%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 70 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.80000114 0 20.80000114 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.94400024 l -90 87.94400024 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 42 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 414 42 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.98600006 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.97200012 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.95800018 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC /Artifact <> BDC q 1 0 0 1 90 781.31402588 cm -90 0 m 505.29998779 0 l 505.29998779 10.98600006 l -90 10.98600006 l h W n Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 0 cm q 188.3500061 0 0 -41.45000076 0 41.45000076 cm /X2 Do Q Q Q q 1 0 0 1 90 130.4940033 cm q 1 0 0 1 22 0 cm /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 91.70999908 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>] TJ ET EMC /P <> BDC BT /FAAACB 22 Tf 1 0 0 -1 207.6499939 23.67700005 Tm [(I)-4(V)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 235.32600403 23.67700005 Tm [<000A>-4<000B>-4<000C>] TJ ET EMC /P <> BDC BT /FAAACB 22 Tf 1 0 0 -1 301.58999634 23.67700005 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 31.20000076 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 207.6499939 11.65499973 Tm 1 Tr 0.30000001 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 91.73000336 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [( )-4( )-4( )-4( )] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 112.73000336 11.65499973 Tm [<000D>-4<000E>-4<000F>-4<0010>-4<0011>-4<0012>-3<0013>-4<0014>-4<0015>-4<0016>-4<0017>-4<0018>-4<0019>-4<001A>-4<0017>-4<001B>-3<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 323.57000732 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 62.40000153 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 1 Tr 0.30000001 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 78 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0020>-4<0021>-4<0022>] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 31.62599945 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [<00030004000500060007>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 52.5 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 11.65499973 Tm [(IV)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.25 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 73.5 11.65499973 Tm [<00230024001B>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 105 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.25 11.65499973 Tm [(E.coli,)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 147 11.65499973 Tm [<002C002D>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 168 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.25 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 194.25 11.65499973 Tm [<0030003100320033>] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.25 11.65499973 Tm [<0034>] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.05000305 11.65499973 Tm [<003500070036003700380039003A>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 315.54998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.79998779 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.54998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 341.79998779 11.65499973 Tm [<003B003C003D003E003F00400041>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 27.25500107 Tm [(/)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 5.25 27.25500107 Tm [<003F00430044>] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.57500076 27.25500107 Tm [<0045>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 46.07500076 27.25500107 Tm [(AP)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 56.57500076 27.25500107 Tm [<0047>] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.90000153 27.25500107 Tm [<00480049>] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.90000153 27.25500107 Tm [<0018>] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.22499847 27.25500107 Tm [<004A0006004B>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 127.72499847 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.9750061 27.25500107 Tm [(AP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.4750061 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 148.7250061 27.25500107 Tm [<00480049>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 169.7250061 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.9750061 27.25500107 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.2250061 27.25500107 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.4750061 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 190.7250061 27.25500107 Tm [<004E003E004F0050005100520004005300540055>] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.7250061 27.25500107 Tm [<0018>] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.04998779 27.25500107 Tm [<000E0056>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 326.04998779 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.29998779 27.25500107 Tm [(3)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 336.54998779 27.25500107 Tm [<004D00580059005A>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 373.29998779 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.54998779 27.25500107 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 383.79998779 27.25500107 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 389.04998779 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 394.29998779 27.25500107 Tm [<003F005B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<0003005C00520004005D004E005E005F001300350007006000610062>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 147 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.76300049 42.85499954 Tm [(3)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 155.01300049 42.85499954 Tm [<004D00530054000700630064001800650066>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 244.26300049 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.02600098 42.85499954 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.77600098 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 265.53900146 42.85499954 Tm [<003E>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 276.03900146 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.80200195 42.85499954 Tm [(3)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 284.05200195 42.85499954 Tm [<004D005D004E00670068005200040069006A006B006C006D006E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [<003E003F005B0003005C>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 52.5 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 58.45499802 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 58.45499802 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.25 58.45499802 Tm [(-)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 73.5 58.45499802 Tm [<00520004005A00520004>] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 58.45499802 Tm [<0034>] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.93400574 58.45499802 Tm [<005F0013>] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.93400574 58.45499802 Tm [<0018>] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.86799622 58.45499802 Tm [<00350007006000610062>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 217.36799622 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.61799622 58.45499802 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.86799622 58.45499802 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.11799622 58.45499802 Tm [(-5)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 243.61799622 58.45499802 Tm [<004D003E00130006000700630064>] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.86801147 58.45499802 Tm [<0018>] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.80200195 58.45499802 Tm [<00350007007000710072003E007300740075>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.05500031 Tm [<00760017007700780079007A007B003C006C>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 94.5 74.05500031 Tm [(DTT)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 110.25 74.05500031 Tm [<006C>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 120.75 74.05500031 Tm [(EDTA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.75 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 147 74.05500031 Tm [<007D003E007E007F00180080008100820083001B00760017001B>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 283.5 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.75 74.05500031 Tm [(3)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 294 74.05500031 Tm [<004D0084005D004E003E0039003A>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 364.875 74.05500031 Tm [(DNA)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 380.625 74.05500031 Tm [<0034>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 391.125 74.05500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 171.6000061 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 187.19999695 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0085>-4<003B>-4<0022>] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 31.62599945 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 202.80000305 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 264 72 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 280.79998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0063>-4<0064>-4<0086>-4<0087>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 39.73400116 11.65499973 Tm 0 Tr [<0022>] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.79999924 11.65499973 Tm [<0088>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 58.29999924 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.54999924 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.80000305 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.30000305 11.65499973 Tm [(Endonuclease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.30000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.55000305 11.65499973 Tm [(IV)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.05000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.30000305 11.65499973 Tm [(Buffer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.80000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.05000305 11.65499973 Tm [(\(100)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.05000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.30000305 11.65499973 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.80000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.05000305 11.65499973 Tm [(NaCl)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 263.04998779 11.65499973 Tm [<0018>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 273.54998779 11.65499973 Tm [(50)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.04998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.29998779 11.65499973 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.79998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.04998779 11.65499973 Tm [(Tris-HCl)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 347.04998779 11.65499973 Tm [<0045>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 357.54998779 11.65499973 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.04998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 373.29998779 11.65499973 Tm [(7.9\))] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 394.29998779 11.65499973 Tm [<0018>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 404.79998779 11.65499973 Tm [(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.75 27.25500107 Tm [(MgCl2)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 42 27.25500107 Tm [<0018>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 50.01300049 27.25500107 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.26300049 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.51300049 27.25500107 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.01300049 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.26300049 27.25500107 Tm [(DTT)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 92.01300049 27.25500107 Tm [<0047>] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.02600098 27.25500107 Tm [<00A0>] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.52600098 27.25500107 Tm [<0018>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 118.53900146 27.25500107 Tm [(10)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 129.03900146 27.25500107 Tm [<00A1>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 139.53900146 27.25500107 Tm [(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.78900146 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 150.03900146 27.25500107 Tm [<00A200A3001200A400050018>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 213.03900146 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.28900146 27.25500107 Tm [(37)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.78900146 27.25500107 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.28900146 27.25500107 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.53900146 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 249.78900146 27.25500107 Tm [<00A200A3>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 270.78900146 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.03900146 27.25500107 Tm [(1h)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 286.53900146 27.25500107 Tm [<0018>] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.55200195 27.25500107 Tm [<00650006004B>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 326.05200195 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.30200195 27.25500107 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.55200195 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 341.80200195 27.25500107 Tm [(pmol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.80200195 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 368.05200195 27.25500107 Tm [<00A700500051>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 399.55200195 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 404.80200195 27.25500107 Tm [(AP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.30200195 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 42.85499954 Tm [<00480049003E>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 31.5 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.75 42.85499954 Tm [(34)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.25 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 42.85499954 Tm [(mer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.25 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 73.5 42.85499954 Tm [<00A9000300AA00040039003A00AB00AC00AD003E000700AE0086008700AF005000510063006400B000480034>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 304.5 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.75 42.85499954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 327.6000061 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 343.20001221 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<00A3>-4<0017>-4<0022>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 31.62599945 11.65499973 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 36.87599945 11.65499973 Tm [<00B000B100B200B300B400B500B6>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 110.37599945 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.62599945 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.37600708 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 136.62600708 11.65499973 Tm [<00300031005A0032003300140015>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 210.12600708 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.37600708 11.65499973 Tm [(SNP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.12600708 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 236.37600708 11.65499973 Tm [<003B00B8>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 257.37600708 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.62600708 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 358.79998779 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 374.3999939 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<00B9>-4<00BA>-4<0063>-4<0022>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm 0 Tr [(85)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.66799927 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.16799927 11.65499973 Tm [(C)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 68.41799927 11.65499973 Tm [<0018>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 78.91799927 11.65499973 Tm [(20min)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 105.16799927 11.65499973 Tm [<0034>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 115.66799927 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.91799927 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 390 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 405.6000061 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0007>-4<00BC>-4<00BD>-4<00BE>] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.71300125 11.65499973 Tm [<0022>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 47.79999924 11.65499973 Tm 0 Tr [(50)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.29999924 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.54999924 11.65499973 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.05000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.30000305 11.65499973 Tm [(Tris-HCl,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.55000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.80000305 11.65499973 Tm [(50)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.30000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.55000305 11.65499973 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.05000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.30000305 11.65499973 Tm [(KCl,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.30000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55000305 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.80000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.05000305 11.65499973 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.55000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.80000305 11.65499973 Tm [(DTT,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.80000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.05000305 11.65499973 Tm [(0.1mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.29998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.54998779 11.65499973 Tm [(EDTA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.79998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.04998779 11.65499973 Tm [(50%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.79998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 326.04998779 11.65499973 Tm [(Glycerol,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 373.29998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.54998779 11.65499973 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 389.04998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 394.29998779 11.65499973 Tm [(7.5)] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 410.04998779 11.65499973 Tm [<0034>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 415.29998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 420.54998779 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 421.20001221 cm /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 436.79998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<00BC>-4<00BD>-4<0022>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 31.62599945 11.65499973 Tm 0 Tr [<00C3001B>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 52.62599945 11.65499973 Tm [(-20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.37599945 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.87599945 11.65499973 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.12599945 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 89.37599945 11.65499973 Tm [<003600C400BD>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 120.87599945 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.12599945 11.65499973 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.37600708 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 136.62600708 11.65499973 Tm [<00C5001800C600C700A2003300C800C90034>] TJ ET EMC Q Q q 1 0 0 1 90 333.29400635 cm /P <> BDC q 1 0 0 1 0 6 cm q 263.25 0 0 -65.25 0 65.25 cm /X3 Do Q Q EMC Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>