%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 124 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q q 1 0 0 1 0 450 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q Q q 1 0 0 1 65.65000153 93.5490036 cm q 474.8500061 0 0 -20.79999924 0 20.79999924 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 95.16999817 l -90 95.16999817 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.40200043 Tm 0 g [( )] TJ /GS1 gs 0 g [-8750( )] TJ ET q 1 0 0 1 0 11.34899998 cm BT 1 0 0 -1 0 41.42499924 Tm /GS2 gs 0 g [( )] TJ 1 0 0 -1 413.36099243 41.42499924 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 52.77399826 cm BT 1 0 0 -1 0 8.40200043 Tm /GS2 gs 0 g [( )] TJ /GS1 gs 0 g [-8250( )] TJ ET Q q 1 0 0 1 0 63.1230011 cm BT 1 0 0 -1 0 8.40200043 Tm [( )] TJ ET Q q 1 0 0 1 0 73.47200012 cm BT 1 0 0 -1 0 8.40200043 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-500( )] TJ /GS1 gs 0 g [-250( )] TJ /FAAAAI 9 Tf 1 0 0 -1 381.29998779 8.40200043 Tm [( )] TJ ET Q q 1 0 0 1 0 83.82099915 cm Q Q EMC /Artifact <> BDC q 1 0 0 1 90 781.95098877 cm -90 0 m 505.29998779 0 l 505.29998779 10.34899998 l -90 10.34899998 l h W n Q EMC q 1 0 0 1 90 53.89899826 cm q 1 0 0 1 225 -0.00000076 cm q 188.3614502 0 0 -41.42535019 0 41.42535019 cm /X2 Do Q Q Q q 1 0 0 1 90 137.72000122 cm /P <> BDC BT /FAAABH 16 Tf 1 0 0 -1 70.2519989 21.47500038 Tm 2 Tr 0 g 0.45714286 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 166.63600159 21.47500038 Tm 0 Tr [(\(leupeptin,1mg/ml\))] TJ ET EMC /P <> BDC BT /FAAABH 16 Tf 1 0 0 -1 296.85501099 21.47500038 Tm 2 Tr [<0009>-4<000A>-4<000B>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 345.04699707 21.47500038 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 31.20000076 cm /P <> BDC BT 1 0 0 -1 207.6499939 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 102.23000336 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000C>-4<000D>-4<000E>-4<000F>-4<0010>-4<0011>-3<0012>-4<0013>-4<0014>-4<0015>-4<0016>-4<0017>-4<0018>-4<0019>-4<0016>-4<001A>-3<001B>-4<001C>-4<001D>-4<001E>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 313.07000732 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 62.40000153 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 78 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000D>-4<000E>-4<001F>-4<0020>-4<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<002200230005000400240025>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 63 11.65499973 Tm [(\(Protease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.06700134 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.69200134 11.65499973 Tm [(Inhibitor\))] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 144.93299866 11.65499973 Tm [<0026002700280022002300050029002A002B002C002D002E002F0030003100320033003400350036>] TJ ET EMC /P <> BDC BT 1 0 0 -1 354.93301392 11.65499973 Tm [<0017>] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.79998779 11.65499973 Tm [<0015002200230005002B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<0037>-41<0038>-41<0039>-41<003A>-42<003B>-41<003C>-41<003D>-41<003E>-41<0018>-41<0015>-41<0022>-42<0023>-41<003F>-41<002C>-41<0030>-41<0040>-41<0041>-41<0042>-42<0022>-41<0023>-41<0005>-41<0004>-41<0024>-41<0025>-41<0043>-42<0044>-41<0045>-41<0046>-41<0017>-41<0047>-41<0048>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 338.89199829 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 344.57400513 27.25500107 Tm [(EDTA)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 372.99899292 27.25500107 Tm [<0049>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 383.93099976 27.25500107 Tm [(E-64)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 404.77301025 27.25500107 Tm [<0049>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 42.85499954 Tm [(NaVO3)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 32.6590004 42.85499954 Tm [<0049>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 42.80899811 42.85499954 Tm [(Bestati)1(n)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 77.22100067 42.85499954 Tm [<0049>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 87.3710022 42.85499954 Tm [(Leupet)1(in)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 124.69000244 42.85499954 Tm [<0049>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 134.83999634 42.85499954 Tm [(Pepstatin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.33799744 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.96299744 42.85499954 Tm [(A)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 183.54600525 42.85499954 Tm [<0049>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 193.69599915 42.85499954 Tm [(Aprotinin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.5269928 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 239.7769928 42.85499954 Tm [<004A004B004C0043004D000400240022002300300039004E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 365.77700806 42.85499954 Tm [<0017>] TJ ET EMC /P <> BDC BT 1 0 0 -1 375.92700195 42.85499954 Tm [<004F005000510052>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [<0043003000220023005300540055005600160042>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 105 58.45499802 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 156 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 171.6000061 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<000300040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 63 11.65499973 Tm [(\(Leupept)1(in,1mg/ml\))] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 147.85600281 11.65499973 Tm [<0057005800590003000400050006>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 221.35600281 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.60600281 11.65499973 Tm [(Leupet)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.92498779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 269.17498779 11.65499973 Tm [<004A005A005B0017>] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.17498779 11.65499973 Tm [<0018005C>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 334.79998779 11.65499973 Tm [(EDTA)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 362.79299927 11.65499973 Tm [<0042005D000300040005>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<0006000700080026005E005F000700080017006000610056005E0062003100630064>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 178.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.75 27.25500107 Tm [(1-10)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 202.99699402 27.25500107 Tm [<0065>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 213.49699402 27.25500107 Tm [(g/ml)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 232.74899292 27.25500107 Tm [<0017004500160064>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 274.74899292 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.99899292 27.25500107 Tm [(3-5)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 293.9960022 27.25500107 Tm [<0065>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 304.4960022 27.25500107 Tm [(g/ml)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 323.74798584 27.25500107 Tm [<001700660016001A006700680069006A0040>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<005A006B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 42.85499954 Tm [<0049>] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.89900017 42.85499954 Tm [<006C006D002D006E006F002200230041>] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.89900208 42.85499954 Tm [<0017>] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.79799652 42.85499954 Tm [<0070007100720043004D00300073001900740030002200230041>] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.29800415 42.85499954 Tm [<0042>] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.19699097 42.85499954 Tm [<006E006F00750076003000220023004C00770016001A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 377.69699097 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 382.94699097 42.85499954 Tm [(Western)] TJ ET EMC /P <> BDC BT 1 0 0 -1 417.92800903 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [(Blot)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 18.08799934 58.45499802 Tm [<004900780079007A007B007C004A007D007E0042>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 123.08799744 58.45499802 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 234 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 249.6000061 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000D>-4<000E>-4<005A>-4<005B>-4<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 265.20001221 cm /P <> BDC BT 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 -10 280.79998779 cm q 0.25 0.5 m 147.5 0.5 l 147.5 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 50.40299988 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<000D>-4<000E>-4<007F>-4<0080>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 86.54699707 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 147.75 0 cm 0.25 0.5 m 44.75 0.5 l 44.75 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 8.06400013 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0081>-4<0082>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 26.13599968 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 192.75 0 cm 0.25 0.5 m 57.5 0.5 l 57.5 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 5.40299988 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0083>-4<0084>-4<0085>-4<0086>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 41.54700089 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 250.5 0 cm 0.25 0.5 m 50 0.5 l 50 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.171 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0009>-4<000A>-4<000B>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 33.27899933 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 300.75 0 cm 0.25 0.5 m 43 0.5 l 43 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 2.671 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0043>-4<004D>-4<0087>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 29.77899933 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 26.35000038 cm q 0.25 0.5 m 147.5 0.5 l 147.5 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 5.1079998 16.22999954 Tm /GS2 gs 0 g [<000300040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 59.10800171 16.22999954 Tm [(\(Leupept)1(in,1mg/ml\))] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 131.84199524 16.22999954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 147.75 0 cm 0.25 0.5 m 44.75 0.5 l 44.75 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 10.09899998 16.15200043 Tm /GS2 gs 0 g [(1ml)] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 24.10000038 16.15200043 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 192.75 0 cm 0.25 0.5 m 57.5 0.5 l 57.5 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 1.72599995 16.22999954 Tm /GS2 gs 0 g [(-20)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 13.72299957 16.22999954 Tm [<0088>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 22.72299957 16.22999954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 27.22299957 16.22999954 Tm [<0089008A>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 45.22299957 16.22999954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 250.5 0 cm 0.25 0.5 m 50 0.5 l 50 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 10.72500038 16.22999954 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.22500038 16.22999954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 19.72500038 16.22999954 Tm [<008B>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 28.72500038 16.22999954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 300.75 0 cm 0.25 0.5 m 43 0.5 l 43 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 8.35000038 16.22999954 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 15.10000038 16.22999954 Tm [<008C>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 24.10000038 16.22999954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 52.70000076 l S Q q 0.5 w 147.75 0.5 m 147.75 26.35000038 l S Q q 0.5 w 147.75 26.85000038 m 147.75 52.70000076 l S Q q 0.5 w 192.75 0.5 m 192.75 26.35000038 l S Q q 0.5 w 192.75 26.85000038 m 192.75 52.70000076 l S Q q 0.5 w 250.5 0.5 m 250.5 26.35000038 l S Q q 0.5 w 250.5 26.85000038 m 250.5 52.70000076 l S Q q 0.5 w 300.75 0.5 m 300.75 26.35000038 l S Q q 0.5 w 300.75 26.85000038 m 300.75 52.70000076 l S Q q 0.5 w 344 0.5 m 344 52.70000076 l S Q q 0.5 w -0.25 0.25 m 344.25 0.25 l S Q q 0.5 w 0.25 26.60000038 m 343.75 26.60000038 l S Q q 0.5 w -0.25 52.95000076 m 344.25 52.95000076 l S Q Q q 1 0 0 1 0 334 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 349.6000061 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<008D>-4<0056>-4<008E>-4<008F>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm 0 Tr [(\()] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 45.66500092 11.65499973 Tm 2 Tr [<000F>-4<0010>-4<0090>-4<0091>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 87.83300018 11.65499973 Tm 0 Tr [(\))] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 91.33000183 11.65499973 Tm 2 Tr [<0021>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 101.87200165 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 365.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<00490092009300940095009600970098002E00310038001700770099009A009B009C001A009D009E003000080011009F003B009D00A00042>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 299.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 380.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<00490015001600A1001700A200A300A4004E00080030001600A500A600A7000300040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 225.75 11.65499973 Tm [(\(Leupept)1(in,1mg/ml\))] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 310.60598755 11.65499973 Tm [<00170015006000610056005E00620064>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 394.60598755 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 396.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1-10)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 19.24699974 11.65499973 Tm [<0065>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 29.74699974 11.65499973 Tm [(g/ml)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 48.99900055 11.65499973 Tm [<0017004500160064>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 90.99900055 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.24900055 11.65499973 Tm [(3-5)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 110.2460022 11.65499973 Tm [<0065>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 120.7460022 11.65499973 Tm [(g/ml)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 139.9980011 11.65499973 Tm [<0042>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 150.4980011 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 412 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 427.6000061 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<00A8>-4<00A9>-4<00AA>-4<00AB>-4<0021>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 443.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<0049000300040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 78.75 11.65499973 Tm [(\(Leupept)1(in,1mg/ml\))] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 163.60600281 11.65499973 Tm [<004300AC00AD00AE00AF002C001700B0002E008D0056001700B100A100B20089007800B300B400B500B60042>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 394.60598755 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 458.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<004900B700B800B9003000BA00BB00BC00BD00BE0017009500BF00C0007E00C1004F00C2003100C3002C00C400C5008D00560042>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 278.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 474.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 490 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0054>-4<00C6>-4<000D>-4<000E>-4<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 505.6000061 cm /P <> BDC BT 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 521.20001221 cm q 0.25 0.5 m 297.75 0.5 l 297.75 24.5 l 0.25 24.5 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<00220023000500040024002500C700360008>] TJ ET EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 94.5 11.65499973 Tm [(\(100)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.5 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 11.65499973 Tm [(PIC\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 147 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 24.5 cm q 0.25 0.5 m 297.75 0.5 l 297.75 24.5 l 0.25 24.5 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.03999996 Tm /GS2 gs 0 g [(RIPA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.84600067 11.03999996 Tm [( )] TJ ET EMC /P <> BDC BT /FAAADB 10.5 Tf 1 0 0 -1 25.09600067 11.03999996 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 56.59600067 11.03999996 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAADG 10.5 Tf 1 0 0 -1 59.77999878 11.03999996 Tm [<0003>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 70.27999878 11.03999996 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 73.46399689 11.03999996 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49 cm q 0.25 0.5 m 297.75 0.5 l 297.75 24.5 l 0.25 24.5 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.03999996 Tm /GS2 gs 0 g [(BCA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.38500023 11.03999996 Tm [( )] TJ ET EMC /P <> BDC BT /FAAADB 10.5 Tf 1 0 0 -1 22.63500023 11.03999996 Tm [<0006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAADG 10.5 Tf 1 0 0 -1 75.13500214 11.03999996 Tm [<00040005>] TJ ET EMC /P <> BDC BT /FAAADB 10.5 Tf 1 0 0 -1 96.13500214 11.03999996 Tm [<000B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 106.63500214 11.03999996 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 73.5 l S Q q 0.5 w 298 0.5 m 298 73.5 l S Q q 0.5 w -0.25 0.25 m 298.25 0.25 l S Q q 0.5 w 0.25 24.75 m 297.75 24.75 l S Q q 0.5 w 0.25 49.25 m 297.75 49.25 l S Q q 0.5 w -0.25 73.75 m 298.25 73.75 l S Q Q q 1 0 0 1 0 595.20001221 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj 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