%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 120 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 77.96499634 l -90 77.96499634 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 41.79999924 Tm 0 g [( )-25014( )-1( )] TJ /FAAAAH 18 Tf 1 0 0 rg [-1370(ww)1(w.)-1(mlbi)-1(o.)-1(cn )] TJ /FAAAAH 9 Tf /GS1 gs 0 g [( )] TJ ET q /GS1 gs 0 0.50196081 0 RG 0.5 w -5.44999981 47.88399887 m 420.75 47.88399887 l S Q q 1 0 0 1 0 56.13399887 cm Q Q EMC q 1 0 0 1 90 42.54999924 cm q 1 0 0 1 22.5 0.99999923 cm q 212.80000305 0 0 -40.79999924 0 40.79999924 cm /X1 Do Q Q Q q 1 0 0 1 90 120.51499939 cm /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 207.6499939 32.98699951 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 54.79999924 cm /P <> BDC BT 1 0 0 -1 84.00700378 32.98699951 Tm /GS2 gs 0 g [(HI)-1(T-T15)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.71499634 32.98699951 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABF 22 Tf 1 0 0 -1 184.71499634 32.98699951 Tm [<0009000A000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 331.29199219 32.98699951 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 109.59999847 cm /P <> BDC BT /FAAABF 10.5 Tf 1 0 0 -1 144.6499939 20.17499924 Tm /GS2 gs 0 0.6901961 0.3137255 rg [<0010>-100<0011>-100<0012>-100<0013>-100<0014>-100<0015>-100<0016>-100<0017>-100<0018>-100<0019>] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.1499939 20.17499924 Tm [<001A>] TJ ET EMC /P <> BDC BT /FAAABC 10.5 Tf 1 0 0 -1 270.6499939 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 148.80000305 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 188 cm /P <> BDC BT /FAAABF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0 0 1 rg [<001B0010001C001D>] TJ ET EMC /P <> BDC BT /FAAABC 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC q /GS1 gs 0 0 1 RG 0.52499998 w 0 22.35549164 m 42 22.35549164 l S Q EMC Q q 1 0 0 1 0 227.19999695 cm /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0 g [<0003000400040005>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 42 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 47.25 20.17499924 Tm [<0006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 99.75 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 266.3999939 cm /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0 g [<000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 42 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 47.25 20.17499924 Tm [<0006000F001000110012001300140015>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 127.06099701 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 305.6000061 cm /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0 g [<001400150016000E>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 42 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 47.25 20.17499924 Tm [<0006>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 57.75 20.17499924 Tm [(H)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.8710022 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.97799683 20.17499924 Tm [(IT-T15)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.95999908 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 344.79998779 cm /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0 g [<00140015001D000E>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 42 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 47.25 20.17499924 Tm [<0006>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 57.75 20.17499924 Tm [(H)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.8710022 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.97799683 20.17499924 Tm [(IT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.08300018 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.19000244 20.17499924 Tm [(T1)-1(5)] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 99.52400208 20.17499924 Tm [<001E>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 110.02400208 20.17499924 Tm [(HIT)-1(.)1(T)-1(15)] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 148.11199951 20.17499924 Tm [<001E>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 158.61199951 20.17499924 Tm [(HIT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.83900452 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.94599915 20.17499924 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.96499634 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.07200623 20.17499924 Tm [(-15)] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 204.92900085 20.17499924 Tm [<001E>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 215.42900085 20.17499924 Tm [(H)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.55000305 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.65699768 20.17499924 Tm [(ITT1)-1(5)] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 254.09599304 20.17499924 Tm [<001E>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 264.5960083 20.17499924 Tm [(HIT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.82299805 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.92999268 20.17499924 Tm [(cl)-1(o)1(n)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.09298706 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.20001221 20.17499924 Tm [(T1)-1(5)] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 333.53399658 20.17499924 Tm [<001E>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 344.03399658 20.17499924 Tm [(H)] TJ ET EMC /P <> BDC BT 1 0 0 -1 352.15499878 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 355.26199341 20.17499924 Tm [(am)] TJ ET EMC /P <> BDC BT 1 0 0 -1 370.9039917 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 374.01098633 20.17499924 Tm [(st)1(e)-1(rIslet)] TJ ET EMC /P <> BDC BT 1 0 0 -1 413.35998535 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 384 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0 g [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.01900005 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.1260004 20.17499924 Tm [(ransf)1(orm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.43299866 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.54000092 20.17499924 Tm [(ed-Tio)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.24500275 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.35199738 20.17499924 Tm [(guanine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.03399658 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.14100647 20.17499924 Tm [(resista)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.80799866 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.91499329 20.17499924 Tm [(tclone)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.98899841 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.09599304 20.17499924 Tm [(15)] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 225.41099548 20.17499924 Tm [<001E>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 235.91099548 20.17499924 Tm [(HIT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.13800049 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 423.20001221 cm /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0 g [<00140015002F0030>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 42 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 47.25 20.17499924 Tm [<000600310032001400150033>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 110.25 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 462.3999939 cm /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0 g [<0009003400350036>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 42 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 47.25 20.17499924 Tm [<00060037003800140015>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 99.75 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 501.6000061 cm /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0 g [<0039003A003B003C>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 42 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 47.25 20.17499924 Tm [<0006003D003E003F>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 89.25 20.17499924 Tm [(95)-1(%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.90599823 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 116.15599823 20.17499924 Tm [<001E>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 126.65599823 20.17499924 Tm [(CO2)] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 148.39399719 20.17499924 Tm [<003F>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 158.89399719 20.17499924 Tm [(5%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.39300537 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.5 20.17499924 Tm [(37)] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 189.81500244 20.17499924 Tm [<0047>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 200.31500244 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 540.79998779 cm /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0 g [<00480049004A004B>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 42 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 47.25 20.17499924 Tm [<0006>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 57.75 20.17499924 Tm [(55)-1(%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.40599823 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 84.65599823 20.17499924 Tm [<004C004D0039003A004C>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 137.15600586 20.17499924 Tm [(+40)-1(%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.6000061 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.70700073 20.17499924 Tm [(FB)-1(S+5%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.22000122 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.32699585 20.17499924 Tm [(D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.32499695 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.43200684 20.17499924 Tm [(M)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.69099426 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.79800415 20.17499924 Tm [(SO)] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 256.04000854 20.17499924 Tm [<00560057>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 277.04000854 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 580 cm /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0 g [<0058>-15<0059>-16<0039>-15<003A>-15<004C>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 53.30500031 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 58.7159996 20.17499924 Tm [<0006>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 69.3769989 20.17499924 Tm [(Ham)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.13999939 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.40799713 20.17499924 Tm [(sF-12)-1(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.3690033 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.63699341 20.17499924 Tm [(\(PM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.82699585 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.09500122 20.17499924 Tm [(15)-1(09)-1(10)-1(\))] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 197.70799255 20.17499924 Tm [<005E>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 208.3690033 20.17499924 Tm [(10)-1(%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.0249939 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.29299927 20.17499924 Tm [(H)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.41400146 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.68200684 20.17499924 Tm [(S\(1)-1(642)-1(15)-1(\))] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 294.86199951 20.17499924 Tm [<005E>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 305.52301025 20.17499924 Tm [(2.5)-1(%)1(F)] TJ ET EMC /P <> BDC BT 1 0 0 -1 335.28500366 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 338.55300903 20.17499924 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 345.14099121 20.17499924 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 348.40899658 20.17499924 Tm [(S\(1)-1(642)-1(10)-1(-)1(5)-1(0\))] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 0 51.375 Tm [<005E>] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 10.5 51.375 Tm [(1%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.99900055 51.375 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.1060009 51.375 Tm [(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.52999878 51.375 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.63700104 51.375 Tm [(/S\(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.11399841 51.375 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.22100067 51.375 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.80899811 51.375 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.91600037 51.375 Tm [(18)-1(01)-1(20)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.36799622 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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