%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 110 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q q 1 0 0 1 0 450 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q Q q 1 0 0 1 64.90000153 93.5490036 cm q 474.8500061 0 0 -20.79999924 0 20.79999924 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 95.16999817 l -90 95.16999817 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.40200043 Tm 0 g [( )] TJ /GS1 gs 0 g [-8750( )] TJ ET q 1 0 0 1 0 11.34899998 cm BT 1 0 0 -1 0 41.42499924 Tm /GS2 gs 0 g [( )] TJ 1 0 0 -1 413.36099243 41.42499924 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 52.77399826 cm BT 1 0 0 -1 0 8.40200043 Tm /GS2 gs 0 g [( )] TJ /GS1 gs 0 g [-8250( )] TJ ET Q q 1 0 0 1 0 63.1230011 cm BT 1 0 0 -1 0 8.40200043 Tm [( )] TJ ET Q q 1 0 0 1 0 73.47200012 cm BT 1 0 0 -1 0 8.40200043 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-500( )] TJ /GS1 gs 0 g [-250( )] TJ /FAAAAI 9 Tf 1 0 0 -1 381.29998779 8.40200043 Tm [( )] TJ ET Q q 1 0 0 1 0 83.82099915 cm Q Q EMC /Artifact <> BDC q 1 0 0 1 90 781.95098877 cm -90 0 m 505.29998779 0 l 505.29998779 10.34899998 l -90 10.34899998 l h W n Q EMC q 1 0 0 1 90 53.89899826 cm q 1 0 0 1 225 -0.00000076 cm q 188.3614502 0 0 -41.42535019 0 41.42535019 cm /X2 Do Q Q Q q 1 0 0 1 90 137.72000122 cm /P <> BDC BT /FAAABH 16 Tf 1 0 0 -1 50.36999893 21.47500038 Tm 2 Tr 0 g 0.45714286 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-3<0009>-4<000A>-4<000B>] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 194.94599915 21.47500038 Tm 0 Tr [(\(10)] TJ ET EMC /P <> BDC BT /FAAACB 16 Tf 1 0 0 -1 216.27400208 21.47500038 Tm 2 Tr [(?] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 232.33799744 21.47500038 Tm 0 Tr [(,RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.77600098 21.47500038 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.77600098 21.47500038 Tm [(free\))] TJ ET EMC /P <> BDC BT /FAAABH 16 Tf 1 0 0 -1 316.73699951 21.47500038 Tm 2 Tr [<000D>-4<000E>-4<000F>] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 364.9289856 21.47500038 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 31.20000076 cm /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 207.6499939 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 102.23000336 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0010>-4<0011>-4<0012>-4<0013>-4<0014>-4<0015>-3<0016>-4<0017>-4<0018>-4<0019>-4<001A>-4<001B>-4<001C>-4<001D>-4<001A>-4<001E>-3<001F>-4<0020>-4<0021>-4<0022>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 313.07000732 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 62.40000153 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 78 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0011>-4<0012>-4<0023>-4<0024>-4<0025>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<0003>-2<0004>-1<0005>-2<0006>-1<0007>-2<0008>-2<0009>-1<000A>-2<000B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 94.65299988 11.65499973 Tm [(\(10)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 108.66699982 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 119.18399811 11.65499973 Tm [(,RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.80200195 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.44400024 11.65499973 Tm [(free\))] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 172.27200317 11.65499973 Tm [<0026>-2<0027>-1<0028>-2<0029>-1<002A>-2<002B>-2<002C>-1<002D>-2<002E>-2<002F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 277.44198608 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.70901489 11.65499973 Tm [(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.20901489 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 298.47601318 11.65499973 Tm [<0030>-2<0031>-1<0032>-2<002F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 340.54400635 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 345.81100464 11.65499973 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 367.98001099 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 373.24700928 11.65499973 Tm [<0033>-2<0008>-1<0009>-2<000A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<000B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.5 27.25500107 Tm [<0034>] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.48200035 27.25500107 Tm [<0010003300080009000A000B0035003600370038>] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.48200226 27.25500107 Tm [<0039>] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.46400452 27.25500107 Tm [<003A0003003B003C003D003E003F0040>] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.46400452 27.25500107 Tm [<001B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.44599915 27.25500107 Tm [<004100420043>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 260.9460144 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.1960144 27.25500107 Tm [(1)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 271.4460144 27.25500107 Tm [<000C004400450046004700480049004A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 355.4460144 27.25500107 Tm [<001B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 365.42800903 27.25500107 Tm [<000700080044004B004C>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<004D001B004E004F00500051005200530054001B0055005600570058003E003F002F0059001A0034>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 210 42.85499954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 140.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 156 cm /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<0003000400050006000700080009000A000B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 94.5 11.65499973 Tm [(\(10)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 108.49700165 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 118.99700165 11.65499973 Tm [(,RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.61500549 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.24000549 11.65499973 Tm [(free\))] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 172.05099487 11.65499973 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 182.55099487 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.80099487 11.65499973 Tm [(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.30099487 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 203.55099487 11.65499973 Tm [<003000310032002F005A000B001B005B005C005D0036003700380039003A0003003B003C>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 392.55099487 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 397.80099487 11.65499973 Tm [(FF)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 409.48001099 11.65499973 Tm [<0039>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<005E005F006000610062001B004100420043>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 94.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.75 27.25500107 Tm [(1)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 105 27.25500107 Tm [<000C0019001A0034>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 147 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 187.19999695 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 202.80000305 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0011>-4<0012>-4<0061>-4<0062>-4<0025>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 218.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 -10 234 cm q 0.25 0.5 m 161 0.5 l 161 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 57.15299988 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0011>-4<0012>-4<0063>-4<0064>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 93.29699707 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 161.25 0 cm 0.25 0.5 m 42.5 0.5 l 42.5 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.93900013 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0065>-4<0066>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 25.01099968 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 204 0 cm 0.25 0.5 m 51.5 0.5 l 51.5 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 2.40300012 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0067>-4<0068>-4<0069>-4<006A>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 38.54700089 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 255.75 0 cm 0.25 0.5 m 44.75 0.5 l 44.75 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 3.546 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<000D>-4<000E>-4<000F>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 30.65399933 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 300.75 0 cm 0.25 0.5 m 43 0.5 l 43 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 2.671 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<006B>-4<006C>-4<006D>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 29.77899933 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 26.35000038 cm q 0.25 0.5 m 161 0.5 l 161 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 1.48899996 16.22999954 Tm /GS2 gs 0 g [<0003000400050006000700080009000A000B>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 82.48899841 16.22999954 Tm [(\(10)] TJ ET EMC /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 94.48600006 16.22999954 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 103.48600006 16.22999954 Tm [(,RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.72999573 16.22999954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.97999573 16.22999954 Tm [(free\))] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 148.96000671 16.22999954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 161.25 0 cm 0.25 0.5 m 42.5 0.5 l 42.5 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 8.97399998 16.15200043 Tm /GS2 gs 0 g [(5ml)] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 22.97500038 16.15200043 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 204 0 cm 0.25 0.5 m 51.5 0.5 l 51.5 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 3.4749999 16.22999954 Tm /GS2 gs 0 g [(RT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.97500038 16.22999954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 19.47500038 16.22999954 Tm [<006E006F>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 37.47499847 16.22999954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 255.75 0 cm 0.25 0.5 m 44.75 0.5 l 44.75 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 8.10000038 16.22999954 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.60000038 16.22999954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 17.10000038 16.22999954 Tm [<0070>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 26.10000038 16.22999954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 300.75 0 cm 0.25 0.5 m 43 0.5 l 43 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 8.35000038 16.22999954 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 15.10000038 16.22999954 Tm [<0071>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 24.10000038 16.22999954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 52.70000076 l S Q q 0.5 w 161.25 0.5 m 161.25 26.35000038 l S Q q 0.5 w 161.25 26.85000038 m 161.25 52.70000076 l S Q q 0.5 w 204 0.5 m 204 26.35000038 l S Q q 0.5 w 204 26.85000038 m 204 52.70000076 l S Q q 0.5 w 255.75 0.5 m 255.75 26.35000038 l S Q q 0.5 w 255.75 26.85000038 m 255.75 52.70000076 l S Q q 0.5 w 300.75 0.5 m 300.75 26.35000038 l S Q q 0.5 w 300.75 26.85000038 m 300.75 52.70000076 l S Q q 0.5 w 344 0.5 m 344 52.70000076 l S Q q 0.5 w -0.25 0.25 m 344.25 0.25 l S Q q 0.5 w 0.25 26.60000038 m 343.75 26.60000038 l S Q q 0.5 w -0.25 52.95000076 m 344.25 52.95000076 l S Q Q q 1 0 0 1 0 287.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 302.79998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0072>-4<0059>-4<0073>-4<0074>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm 0 Tr [(\()] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 45.66500092 11.65499973 Tm 2 Tr [<0013>-4<0014>-4<0075>-4<0076>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 87.83300018 11.65499973 Tm 0 Tr [(\))] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 91.33000183 11.65499973 Tm 2 Tr [<0025>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 101.87200165 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 318.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<0039007700780079>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 47.25 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 11.65499973 Tm [(9)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 57.75 11.65499973 Tm [<007A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 68.25 11.65499973 Tm [(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.16699982 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.79199982 11.65499973 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.96099854 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 101.21099854 11.65499973 Tm [<000800120007007B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 143.21099854 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.46099854 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 153.71099854 11.65499973 Tm [<007A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 164.21099854 11.65499973 Tm [(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.12800598 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 172.37800598 11.65499973 Tm [<0003000400050006000700080009000A000B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 266.87799072 11.65499973 Tm [(\(10)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 280.875 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 291.375 11.65499973 Tm [(,RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 321.99301147 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.61801147 11.65499973 Tm [(free\))] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 344.4289856 11.65499973 Tm [<002F0045007C001B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 386.4289856 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 391.6789856 11.65499973 Tm [<007D007E>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 412.6789856 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 334 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.16900063 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 27.41900063 11.65499973 Tm [<00080012007F0003000400050006000700080009000A000B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 153.41900635 11.65499973 Tm [(\(10)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 167.41600037 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 177.91600037 11.65499973 Tm [(,RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.53399658 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.15899658 11.65499973 Tm [(free\))] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 230.97000122 11.65499973 Tm [<0034>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 241.47000122 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 349.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<0039008000810007005600060082001B005700580034>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 120.75 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 365.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 380.79998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0083>-4<0084>-4<0085>-4<0086>-4<0025>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 396.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<00390087008800790089002F0019001A008A008B008C001B00530035002B002C008D008E0044008F0019001A0034>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 246.75 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 412 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<003900900091002A00920093006E0094>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 89.25 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5 11.65499973 Tm [(RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.49299622 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 127.74299622 11.65499973 Tm [<009500960034>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 159.24299622 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 427.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(3)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<0039003D00970098002F0099009A007F009B009C001B009D009E00900091009F00A000A10027008900A200A300A4007200590034>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 278.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 443.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 458.79998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<00A5>-4<00A6>-4<0011>-4<0012>-4<0025>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 474.3999939 cm /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 490 cm q 0.25 0.5 m 297.75 0.5 l 297.75 24.45000076 l 0.25 24.45000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(Tris-MOPS-SDS)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 70.875 11.65499973 Tm [<005700580009000A000B>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 123.375 11.65499973 Tm [(\(20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.125 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.625 11.65499973 Tm [(,pH8.3\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 186.375 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 24.45000076 cm q 0.25 0.5 m 297.75 0.5 l 297.75 24.45000076 l 0.25 24.45000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(Tris-Tricine)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 65.625 11.65499973 Tm [<00BE00BF0009000A000B>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 118.125 11.65499973 Tm [(\(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.625 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.125 11.65499973 Tm [(,pH8.9\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 175.875 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.90000153 cm q 0.25 0.5 m 297.75 0.5 l 297.75 24.45000076 l 0.25 24.45000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(Tris-Tricine)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 65.625 11.65499973 Tm [<00C200BF0009000A000B>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 118.125 11.65499973 Tm [(\(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.625 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.125 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 144.375 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 73.34999847 cm q 0.25 0.5 m 297.75 0.5 l 297.75 24.45000076 l 0.25 24.45000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(Tris-)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 26.25 11.65499973 Tm [<005E00C300C40057005800C50040>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 99.75 11.65499973 Tm [(\(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.25 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.75 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 126 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 97.80000305 l S Q q 0.5 w 298 0.5 m 298 97.80000305 l S Q q 0.5 w -0.25 0.25 m 298.25 0.25 l S Q q 0.5 w 0.25 24.70000076 m 297.75 24.70000076 l S Q q 0.5 w 0.25 49.15000153 m 297.75 49.15000153 l S Q q 0.5 w 0.25 73.6000061 m 297.75 73.6000061 l S Q q 0.5 w -0.25 98.05000305 m 298.25 98.05000305 l S Q Q q 1 0 0 1 0 588.29998779 cm /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 603.90002441 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>