%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 89 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.80000114 0 20.80000114 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.94400024 l -90 87.94400024 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 42 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 414 42 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.98600006 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.97200012 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.95800018 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC /Artifact <> BDC q 1 0 0 1 90 781.31402588 cm -90 0 m 505.29998779 0 l 505.29998779 10.98600006 l -90 10.98600006 l h W n Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 0 cm q 188.3500061 0 0 -41.45000076 0 41.45000076 cm /X2 Do Q Q Q q 1 0 0 1 90 130.4940033 cm q 1 0 0 1 22 0 cm /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 19.37400055 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [(U)-4(N)-4(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.63800049 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.72600174 23.67700005 Tm [(\()-4(U)-4(r)-4(a)-4(c)-4(i)-3(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.34199524 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.42999268 23.67700005 Tm [(N)-4(-)-4(G)-4(l)-4(y)-4(c)-3(o)-4(s)-4(y)-4(l)-4(a)-4(s)-4(e)-4(\))] TJ ET EMC /P <> BDC BT /FAAABJ 22 Tf 1 0 0 -1 307.6619873 23.67700005 Tm [<0012>-4<0013>-4<0014>] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 373.92599487 23.67700005 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 31.20000076 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 207.6499939 11.65499973 Tm 1 Tr 0.30000001 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 102.23000336 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0015>-4<0016>-4<0017>-4<0018>-4<0019>-4<001A>-3<001B>-4<001C>-4<001D>-4<001E>-4<001F>-4<0020>-4<0021>-4<0022>-4<001F>-4<0023>-3<0024>-4<0025>-4<0026>-4<0027>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 313.07000732 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 62.40000153 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 78 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 1 Tr 0.30000001 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0028>-4<0029>-4<002A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 31.62599945 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 109.19999695 cm /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [<002B002C002D>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 31.5 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.32899857 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.07899857 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 54.90800095 11.65499973 Tm [<002F00300031>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 86.40799713 11.65499973 Tm [(\(Uracil)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.15799713 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.98699951 11.65499973 Tm [(N-Glycosylase,UNG\))] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 221.48699951 11.65499973 Tm [<00330034>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 242.48699951 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.31599426 11.65499973 Tm [(Uracil-DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.81600952 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.64498901 11.65499973 Tm [(Glycosylase,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 365.64498901 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 369.47399902 11.65499973 Tm [(UDG,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 390.47399902 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 394.30300903 11.65499973 Tm [<00350036>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 10.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.76099968 27.25500107 Tm [(E.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.26099968 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.52199936 27.25500107 Tm [(coliuracil)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.02200317 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.28299713 27.25500107 Tm [(N-glycosylase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.53300476 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 154.79400635 27.25500107 Tm [<0030003B003C003D003E003F004000200041004200430044>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 280.79400635 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.05499268 27.25500107 Tm [(26kDa)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 310.30499268 27.25500107 Tm [<00480049004A004B004C004D002B002C002D003C>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<004E004F00500051004F>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 52.5 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.125 42.85499954 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.875 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 73.5 42.85499954 Tm [<0052005300540055002B002C002D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 42.85499954 Tm [<0048>] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.93400574 42.85499954 Tm [<00560057>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 176.93400574 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.55900574 42.85499954 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.30900574 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 197.93400574 42.85499954 Tm [<0059005A005B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.43400574 42.85499954 Tm [<0020>] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.36799622 42.85499954 Tm [<005C005D005E001F0023>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 290.86801147 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.49301147 42.85499954 Tm [(PCR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.24301147 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 311.86801147 42.85499954 Tm [<0061006200160063003C006400650066>] TJ ET EMC /P <> BDC BT 1 0 0 -1 395.86801147 42.85499954 Tm [<0048>] TJ ET EMC /P <> BDC BT 1 0 0 -1 404.80200195 42.85499954 Tm [<0056>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [<003C0067001F0068006900300023002A006A006B006C>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 115.5 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.70400238 58.45499802 Tm [(PCR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.45399475 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 139.65800476 58.45499802 Tm [<006D005E006E006F>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 181.65800476 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.86199951 58.45499802 Tm [(dUTP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.86199951 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 211.06599426 58.45499802 Tm [<00720073>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 234.69099426 58.45499802 Tm [(dTTP)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 258.31600952 58.45499802 Tm [<00740075>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 281.94100952 58.45499802 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.69100952 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 301.89498901 58.45499802 Tm [<006E0020007600770078004D>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 364.89498901 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 369.09899902 58.45499802 Tm [(dU)] TJ ET EMC /P <> BDC BT 1 0 0 -1 379.59899902 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 383.80300903 58.45499802 Tm [<00790030003C>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 415.30300903 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.05500031 Tm [(PCR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.75 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 18.375 74.05500031 Tm [<00610062001600630020007A0031007B007C007D005B0027007E004E004F00500051004F>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 207.375 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210 74.05500031 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.75 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 228.375 74.05500031 Tm [<006E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 238.875 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.5 74.05500031 Tm [(U)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.75 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 249.375 74.05500031 Tm [<0030003C002F007F0080002000810082007A>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 343.875 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 346.5 74.05500031 Tm [(PCR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.25 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 364.875 74.05500031 Tm [<0061006200160063>] TJ ET EMC /P <> BDC BT 1 0 0 -1 406.875 74.05500031 Tm [<0048>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 415.29998779 74.05500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 187.19999695 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 202.80000305 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<003E>-4<0041>-4<002A>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 31.62599945 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 218.3999939 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 271.5 45.90000153 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 265.20001221 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 280.79998779 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<005A>-4<005B>-4<0083>-4<0084>] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.71300125 11.65499973 Tm [<002A>] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 47.79999924 11.65499973 Tm 0 Tr [<006C00850086>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 79.30000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.55000305 11.65499973 Tm [(PCR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.30000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 105.55000305 11.65499973 Tm [<006D005E001A008700880020>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 168.55000305 11.65499973 Tm [(37)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 179.05000305 11.65499973 Tm [<008B008C008D00880020>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 231.55000305 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.80000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 242.05000305 11.65499973 Tm [<008F009000810082>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 284.04998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.29998779 11.65499973 Tm [(1µg)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.04998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 310.29998779 11.65499973 Tm [<004D>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 320.79998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 326.04998779 11.65499973 Tm [(dU)] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.54998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 341.79998779 11.65499973 Tm [<00790030003C004E004F>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 394.29998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 399.54998779 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 27.25500107 Tm [<003C003100430044>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 42 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.25 27.25500107 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 57.75 27.25500107 Tm [<005A005B004E00920048>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 110.25 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.5 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 312 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 327.6000061 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<006D>-65<005E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 22.36599922 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.25699997 11.65499973 Tm [(B)-4(u)-4(f)-4(f)-4(e)-4(r)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.65000153 11.65499973 Tm [<002A>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 71.83300018 11.65499973 Tm 0 Tr [(UNG)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 90.84899902 11.65499973 Tm [<0095>-61<0096>-61<0097>-61<0098>-61<0099>-61<003C>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 160.32000732 11.65499973 Tm [(PCR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.07000732 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 181.96099854 11.65499973 Tm [<009A>-61<009B>-61<0031>-61<006D>-61<005E>-61<009C>-61<009D>-61<009E>-61<009F>-61<00A0>-61<00A1>-62<00A2>-61<003C>-61<0020>-61<00A3>-61<006C>-61<00A4>-61<0055>-61<0042>-61<00A5>-61<00A6>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 27.25500107 Tm [(\(>100mM\))] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 42 27.25500107 Tm [<0088005A005B00AB00AC00AD00AE00AF0048>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 136.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.75 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 358.79998779 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 374.3999939 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0031>-4<00B0>-4<00B1>-4<009E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.71300125 11.65499973 Tm [<002A>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 47.79999924 11.65499973 Tm 0 Tr [(20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.29999924 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.54999924 11.65499973 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.05000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.30000305 11.65499973 Tm [(Tris-HCl,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.55000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.80000305 11.65499973 Tm [(50)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.30000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.55000305 11.65499973 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.05000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.30000305 11.65499973 Tm [(NaCl,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.80000305 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.05000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.30000305 11.65499973 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.80000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.05000305 11.65499973 Tm [(DTT,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.05000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.30000305 11.65499973 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.55000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.79998779 11.65499973 Tm [(50%Glycerol,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.79998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 326.04998779 11.65499973 Tm [(0.1%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 347.04998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 352.29998779 11.65499973 Tm [(\(w/v\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.54998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 383.79998779 11.65499973 Tm [(Triton)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [(X-100,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.75 27.25500107 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.25 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 27.25500107 Tm [(7.5)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 68.25 27.25500107 Tm [<0048>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 78.75 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 405.6000061 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 421.20001221 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<00B0>-4<00B1>-4<002A>] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 31.62599945 11.65499973 Tm 0 Tr [<00BC0023>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 52.62599945 11.65499973 Tm [(-20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.37599945 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.87599945 11.65499973 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.12599945 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 89.37599945 11.65499973 Tm [<004A00BE00B1>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 120.87599945 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.12599945 11.65499973 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.37600708 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 136.62600708 11.65499973 Tm [<00BF002000C000C1006D00C200C300C40048>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 231.12600708 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.37600708 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 436.79998779 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 452.3999939 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<00C5>-4<00C6>-4<005A>-4<002A>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm 0 Tr [(95)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.66799927 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.16799927 11.65499973 Tm [(C)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 68.41799927 11.65499973 Tm [<0020>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 78.91799927 11.65499973 Tm [(5min)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 99.91799927 11.65499973 Tm [<0048>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 110.41799927 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 468 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 483.6000061 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 244.5 106.34999847 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 90 348.89398193 cm /P <> BDC q 1 0 0 1 0 0.90000153 cm q 271.5 0 0 -44.25 0 44.25 cm /X3 Do Q Q EMC Q q 1 0 0 1 90 614.09399414 cm /P <> BDC q 1 0 0 1 0 2.84999847 cm q 243.75 0 0 -103.5 0 103.5 cm /X4 Do Q Q EMC Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>