%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 89 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.80000114 0 20.80000114 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.94400024 l -90 87.94400024 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 42 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 414 42 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.98600006 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.97200012 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.95800018 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC /Artifact <> BDC q 1 0 0 1 90 781.31402588 cm -90 0 m 505.29998779 0 l 505.29998779 10.98600006 l -90 10.98600006 l h W n Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 0 cm q 188.3500061 0 0 -41.45000076 0 41.45000076 cm /X2 Do Q Q Q q 1 0 0 1 90 130.4940033 cm q 1 0 0 1 22 0 cm /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 60.97600174 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [(R)-4(n)-4(a)-4(s)-4(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.41600037 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.5039978 23.67700005 Tm [(F)-4(r)-4(e)-4(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.85600281 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.94400024 23.67700005 Tm [(D)-4(N)-4(a)-4(s)-4(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.38400269 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.47200012 23.67700005 Tm [(I)] TJ ET EMC /P <> BDC BT /FAAABJ 22 Tf 1 0 0 -1 266.05999756 23.67700005 Tm [<000D>-4<000E>-4<000F>] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 332.32400513 23.67700005 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 31.20000076 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 207.6499939 11.65499973 Tm 1 Tr 0.30000001 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 102.23000336 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0010>-4<0011>-4<0012>-4<0013>-4<0014>-4<0015>-3<0016>-4<0017>-4<0018>-4<0019>-4<001A>-4<001B>-4<001C>-4<001D>-4<001A>-4<001E>-3<001F>-4<0020>-4<0021>-4<0022>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 313.07000732 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 62.40000153 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 78 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0023>-4<0024>-4<0025>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 31.62599945 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 109.19999695 cm /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [<00100026002700280029002A002B002C002A>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 94.5 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.75 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.5 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 120.75 11.65499973 Tm [<002D002E002F003000310032003300340035>] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.25 11.65499973 Tm [<001B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.05000305 11.65499973 Tm [<0036003700380039>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 263.04998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.29998779 11.65499973 Tm [(5)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 273.54998779 11.65499973 Tm [<003B>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 284.04998779 11.65499973 Tm [(-P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.54998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 299.79998779 11.65499973 Tm [<003E003F004000410042004300310044004500410046>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<00410043004700480026>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 27.25500107 Tm [<0049>] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.96300125 27.25500107 Tm [<004A001E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 85.58799744 27.25500107 Tm [(RNase-free)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.08799744 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.33799744 27.25500107 Tm [(DNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.58799744 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.83799744 27.25500107 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.08799744 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 185.33799744 27.25500107 Tm [<004C>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 195.83799744 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.08799744 27.25500107 Tm [(Protease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.08799744 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 248.33799744 27.25500107 Tm [<004F0050005100520053005400550056>] TJ ET EMC /P <> BDC BT 1 0 0 -1 332.3380127 27.25500107 Tm [<001B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 341.80099487 27.25500107 Tm [<005700580059005A005B005C0026>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<005D>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 10.5 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.125 42.85499954 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.625 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 26.25 42.85499954 Tm [<004C0060006100620031006300640060>] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.25 42.85499954 Tm [<0049>] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.40000153 42.85499954 Tm [<00650016005C0026004C00660067005B>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 205.0249939 42.85499954 Tm [(Rnase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.2749939 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.8999939 42.85499954 Tm [(Inhibitor)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 281.1499939 42.85499954 Tm [<001B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.29998779 42.85499954 Tm [<001A001E006B006C>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 331.29998779 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.92498779 42.85499954 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 349.67498779 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 352.29998779 42.85499954 Tm [<006D0012004C006E006F0031>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 415.29998779 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [(RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.25 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 31.5 58.45499802 Tm [<004100430026>] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 58.45499802 Tm [<001B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.46299744 58.45499802 Tm [<007000650071007200390073006B006C>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 156.46299744 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.71299744 58.45499802 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.46299744 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 182.71299744 58.45499802 Tm [<005900740075002F004C>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 235.21299744 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.46299744 58.45499802 Tm [(Rnase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.7130127 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 271.9630127 58.45499802 Tm [<00260076>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 292.9630127 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.2130127 58.45499802 Tm [(RNA)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 316.5880127 58.45499802 Tm [<003100770035>] TJ ET EMC /P <> BDC BT 1 0 0 -1 348.0880127 58.45499802 Tm [<0049>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 357.55099487 58.45499802 Tm [(Stop)] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.55099487 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 383.80099487 58.45499802 Tm [(Buffer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.30099487 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 74.05500031 Tm [<007B007C007D007E007F001B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 74.05500031 Tm [<007100800075008100820067008300840085>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 160.125 74.05500031 Tm [(DNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.375 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.625 74.05500031 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.875 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 202.125 74.05500031 Tm [<008500600049>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 233.625 74.05500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 187.19999695 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 202.80000305 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0086>-4<0034>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 21.08399963 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 218.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 229.5 91.05000305 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 312 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 327.6000061 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [(*Rnase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.5 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.47800064 11.65499973 Tm [(Free)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.47800064 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.45600128 11.65499973 Tm [(DNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.70600128 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.68399811 11.65499973 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.93399811 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.91200256 11.65499973 Tm [(\(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.66200256 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.63999939 11.65499973 Tm [(U/)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 125.13999939 11.65499973 Tm [<008D>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 135.63999939 11.65499973 Tm [(l\))] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 146.13999939 11.65499973 Tm [<004C00900039>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 177.63999939 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.61799622 11.65499973 Tm [(20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.11799622 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.09599304 11.65499973 Tm [(U/)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 204.59599304 11.65499973 Tm [<008D>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 215.09599304 11.65499973 Tm [(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.34599304 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 223.32400513 11.65499973 Tm [<0031>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 233.82400513 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.80200195 11.65499973 Tm [(RnaseInhibitor)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 310.30200195 11.65499973 Tm [<001B00920093009400950096009700980099001C>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<009A009B009C009D001600660067>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 73.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.75 27.25500107 Tm [(RnaseInhibitor)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 152.25 27.25500107 Tm [<0049>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 162.75 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 358.79998779 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0085>-4<0060>-4<0064>-4<009E>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.41799927 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 374.3999939 cm /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [<0072009F00A000A100A2>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 52.5 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.5 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 78.75 11.65499973 Tm [<00A300A400A5>] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.25 11.65499973 Tm [<001B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.18399811 11.65499973 Tm [<005D>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 129.68400574 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.93400574 11.65499973 Tm [(25)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 145.43400574 11.65499973 Tm [<00A6>] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.93400574 11.65499973 Tm [<00A7>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 164.86799622 11.65499973 Tm [(pH5.0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.11799622 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 196.36799622 11.65499973 Tm [<003100A900AA00AB>] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.36799622 11.65499973 Tm [<001B>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 247.30200195 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.55200195 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 257.80200195 11.65499973 Tm [<003400AC00470019007D007E00AD0031>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 341.80200195 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 347.05200195 11.65499973 Tm [(260)] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.80200195 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.05200195 11.65499973 Tm [(nm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.55200195 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 383.80200195 11.65499973 Tm [<00B000B10030>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<00B20067>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 21 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.25 27.25500107 Tm [(0.001)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 57.75 27.25500107 Tm [<00B3009A009B0031002600B40064009E00A3>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 152.25 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.5 27.25500107 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.75 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 168 27.25500107 Tm [<00B500850060002900B600B7>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 231 27.25500107 Tm [(Kunitz)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.75 27.25500107 Tm [(Unit)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 288.75 27.25500107 Tm [<00BA0049>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 309.75 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 405.6000061 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<00BB>-4<0030>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 21.08399963 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.33399963 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 421.20001221 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.5 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.125 11.65499973 Tm [(U)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.375 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 21 11.65499973 Tm [<00310010002600BC>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 63 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.625 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.875 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 73.5 11.65499973 Tm [<008D>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 84 11.65499973 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.25 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 91.875 11.65499973 Tm [<0031>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 102.375 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 11.65499973 Tm [(16S,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.625 11.65499973 Tm [(23S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.375 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 11.65499973 Tm [(rRNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 170.625 11.65499973 Tm [<005D>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 181.125 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.75 11.65499973 Tm [(37)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 194.25 11.65499973 Tm [<00A6>] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.75 11.65499973 Tm [<00A7>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 212.8999939 11.65499973 Tm [(pH7.5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.1499939 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 241.7749939 11.65499973 Tm [<003100A900AA00AB007D007E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 304.7749939 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.3999939 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.6499939 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 315.2749939 11.65499973 Tm [<009F0099>] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.2749939 11.65499973 Tm [<001B>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 344.42498779 11.65499973 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 360.17498779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 362.79998779 11.65499973 Tm [<003100C100C200C300C4>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<001C00C5003600C60096>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 52.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 452.3999939 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<007E>-4<001A>-4<0025>] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 31.62599945 11.65499973 Tm 0 Tr [<00550056>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 52.62599945 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.87599945 11.65499973 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.62599945 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 78.87599945 11.65499973 Tm [<006D0012004C0031>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 120.87599945 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.12599945 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.87600708 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 147.12600708 11.65499973 Tm [<00C700C80049>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 178.62600708 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.87600708 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 468 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<00C9>-4<00CA>-4<0025>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 31.62599945 11.65499973 Tm 0 Tr [(-20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.37599945 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.87599945 11.65499973 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.12599945 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 68.37599945 11.65499973 Tm [<007100CD00CA>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 99.87599945 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.12599945 11.65499973 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.37599945 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 115.62599945 11.65499973 Tm [<00CE0049>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 136.62600708 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 483.6000061 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 499.20001221 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<00CF>-4<00D0>-4<00D1>-4<00D2>-4<00B7>-4<0055>-3<0056>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 73.79399872 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.04399872 11.65499973 Tm [(R)-4(N)-4(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.91999817 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 100.16999817 11.65499973 Tm [<004C>-4<0031>-4<00D3>-4<0070>-4<0086>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 152.88000488 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.13000488 11.65499973 Tm [(D)-4(N)-4(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.0059967 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 179.2559967 11.65499973 Tm [<00C7>-4<00C8>-4<00BA>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 210.88200378 11.65499973 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.13200378 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 514.79998779 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [(1.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.5 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 15.75 11.65499973 Tm [<00D4007200AB0086003400D5006C007D007E001500D6>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 131.25 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 530.40002441 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 546 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 243 86.55000305 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 90 348.89398193 cm /P <> BDC q 1 0 0 1 0 2.55000305 cm q 229.5 0 0 -87.75 0 87.75 cm /X3 Do Q Q EMC Q q 1 0 0 1 90 676.49401855 cm /P <> BDC q 1 0 0 1 0 7.05000305 cm q 243 0 0 -78.75 0 78.75 cm /X4 Do Q Q EMC Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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