%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 119 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.80000114 0 20.80000114 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.94400024 l -90 87.94400024 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 42 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 414 42 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.98600006 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.97200012 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.95800018 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 0 cm q 188.3500061 0 0 -41.45000076 0 41.45000076 cm /X2 Do Q Q Q q 1 0 0 1 90 130.4940033 cm /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 0 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 44 31.20000076 cm /P <> BDC BT /FAAABJ 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr /GS2 gs 0 g 0.62857145 w 0 G [(D)-4(T)-4(T)-4(-)-4(P)-4(B)-3(S)] TJ ET EMC /P <> BDC BT /FAAACB 22 Tf 1 0 0 -1 83.11599731 23.67700005 Tm [<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABJ 22 Tf 1 0 0 -1 127.29199982 23.67700005 Tm [(\()-4(1)-4(0)-4(m)-4(m)-4(o)-3(l)-4(/)-4(L)-4(\))] TJ ET EMC /P <> BDC BT /FAAACB 22 Tf 1 0 0 -1 238.17199707 23.67700005 Tm [<0014>-4<0015>-4<0016>] TJ ET EMC /P <> BDC BT /FAAABJ 22 Tf 1 0 0 -1 304.43600464 23.67700005 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 94.5 62.40000153 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 160.3999939 11.65499973 Tm 1 Tr 0.30000001 w /GS4 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 84 78 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w 0 G [<0017>-4<0018>-4<0019>-4<001A>-4<001B>-4<001C>-3<001D>-4<001E>-4<001F>-4<0020>-4<0021>-4<0022>-4<0023>-4<0024>-4<0021>-4<0025>-3<0026>-4<0027>-4<0028>-4<0029>] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 210.83999634 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 109.19999695 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w 0 G [<0018>-4<0019>-4<002A>-4<002B>-4<002C>] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 124.80000305 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<002D002E002F0009000A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 52.5 11.65499973 Tm [(\(Balanced)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.75 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.51300049 11.65499973 Tm [(Salt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.51300049 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.27600098 11.65499973 Tm [(Solution)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 168.27600098 11.65499973 Tm [<0022>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 178.77600098 11.65499973 Tm [(BSS\))] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 199.77600098 11.65499973 Tm [<00380039003A003B003C003D003E003F0040>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 294.27600098 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.03900146 11.65499973 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.53900146 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 310.30200195 11.65499973 Tm [<0043004400450046004700480049004A003D003E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<004B004C>] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 27.25500107 Tm [<0022>] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.93400002 27.25500107 Tm [<004D004E004F0050004500460047>] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.43399811 27.25500107 Tm [<0044>] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.36799622 27.25500107 Tm [<0051005200530054002D002E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.36799622 27.25500107 Tm [<0044>] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.30200195 27.25500107 Tm [<001B00550039003A003B0056005700580059005A005B0040005C005D005E005F0060002F0061006200480063>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<00210022006400650066001C001D0067006800690039003A003B0056006A004F0050004B006B0040005700580040006C0017005B006D006E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 294 42.85499954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 171.6000061 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(DTT-PBS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.75 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 39.375 11.65499973 Tm [<0009000A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 60.375 11.65499973 Tm [(\(10mmol/L\))] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 112.875 11.65499973 Tm [<006F0070>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 133.875 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.5 11.65499973 Tm [(PBS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.25 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 154.875 11.65499973 Tm [<005E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 165.375 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168 11.65499973 Tm [(10mMDTT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.75 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 207.375 11.65499973 Tm [<00720061>] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.375 11.65499973 Tm [<0022>] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.18400574 11.65499973 Tm [<007300690074>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 269.68399048 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.30899048 11.65499973 Tm [(PBS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.05899048 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 290.68399048 11.65499973 Tm [<0070007500760077>] TJ ET EMC /P <> BDC BT 1 0 0 -1 332.68399048 11.65499973 Tm [<0044>] TJ ET EMC /P <> BDC BT 1 0 0 -1 342.49301147 11.65499973 Tm [<007500760078>] TJ ET EMC /P <> BDC BT 1 0 0 -1 373.99301147 11.65499973 Tm [<0044>] TJ ET EMC /P <> BDC BT 1 0 0 -1 383.80200195 11.65499973 Tm [<00790053007A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<007B002F>] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 27.25500107 Tm [<0044>] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.21699905 27.25500107 Tm [<00790053007B007A002F00720061>] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.71700287 27.25500107 Tm [<0022>] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.93399811 27.25500107 Tm [<0023007C>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 127.93399811 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.18400574 27.25500107 Tm [(Ca2+)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 154.18400574 27.25500107 Tm [<0044>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 160.40100098 27.25500107 Tm [(Mg2+)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 181.40100098 27.25500107 Tm [<0022>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 187.61799622 27.25500107 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.11799622 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 203.36799622 27.25500107 Tm [<004300810082>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 234.86799622 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.11799622 27.25500107 Tm [(7.4)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 255.86799622 27.25500107 Tm [<0022>] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.08499146 27.25500107 Tm [<00860087008800470089008A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.08499146 27.25500107 Tm [<0022>] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.30200195 27.25500107 Tm [<0074008B008C0082>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 373.30200195 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.55200195 27.25500107 Tm [(1)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 383.80200195 27.25500107 Tm [<008D008E0063>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<000A0022008F002100250039003A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 73.5 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.75 42.85499954 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 99.75 42.85499954 Tm [<0092009300940095006E0074008B008C001A002100250096001E00970098002200230099002100250026002700280029009A0073009B0021009C006E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 414.75 42.85499954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 218.3999939 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 234 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w 0 G [<0018>-4<0019>-4<0072>-4<0061>-4<002C>] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 385.6499939 249.6000061 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 385.6499939 265.20001221 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 385.6499939 280.79998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 385.6499939 296.3999939 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 385.6499939 312 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.6000061 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w 0 G [<009D>-4<0063>-4<009E>-4<009F>] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 47.45999908 11.65499973 Tm [<001A>-4<001B>-4<00A0>-4<00A1>] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 89.62799835 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 94.91999817 11.65499973 Tm [<002C>] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 105.46199799 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 343.20001221 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<0044005F005B00A20052002200A300A400200021006E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 120.75 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 358.79998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 374.3999939 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w 0 G [<00A5>-4<00A6>-4<00A7>-4<00A8>-4<002C>] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 390 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<004400A500A600A900AA>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 57.75 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 11.65499973 Tm [(RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.25 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 94.5 11.65499973 Tm [<00AC00AD006E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 126 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 405.6000061 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<0044008200AE00AF004000B000B1005E00B200B3002200B400B50067006800B6006A00B7004B00B800B900BA00BB009D0063006E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 278.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 421.20001221 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 436.79998779 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w 0 G [<00BC>-4<00BD>-4<0018>-4<0019>-4<002C>] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 452.3999939 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 1.79999995 468 cm q 0.25 0.5 m 369.5 0.5 l 369.5 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 11 Tf 1 0 0 -1 0 11.83899975 Tm /GS2 gs 0 g [(Kodak+D-19)] TJ ET EMC /P <> BDC BT /FAAACH 11 Tf 1 0 0 -1 57.75 11.83899975 Tm [<00C100C200C3008C>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 101.75 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.10000038 cm q 0.25 0.5 m 369.5 0.5 l 369.5 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 11 Tf 1 0 0 -1 0 11.83899975 Tm /GS2 gs 0 g [(Kodak+D-19)] TJ ET EMC /P <> BDC BT /FAAACH 11 Tf 1 0 0 -1 57.75 11.83899975 Tm [<00C100C2000A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 90.75 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.20000076 cm q 0.25 0.5 m 369.5 0.5 l 369.5 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 11 Tf 1 0 0 -1 0 11.83899975 Tm /GS2 gs 0 g [(Kodak+F-5)] TJ ET EMC /P <> BDC BT /FAAACH 11 Tf 1 0 0 -1 52.25 11.83899975 Tm [<006B00C200C3008C>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 96.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q 0.25 0.5 m 369.5 0.5 l 369.5 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 11 Tf 1 0 0 -1 0 11.83899975 Tm /GS2 gs 0 g [(Kodak+F-5)] TJ ET EMC /P <> BDC BT /FAAACH 11 Tf 1 0 0 -1 52.25 11.83899975 Tm [<006B00C2000A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 85.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.40000153 cm q 0.25 0.5 m 369.5 0.5 l 369.5 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 11 Tf 1 0 0 -1 0 11.83899975 Tm /GS2 gs 0 g [(RNA)] TJ ET EMC /P <> BDC BT /FAAACH 11 Tf 1 0 0 -1 19.25 11.83899975 Tm [<0094009500C600C7000A>] TJ ET EMC /P <> BDC BT /FAAABH 11 Tf 1 0 0 -1 74.25 11.83899975 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACH 11 Tf 1 0 0 -1 79.75 11.83899975 Tm [<007C00C800C900CA>] TJ ET EMC /P <> BDC BT /FAAABH 11 Tf 1 0 0 -1 123.75 11.83899975 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 129.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 80.5 cm q 0.25 0.5 m 369.5 0.5 l 369.5 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 11 Tf 1 0 0 -1 0 11.83899975 Tm /GS2 gs 0 g [(RNA)] TJ ET EMC /P <> BDC BT /FAAACH 11 Tf 1 0 0 -1 19.25 11.83899975 Tm [<0094009500C600C7000A>] TJ ET EMC /P <> BDC BT /FAAABH 11 Tf 1 0 0 -1 74.25 11.83899975 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACH 11 Tf 1 0 0 -1 79.75 11.83899975 Tm [<005F00C800C900CA>] TJ ET EMC /P <> BDC BT /FAAABH 11 Tf 1 0 0 -1 123.75 11.83899975 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 129.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0 G 0.5 w 0 0.5 m 0 96.59999847 l S Q q /GS1 gs 0 G 0.5 w 369.75 0.5 m 369.75 96.59999847 l S Q q /GS1 gs 0 G 0.5 w -0.25 0.25 m 370 0.25 l S Q q /GS1 gs 0 G 0.5 w 0.25 16.35000038 m 369.5 16.35000038 l S Q q /GS1 gs 0 G 0.5 w 0.25 32.45000076 m 369.5 32.45000076 l S Q q /GS1 gs 0 G 0.5 w 0.25 48.55000305 m 369.5 48.55000305 l S Q q /GS1 gs 0 G 0.5 w 0.25 64.65000153 m 369.5 64.65000153 l S Q q /GS1 gs 0 G 0.5 w 0.25 80.75 m 369.5 80.75 l S Q q /GS1 gs 0 G 0.5 w -0.25 96.84999847 m 370 96.84999847 l S Q Q q 1 0 0 1 0 565.09997559 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 580.70001221 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 596.29998779 cm Q Q q 1 0 0 1 90.55000305 389.64401245 cm q 0.25 0.5 m 144.05000305 0.5 l 144.05000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 48.75 15.00500011 Tm 0 g [<0018001900CB00CC>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 84.75 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 144.30000305 0 cm 0.25 0.5 m 68.5 0.5 l 68.5 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 19.97500038 15.00500011 Tm 0 g [<00CD00CE>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 37.97499847 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 213.05000305 0 cm 0.25 0.5 m 52.84999847 0.5 l 52.84999847 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 7.6500001 15.00500011 Tm 0 g [<001400150016>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 34.65000153 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 266.1499939 0 cm 0.25 0.5 m 55.45000076 0.5 l 55.45000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 8.94999981 15.00500011 Tm 0 g [<004E00CF00D0>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 35.95000076 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 321.8500061 0 cm 0.25 0.5 m 53.75 0.5 l 53.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 3.5999999 15.00500011 Tm 0 g [<00D1005600D200D3>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 39.59999847 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 23.89999962 cm q 0.25 0.5 m 144.05000305 0.5 l 144.05000305 28.60000038 l 0.25 28.60000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 9 17.90500069 Tm 0 g [(DTT-PBS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.75 17.90500069 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 51 17.90500069 Tm [<0009000A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 72 17.90500069 Tm [(\(10mmol/L\))] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 124.5 17.90500069 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 144.30000305 0 cm 0.25 0.5 m 68.5 0.5 l 68.5 28.60000038 l 0.25 28.60000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 15.85000038 17.90500069 Tm 0 g [(100ml)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 42.09999847 17.90500069 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 213.05000305 0 cm 0.25 0.5 m 52.84999847 0.5 l 52.84999847 28.60000038 l 0.25 28.60000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 13.24400043 17.35499954 Tm 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 20.05599976 17.35499954 Tm [<00D4>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 29.05599976 17.35499954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 266.1499939 0 cm 0.25 0.5 m 55.45000076 0.5 l 55.45000076 28.60000038 l 0.25 28.60000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 10.04399967 17.35499954 Tm 0 g [(6)] TJ ET EMC /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 16.8560009 17.35499954 Tm [<00D500D6>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 34.85599899 17.35499954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 321.8500061 0 cm 0.25 0.5 m 53.75 0.5 l 53.75 28.60000038 l 0.25 28.60000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 16.35000038 17.90500069 Tm 0 g [(RT)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 26.85000038 17.90500069 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0 G 0.5 w 0 0.5 m 0 52.5 l S Q q 0 G 0.5 w 144.30000305 0.5 m 144.30000305 23.89999962 l S Q q 0 G 0.5 w 144.30000305 24.39999962 m 144.30000305 52.5 l S Q q 0 G 0.5 w 213.05000305 0.5 m 213.05000305 23.89999962 l S Q q 0 G 0.5 w 213.05000305 24.39999962 m 213.05000305 52.5 l S Q q 0 G 0.5 w 266.1499939 0.5 m 266.1499939 23.89999962 l S Q q 0 G 0.5 w 266.1499939 24.39999962 m 266.1499939 52.5 l S Q q 0 G 0.5 w 321.8500061 0.5 m 321.8500061 23.89999962 l S Q q 0 G 0.5 w 321.8500061 24.39999962 m 321.8500061 52.5 l S Q q 0 G 0.5 w 375.8500061 0.5 m 375.8500061 52.5 l S Q q 0 G 0.5 w -0.25 0.25 m 376.1000061 0.25 l S Q q 0 G 0.5 w 0.25 24.14999962 m 375.6000061 24.14999962 l S Q q 0 G 0.5 w -0.25 52.75 m 376.1000061 52.75 l S Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>