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EMC q 1 0 0 1 69.80000305 62.40000153 cm /P <</MCID 7 >> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 0 11.38799953 Tm /GS2 gs 0 g [(       )-1( )] TJ ET EMC /P <</MCID 8 >> BDC BT 1 0 0 -1 42 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 9 >> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 10.5 27.25500107 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0009>-4<000A>-4<000B>-4<000C>-4<000D>-4<000E>-3<000F>-4<0010>-4<0011>-4<0012>-4<0013>-4<0014>-4<0015>-4<0016>-4<0013>-4<0017>-3<0018>-4<0019>-4<001A>-4<001B>] TJ ET EMC /P <</MCID 10 >> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 221.33999634 27.25500107 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <</MCID 11 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 109.19999695 cm /P <</MCID 12 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 124.80000305 cm /P <</MCID 13 >> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 140.3999939 cm /P <</Lang (zh-CN) /MCID 14 >> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000A>-4<000B>-4<001C>-4<001D>-4<001E>] TJ ET EMC /P <</MCID 15 >> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 156 cm /P <</MCID 16 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(HEPES)-1(-CHAP)1(S)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 58.72399902 11.65499973 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 18 >> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63.97399902 11.65499973 Tm [<000300040005001F00200021>] TJ ET EMC /P <</MCID 19 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 126.97399902 11.65499973 Tm [( )] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 132.22399902 11.65499973 Tm [(25mM)] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 160.23300171 11.65499973 Tm [( )] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 162.60699463 11.65499973 Tm [(HEPES)] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 189.6519928 11.65499973 Tm [<0022>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 200.1519928 11.65499973 Tm [(DT)-1(T)] TJ ET EMC /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 216.84500122 11.65499973 Tm [<0022>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 227.34500122 11.65499973 Tm [(0.1%CHAP)1(S)] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 276.60998535 11.65499973 Tm [<00220023002400250026002700280029002A002B0014>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 392.10998535 11.65499973 Tm [(pH)] TJ ET EMC /P <</Lang (zh-CN) /MCID 29 >> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 406.79400635 11.65499973 Tm [<002C>] TJ ET EMC /P <</Lang (zh-CN) /MCID 30 >> BDC BT 1 0 0 -1 0 27.25500107 Tm [<002D002E>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 21 27.25500107 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 26.25 27.25500107 Tm [(7.5)] TJ ET EMC /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 39.54399872 27.25500107 Tm [<0014>] TJ ET EMC /P <</Lang (zh-CN) /MCID 34 >> BDC BT 1 0 0 -1 50.04399872 27.25500107 Tm [<002F00130017>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 84.16899872 27.25500107 Tm [(Casp)-1(ase)] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 121.40599823 27.25500107 Tm [<003000310032003300340028000C0013001700350010003600370014001500380013001700180019001A001B0039003A003B0013003C0032>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 415.40600586 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 187.19999695 cm /P <</MCID 38 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 202.80000305 cm /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000A>-4<000B>-4<002A>-4<002B>-4<001E>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 218.3999939 cm /P <</MCID 41 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 234 cm q 0.25 0.5 m 126.55000305 0.5 l 126.55000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABH 9 Tf 1 0 0 -1 39.9280014 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<000A>-4<000B>-4<003D>-4<003E>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAI 9 Tf 1 0 0 -1 76.0719986 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 126.80000305 0 cm 0.25 0.5 m 78.5 0.5 l 78.5 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABH 9 Tf 1 0 0 -1 24.93899918 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<003F>-4<0040>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAI 9 Tf 1 0 0 -1 43.01100159 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 205.55000305 0 cm 0.25 0.5 m 76.25 0.5 l 76.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABH 9 Tf 1 0 0 -1 14.77799988 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0041>-4<0042>-4<0043>-4<0044>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAI 9 Tf 1 0 0 -1 50.92200089 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.89599991 15.00500011 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0006>-4<0007>-4<0008>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAI 9 Tf 1 0 0 -1 34.00400162 15.00500011 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.546 15.00500011 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0045>-4<0046>-4<0047>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAABD 9 Tf 1 0 0 -1 33.65399933 15.00500011 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 23.89999962 cm q 0.25 0.5 m 126.55000305 0.5 l 126.55000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 52 >> BDC BT /FAAAAI 9 Tf 1 0 0 -1 4.61299992 14.77600098 Tm /GS2 gs 0 g [(HEPES)-1(-CHAP)1(S)] TJ ET EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAACB 9 Tf 1 0 0 -1 57.19800186 15.00499916 Tm [<000300040005>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAI 9 Tf 1 0 0 -1 84.19799805 14.77600098 Tm [(\(p)-1(H7)1(.)-1(5\))] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 111.38700104 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 126.80000305 0 cm 0.25 0.5 m 78.5 0.5 l 78.5 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 56 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 22.72500038 15.00499916 Tm /GS2 gs 0 g [(100ml)] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAI 9 Tf 1 0 0 -1 45.22499847 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 205.55000305 0 cm 0.25 0.5 m 76.25 0.5 l 76.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 58 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 28.35000038 15.00499916 Tm /GS2 gs 0 g [(RT)] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAI 9 Tf 1 0 0 -1 37.34999847 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 60 >> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.54399967 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAACB 9 Tf 1 0 0 -1 19.3560009 15.00500011 Tm [<004E>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.3560009 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 63 >> BDC BT /FAAAAI 9 Tf 1 0 0 -1 7.69399977 15.00500011 Tm /GS2 gs 0 g [(6)] TJ ET EMC /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAACB 9 Tf 1 0 0 -1 14.50599957 15.00500011 Tm [<004F0050>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAI 9 Tf 1 0 0 -1 32.50600052 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 47.79999924 l S Q q 0.5 w 126.80000305 0.5 m 126.80000305 23.89999962 l S Q q 0.5 w 126.80000305 24.39999962 m 126.80000305 47.79999924 l S Q q 0.5 w 205.55000305 0.5 m 205.55000305 23.89999962 l S Q q 0.5 w 205.55000305 24.39999962 m 205.55000305 47.79999924 l S Q q 0.5 w 282.04998779 0.5 m 282.04998779 23.89999962 l S Q q 0.5 w 282.04998779 24.39999962 m 282.04998779 47.79999924 l S Q q 0.5 w 333.75 0.5 m 333.75 23.89999962 l S Q q 0.5 w 333.75 24.39999962 m 333.75 47.79999924 l S Q q 0.5 w 384.75 0.5 m 384.75 47.79999924 l S Q q 0.5 w -0.25 0.25 m 385 0.25 l S Q q 0.5 w 0.25 24.14999962 m 384.5 24.14999962 l S Q q 0.5 w -0.25 48.04999924 m 385 48.04999924 l S Q Q q 1 0 0 1 0 282.29998779 cm /P <</MCID 66 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 21 11.38799953 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 42 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 297.8999939 cm /P <</MCID 69 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 313.5 cm /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0051>-4<0052>-4<0053>-4<0054>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm 0 Tr [(\()] TJ ET EMC /P <</Lang (zh-CN) /MCID 72 >> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 45.43899918 11.65499973 Tm 2 Tr [<000C>-4<000D>-4<0055>-4<0056>] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 87.60700226 11.65499973 Tm 0 Tr [(\))] TJ ET EMC /P <</Lang (zh-CN) /MCID 74 >> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 90.87799835 11.65499973 Tm 2 Tr [<001E>] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 101.41999817 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 329.1000061 cm /P <</MCID 76 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<0022005700580059005A0020005B005100520032>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 110.3219986 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 344.70001221 cm /P <</MCID 79 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 360.29998779 cm /P <</Lang (zh-CN) /MCID 80 >> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<005C>-4<005D>-4<005E>-4<005F>-4<001E>] TJ ET EMC /P <</MCID 81 >> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 375.8999939 cm /P <</MCID 82 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 83 >> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<0022002E006000610062006300640065006600670014006800690059005A006A006B006C006D006E006F00700071005100520032>] TJ ET EMC /P <</MCID 84 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 278.32199097 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 391.5 cm /P <</MCID 85 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 407.1000061 cm /P <</Lang (zh-CN) /MCID 86 >> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0072>-4<0073>-4<000A>-4<000B>-4<001E>] TJ ET EMC /P <</MCID 87 >> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 422.70001221 cm /P <</MCID 88 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 438.29998779 cm q 0.25 0.5 m 358.75 0.5 l 358.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</Lang (zh-CN) /MCID 89 >> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<00740075000E0076007700780079007A00340028007B>] TJ ET EMC /P <</MCID 90 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 115.5 11.65499973 Tm [(\(JC-1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 91 >> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 144.375 11.65499973 Tm [<0080>] TJ ET EMC /P <</MCID 92 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 154.875 11.65499973 Tm [(\))] TJ ET EMC /P <</MCID 93 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 160.125 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.10000038 cm q 0.25 0.5 m 358.75 0.5 l 358.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</Lang (zh-CN) /MCID 94 >> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<008200830084008500860087008800420089008A0079007A00340028007B>] TJ ET EMC /P <</MCID 95 >> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 157.5 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.20000076 cm q 0.25 0.5 m 358.75 0.5 l 358.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</Lang (zh-CN) /MCID 96 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