%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 118 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.80000114 0 20.80000114 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.94400024 l -90 87.94400024 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 42 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 414 42 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.98600006 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.97200012 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.95800018 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 0 cm q 188.3500061 0 0 -41.45000076 0 41.45000076 cm /X2 Do Q Q Q q 1 0 0 1 90 130.4940033 cm /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 44.65200043 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [(R)-4(N)-4(A)] TJ ET EMC /P <> BDC BT /FAAABJ 22 Tf 1 0 0 -1 83.41600037 23.67700005 Tm [<0005>-4<0006>-4<0007>-4<0008>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 193.85600281 23.67700005 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAABJ 22 Tf 1 0 0 -1 204.94400024 23.67700005 Tm [<000B>-4<000C>-4<000D>-4<000E>] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 293.29598999 23.67700005 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAABJ 22 Tf 1 0 0 -1 304.38400269 23.67700005 Tm [<0010>-4<0011>-4<0012>] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 370.64801025 23.67700005 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC q 1 0 0 1 94.5 31.20000076 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 160.3999939 11.65499973 Tm 0.30000001 w [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 102.23000336 11.65499973 Tm 2 Tr 0.30000001 w /GS2 gs 0 G [<0013>-4<0014>-4<0015>-4<0016>-4<0017>-4<0018>-3<0019>-4<001A>-4<001B>-4<001C>-4<001D>-4<001E>-4<001F>-4<0020>-4<001D>-4<0021>-3<0022>-4<0023>-4<0024>-4<0025>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 313.07000732 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 62.40000153 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0.30000001 w [( )] TJ ET EMC Q q 1 0 0 1 0 78 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0.30000001 w /GS2 gs 0 G [<0014>-4<0015>-4<0026>-4<0027>-4<0028>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr [<0029>-14<002A>-14<002B>-14<002C>-14<0005>-14<0006>-15<002D>-14<002E>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 85.18399811 11.65499973 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 90.58200073 11.65499973 Tm [<002F>-14<0030>-14<0031>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 122.52600098 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 127.9240036 11.65499973 Tm [<0032>-14<0033>-14<0034>-14<0035>-14<0036>-14<0037>-15<0013>-14<0038>-14<0039>-14<003A>-14<003B>-14<003C>-14<0029>-14<003D>-14<002A>-14<003E>-15<003F>-14<0040>-14<0041>-14<0042>-14<0043>-14<0044>-14<0045>-14<003C>-14<0046>-14<0047>-14<0048>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<0049004A004B004C004D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 27.25500107 Tm [<001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.43399811 27.25500107 Tm [<004E004F>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 82.43399811 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.68399811 27.25500107 Tm [(DNA-DNA)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 124.43399811 27.25500107 Tm [<0052>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 133.36799622 27.25500107 Tm [(DNA-RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.11799622 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 175.36799622 27.25500107 Tm [<002F>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 185.86799622 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.11799622 27.25500107 Tm [(RNA-RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.86799622 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 233.11799622 27.25500107 Tm [<0053003F002B002C004500540055>] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.61801147 27.25500107 Tm [<001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.55200195 27.25500107 Tm [<0056005700580059005A0045>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 378.55200195 27.25500107 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 383.80200195 27.25500107 Tm [<0058005B005C>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<005D0029005E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.5 42.85499954 Tm [<001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.06000137 42.85499954 Tm [<005F>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 51.56000137 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.81000137 42.85499954 Tm [(3H)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 67.30999756 42.85499954 Tm [<0052>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 76.87000275 42.85499954 Tm [(35S)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 92.62000275 42.85499954 Tm [<0052>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 102.18000031 42.85499954 Tm [(32P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.93000031 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 123.18000031 42.85499954 Tm [<006600670068005E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.17999268 42.85499954 Tm [<0052>] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.74000549 42.85499954 Tm [<0069006A005E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.24000549 42.85499954 Tm [<0052>] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.80000305 42.85499954 Tm [<006B006C006D006E006F005B005C005D006A0070>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 320.79998779 42.85499954 Tm [(\)DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 341.79998779 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 347.04998779 42.85499954 Tm [<002F>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 357.54998779 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.79998779 42.85499954 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.54998779 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 383.79998779 42.85499954 Tm [<004000410071>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [<00720029002A00730074>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 58.45499802 Tm [<001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.82500076 58.45499802 Tm [<0075002D002E00760040002F003000310077007800790029002A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.1499939 58.45499802 Tm [<007A>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 207.6499939 58.45499802 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.3999939 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 228.6499939 58.45499802 Tm [<002F>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 239.1499939 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.3999939 58.45499802 Tm [(DNA)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 260.1499939 58.45499802 Tm [<007B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4750061 58.45499802 Tm [<00400041007C007D00050006>] TJ ET EMC /P <> BDC BT 1 0 0 -1 332.4750061 58.45499802 Tm [<001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 341.79998779 58.45499802 Tm [<007E007F0080001D005B005C0081>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.05500031 Tm [<00820083006E008400850086008700820088004200680089002F008A00890047008B008C008D0045>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 210 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.25 74.05500031 Tm [(mRNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.25 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 241.5 74.05500031 Tm [<002F>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 252 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.25 74.05500031 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 278.25 74.05500031 Tm [<0045008F00420075009000910092>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 351.75 74.05500031 Tm /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 171.6000061 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr [<00930029002A000500060094009500960097007C007D009800050006>] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 11.65499973 Tm [<001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.5249939 11.65499973 Tm [<0099001D006F0054009A00450029002A009B0009009C009D009E009F0045006F0054009A005D004C004D00910055>] TJ ET EMC /P <> BDC BT 1 0 0 -1 394.0249939 11.65499973 Tm [<001E>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 399.54998779 11.65499973 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 27.25500107 Tm [<00050006000700080009>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 52.5 27.25500107 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 57.75 27.25500107 Tm [<000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 99.75 27.25500107 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 105 27.25500107 Tm [<00A0009700A1>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 136.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.75 27.25500107 Tm [(PIPES)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 168 27.25500107 Tm [<0052>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 176.93400574 27.25500107 Tm [(1mmol/L)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.68400574 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.93400574 27.25500107 Tm [(EDTA)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 239.93400574 27.25500107 Tm [<0052>] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.86799622 27.25500107 Tm [<00AA00AB002C000C000D000E0087006600AC00AB002C002D004F>] TJ ET EMC /P <> BDC BT 1 0 0 -1 385.36801147 27.25500107 Tm [<001E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 394.30200195 27.25500107 Tm [<00AD001D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<0021>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 10.5 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.75 42.85499954 Tm [(DNA-RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 57.75 42.85499954 Tm [<002F>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 68.25 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.5 42.85499954 Tm [(RNA-RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.25 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 115.5 42.85499954 Tm [<004500050006009200AE00AF00B00016001D002100B1001A00B200B3001E001F0043001D00210022002300240025002F003600B4001D00B5>] TJ ET EMC /P <> BDC BT 1 0 0 -1 409.5 42.85499954 Tm [<0092>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 415.29998779 42.85499954 Tm /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 218.3999939 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 234 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0.30000001 w /GS2 gs 0 G [<0014>-4<0015>-4<002D>-4<004F>-4<0028>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 391.70001221 249.6000061 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 391.70001221 265.20001221 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr /GS4 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 391.70001221 280.79998779 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 391.70001221 296.3999939 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 312 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 327.6000061 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0.30000001 w /GS2 gs 0 G [<00B6>-4<0071>-4<00B7>-4<00B8>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 47.45999908 11.65499973 Tm [<0016>-4<0017>-4<00B9>-4<00BA>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 89.62799835 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 94.91999817 11.65499973 Tm [<0028>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 105.46199799 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 343.20001221 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr [(1)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<00520005000600BB009800BC0039001E00BD002000BE00BF0045>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 141.75 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 11.65499973 Tm [(RNA)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 162.75 11.65499973 Tm [<0092>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 173.25 11.65499973 Tm /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 358.79998779 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr [(2)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<0052001D>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 26.25 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.5 11.65499973 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.25 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 52.5 11.65499973 Tm [<00050006000700080009>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 105 11.65499973 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 110.25 11.65499973 Tm [<000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 152.25 11.65499973 Tm [(\)20)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 168 11.65499973 Tm [<00C1>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 178.5 11.65499973 Tm [(40)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 189 11.65499973 Tm [<00C3>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 199.5 11.65499973 Tm [(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.75 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 210 11.65499973 Tm [<009B00C4>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 231 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.25 11.65499973 Tm [(RNA)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 252 11.65499973 Tm [<001E00C500C600C700C8009B0009008700C900CA>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 357 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.25 11.65499973 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 378 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 383.25 11.65499973 Tm [<00CB00CC00CD>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 414.75 11.65499973 Tm /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 374.3999939 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr [<00CE009B00C40092>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 42 11.65499973 Tm /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 390 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr [(3)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 5.26399994 11.65499973 Tm [<0052>-1<0048>-2<00CF>-1<00D0>-1<00D1>-2<0047>-1<001E>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 78.86199951 11.65499973 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.61199951 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 99.87599945 11.65499973 Tm [<00CB>-1<00CC>-2<0042>-1<0005>-1<0006>-2<0007>-1<0008>-1<0009>-2<00D2>-1<00D3>-1<0087>-2<00D4>-1<00D5>-1<009B>-2<00C4>-1<001E>-1<00D6>-2<0036>-1<003A>-1<00CB>-2<00CC>-1<00D7>-1<00D8>-2<007F>-1<001E>-1<0080>-2<00D9>-1<00CB>-1<00CC>-2<00DA>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<00DB00DC>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 21 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.25 27.25500107 Tm [(60)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 36.75 27.25500107 Tm [<00DE00C500C600C700C8009B00C40092>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 120.75 27.25500107 Tm /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 421.20001221 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 436.79998779 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0.30000001 w /GS2 gs 0 G [<00DF>-4<00E0>-4<00E1>-4<00E2>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.45999908 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 452.3999939 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr [(1)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<005200AE00AF00B0001C001D00BB007600E40029002A00E50029002A00E600E700E80092>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 194.25 11.65499973 Tm /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 468 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr [(2)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<0052007200E900EA004500EB00D500E500EC00ED001E00EE00EF00F000F100F200F300F400F500F6005D00F700F800B600710092>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 278.25 11.65499973 Tm /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 483.6000061 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 Tr /GS4 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 499.20001221 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0.30000001 w /GS2 gs 0 G [<00BE>-4<00F9>-4<0014>-4<0015>-4<0028>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 1.79999995 514.79998779 cm q 0.25 0.5 m 380.75 0.5 l 380.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACI 11 Tf 1 0 0 -1 0 11.83899975 Tm 0 Tr [(RNA)] TJ ET EMC /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 19.25 11.83899975 Tm [<00050006000700080009>] TJ ET EMC /P <> BDC BT /FAAACI 11 Tf 1 0 0 -1 74.25 11.83899975 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 79.75 11.83899975 Tm [<00FA000C000D000E>] TJ ET EMC /P <> BDC BT /FAAACI 11 Tf 1 0 0 -1 123.75 11.83899975 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 129.25 11.65499973 Tm /GS4 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.10000038 cm q 0.25 0.5 m 380.75 0.5 l 380.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACI 11 Tf 1 0 0 -1 0 11.83899975 Tm 0 Tr [(SSC)] TJ ET EMC /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 19.25 11.83899975 Tm [<0007000800FC00B0>] TJ ET EMC /P <> BDC BT /FAAACI 11 Tf 1 0 0 -1 63.25 11.83899975 Tm [(\(20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.75 11.83899975 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.75 11.83899975 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 96.25 11.65499973 Tm /GS4 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.20000076 cm q 0.25 0.5 m 380.75 0.5 l 380.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACI 11 Tf 1 0 0 -1 0 11.83899975 Tm 0 Tr [(SSC)] TJ ET EMC /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 19.25 11.83899975 Tm [<000700080009>] TJ ET EMC /P <> BDC BT /FAAACI 11 Tf 1 0 0 -1 52.25 11.83899975 Tm [(\(20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.75 11.83899975 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.75 11.83899975 Tm [(,pH5.3\))] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 118.25 11.65499973 Tm /GS4 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q 0.25 0.5 m 380.75 0.5 l 380.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACI 11 Tf 1 0 0 -1 0 11.83899975 Tm 0 Tr [(SSC)] TJ ET EMC /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 19.25 11.83899975 Tm [<000700080009>] TJ ET EMC /P <> BDC BT /FAAACI 11 Tf 1 0 0 -1 52.25 11.83899975 Tm [(\(20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.75 11.83899975 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.75 11.83899975 Tm [(,pH7.0\))] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 118.25 11.65499973 Tm /GS4 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.40000153 cm q 0.25 0.5 m 380.75 0.5 l 380.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACI 11 Tf 1 0 0 -1 0 11.83899975 Tm 0 Tr [(SSC)] TJ ET EMC /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 19.25 11.83899975 Tm [<000700080009>] TJ ET EMC /P <> BDC BT /FAAACI 11 Tf 1 0 0 -1 52.25 11.83899975 Tm [(\(20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.75 11.83899975 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.75 11.83899975 Tm [(,pH7.0,RNase+free\))] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 178.75 11.65499973 Tm /GS4 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 80.5 cm q 0.25 0.5 m 380.75 0.5 l 380.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACI 11 Tf 1 0 0 -1 0 11.83899975 Tm 0 Tr [(SSC)] TJ ET EMC /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 19.25 11.83899975 Tm [<000700080009>] TJ ET EMC /P <> BDC BT /FAAACI 11 Tf 1 0 0 -1 52.25 11.83899975 Tm [(\(20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.75 11.83899975 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.75 11.83899975 Tm [(,pH7.4\))] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 118.25 11.65499973 Tm /GS4 gs 0 g [( )] TJ ET EMC Q Q Q q /GS2 gs 0 G 0.5 w 0 0.5 m 0 96.59999847 l S Q q /GS2 gs 0 G 0.5 w 381 0.5 m 381 96.59999847 l S Q q /GS2 gs 0 G 0.5 w -0.25 0.25 m 381.25 0.25 l S Q q /GS2 gs 0 G 0.5 w 0.25 16.35000038 m 380.75 16.35000038 l S Q q /GS2 gs 0 G 0.5 w 0.25 32.45000076 m 380.75 32.45000076 l S Q q /GS2 gs 0 G 0.5 w 0.25 48.55000305 m 380.75 48.55000305 l S Q q /GS2 gs 0 G 0.5 w 0.25 64.65000153 m 380.75 64.65000153 l S Q q /GS2 gs 0 G 0.5 w 0.25 80.75 m 380.75 80.75 l S Q q /GS2 gs 0 G 0.5 w -0.25 96.84999847 m 381.25 96.84999847 l S Q Q q 1 0 0 1 0 611.90002441 cm Q Q q 1 0 0 1 90.55000305 389.64401245 cm q 0.25 0.5 m 146.3999939 0.5 l 146.3999939 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 49.92499924 15.00500011 Tm 0 g [<0014001501080109>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 85.92500305 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 146.6499939 0 cm 0.25 0.5 m 69.59999847 0.5 l 69.59999847 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 20.52499962 15.00500011 Tm 0 g [<010A010B>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 38.52500153 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 216.5 0 cm 0.25 0.5 m 53.70000076 0.5 l 53.70000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 8.07499981 15.00500011 Tm 0 g [<001000110012>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 35.07500076 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 270.45001221 0 cm 0.25 0.5 m 56.34999847 0.5 l 56.34999847 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 9.39999962 15.00500011 Tm 0 g [<0058010C010D>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 36.40000153 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 327.04998779 0 cm 0.25 0.5 m 54.59999847 0.5 l 54.59999847 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 4.0250001 15.00500011 Tm 0 g [<00C9008F003C0046>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 40.02500153 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 23.89999962 cm q 0.25 0.5 m 146.3999939 0.5 l 146.3999939 24.20000076 l 0.25 24.20000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 14.49400043 15.15499973 Tm 0 g [(RN)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.39800072 15.15499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 34.89799881 15.15499973 Tm [<00050006000700080009>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 79.89800262 15.15499973 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 82.6269989 15.15499973 Tm [<000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 118.6269989 15.15499973 Tm [(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.35600281 15.15499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 146.6499939 0 cm 0.25 0.5 m 69.59999847 0.5 l 69.59999847 24.20000076 l 0.25 24.20000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 18.05500031 14.92599964 Tm 0 g [(100m)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.99399948 14.92599964 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 216.5 0 cm 0.25 0.5 m 53.70000076 0.5 l 53.70000076 24.20000076 l 0.25 24.20000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 13.66899967 15.15499973 Tm 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 20.4810009 15.15499973 Tm [<010E>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 29.4810009 15.15499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 270.45001221 0 cm 0.25 0.5 m 56.34999847 0.5 l 56.34999847 24.20000076 l 0.25 24.20000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 10.49400043 15.15499973 Tm 0 g [(6)] TJ ET EMC /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 17.30599976 15.15499973 Tm [<010F0110>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 35.30599976 15.15499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 327.04998779 0 cm 0.25 0.5 m 54.59999847 0.5 l 54.59999847 24.20000076 l 0.25 24.20000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 3.99399996 15.15499973 Tm 0 g [(4)] TJ ET EMC /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 8.55599976 15.15499973 Tm [<00DE>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 17.55599976 15.15499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 22.05599976 15.15499973 Tm [<01110068>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 40.05599976 15.15499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0 G 0.5 w 0 0.5 m 0 48.09999847 l S Q q 0 G 0.5 w 146.6499939 0.5 m 146.6499939 23.89999962 l S Q q 0 G 0.5 w 146.6499939 24.39999962 m 146.6499939 48.09999847 l S Q q 0 G 0.5 w 216.5 0.5 m 216.5 23.89999962 l S Q q 0 G 0.5 w 216.5 24.39999962 m 216.5 48.09999847 l S Q q 0 G 0.5 w 270.45001221 0.5 m 270.45001221 23.89999962 l S Q q 0 G 0.5 w 270.45001221 24.39999962 m 270.45001221 48.09999847 l S Q q 0 G 0.5 w 327.05001831 0.5 m 327.05001831 23.89999962 l S Q q 0 G 0.5 w 327.05001831 24.39999962 m 327.05001831 48.09999847 l S Q q 0 G 0.5 w 381.8999939 0.5 m 381.8999939 48.09999847 l S Q q 0 G 0.5 w -0.25 0.25 m 382.1499939 0.25 l S Q q 0 G 0.5 w 0.25 24.14999962 m 381.6499939 24.14999962 l S Q q 0 G 0.5 w -0.25 48.34999847 m 382.1499939 48.34999847 l S Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>