%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 118 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q q 1 0 0 1 0 450 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q Q q 1 0 0 1 65.65000153 93.5490036 cm q 474.8500061 0 0 -20.79999924 0 20.79999924 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 95.16999817 l -90 95.16999817 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.40200043 Tm 0 g [( )] TJ /GS1 gs 0 g [-8750( )] TJ ET q 1 0 0 1 0 11.34899998 cm BT 1 0 0 -1 0 41.42499924 Tm /GS2 gs 0 g [( )] TJ 1 0 0 -1 413.36099243 41.42499924 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 52.77399826 cm BT 1 0 0 -1 0 8.40200043 Tm /GS2 gs 0 g [( )] TJ /GS1 gs 0 g [-8250( )] TJ ET Q q 1 0 0 1 0 63.1230011 cm BT 1 0 0 -1 0 8.40200043 Tm [( )] TJ ET Q q 1 0 0 1 0 73.47200012 cm BT 1 0 0 -1 0 8.40200043 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-500( )] TJ /GS1 gs 0 g [-250( )] TJ /FAAAAI 9 Tf 1 0 0 -1 381.29998779 8.40200043 Tm [( )] TJ ET Q q 1 0 0 1 0 83.82099915 cm Q Q EMC /Artifact <> BDC q 1 0 0 1 90 781.95098877 cm -90 0 m 505.29998779 0 l 505.29998779 10.34899998 l -90 10.34899998 l h W n Q EMC q 1 0 0 1 90 53.89899826 cm q 1 0 0 1 225 -0.00000076 cm q 188.3614502 0 0 -41.42535019 0 41.42535019 cm /X2 Do Q Q Q q 1 0 0 1 90 137.72000122 cm /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 61.38899994 21.47500038 Tm 0 g [(MOPS)] TJ ET EMC /P <> BDC BT /FAAABH 16 Tf 1 0 0 -1 111.60800171 21.47500038 Tm 2 Tr 0.45714286 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 191.92799377 21.47500038 Tm 0 Tr [(\(1)] TJ ET EMC /P <> BDC BT /FAAACB 16 Tf 1 0 0 -1 205.2559967 21.47500038 Tm 2 Tr [(?] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 221.32000732 21.47500038 Tm 0 Tr [(,RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.75799561 21.47500038 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.75799561 21.47500038 Tm [(free\))] TJ ET EMC /P <> BDC BT /FAAABH 16 Tf 1 0 0 -1 305.71899414 21.47500038 Tm 2 Tr [<0009>-4<000A>-4<000B>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 353.91101074 21.47500038 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 31.20000076 cm /P <> BDC BT 1 0 0 -1 207.6499939 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 102.23000336 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000C>-4<000D>-4<000E>-4<000F>-4<0010>-4<0011>-3<0012>-4<0013>-4<0014>-4<0015>-4<0016>-4<0017>-4<0018>-4<0019>-4<0016>-4<001A>-3<001B>-4<001C>-4<001D>-4<001E>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 313.07000732 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 62.40000153 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 78 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000D>-4<000E>-4<001F>-4<0020>-4<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(MOPS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.59799957 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 34.63899994 11.65499973 Tm [<0022>-75<001A>-76<0023>-75<0024>-75<0005>-76<0006>-75<0025>-75<0017>-76<0026>-75<0027>-75<0016>-76<001A>-75<0028>-75<0029>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 192.71299744 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.7539978 11.65499973 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.92300415 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 226.96400452 11.65499973 Tm [<0003>-75<0004>-76<0005>-75<0006>-75<0007>-76<0017>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 294.70999146 11.65499973 Tm [(3-\(N-)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 318.82400513 11.65499973 Tm [<002A>-75<002B>-76<002C>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 352.69699097 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 356.98498535 11.65499973 Tm [<002D>-75<002E>-76<002F>-75<001F>-75<0030>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 27.25500107 Tm [(MOPS)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 28.59799957 27.25500107 Tm [<00170031003200330034>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 81.09799957 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.34799957 27.25500107 Tm [(C7H15NO4S)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 142.93899536 27.25500107 Tm [<00170031003200350034>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 195.43899536 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.68899536 27.25500107 Tm [(209.26)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 229.56399536 27.25500107 Tm [<0017>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 240.06399536 27.25500107 Tm [(CAS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.48999023 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 265.73999023 27.25500107 Tm [<00360034>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 286.73999023 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.98999023 27.25500107 Tm [(1132-61-2)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 335.73300171 27.25500107 Tm [<0037>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 346.23300171 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 124.80000305 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 140.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(MOPS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.59799957 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 33.97700119 11.65499973 Tm [<0003>-12<0004>-13<0005>-12<0006>-12<0007>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 87.12200165 11.65499973 Tm [(\(1)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 95.9980011 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 106.6269989 11.65499973 Tm [(,RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.24499512 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.99899292 11.65499973 Tm [(free\))] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 159.93899536 11.65499973 Tm [<0038>-12<0039>-13<003A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 191.82600403 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.20500183 11.65499973 Tm [(MOPS)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 225.93200684 11.65499973 Tm [<003B>-12<003C>-13<002F>-12<003D>-12<003B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 279.07699585 11.65499973 Tm [(EDTA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.07000732 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 312.44900513 11.65499973 Tm [<003E>-12<003F>-13<0040>-12<0017>] TJ ET EMC /P <> BDC BT 1 0 0 -1 354.96499634 11.65499973 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 368.21899414 11.65499973 Tm [(RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 396.21200562 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 398.96600342 11.65499973 Tm [(free)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.27999878 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 0 27.25500107 Tm [<004100420017003800390016001A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 73.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.75 27.25500107 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.91899872 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 106.16899872 27.25500107 Tm [<000300040037004300440025000F0016001A00450013004600470017001800480016001A001B001C001D001E0049004A004B0016004C0037>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 400.16900635 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 171.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 187.19999695 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000D>-4<000E>-4<003F>-4<0040>-4<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 202.80000305 cm /P <> BDC BT 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 -10 218.3999939 cm q 0.25 0.5 m 147.5 0.5 l 147.5 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 50.40299988 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<000D>-4<000E>-4<004D>-4<0030>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 86.54699707 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 147.75 0 cm 0.25 0.5 m 48.84999847 0.5 l 48.84999847 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 10.11400032 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<004E>-4<004F>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 28.18600082 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 196.8500061 0 cm 0.25 0.5 m 53.40000153 0.5 l 53.40000153 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 3.35299993 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0050>-4<0051>-4<0052>-4<0053>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 39.49700165 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 250.5 0 cm 0.25 0.5 m 50 0.5 l 50 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.171 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0009>-4<000A>-4<000B>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 33.27899933 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 300.75 0 cm 0.25 0.5 m 43 0.5 l 43 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 2.671 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0054>-4<0055>-4<0056>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 29.77899933 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 26.35000038 cm q 0.25 0.5 m 147.5 0.5 l 147.5 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 0.48300001 16.22999954 Tm /GS2 gs 0 g [(MOPS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.99600029 16.22999954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 29.49600029 16.22999954 Tm [<00030004000500060007>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 74.4960022 16.22999954 Tm [(\(1)] TJ ET EMC /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 81.99299622 16.22999954 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 90.99299622 16.22999954 Tm [(,RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.23699951 16.22999954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.48699951 16.22999954 Tm [(free\))] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 136.46699524 16.22999954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 147.75 0 cm 0.25 0.5 m 48.84999847 0.5 l 48.84999847 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 7.64900017 16.15200043 Tm /GS2 gs 0 g [(500ml)] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 30.64999962 16.15200043 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 196.8500061 0 cm 0.25 0.5 m 53.40000153 0.5 l 53.40000153 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 15.67500019 16.15200043 Tm /GS2 gs 0 g [(RT)] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 27.17499924 16.15200043 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 250.5 0 cm 0.25 0.5 m 50 0.5 l 50 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 10.72500038 16.22999954 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.22500038 16.22999954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 19.72500038 16.22999954 Tm [<0057>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 28.72500038 16.22999954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 300.75 0 cm 0.25 0.5 m 43 0.5 l 43 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 3.8499999 16.22999954 Tm /GS2 gs 0 g [(6)] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 10.60000038 16.22999954 Tm [<00580059>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 28.60000038 16.22999954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 52.70000076 l S Q q 0.5 w 147.75 0.5 m 147.75 26.35000038 l S Q q 0.5 w 147.75 26.85000038 m 147.75 52.70000076 l S Q q 0.5 w 196.8500061 0.5 m 196.8500061 26.35000038 l S Q q 0.5 w 196.8500061 26.85000038 m 196.8500061 52.70000076 l S Q q 0.5 w 250.5 0.5 m 250.5 26.35000038 l S Q q 0.5 w 250.5 26.85000038 m 250.5 52.70000076 l S Q q 0.5 w 300.75 0.5 m 300.75 26.35000038 l S Q q 0.5 w 300.75 26.85000038 m 300.75 52.70000076 l S Q q 0.5 w 344 0.5 m 344 52.70000076 l S Q q 0.5 w -0.25 0.25 m 344.25 0.25 l S Q q 0.5 w 0.25 26.60000038 m 343.75 26.60000038 l S Q q 0.5 w -0.25 52.95000076 m 344.25 52.95000076 l S Q Q q 1 0 0 1 0 271.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 287.20001221 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<005A>-4<005B>-4<005C>-4<005D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm 0 Tr [(\()] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 45.66500092 11.65499973 Tm 2 Tr [<000F>-4<0010>-4<005E>-4<005F>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 87.83300018 11.65499973 Tm 0 Tr [(\))] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 91.33000183 11.65499973 Tm 2 Tr [<0021>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 101.87200165 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 302.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<003B00600061001500160037>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 68.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 318.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 334 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0062>-4<0063>-4<0064>-4<0065>-4<0021>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 349.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<003B0066006700680069006A001500160035006B006C0017006D006E0048006F0031007000710072001500160037>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 246.75 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 365.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<003B0005000600070073007400710075007600770017007800770079007A007B006D006E001500160017007C0079007D007E00710018007F001500160037>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 330.75 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 380.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(3)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<003B003400800081006A0082007B00830084008500170086008700880089008A008B008C008D0069008E008F0090005A005B0037>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 278.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 396.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 412 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0091>-4<0092>-4<000D>-4<000E>-4<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.95999908 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 427.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 443.20001221 cm q 0.25 0.5 m 297.75 0.5 l 297.75 25.64999962 l 0.25 25.64999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(Tris-)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 26.25 11.65499973 Tm [<00980099002F00030004009A0025>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 99.75 11.65499973 Tm [(\(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.25 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.75 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 126 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 25.64999962 cm q 0.25 0.5 m 297.75 0.5 l 297.75 25.64999962 l 0.25 25.64999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(Tris-)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 26.25 11.65499973 Tm [<00980099002F00030004009A0025>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 99.75 11.65499973 Tm [(\(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.25 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.75 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 126 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 51.29999924 cm q 0.25 0.5 m 297.75 0.5 l 297.75 25.64999962 l 0.25 25.64999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(Tris-Tricine)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 65.625 11.65499973 Tm [<00A200A3000500060007>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 118.125 11.65499973 Tm [(\(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.625 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.125 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 144.375 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 76.94999695 cm q 0.25 0.5 m 297.75 0.5 l 297.75 25.64999962 l 0.25 25.64999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(Tris-Tricine)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 65.625 11.65499973 Tm [<00A400A3000500060007>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 118.125 11.65499973 Tm [(\(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.625 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.125 11.65499973 Tm [(,pH8.9\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 175.875 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 102.59999847 cm q 0.25 0.5 m 297.75 0.5 l 297.75 25.64999962 l 0.25 25.64999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(Tris-MOPS-SDS)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 70.875 11.65499973 Tm [<00030004000500060007>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 123.375 11.65499973 Tm [(\(20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.125 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.625 11.65499973 Tm [(,pH8.3\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 186.375 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 128.25 cm q 0.25 0.5 m 297.75 0.5 l 297.75 25.64999962 l 0.25 25.64999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(Tris-MOPS-SDS)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 70.875 11.65499973 Tm [<00030004009A0025>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 112.875 11.65499973 Tm [(\(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.375 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.875 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 139.125 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 153.8999939 l S Q q 0.5 w 298 0.5 m 298 153.8999939 l S Q q 0.5 w -0.25 0.25 m 298.25 0.25 l S Q q 0.5 w 0.25 25.89999962 m 297.75 25.89999962 l S Q q 0.5 w 0.25 51.54999924 m 297.75 51.54999924 l S Q q 0.5 w 0.25 77.19999695 m 297.75 77.19999695 l S Q q 0.5 w 0.25 102.84999847 m 297.75 102.84999847 l S Q q 0.5 w 0.25 128.5 m 297.75 128.5 l S Q q 0.5 w -0.25 154.1499939 m 298.25 154.1499939 l S Q Q q 1 0 0 1 0 597.59997559 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 613.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>