%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 64 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.80000114 0 20.80000114 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.94400024 l -90 87.94400024 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 42 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 414 42 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.98600006 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.97200012 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.95800018 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC /Artifact <> BDC q 1 0 0 1 90 781.31402588 cm -90 0 m 505.29998779 0 l 505.29998779 10.98600006 l -90 10.98600006 l h W n Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 0 cm q 188.3500061 0 0 -41.45000076 0 41.45000076 cm /X2 Do Q Q Q q 1 0 0 1 90 130.4940033 cm q 1 0 0 1 18 0 cm /P <> BDC BT /FAAABH 18 Tf 1 0 0 -1 0 22.20999908 Tm 2 Tr 0 g 0.51428574 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-3<0009>-4<000A>-4<000B>] TJ ET EMC /P <> BDC BT /FAAACB 18 Tf 1 0 0 -1 161.42799377 22.20999908 Tm [(\()-4(T)-4(r)-4(y)-4(p)-4(s)-3(i)-4(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.0039978 22.20999908 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.07600403 22.20999908 Tm [(i)-4(n)-4(h)-4(i)-4(b)-4(i)-3(t)-4(o)-4(r)-4(,)-4(5)-4(m)-4(g)-4(/)-4(m)-4(l)-4(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 397.29998779 22.20999908 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 31.20000076 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 207.6499939 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [( )-4( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.1499939 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 102.23000336 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<001F>-4<0020>-4<0021>-4<0022>-4<0023>-4<0024>-3<0025>-4<0026>-4<0027>-4<0028>-4<0029>-4<002A>-4<002B>-4<002C>-4<0029>-4<002D>-3<002E>-4<002F>-4<0030>-4<0031>] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 313.07000732 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 62.40000153 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 78 cm /P <> BDC BT /FAAACB 16 Tf 1 0 0 -1 0 21.47500038 Tm 1 Tr 0.45714286 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 109.19999695 cm /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 0 21.47500038 Tm 0 g [<00200021003200330034>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 80 21.47500038 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 140.3999939 cm /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 0 21.47500038 Tm 0 g [<000400050006000700080009>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 95.30000305 21.47500038 Tm [(\(Protease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.30000305 21.47500038 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.30000305 21.47500038 Tm [(Inhibitor\))] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 255.30000305 21.47500038 Tm [<0039003A003B000400050006003C003D003E003F>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 52.67500305 Tm [<0040004100420043004400450046004700480049>] TJ ET EMC /P <> BDC BT 1 0 0 -1 160 52.67500305 Tm [<002A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.30000305 52.67500305 Tm [<0028000400050006003E004A004B004C004D004E004F00500051002B0028>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 83.875 Tm [<0004>-77<0005>-78<0052>-77<003F>-78<0043>-77<0053>-78<0054>-77<0055>-78<0004>-77<0005>-78<0006>-78<0007>-77<0008>-78<0009>-77<0056>-78<0057>-77<0058>-78<0059>-77<002A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 327.55999756 83.875 Tm [<005A>-77<005B>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 366.04000854 83.875 Tm [(EDTA)] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 399.27999878 83.875 Tm [<005E>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 0 115.07499695 Tm [(E-64)] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 32 115.07499695 Tm [<005E>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 43.06000137 115.07499695 Tm [(NaVO3)] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 83.05999756 115.07499695 Tm [<005E>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 94.12000275 115.07499695 Tm [(Bestatin)] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 158.11999512 115.07499695 Tm [<005E>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 169.17999268 115.07499695 Tm [(Leupetin)] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 233.17999268 115.07499695 Tm [<005E>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 244.24000549 115.07499695 Tm [(Pepstatin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.23999023 115.07499695 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.23999023 115.07499695 Tm [(A)] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 332.23999023 115.07499695 Tm [<005E>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 343.29998779 115.07499695 Tm [(Aprotinin)] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 0 146.27500916 Tm [<0069006A006B0056006C00070008000400050043004C006D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 192 146.27500916 Tm [<002A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 200 146.27500916 Tm [<006E006F00700071005600430004000500720073007400750029>] TJ ET EMC /P <> BDC BT 1 0 0 -1 408 146.27500916 Tm [<0055>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 416 146.27500916 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 296.3999939 cm /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 0 21.47500038 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 327.6000061 cm /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 0 21.47500038 Tm 0 g [<0003>-54<0004>-55<0005>-54<0006>-54<0007>-55<0008>-54<0009>-54<000A>-55<000B>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 151.82099915 21.47500038 Tm [(\(Trypsin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.82099915 21.47500038 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.69000244 21.47500038 Tm [(inhibitor,5mg/ml\))] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 361.55899048 21.47500038 Tm [<0076>-54<0077>-55<0078>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 0 52.67500305 Tm [(Trypsin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56 52.67500305 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64 52.67500305 Tm [(inhibitor)] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 140 52.67500305 Tm [<0079007A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 172 52.67500305 Tm [<002A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.6499939 52.67500305 Tm [<002B007B>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 223.6499939 52.67500305 Tm [(EDTA)] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 255.6499939 52.67500305 Tm [<0055>] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.29998779 52.67500305 Tm [<007C0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 83.875 Tm [<000B0039007D007E000A000B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 96 83.875 Tm [<002A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.65000153 83.875 Tm [<007F00800075007D0081004400820083>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 243.6499939 83.875 Tm [(1-10)] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 275.6499939 83.875 Tm [<0086>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 291.6499939 83.875 Tm [(g/ml)] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 323.6499939 83.875 Tm [<002A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 339.29998779 83.875 Tm [<0087006B0083>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 391.29998779 83.875 Tm [(0.1)] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 0 115.07499695 Tm [<0086>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 16.31699944 115.07499695 Tm [(mol/L)] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 56.63399887 115.07499695 Tm [<002A>-20<0089>-20<0029>-19<002D>-20<008A>-20<008B>-20<008C>-20<008D>-19<0053>-20<0079>-20<008E>-20<005E>-20<008F>-20<0090>-19<0040>-20<0091>-20<0092>-20<0004>-20<0005>-19<0054>-20<002A>-20<0093>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 146.27500916 Tm [<0094>-74<0095>-74<0056>-74<006C>-75<0043>-74<0096>-74<002C>-74<0097>-74<0043>-74<0004>-74<0005>-74<0054>-75<0055>] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.41799927 146.27500916 Tm [<0091>-74<0092>-74<0098>-74<0099>-75<0043>-74<0004>-74<0005>-74<006B>-74<009A>-74<0029>-74<002D>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 0 177.4750061 Tm [(Western)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56 177.4750061 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64 177.4750061 Tm [(Blot)] TJ ET EMC /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 96 177.4750061 Tm [<005E009C009D009E009F00A0006900A100A20055>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 256 177.4750061 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 514.79998779 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 530.40002441 cm /P <> BDC BT /FAAACG 16 Tf 1 0 0 -1 0 21.47500038 Tm 0 g [<002000210079007A0034>] TJ ET EMC /P <> BDC BT /FAAACE 16 Tf 1 0 0 -1 80 21.47500038 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 561.59997559 cm Q Q q 1 0 0 1 90 692.09399414 cm /P <> BDC q 1 0 0 1 0 3.75 cm q 402.75 0 0 -70.5 0 70.5 cm /X3 Do Q Q EMC Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>