%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 71 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.80000114 0 20.80000114 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.94400024 l -90 87.94400024 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 42 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 414 42 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.98600006 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.97200012 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.95800018 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC /Artifact <> BDC q 1 0 0 1 90 781.31402588 cm -90 0 m 505.29998779 0 l 505.29998779 10.98600006 l -90 10.98600006 l h W n Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 0 cm q 188.3500061 0 0 -41.45000076 0 41.45000076 cm /X2 Do Q Q Q q 1 0 0 1 90 130.4940033 cm q 1 0 0 1 88 0 cm /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [(P)-4(M)-4(S)-4(F)-4(\()-4(1)-3(0)-4(0)-4(m)-4(m)-4(o)-4(l)-4(/)-4(L)-4(\))] TJ ET EMC /P <> BDC BT /FAAABJ 22 Tf 1 0 0 -1 166.32000732 23.67700005 Tm [<0010>-4<0011>-4<0012>] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 232.58399963 23.67700005 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 31.20000076 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 207.6499939 11.65499973 Tm 1 Tr 0.30000001 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 102.23000336 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0013>-4<0014>-4<0015>-4<0016>-4<0017>-4<0018>-3<0019>-4<001A>-4<001B>-4<001C>-4<001D>-4<001E>-4<001F>-4<0020>-4<001D>-4<0021>-3<0022>-4<0023>-4<0024>-4<0025>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 313.07000732 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 62.40000153 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 78 cm /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [<00140015002600270028>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 52.5 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [<0029002A002B002C002D002E002F003000310032>] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 11.65499973 Tm [<001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.15499878 11.65499973 Tm [<00330034>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 138.77999878 11.65499973 Tm [(EDTA)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 159.77999878 11.65499973 Tm [<0038>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 169.93499756 11.65499973 Tm [(E-64)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 190.93499756 11.65499973 Tm [<0038>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 201.08999634 11.65499973 Tm [(NaVO3)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 227.33999634 11.65499973 Tm [<0038>] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.49499512 11.65499973 Tm [<0041002C002B0042>] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.49499512 11.65499973 Tm [<0038>] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.6499939 11.65499973 Tm [<002C0042002B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 321.1499939 11.65499973 Tm [<0038>] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.30499268 11.65499973 Tm [<00430029002A002B002C002D002E0044>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<0045004600470048002C002D0029002A0049004A004B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.5 27.25500107 Tm [<001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.65000153 27.25500107 Tm [<004C004D004E004F004700490029002A0050005100520053001D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.1499939 27.25500107 Tm [<0054>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 268.29998779 27.25500107 Tm [(PMSF)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 291.92498779 27.25500107 Tm [<0055>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 305.04998779 27.25500107 Tm [(Phenylmethanesulfonyl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29998779 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [(fluoride)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 42 42.85499954 Tm [<001E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 52.5 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 57.75 42.85499954 Tm [<002600610062>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 91.875 42.85499954 Tm [(PMSF)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 112.875 42.85499954 Tm [<001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.375 42.85499954 Tm [<0063006400650062>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 168 42.85499954 Tm [(C7H7FO2S)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 210 42.85499954 Tm [<001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.5 42.85499954 Tm [<00630064006A0062>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 265.125 42.85499954 Tm [(174.19)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 296.625 42.85499954 Tm [<001E006D006E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 328.125 42.85499954 Tm [(>99%)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 349.125 42.85499954 Tm [<0054>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 359.625 42.85499954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 140.3999939 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [(PMSF)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 23.625 11.65499973 Tm [<00620071001D007200730074002E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.125 11.65499973 Tm [<001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.58799744 11.65499973 Tm [<0075001D007600770074002E0078002D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.58799744 11.65499973 Tm [<001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.05099487 11.65499973 Tm [<0046002C002D0079007A007B0029002A002B007C00430029002A002B>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 347.05099487 11.65499973 Tm [(\(trypsin\))] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 394.30099487 11.65499973 Tm [<007E0043>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<007F>-42<0080>-42<0029>-42<002A>-42<002B>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 54.70500183 27.25500107 Tm [(\(chymotrypsin\))] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 128.64599609 27.25500107 Tm [<001E>-42<0082>-42<0046>-42<002C>-42<002D>-42<0083>-42<0084>-42<007A>-42<007B>-42<0029>-42<002A>-42<002B>-42<007E>-42<0085>-42<0086>-42<0087>-42<0088>-42<0089>-42<002B>-42<001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 347.46600342 27.25500107 Tm [<008A>-42<0047>-42<0048>-42<008B>-42<006E>-42<0062>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 42.85499954 Tm [(0.1)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 15.75 42.85499954 Tm [<008C>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 26.25 42.85499954 Tm [(1mM)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 42 42.85499954 Tm [<0054>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 52.5 42.85499954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 187.19999695 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 202.80000305 cm /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [<00140015008D008E0028>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 52.5 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 218.3999939 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 382.5 55.20000076 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 280.79998779 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 296.3999939 cm /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [<008F005300900091>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 42 11.65499973 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 47.25 11.65499973 Tm [<0016001700920093>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 89.25 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 94.5 11.65499973 Tm [<0028>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 105 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 312 cm /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [<001C001D0094>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 34.125 11.65499973 Tm [(PMSF)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 57.75 11.65499973 Tm [<009500630096004B00970098001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.25 11.65499973 Tm [<0099009A0096009B0049006A009C009D>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 217.875 11.65499973 Tm [(PMSF)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 238.875 11.65499973 Tm [<001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.375 11.65499973 Tm [<001C008A009E008B006E009F00A0>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 325.5 11.65499973 Tm [(1mM)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 341.25 11.65499973 Tm [<0054>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 351.75 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 327.6000061 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 343.20001221 cm /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [<00A100A200A300A40028>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 52.5 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 358.79998779 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [(PMSF)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 23.625 11.65499973 Tm [<004700A500A600A700A8001E00A900AA008F00530054>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 139.125 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 374.3999939 cm /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [<006200AB00AC004900AD00AE007E00AF00B0001E00B100B200B300B400B5004C00B600B700B800A800B900BA008F00530054>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 262.5 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 390 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 405.6000061 cm /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [<0047004800BB0028>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 42 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.25 11.65499973 Tm [(12)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 60.375 11.65499973 Tm [<00BC00BD004700480054>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 112.875 11.65499973 Tm [(4)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 118.125 11.65499973 Tm [<00BE001E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 139.125 11.65499973 Tm [(3)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 147 11.65499973 Tm [<00BC00BD004700480054>] TJ ET EMC Q Q q 1 0 0 1 90 348.89398193 cm /P <> BDC q 1 0 0 1 0 7.20000076 cm q 382.5 0 0 -48 0 48 cm /X3 Do Q Q EMC Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>