%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 118 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.80000114 0 20.80000114 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.94400024 l -90 87.94400024 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 42 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 414 42 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.98600006 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.97200012 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.95800018 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 0 cm q 188.3500061 0 0 -41.45000076 0 41.45000076 cm /X2 Do Q Q Q q 1 0 0 1 90 130.4940033 cm q 1 0 0 1 66 0 cm /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [(T)-4(D)] TJ ET EMC /P <> BDC BT /FAAABJ 22 Tf 1 0 0 -1 27.6760006 23.67700005 Tm [<0005>-4<0006>] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 71.85199738 23.67700005 Tm [(\()-4(1)-4(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.11599731 23.67700005 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.20400238 23.67700005 Tm [(,)-4(p)-4(H)-4(7)-4(.)-4(4)-3(\))] TJ ET EMC /P <> BDC BT /FAAABJ 22 Tf 1 0 0 -1 204.82000732 23.67700005 Tm [<0012>-4<0013>-4<0014>] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 271.08401489 23.67700005 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 94.5 31.20000076 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 160.3999939 11.65499973 Tm 1 Tr 0.30000001 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 94.5 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0015>-4<0016>-4<0017>-4<0018>-4<0019>-4<001A>-3<001B>-4<001C>-4<001D>-4<001E>-4<001F>-4<0020>-4<0021>-4<0022>-4<001F>-4<0023>-3<0024>-4<0025>-4<0026>-4<0027>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 210.83999634 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 62.40000153 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 78 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0016>-4<0017>-4<0028>-4<0029>-4<002A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [(Tris\()] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 26.25 11.65499973 Tm [<002E002F003000310032003100300033>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 110.25 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 115.5 11.65499973 Tm [<003400350036>] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 11.65499973 Tm [<0020>] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.1499939 11.65499973 Tm [<0037003800390034>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 197.1499939 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.3999939 11.65499973 Tm [(C4H11NO3)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 244.3999939 11.65499973 Tm [<0020>] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.55000305 11.65499973 Tm [<003E003F0037003800400034>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 315.54998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.79998779 11.65499973 Tm [(121.14,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.54998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 362.79998779 11.65499973 Tm [<0042>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 373.29998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.54998779 11.65499973 Tm [(25)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 389.04998779 11.65499973 Tm [<0044>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 399.54998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 404.79998779 11.65499973 Tm [<0045>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 415.29998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [(pKa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.75 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 19.01099968 27.25500107 Tm [<0034>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 29.51099968 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.77199936 27.25500107 Tm [(8.1)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 48.52199936 27.25500107 Tm [<0020>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 59.02199936 27.25500107 Tm [(Tris)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.02200317 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 83.28299713 27.25500107 Tm [<0049004A0006004B004C004D0049004A004E004F0042>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 198.78300476 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.04400635 27.25500107 Tm [(pH7.0)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 228.29400635 27.25500107 Tm [<0050>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 238.79400635 27.25500107 Tm [(9.2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.54400635 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 257.80499268 27.25500107 Tm [<005200530020001F005400550034005600570049004A0006004B00310058>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<00590037>] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 42.85499954 Tm [<0020>] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.32500076 42.85499954 Tm [<005A005B005C0036005D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.82499695 42.85499954 Tm [<005E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 92.15000153 42.85499954 Tm [(TD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.65000153 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 105.27500153 42.85499954 Tm [<00050006>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 126.27500153 42.85499954 Tm [(\(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.0249939 42.85499954 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.5249939 42.85499954 Tm [(,pH7.4\))] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 189.2749939 42.85499954 Tm [<005F>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 199.7749939 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.3999939 42.85499954 Tm [(100mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.6499939 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.2749939 42.85499954 Tm [(Tris)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 252.2749939 42.85499954 Tm [<0062>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 261.6000061 42.85499954 Tm [(50mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.6000061 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.2250061 42.85499954 Tm [(KCl)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 300.9750061 42.85499954 Tm [<0062>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 310.29998779 42.85499954 Tm [(1.4mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.54998779 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 339.17498779 42.85499954 Tm [(NaCl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 360.17498779 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 362.79998779 42.85499954 Tm [<00640065006600400067>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [<005C00680069005900200028006A>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 73.5 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.75 58.45499802 Tm [(TD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.25 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 94.5 58.45499802 Tm [<000500060020001F0023006B006C006D006E006F0070>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 210 58.45499802 Tm [(\(Western)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.25 58.45499802 Tm [(blot\))] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 283.5 58.45499802 Tm [<007700550034007800790006005E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 357 58.45499802 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 156 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 171.6000061 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0016>-4<0017>-4<0069>-4<0059>-4<002A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 381.6499939 187.19999695 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 381.6499939 202.80000305 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 381.6499939 218.3999939 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 11.65499973 Tm [( )] TJ ET EMC Q q 1 0 0 1 381.6499939 234 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -381.6499939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -360.6499939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -339.6499939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -318.6499939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -297.6499939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -276.6499939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -255.6499939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -234.6499939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -213.6499939 27.25500107 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.20001221 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<007A>-4<0055>-4<007B>-4<007C>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 47.45999908 11.65499973 Tm [<0018>-4<0019>-4<007D>-4<007E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 89.62799835 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 94.91999817 11.65499973 Tm [<002A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 105.46199799 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 280.79998779 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<0062007F008000810082001A00830084007A00550020008500860087>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 152.25 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.5 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 162.75 11.65499973 Tm [<000A0088001E001F005E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 215.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 296.3999939 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 312 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0089>-4<008A>-4<008B>-4<008C>-4<002A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 327.6000061 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<00620034008D008E004B008F0090009100920093002000940095008000810096009700980099009A009B009C009D007A0055005E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 278.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 343.20001221 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 358.79998779 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<003E>-4<009E>-4<0016>-4<0017>-4<002A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 374.3999939 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 1.79999995 390 cm q 0.25 0.5 m 369.5 0.5 l 369.5 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 0 11.83899975 Tm 0 g [(DAB)] TJ ET EMC /P <> BDC BT /FAAACG 11 Tf 1 0 0 -1 19.25 11.83899975 Tm [<00A000A100A200A300A400A500A600A700A800A900AA00AB>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 151.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.10000038 cm q 0.25 0.5 m 369.5 0.5 l 369.5 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 0 11.83899975 Tm 0 g [(CAPS)] TJ ET EMC /P <> BDC BT /FAAACG 11 Tf 1 0 0 -1 24.75 11.83899975 Tm [<00AE00AF0049004A0006>] TJ ET EMC /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 79.75 11.83899975 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACG 11 Tf 1 0 0 -1 85.25 11.83899975 Tm [<0077003700380040>] TJ ET EMC /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 129.25 11.83899975 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 134.75 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.20000076 cm q 0.25 0.5 m 369.5 0.5 l 369.5 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 0 11.83899975 Tm 0 g [(CAPS)] TJ ET EMC /P <> BDC BT /FAAACG 11 Tf 1 0 0 -1 24.75 11.83899975 Tm [<00AE00AF0049004A0006>] TJ ET EMC /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 79.75 11.83899975 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACG 11 Tf 1 0 0 -1 85.25 11.83899975 Tm [<00B00023>] TJ ET EMC /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 110 11.83899975 Tm [(10KD\))] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 137.5 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q 0.25 0.5 m 369.5 0.5 l 369.5 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 0 11.83899975 Tm 0 g [(CAPS)] TJ ET EMC /P <> BDC BT /FAAACG 11 Tf 1 0 0 -1 24.75 11.83899975 Tm [<00AE00AF0049004A0006>] TJ ET EMC /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 79.75 11.83899975 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACG 11 Tf 1 0 0 -1 85.25 11.83899975 Tm [<00B1003700380040>] TJ ET EMC /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 129.25 11.83899975 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 134.75 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.40000153 cm q 0.25 0.5 m 369.5 0.5 l 369.5 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 0 11.83899975 Tm 0 g [(BCIP_NBT)] TJ ET EMC /P <> BDC BT /FAAACG 11 Tf 1 0 0 -1 46.75 11.83899975 Tm [<0036009B0067005C00A600A700A800A900AA00AB>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 156.75 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 80.5 cm q 0.25 0.5 m 369.5 0.5 l 369.5 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 0 11.83899975 Tm 0 g [(4CN)] TJ ET EMC /P <> BDC BT /FAAACG 11 Tf 1 0 0 -1 19.25 11.83899975 Tm [<00A700A800A900AA00AB>] TJ ET EMC /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 74.25 11.83899975 Tm [(\(HRP)] TJ ET EMC /P <> BDC BT /FAAACG 11 Tf 1 0 0 -1 99 11.83899975 Tm [<00A700A8>] TJ ET EMC /P <> BDC BT /FAAACE 11 Tf 1 0 0 -1 121 11.83899975 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 126.5 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0 G 0.5 w 0 0.5 m 0 96.59999847 l S Q q 0 G 0.5 w 369.75 0.5 m 369.75 96.59999847 l S Q q 0 G 0.5 w -0.25 0.25 m 370 0.25 l S Q q 0 G 0.5 w 0.25 16.35000038 m 369.5 16.35000038 l S Q q 0 G 0.5 w 0.25 32.45000076 m 369.5 32.45000076 l S Q q 0 G 0.5 w 0.25 48.55000305 m 369.5 48.55000305 l S Q q 0 G 0.5 w 0.25 64.65000153 m 369.5 64.65000153 l S Q q 0 G 0.5 w 0.25 80.75 m 369.5 80.75 l S Q q 0 G 0.5 w -0.25 96.84999847 m 370 96.84999847 l S Q Q q 1 0 0 1 0 487.1000061 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 502.70001221 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 518.29998779 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 533.90002441 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 549.5 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 565.09997559 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 580.70001221 cm Q Q q 1 0 0 1 90.55000305 327.24398804 cm q 0.25 0.5 m 128.5 0.5 l 128.5 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 40.97499847 15.00500011 Tm 0 g [<0016001700B5006A>] TJ ET EMC /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 76.97499847 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 128.75 0 cm 0.25 0.5 m 71.75 0.5 l 71.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 21.60000038 15.00500011 Tm 0 g [<00B600B7>] TJ ET EMC /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 39.59999847 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 200.75 0 cm 0.25 0.5 m 54 0.5 l 54 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 8.22500038 15.00500011 Tm 0 g [<001200130014>] TJ ET EMC /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 35.22499847 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 255 0 cm 0.25 0.5 m 63.20000076 0.5 l 63.20000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 12.82499981 15.00500011 Tm 0 g [<004C004D00B8>] TJ ET EMC /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 39.82500076 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 318.45001221 0 cm 0.25 0.5 m 53.15000153 0.5 l 53.15000153 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 3.29999995 15.00500011 Tm 0 g [<00B900BA00BB00BC>] TJ ET EMC /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 39.29999924 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 23.89999962 cm q 0.25 0.5 m 128.5 0.5 l 128.5 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 17.35000038 15.00500011 Tm 0 g [(TD)] TJ ET EMC /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 28.60000038 15.00500011 Tm [<00050006>] TJ ET EMC /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 46.59999847 15.00500011 Tm [(\(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.09999847 15.00500011 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.09999847 15.00500011 Tm [(,pH7.4\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.59999847 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 128.75 0 cm 0.25 0.5 m 71.75 0.5 l 71.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 19.35000038 15.00500011 Tm 0 g [(500ml)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.84999847 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 200.75 0 cm 0.25 0.5 m 54 0.5 l 54 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 13.85000038 15.00500011 Tm 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 20.60000038 15.00500011 Tm [<00BD>] TJ ET EMC /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 29.60000038 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 255 0 cm 0.25 0.5 m 63.20000076 0.5 l 63.20000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 11.69999981 15.00500011 Tm 0 g [(12)] TJ ET EMC /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 22.95000076 15.00500011 Tm [<00BE00BF>] TJ ET EMC /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 40.95000076 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 318.45001221 0 cm 0.25 0.5 m 53.15000153 0.5 l 53.15000153 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 14.55000019 15.00500011 Tm 0 g [(4)] TJ ET EMC /P <> BDC BT /FAAACG 9 Tf 1 0 0 -1 19.04999924 15.00500011 Tm [<0044>] TJ ET EMC /P <> BDC BT /FAAACE 9 Tf 1 0 0 -1 28.04999924 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0 G 0.5 w 0 0.5 m 0 47.79999924 l S Q q 0 G 0.5 w 128.75 0.5 m 128.75 23.89999962 l S Q q 0 G 0.5 w 128.75 24.39999962 m 128.75 47.79999924 l S Q q 0 G 0.5 w 200.75 0.5 m 200.75 23.89999962 l S Q q 0 G 0.5 w 200.75 24.39999962 m 200.75 47.79999924 l S Q q 0 G 0.5 w 255 0.5 m 255 23.89999962 l S Q q 0 G 0.5 w 255 24.39999962 m 255 47.79999924 l S Q q 0 G 0.5 w 318.45001221 0.5 m 318.45001221 23.89999962 l S Q q 0 G 0.5 w 318.45001221 24.39999962 m 318.45001221 47.79999924 l S Q q 0 G 0.5 w 371.8500061 0.5 m 371.8500061 47.79999924 l S Q q 0 G 0.5 w -0.25 0.25 m 372.1000061 0.25 l S Q q 0 G 0.5 w 0.25 24.14999962 m 371.6000061 24.14999962 l S Q q 0 G 0.5 w -0.25 48.04999924 m 372.1000061 48.04999924 l S Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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