%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 108 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q q 1 0 0 1 0 450 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q Q q 1 0 0 1 65.65000153 93.5490036 cm q 474.8500061 0 0 -20.79999924 0 20.79999924 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 95.16999817 l -90 95.16999817 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.40200043 Tm 0 g [( )] TJ /GS1 gs 0 g [-8750( )] TJ ET q 1 0 0 1 0 11.34899998 cm BT 1 0 0 -1 0 41.42499924 Tm /GS2 gs 0 g [( )] TJ 1 0 0 -1 413.36099243 41.42499924 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 52.77399826 cm BT 1 0 0 -1 0 8.40200043 Tm /GS2 gs 0 g [( )] TJ /GS1 gs 0 g [-8250( )] TJ ET Q q 1 0 0 1 0 63.1230011 cm BT 1 0 0 -1 0 8.40200043 Tm [( )] TJ ET Q q 1 0 0 1 0 73.47200012 cm BT 1 0 0 -1 0 8.40200043 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-500( )] TJ /GS1 gs 0 g [-250( )] TJ /FAAAAI 9 Tf 1 0 0 -1 381.29998779 8.40200043 Tm [( )] TJ ET Q q 1 0 0 1 0 83.82099915 cm Q Q EMC /Artifact <> BDC q 1 0 0 1 90 781.95098877 cm -90 0 m 505.29998779 0 l 505.29998779 10.34899998 l -90 10.34899998 l h W n Q EMC q 1 0 0 1 90 53.89899826 cm q 1 0 0 1 225 -0.00000076 cm q 188.3614502 0 0 -41.42535019 0 41.42535019 cm /X2 Do Q Q Q q 1 0 0 1 90 137.72000122 cm /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 97.8030014 21.47500038 Tm 0 g [(GTBE)] TJ ET EMC /P <> BDC BT /FAAABH 16 Tf 1 0 0 -1 146.26400757 21.47500038 Tm 2 Tr 0.45714286 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 226.58399963 21.47500038 Tm 0 Tr [(\(10)] TJ ET EMC /P <> BDC BT /FAAACB 16 Tf 1 0 0 -1 247.91200256 21.47500038 Tm 2 Tr [(?] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 263.97601318 21.47500038 Tm 0 Tr [(\))] TJ ET EMC /P <> BDC BT /FAAABH 16 Tf 1 0 0 -1 269.3039856 21.47500038 Tm 2 Tr [<0009>-4<000A>-4<000B>] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 317.4960022 21.47500038 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 31.20000076 cm /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 207.6499939 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 102.23000336 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000C>-4<000D>-4<000E>-4<000F>-4<0010>-4<0011>-3<0012>-4<0013>-4<0014>-4<0015>-4<0016>-4<0017>-4<0018>-4<0019>-4<0016>-4<001A>-3<001B>-4<001C>-4<001D>-4<001E>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 313.07000732 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 62.40000153 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 78 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000D>-4<000E>-4<001F>-4<0020>-4<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(TBE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.83099937 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 26.1420002 11.65499973 Tm [<0022>-101<0023>-101<0016>-101<0024>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 72.38600159 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.6969986 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.44499969 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 107.7559967 11.65499973 Tm [<0003>-101<0004>-101<0005>-101<0006>-101<0007>-101<0017>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 177.12199402 11.65499973 Tm [(0.5)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 191.30799866 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 202.8690033 11.65499973 Tm [(TBE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.69999695 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 229.01100159 11.65499973 Tm [<0025>-101<0026>-101<0007>-101<0027>-101<0028>-101<0029>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 298.37701416 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.68798828 11.65499973 Tm [(45mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 332.69100952 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.37701416 11.65499973 Tm [(Tris-)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 357.84799194 11.65499973 Tm [<002A>-101<002B>-101<002C>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 392.53100586 11.65499973 Tm [(1mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.28399658 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [(EDTA\(pH8.0\))] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 61.11800003 27.25500107 Tm [<0017>-17<002D>-16<002E>-17<002F>-16<0030>-17<0031>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 125.16200256 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.58599854 27.25500107 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.33399963 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 158.75799561 27.25500107 Tm [<0003>-17<0004>-16<0023>-17<0015>-16<0016>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 212.12800598 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.55200195 27.25500107 Tm [(0.5)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 230.85099792 27.25500107 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 241.5249939 27.25500107 Tm [(TBE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.35598755 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 266.77999878 27.25500107 Tm [<0025>-17<0026>-16<0007>-17<0017>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 309.47601318 27.25500107 Tm [(Tris-)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 330.05999756 27.25500107 Tm [<0032>-17<002B>-16<0003>-17<0004>-16<0005>-17<0006>-16<0007>-17<0024>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<00330034002100050006003500360037001700380039003A003B003C003D003E003F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 178.5 42.85499954 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 181.99699402 42.85499954 Tm [<003F001A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 202.99699402 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.24699402 42.85499954 Tm [(2000bp\))] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 243.2440033 42.85499954 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 253.7440033 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.99398804 42.85499954 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.74200439 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 286.99200439 42.85499954 Tm [<004000410042>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 318.49200439 42.85499954 Tm [(GTBE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 345.90600586 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 351.15600586 42.85499954 Tm [<00030004000500060007>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 403.65600586 42.85499954 Tm [(\(10)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 58.45499802 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 10.5 58.45499802 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 13.99699974 58.45499802 Tm [<004300440045002B002C>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 66.49700165 58.45499802 Tm [(TBE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.32800293 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 91.57800293 58.45499802 Tm [<00460047001700480016001A00490006004A004B004C000300040017004D004E004F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 270.07800293 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.32800293 58.45499802 Tm [(1)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 280.57800293 58.45499802 Tm [<00080050001500160051005200530054000F0016001A00550013>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.05500031 Tm [<005600570017001800380016001A001B001C001D001E00580059005A0016005B0051>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 178.5 74.05500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 171.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 187.19999695 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000D>-4<000E>-4<0046>-4<0047>-4<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 202.80000305 cm /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 -10 218.3999939 cm q 0.25 0.5 m 147.5 0.5 l 147.5 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 50.40299988 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<000D>-4<000E>-4<005C>-4<005D>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 86.54699707 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 147.75 0 cm 0.25 0.5 m 52.25 0.5 l 52.25 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 11.81400013 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<005E>-4<005F>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 29.88599968 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 200.25 0 cm 0.25 0.5 m 50 0.5 l 50 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 1.653 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0060>-4<0061>-4<0062>-4<0063>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 37.79700089 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 250.5 0 cm 0.25 0.5 m 50 0.5 l 50 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.171 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0009>-4<000A>-4<000B>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 33.27899933 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 300.75 0 cm 0.25 0.5 m 43 0.5 l 43 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 2.671 16.22999954 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0029>-4<0064>-4<0065>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 29.77899933 16.22999954 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 26.35000038 cm q 0.25 0.5 m 147.5 0.5 l 147.5 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 19.97900009 16.22999954 Tm /GS2 gs 0 g [(GTBE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.47700119 16.22999954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 47.97700119 16.22999954 Tm [<00030004000500060007>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 92.97699738 16.22999954 Tm [(\(10)] TJ ET EMC /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 104.97399902 16.22999954 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 113.97399902 16.22999954 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 116.97100067 16.22999954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 147.75 0 cm 0.25 0.5 m 52.25 0.5 l 52.25 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 9.34899998 16.15200043 Tm /GS2 gs 0 g [(500ml)] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 32.34999847 16.15200043 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 200.25 0 cm 0.25 0.5 m 50 0.5 l 50 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 13.97500038 16.15200043 Tm /GS2 gs 0 g [(RT)] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 25.47500038 16.15200043 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 250.5 0 cm 0.25 0.5 m 50 0.5 l 50 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 10.72500038 16.22999954 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.22500038 16.22999954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 19.72500038 16.22999954 Tm [<0066>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 28.72500038 16.22999954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 300.75 0 cm 0.25 0.5 m 43 0.5 l 43 26.35000038 l 0.25 26.35000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 8.35000038 16.22999954 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 15.10000038 16.22999954 Tm [<0067>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 24.10000038 16.22999954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 52.70000076 l S Q q 0.5 w 147.75 0.5 m 147.75 26.35000038 l S Q q 0.5 w 147.75 26.85000038 m 147.75 52.70000076 l S Q q 0.5 w 200.25 0.5 m 200.25 26.35000038 l S Q q 0.5 w 200.25 26.85000038 m 200.25 52.70000076 l S Q q 0.5 w 250.5 0.5 m 250.5 26.35000038 l S Q q 0.5 w 250.5 26.85000038 m 250.5 52.70000076 l S Q q 0.5 w 300.75 0.5 m 300.75 26.35000038 l S Q q 0.5 w 300.75 26.85000038 m 300.75 52.70000076 l S Q q 0.5 w 344 0.5 m 344 52.70000076 l S Q q 0.5 w -0.25 0.25 m 344.25 0.25 l S Q q 0.5 w 0.25 26.60000038 m 343.75 26.60000038 l S Q q 0.5 w -0.25 52.95000076 m 344.25 52.95000076 l S Q Q q 1 0 0 1 0 271.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 287.20001221 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0068>-4<0026>-4<0069>-4<006A>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm 0 Tr [(\()] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 45.66500092 11.65499973 Tm 2 Tr [<000F>-4<0010>-4<006B>-4<006C>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 87.83300018 11.65499973 Tm 0 Tr [(\))] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 91.33000183 11.65499973 Tm 2 Tr [<0021>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 101.87200165 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 302.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<002C0016006D003B006E006F004D004E>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 89.25 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5 11.65499973 Tm [(GTBE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.91400146 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 127.16400146 11.65499973 Tm [<00030004000500060007>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 179.66400146 11.65499973 Tm [(\(10)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 193.66099548 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 204.16099548 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 207.65800476 11.65499973 Tm [<004F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 218.15800476 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.40800476 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 228.65800476 11.65499973 Tm [<00080050001500160051>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 281.1579895 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 318.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<002C0016>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 26.25 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.5 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 36.75 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 47.25 11.65499973 Tm [(GTBE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.66400146 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 79.91400146 11.65499973 Tm [<007000710016001A006F0072000300040024007300740075004B004C0051>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 237.41400146 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 334 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(3)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<002C00760077000E001A0073007400750076007700780017000300040051>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 162.75 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 349.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 365.20001221 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0079>-4<007A>-4<007B>-4<007C>-4<0021>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 380.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.25 11.65499973 Tm [<002C007D007E007F002400800081008200830084001700850086008700880089008A008B002D008C008D008E008F006800260051>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 278.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 396.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 412 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<003C>-4<0090>-4<000D>-4<000E>-4<0021>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.95999908 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 427.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.56599998 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 443.20001221 cm q 0.25 0.5 m 297.75 0.5 l 297.75 24.85000038 l 0.25 24.85000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(PAGE)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 23.625 11.65499973 Tm [<001800940095004B004C00030004000500060007>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 128.625 11.65499973 Tm [(\(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.125 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.625 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 154.875 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 24.85000038 cm q 0.25 0.5 m 297.75 0.5 l 297.75 24.85000038 l 0.25 24.85000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(PAGE)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 23.625 11.65499973 Tm [<0018009400950099009A00760077000500060007>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 128.625 11.65499973 Tm [(\(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.125 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.625 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 154.875 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.70000076 cm q 0.25 0.5 m 297.75 0.5 l 297.75 24.85000038 l 0.25 24.85000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(Laemmli)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 39.375 11.65499973 Tm [<00760077000500060007>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 91.875 11.65499973 Tm [(\(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.375 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.875 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 118.125 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 74.55000305 cm q 0.25 0.5 m 297.75 0.5 l 297.75 24.85000038 l 0.25 24.85000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(IEF)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 18.375 11.65499973 Tm [<000300A4000500060007>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 70.875 11.65499973 Tm [(\(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.375 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.875 11.65499973 Tm [(,pH3.5-9.5\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 149.625 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 99.40000153 cm q 0.25 0.5 m 297.75 0.5 l 297.75 28.54999924 l 0.25 28.54999924 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(IEF)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 18.375 11.65499973 Tm [<000300A4000500060007>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 70.875 11.65499973 Tm [(\(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.375 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.875 11.65499973 Tm [(,pH2.5-4.5\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 149.625 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 127.94999695 l S Q q 0.5 w 298 0.5 m 298 127.94999695 l S Q q 0.5 w -0.25 0.25 m 298.25 0.25 l S Q q 0.5 w 0.25 25.10000038 m 297.75 25.10000038 l S Q q 0.5 w 0.25 49.95000076 m 297.75 49.95000076 l S Q q 0.5 w 0.25 74.80000305 m 297.75 74.80000305 l S Q q 0.5 w 0.25 99.65000153 m 297.75 99.65000153 l S Q q 0.5 w -0.25 128.19999695 m 298.25 128.19999695 l S Q Q q 1 0 0 1 0 571.65002441 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ 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