FAAAEJ 10.5 Tf 1 0 0 -1 78.35099792 20.17499924 Tm [<0012>] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.88300323 20.17499924 Tm [<0032003300140034>] TJ ET EMC /P <> BDC BT /FAAAFD 10.5 Tf 1 0 0 -1 132.50799561 20.17499924 Tm [(CoA)] TJ ET EMC /P <> BDC BT /FAAAEJ 10.5 Tf 1 0 0 -1 156.22000122 20.17499924 Tm [<0036001400150005002300370003000400050036>] TJ ET EMC /P <> BDC BT /FAAAFD 10.5 Tf 1 0 0 -1 263.84500122 20.17499924 Tm [(CoA)] TJ ET EMC /P <> BDC BT /FAAAEJ 10.5 Tf 1 0 0 -1 284.93200684 20.17499924 Tm [<000B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.46398926 20.17499924 Tm [<002300370018>] TJ ET EMC /P <> BDC BT /FAAAFD 10.5 Tf 1 0 0 -1 328.58898926 20.17499924 Tm [(CoA)] TJ ET EMC /P <> BDC BT /FAAAEJ 10.5 Tf 1 0 0 -1 352.30099487 20.17499924 Tm [<0038002F00390022003A003B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 51.375 Tm [<003C>-5<003D>] TJ ET EMC /P <> BDC BT /FAAAFD 10.5 Tf 1 0 0 -1 23.72699928 51.375 Tm [(DTNB)] TJ ET EMC /P <> BDC BT /FAAAEJ 10.5 Tf 1 0 0 -1 55.54499817 51.375 Tm [<0042>-5<0043>-5<0023>-5<0037>-4<0044>-5<0045>-5<0025>-5<0046>-5<000B>-5<0047>-5<002F>-4<0045>-5<0025>-5<0046>-5<001D>] TJ ET EMC /P <> BDC BT /FAAAFD 10.5 Tf 1 0 0 -1 213.80999756 51.375 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.11099243 51.375 Tm [(41)-1(2nm)] TJ ET EMC /P <> BDC BT /FAAAEJ 10.5 Tf 1 0 0 -1 256.56799316 51.375 Tm [<004C>-5<002F>-5<004D>-5<004E>-4<004F>-5<0050>-5<0051>-5<000B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 340.97601318 51.375 Tm [<0052>-5<003C>-5<0053>-5<0054>] TJ ET EMC /P <> BDC BT /FAAAFD 10.5 Tf 1 0 0 -1 385.80499268 51.375 Tm [(MS)] TJ ET EMC /P <> BDC BT /FAAAEJ 10.5 Tf 1 0 0 -1 404.79998779 51.375 Tm [<0007>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 82.57499695 Tm [<0055003A005600570031>] TJ ET EMC /P <> BDC BT /FAAAFD 10.5 Tf 1 0 0 -1 52.5 82.57499695 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 280.79998779 cm /P <> BDC BT /FAAAEJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0 g [<00580059005A005B>] TJ ET EMC /P <> BDC BT /FAAAFD 10.5 Tf 1 0 0 -1 42 20.17499924 Tm [(ace)-1(t)1(yl)-1(-)1(CoA)1(+glyoxylate+H2O=\(S\)-mala)1(te+CoA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.80999756 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.91699219 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAAED 12 Tf 1 0 0 -1 0 51.84000015 Tm 2 Tr /GS2 gs 0 0.6901961 0.3137255 rg 0.34285715 w 0 0.6901961 0.3137255 RG [<4A3E>-857-857<6DB8>-857<27C9>-857<343C>-857<3124>-858<6B3D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.99499512 51.84000015 Tm [<3177>] TJ ET EMC /P <> BDC BT 1 0 0 -1 168 51.84000015 Tm [<001B>] TJ ET EMC /P <> BDC q 0.60000002 w 0 55.27500153 m 168 55.27500153 l S Q EMC /P <> BDC BT 1 0 0 -1 170.77200317 51.84000015 Tm 1 Tr /GS3 gs 0 G [<0001>] TJ ET EMC Q q 1 0 0 1 0 343.20001221 cm /P <> BDC BT /FAAAEJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0 g [<0007006B006C0020>] TJ ET EMC /P <> BDC BT /FAAAFD 10.5 Tf 1 0 0 -1 42 20.17499924 Tm [(96)] TJ ET EMC /P <> BDC BT /FAAAEJ 10.5 Tf 1 0 0 -1 56.93999863 20.17499924 Tm [<006E006F00200070007100720073007400200075007600770020003C0078005A0079007A007B0020007C007D0020007E0036007F00800075>] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>