%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 125 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.80000114 0 20.80000114 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.94400024 l -90 87.94400024 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 42 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 414 42 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.98600006 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.97200012 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.95800018 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 0 cm q 188.3500061 0 0 -41.45000076 0 41.45000076 cm /X2 Do Q Q Q q 1 0 0 1 90 130.4940033 cm /P <> BDC BT /FAAABH 18 Tf 1 0 0 -1 207.6499939 22.20999908 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 31.20000076 cm /P <> BDC BT /FAAABJ 18 Tf 1 0 0 -1 26.5340004 22.20999908 Tm 2 Tr /GS2 gs 0 g 0.51428574 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAACD 18 Tf 1 0 0 -1 85.25 22.20999908 Tm [(K)] TJ ET EMC /P <> BDC BT /FAAABJ 18 Tf 1 0 0 -1 98.8219986 22.20999908 Tm [<0007>-4<0008>] TJ ET EMC /P <> BDC BT /FAAACD 18 Tf 1 0 0 -1 134.96600342 22.20999908 Tm [(\()-4(P)-4(r)-4(o)-4(t)-4(e)-3(i)-4(n)-4(a)-4(s)-4(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.75799561 22.20999908 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.83000183 22.20999908 Tm [(K)-4(,)-4(2)-4(0)-4(m)-4(g)-3(/)-4(m)-4(l)-4(\))] TJ ET EMC /P <> BDC BT /FAAABJ 18 Tf 1 0 0 -1 334.54998779 22.20999908 Tm [<001B>-4<001C>-4<001D>] TJ ET EMC /P <> BDC BT /FAAACD 18 Tf 1 0 0 -1 388.76599121 22.20999908 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 94.5 62.40000153 cm /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 160.3999939 11.65499973 Tm 1 Tr 0.30000001 w /GS4 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 84 78 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w 0 G [<001E>-4<001F>-4<0020>-4<0021>-4<0022>-4<0023>-3<0024>-4<0025>-4<0026>-4<0027>-4<0028>-4<0029>-4<002A>-4<002B>-4<0028>-4<002C>-3<002D>-4<002E>-4<002F>-4<0030>] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 210.83999634 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 109.19999695 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w 0 G [<001F>-4<0020>-4<0031>-4<0032>-4<0033>] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 124.80000305 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(Proteinase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 11.65499973 Tm [(K)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 65.625 11.65499973 Tm [<0034003500360037000300040005>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 139.125 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.375 11.65499973 Tm [(K)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 149.625 11.65499973 Tm [<0029>] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.55900574 11.65499973 Tm [<002A0038>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 182.18400574 11.65499973 Tm [(DNase)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 208.43400574 11.65499973 Tm [<0029>] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.36799622 11.65499973 Tm [<002A0038>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 238.36799622 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.61799622 11.65499973 Tm [(RNase)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 269.86801147 11.65499973 Tm [<0029>] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.80200195 11.65499973 Tm [<003C003D003E0028002C003F0040004100420003000400430044>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<00450046004700480049004A004B004C>] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 27.25500107 Tm [<004D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.32499695 27.25500107 Tm [<004E004F004A004B004C00500051005200530054>] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.32499695 27.25500107 Tm [<0029>] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.6499939 27.25500107 Tm [<00550056005700580059>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 260.1499939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.7749939 27.25500107 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.5249939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 281.1499939 27.25500107 Tm [<005A005B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.1499939 27.25500107 Tm [<004D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.4750061 27.25500107 Tm [<00050047003F0040005C005D0050>] TJ ET EMC /P <> BDC BT 1 0 0 -1 384.9750061 27.25500107 Tm [<005E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 394.29998779 27.25500107 Tm [<0005005F>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<0060>-1<0033>-2<0061>-1<0038>-1<0062>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 52.56999969 42.85499954 Tm [(>30U/mg,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.56999969 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 99.83399963 42.85499954 Tm [<0066>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 110.34799957 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.61199951 42.85499954 Tm [(37)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 126.12599945 42.85499954 Tm [<0068>-1<0043>-2<0069>-1<006A>-1<0003>-2<0004>-1<0037>-1<006B>-2<004B>-1<0029>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 231.26600647 42.85499954 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.51600647 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 241.77999878 42.85499954 Tm [<0048>-1<006D>-2<006E>-1<003C>-1<0043>-2<001F>-1<004A>-1<0051>-2<006F>-1<002C>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 346.92001343 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 352.18399048 42.85499954 Tm [(1)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 357.44799805 42.85499954 Tm [<0070>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 367.96200562 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 373.22601318 42.85499954 Tm [(M)] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.47601318 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 383.73999023 42.85499954 Tm [<0072>-1<0073>-2<0074>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 415.28201294 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [(Folin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.25 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 31.5 58.45499802 Tm [<00760077004700730057007400780079007A0047000300040005>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 168 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.25 58.45499802 Tm [(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.5 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 183.75 58.45499802 Tm [<00470062>] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.75 58.45499802 Tm [<0029>] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.2749939 58.45499802 Tm [<007B007C0037007D007E007F0080000300040005>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 315.2749939 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.5249939 58.45499802 Tm [(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.7749939 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 331.0249939 58.45499802 Tm [<0005005F0060>] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.5249939 58.45499802 Tm [<005E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.04998779 58.45499802 Tm [<008100820047>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 399.54998779 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 404.79998779 58.45499802 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29998779 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 74.05500031 Tm [<0085008600870037>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 42 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.25 74.05500031 Tm [(pH4.0)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 73.5 74.05500031 Tm [<008A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 84 74.05500031 Tm [(12.5)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 105 74.05500031 Tm [<0029008C008D>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 136.5 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.75 74.05500031 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.25 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 157.5 74.05500031 Tm [<0085008600870037>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 199.5 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.75 74.05500031 Tm [(pH7.5)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 231 74.05500031 Tm [<008A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 241.5 74.05500031 Tm [(8.0)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 257.25 74.05500031 Tm [<005E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 267.75 74.05500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 202.80000305 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<000300040005>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 31.5 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.75 11.65499973 Tm [(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 47.25 11.65499973 Tm [<0047008C008D008F0090009100920037>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 131.25 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.5 11.65499973 Tm [(65)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 147 11.65499973 Tm [<0068>] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.5 11.65499973 Tm [<0029>] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.0249939 11.65499973 Tm [<0094002C>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 184.0249939 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.2749939 11.65499973 Tm [(65)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 199.7749939 11.65499973 Tm [<0068000300040005>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 241.7749939 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.0249939 11.65499973 Tm [(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.2749939 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 257.5249939 11.65499973 Tm [<00950096009700980099009A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.5249939 11.65499973 Tm [<0029>] TJ ET EMC /P <> BDC BT 1 0 0 -1 326.04998779 11.65499973 Tm [<007D009B009C0028008F0090>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 389.04998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 394.29998779 11.65499973 Tm [(50)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 404.79998779 11.65499973 Tm [<008A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 27.25500107 Tm [(55)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 10.5 27.25500107 Tm [<0068>] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 27.25500107 Tm [<0029>] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.93400002 27.25500107 Tm [<0066>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 40.43399811 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.05899811 27.25500107 Tm [(0.2)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 58.80899811 27.25500107 Tm [<008A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 69.30899811 27.25500107 Tm [(1%SDS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.55899811 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 98.18399811 27.25500107 Tm [<0078009F>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 119.18399811 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.80899811 27.25500107 Tm [(10mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.80900574 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 145.43400574 27.25500107 Tm [<00A000A100A20066004700A300A400A5>] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.43400574 27.25500107 Tm [<0029>] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.36799622 27.25500107 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 269.86801147 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.49301147 27.25500107 Tm [(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.74301147 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 280.36801147 27.25500107 Tm [<00A600A700A800A900470005005F0077>] TJ ET EMC /P <> BDC BT 1 0 0 -1 364.36801147 27.25500107 Tm [<0029>] TJ ET EMC /P <> BDC BT 1 0 0 -1 373.30200195 27.25500107 Tm [<0045002800AA00AB>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<00AC00920037>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 31.5 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.75 42.85499954 Tm [(0.05)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 57.75 42.85499954 Tm [<008A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 68.25 42.85499954 Tm [(1mg/ml)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 99.75 42.85499954 Tm [<005E00AD00AE00AF00210028002C00B0002500B100B20029002A00B30028002C002D002E002F00300078006100B4002800B5005E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 372.75 42.85499954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 249.6000061 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.20001221 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w 0 G [<001F>-4<0020>-4<0059>-4<00B6>-4<0033>] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 379.70001221 280.79998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 379.70001221 296.3999939 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 379.70001221 312 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 379.70001221 327.6000061 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 379.70001221 343.20001221 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 358.79998779 cm /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 1 Tr 0.30000001 w /GS4 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 374.3999939 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w 0 G [<00B7>-4<00AB>-4<00B8>-4<00B9>] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 47.45999908 11.65499973 Tm [<0021>-4<0022>-4<00BA>-4<00BB>] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 89.62799835 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 94.91999817 11.65499973 Tm [<0033>] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 105.46199799 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 390 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<004D00BC00BD00BE00230053005400BF00C000B700AB005E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 131.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 405.6000061 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<004D007D009B00AA00AB00AC00920037>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 89.25 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5 11.65499973 Tm [(0.05)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 115.5 11.65499973 Tm [<008A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 126 11.65499973 Tm [(1mg/ml)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 157.5 11.65499973 Tm [<005E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 168 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 421.20001221 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 436.79998779 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w 0 G [<00C1>-4<00C2>-4<00C3>-4<00C4>-4<0033>] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 452.3999939 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<004D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.57499981 11.65499973 Tm [<00BC00BD00C5002800C600C7000800C800C900380081>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 130.07499695 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.32499695 11.65499973 Tm [(SDS)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 151.07499695 11.65499973 Tm [<004D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.3999939 11.65499973 Tm [<00A000A1>] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.3999939 11.65499973 Tm [<004D>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 190.7250061 11.65499973 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.2250061 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 206.4750061 11.65499973 Tm [<00C800C900B300CA>] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.4750061 11.65499973 Tm [<004D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.79998779 11.65499973 Tm [<0091009200C800C900B300CA0050005800A100CB007B00BE0023004700AA>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<00AB00AC0092005E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 42 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 483.6000061 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<004D0045002800AC00920047>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 68.25 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.51100159 11.65499973 Tm [(EDTA)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 92.51100159 11.65499973 Tm [<004D>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 103.01100159 11.65499973 Tm [(Triton)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.51100159 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.77200317 11.65499973 Tm [(X-100)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 164.02200317 11.65499973 Tm [<004D>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 174.52200317 11.65499973 Tm [(Tween)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.77200317 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.03300476 11.65499973 Tm [(20)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 214.53300476 11.65499973 Tm [<004D>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 225.03300476 11.65499973 Tm [(Sarkosyl)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 267.0329895 11.65499973 Tm [<004D00D3007400D400D5000300040005>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 351.0329895 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 354.29400635 11.65499973 Tm [(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 359.54400635 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 362.80499268 11.65499973 Tm [<005F006000D600D7002A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<0094005E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 21 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 514.79998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(3)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<004D009000D800D9008F00DA00DB00DC0029004300D90005005F006000A50099005E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 183.75 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 530.40002441 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(4)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<004D003700DD00DE004700DF00E000E100E200E3002900E400E50053005400E600E700E8007D00E9007700EA00EB00B700AB005E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 278.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 546 cm /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 1 Tr 0.30000001 w /GS4 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 561.59997559 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w 0 G [<0051>-4<0052>-4<001F>-4<0020>-4<0033>] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 577.20001221 cm /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 1 Tr 0.30000001 w /GS4 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 1.79999995 592.79998779 cm q 0.25 0.5 m 369.5 0.5 l 369.5 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 11 Tf 1 0 0 -1 0 11.83899975 Tm /GS2 gs 0 g [<00EC007400ED00EE00EF0008>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 66 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.10000038 cm q 0.25 0.5 m 369.5 0.5 l 369.5 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 11 Tf 1 0 0 -1 0 11.83899975 Tm /GS2 gs 0 g [<00EC007400EE00EF00F000F10008>] TJ ET EMC /P <> BDC BT /FAAABH 11 Tf 1 0 0 -1 77 11.83899975 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACH 11 Tf 1 0 0 -1 82.5 11.83899975 Tm [<00F200F30060>] TJ ET EMC /P <> BDC BT /FAAABH 11 Tf 1 0 0 -1 115.5 11.83899975 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 121 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0 G 0.5 w 0 0.5 m 0 32.20000076 l S Q q /GS1 gs 0 G 0.5 w 369.75 0.5 m 369.75 32.20000076 l S Q q /GS1 gs 0 G 0.5 w -0.25 0.25 m 370 0.25 l S Q q /GS1 gs 0 G 0.5 w 0.25 16.35000038 m 369.5 16.35000038 l S Q q /GS1 gs 0 G 0.5 w -0.25 32.45000076 m 370 32.45000076 l S Q Q Q q 1 0 0 1 90.55000305 420.84399414 cm q 0.25 0.5 m 151 0.5 l 151 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 52.22499847 15.00500011 Tm 0 g [<001F0020003600F4>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 88.22499847 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 151.25 0 cm 0.25 0.5 m 58.25 0.5 l 58.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 14.85000038 15.00500011 Tm 0 g [<00F500F6>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 32.84999847 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 209.75 0 cm 0.25 0.5 m 51.95000076 0.5 l 51.95000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 7.19999981 15.00500011 Tm 0 g [<001B001C001D>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 34.20000076 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 261.95001221 0 cm 0.25 0.5 m 54.59999847 0.5 l 54.59999847 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 8.52499962 15.00500011 Tm 0 g [<0081008200F7>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 35.52500153 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 316.79998779 0 cm 0.25 0.5 m 52.84999847 0.5 l 52.84999847 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 3.1500001 15.00500011 Tm 0 g [<00F800A200F900FA>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 39.15000153 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 23.89999962 cm q 0.25 0.5 m 151 0.5 l 151 31.25 l 0.25 31.25 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 0 18.68000031 Tm 0 g [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 29.06699944 18.68000031 Tm [(K)] TJ ET EMC /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 35.81000137 18.68000031 Tm [<00070008>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 53.6269989 18.68000031 Tm [(\(Pr)1(o)-1(te)1(i)-1(nase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.48500061 18.68000031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.51999664 18.68000031 Tm [(K,)1(20mg)1(/ml)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.44999695 18.68000031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 151.25 0 cm 0.25 0.5 m 58.25 0.5 l 58.25 31.25 l 0.25 31.25 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 8.10000038 18.68000031 Tm 0 g [(1ml/5ml)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 39.59999847 18.68000031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 209.75 0 cm 0.25 0.5 m 51.95000076 0.5 l 51.95000076 31.25 l 0.25 31.25 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.79399967 18.68000031 Tm 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 19.6060009 18.68000031 Tm [<00FB>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.6060009 18.68000031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 261.95001221 0 cm 0.25 0.5 m 54.59999847 0.5 l 54.59999847 31.25 l 0.25 31.25 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 7.33799982 18.68000031 Tm 0 g [(12)] TJ ET EMC /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 18.71100044 18.68000031 Tm [<007E00FC>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 36.71099854 18.68000031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 316.79998779 0 cm 0.25 0.5 m 52.84999847 0.5 l 52.84999847 31.25 l 0.25 31.25 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 9.89999962 18.68000031 Tm 0 g [(-20)] TJ ET EMC /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 23.39999962 18.68000031 Tm [<0068>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 32.40000153 18.68000031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0 G 0.5 w 0 0.5 m 0 55.15000153 l S Q q 0 G 0.5 w 151.25 0.5 m 151.25 23.89999962 l S Q q 0 G 0.5 w 151.25 24.39999962 m 151.25 55.15000153 l S Q q 0 G 0.5 w 209.75 0.5 m 209.75 23.89999962 l S Q q 0 G 0.5 w 209.75 24.39999962 m 209.75 55.15000153 l S Q q 0 G 0.5 w 261.95001221 0.5 m 261.95001221 23.89999962 l S Q q 0 G 0.5 w 261.95001221 24.39999962 m 261.95001221 55.15000153 l S Q q 0 G 0.5 w 316.80001831 0.5 m 316.80001831 23.89999962 l S Q q 0 G 0.5 w 316.80001831 24.39999962 m 316.80001831 55.15000153 l S Q q 0 G 0.5 w 369.8999939 0.5 m 369.8999939 55.15000153 l S Q q 0 G 0.5 w -0.25 0.25 m 370.1499939 0.25 l S Q q 0 G 0.5 w 0.25 24.14999962 m 369.6499939 24.14999962 l S Q q 0 G 0.5 w -0.25 55.40000153 m 370.1499939 55.40000153 l S Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>