%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 78 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.80000114 0 20.80000114 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.94400024 l -90 87.94400024 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 42 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 414 42 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.98600006 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.97200012 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.95800018 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC /Artifact <> BDC q 1 0 0 1 90 781.31402588 cm -90 0 m 505.29998779 0 l 505.29998779 10.98600006 l -90 10.98600006 l h W n Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 0 cm q 188.3500061 0 0 -41.45000076 0 41.45000076 cm /X2 Do Q Q Q q 1 0 0 1 90 130.4940033 cm q 1 0 0 1 22 0 cm /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 80.66600037 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [(T)-4(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.84200287 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 22 Tf 1 0 0 -1 113.84200287 23.67700005 Tm [<0005>-4<0006>-4<0007>-4<0008>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 229.78199768 23.67700005 Tm [(I)] TJ ET EMC /P <> BDC BT /FAAABJ 22 Tf 1 0 0 -1 246.36999512 23.67700005 Tm [<000B>-4<000C>-4<000D>] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 312.63400269 23.67700005 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 31.20000076 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 207.6499939 11.65499973 Tm 1 Tr 0.30000001 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 102.23000336 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<000E>-4<000F>-4<0010>-4<0011>-4<0012>-4<0013>-3<0014>-4<0015>-4<0016>-4<0017>-4<0018>-4<0019>-4<001A>-4<001B>-4<0018>-4<001C>-3<001D>-4<001E>-4<001F>-4<0020>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 313.07000732 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 62.40000153 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 78 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0021>-4<0022>-4<0023>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 31.62599945 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 109.19999695 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [(T7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.5 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 15.75 11.65499973 Tm [<00050006000700080009>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 68.25 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.5 11.65499973 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.75 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 84 11.65499973 Tm [<00240025002600080027001A00280029002A002B>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 189 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.25 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 210 11.65499973 Tm [<002E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.25 11.65499973 Tm [<002F0030003100320033>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 267.75 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 288.75 11.65499973 Tm [<002E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 294 11.65499973 Tm [(Holliday)] TJ ET EMC /P <> BDC BT 1 0 0 -1 336 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 341.25 11.65499973 Tm [<00320033003B003C003D>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 393.75 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 399 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 414.75 11.65499973 Tm [<002E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<003E003F00400041>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 42 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.25 27.25500107 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 68.25 27.25500107 Tm [<003B00420043004400450046004700480008002700490008004A004600400041>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 236.25 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.5 27.25500107 Tm [(DNA)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 257.25 27.25500107 Tm [<004B004C000900080027004D002A004E004F>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 351.75 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 357 27.25500107 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.25 27.25500107 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 367.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 372.75 27.25500107 Tm [<0052004600530054002E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<00530055003B0053005600570058000600550059004B000E000F0010005A005B005C005D005E005F006000610062>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 241.5 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.26300049 42.85499954 Tm [(T7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.76300049 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 257.52600098 42.85499954 Tm [<00050006000700080009>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 310.02600098 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.78900146 42.85499954 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 318.03900146 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 320.80200195 42.85499954 Tm [<004F006300190064001B0046006500660048>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [<006700680019004C00090069006A006B000700080009003B001400080009006C006D004B>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 189 58.45499802 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 171.6000061 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 187.19999695 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0060>-4<006E>-4<0023>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 31.62599945 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 202.80000305 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 264 72.75 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 280.79998779 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 296.3999939 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<006F>-4<0070>-4<0071>-4<0072>] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.71300125 11.65499973 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 47.79999924 11.65499973 Tm 0 Tr [<0073>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 58.29999924 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.92499924 11.65499973 Tm [(50)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.42500305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 74.05000305 11.65499973 Tm [<0075>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 84.55000305 11.65499973 Tm [(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.80000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 92.42500305 11.65499973 Tm [<00760077001300780019>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 144.92500305 11.65499973 Tm [(37)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 155.42500305 11.65499973 Tm [<007A>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 165.92500305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 168.55000305 11.65499973 Tm [<007B007C007D0019>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 210.55000305 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.80000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 218.42500305 11.65499973 Tm [<007F00800081>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 252.55000305 11.65499973 Tm [(90%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.29998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 270.92498779 11.65499973 Tm [<004300840046>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 302.42498779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.04998779 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.29998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 312.92498779 11.65499973 Tm [<0075>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 323.42498779 11.65499973 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.67498779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 331.29998779 11.65499973 Tm [<008600870088002F0030003100320033>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<0046>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 10.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.75 27.25500107 Tm [(pUC)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 31.5 27.25500107 Tm [<008C>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 42 27.25500107 Tm [(AT)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 52.5 27.25500107 Tm [<008D>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 63 27.25500107 Tm [(*)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.25 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 73.5 27.25500107 Tm [<008F00900091>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 105 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.25 27.25500107 Tm [(90%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 131.25 27.25500107 Tm [<004300840046009200700032003300930094009500460009009600710072009700540057006F007000980099004B>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 372.75 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 378 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 327.6000061 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 343.20001221 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0077>-4<0018>-4<0023>] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 31.62599945 11.65499973 Tm 0 Tr [<004F0063009A009B002E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 84.12599945 11.65499973 Tm [(SNP)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 99.87599945 11.65499973 Tm [<002E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 110.37599945 11.65499973 Tm [(TALEN)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.62600708 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 141.87600708 11.65499973 Tm [<003B>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 152.37600708 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.62600708 11.65499973 Tm [(CRISPR/Cas9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.37600708 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 220.62600708 11.65499973 Tm [<00A300910046009A009B>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 273.12600708 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.37600708 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 358.79998779 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 374.3999939 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0013>-4<00A4>-4<00A5>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 31.62599945 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.87599945 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 390 cm /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [<00240025004D002A>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 42 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.25 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 65.625 11.65499973 Tm [<006E00A600A700A800A9003C003D>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 139.125 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.375 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.125 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 165.375 11.65499973 Tm [<003B006E00AA>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 196.875 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.125 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.875 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.125 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 405.6000061 cm /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [<00A400A5003B00080027003E003F005500AB0013>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 105 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.25 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 131.25 11.65499973 Tm [<00AC0008004A>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 162.75 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.75 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 421.20001221 cm /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [<00AD>-13<00AE>-12<0008>-13<0027>-12<0092>-13<0070>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 63.79199982 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.1740036 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.9240036 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 90.30599976 11.65499973 Tm [<00AF>-13<00B0>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 111.56999969 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.95200348 11.65499973 Tm [(shot-gun)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.95199585 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 164.33399963 11.65499973 Tm [<005D>-13<005E>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 188.2230072 11.65499973 Tm [(1X)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.7230072 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.10499573 11.65499973 Tm [(T7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.60499573 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.98699951 11.65499973 Tm [(Endonuclease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.98699951 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.36898804 11.65499973 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.61898804 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.00100708 11.65499973 Tm [(Buffer)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 330.63299561 11.65499973 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 341.26501465 11.65499973 Tm [(50)] TJ ET EMC /P <> BDC BT 1 0 0 -1 351.76501465 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.14700317 11.65499973 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 367.64700317 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 373.0289917 11.65499973 Tm [(NaCl)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 394.16101074 11.65499973 Tm [<0019>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 404.79299927 11.65499973 Tm [(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29299927 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.75 27.25500107 Tm [(Tris-HCl)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 57.75 27.25500107 Tm [<0019>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 68.25 27.25500107 Tm [(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.75 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 27.25500107 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.75 27.25500107 Tm [(MgCl2)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 126 27.25500107 Tm [<0019>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 136.5 27.25500107 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.75 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 27.25500107 Tm [(mMDTT)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 173.25 27.25500107 Tm [<008C>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 183.75 27.25500107 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.25 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.5 27.25500107 Tm [(7.9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.25 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.5 27.25500107 Tm [(@)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.75 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231 27.25500107 Tm [(25)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 241.5 27.25500107 Tm [<007A008D>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 262.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.75 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 452.3999939 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<0009>-4<00C1>-4<00C2>-4<00C3>] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.71300125 11.65499973 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 47.79999924 11.65499973 Tm 0 Tr [(50)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.29999924 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.54999924 11.65499973 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.05000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.30000305 11.65499973 Tm [(Tris-HCl,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.55000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.80000305 11.65499973 Tm [(50)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.30000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.55000305 11.65499973 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.05000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.30000305 11.65499973 Tm [(KCl,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.30000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55000305 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.80000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.05000305 11.65499973 Tm [(mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.55000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.80000305 11.65499973 Tm [(DTT,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.80000305 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.05000305 11.65499973 Tm [(0.1mM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.29998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.54998779 11.65499973 Tm [(EDTA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.79998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.04998779 11.65499973 Tm [(50%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.79998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 326.04998779 11.65499973 Tm [(Glycerol,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 373.29998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.54998779 11.65499973 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 389.04998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 394.29998779 11.65499973 Tm [(7.5)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 410.04998779 11.65499973 Tm [<004B>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 415.29998779 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 420.54998779 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 468 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 483.6000061 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<00C1>-4<00C2>-4<0023>] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 31.62599945 11.65499973 Tm 0 Tr [<00C7001C>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 52.62599945 11.65499973 Tm [(-20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.37599945 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.87599945 11.65499973 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.12599945 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 89.37599945 11.65499973 Tm [<00C900CA00C2>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 120.87599945 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.12599945 11.65499973 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.37600708 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 136.62600708 11.65499973 Tm [<00CB001900CC00CD007600CE00CF00D0004B>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 231.12600708 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.37600708 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 499.20001221 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 514.79998779 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr 0 g 0.30000001 w 0 G [<00D1>-4<00D2>-4<00D3>-4<00D4>] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.41799927 11.65499973 Tm 1 Tr /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 0 530.40002441 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [(\(1\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.75 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.15600014 11.65499973 Tm [(T7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.65600014 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 37.06200027 11.65499973 Tm [<0005>-15<0006>-15<0007>-15<0008>-14<0009>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 90.34200287 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.7480011 11.65499973 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.9980011 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 106.40399933 11.65499973 Tm [<005A>-15<0054>-15<00D7>-15<00D8>-14<00D9>-15<00DA>-15<00DB>-15<0032>-15<0033>-15<00DC>-15<00DD>-14<0070>-15<0046>-15<0009>-15<00DE>-15<004C>-15<0009>-15<0043>-14<001A>-15<00DF>-15<0046>-15<006F>-15<0070>-15<00E0>-15<0018>-14<001C>-15<001A>-15<00DF>-15<0046>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 415.42800903 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.75 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 21 27.25500107 Tm [<00DA00DB004B0008002700E1007100DA00DB001900E200E300E400E50009009600AC00760077008000E6004B>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 252 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.25 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 561.59997559 cm /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 0 g [(\(2\))] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 15.75 11.65499973 Tm [<0076007700E700480086005C>] TJ ET EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 78.75 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 11.65499973 Tm [(42)] TJ ET EMC /P <> BDC BT /FAAACG 10.5 Tf 1 0 0 -1 94.5 11.65499973 Tm [<007A0080001900E900EA00EB00EC00E1003E0070000500060009006F0070004B>] TJ ET EMC Q Q q 1 0 0 1 90 333.29400635 cm /P <> BDC q 1 0 0 1 0 5.25 cm q 263.25 0 0 -66.75 0 66.75 cm /X3 Do Q Q EMC Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>