%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 142 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q q 1 0 0 1 0 450 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q Q q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.79999924 0 20.79999924 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.3690033 l -90 87.3690033 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 41.42499924 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 413.36099243 41.42499924 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.4109993 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.39700317 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.38300323 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 -0.00000076 cm q 188.3614502 0 0 -41.42535019 0 41.42535019 cm /X2 Do Q Q Q q 1 0 0 1 90 129.91900635 cm /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 0 21.06800079 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 0 54.8769989 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 62.94900131 54.8769989 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 173.38900757 54.8769989 Tm 0 Tr [(\(2)] TJ ET EMC /P <> BDC BT /FAAACB 22 Tf 1 0 0 -1 191.39300537 54.8769989 Tm 2 Tr [(?] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 213.48100281 54.8769989 Tm 0 Tr [(HeBS)1(,pH6.7\))] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 327.55200195 54.8769989 Tm 2 Tr [<0009>-4<000A>-4<000B>] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 393.81600952 54.8769989 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 69.80000305 62.40000153 cm /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 0 11.38799953 Tm /GS2 gs 0 g [( )-1( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 10.5 27.25500107 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000C>-4<000D>-4<000E>-4<000F>-4<0010>-4<0011>-3<0012>-4<0013>-4<0014>-4<0015>-4<0016>-4<0017>-4<0018>-4<0019>-4<0016>-4<001A>-3<001B>-4<001C>-4<001D>-4<001E>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 221.33999634 27.25500107 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 109.19999695 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 124.80000305 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000D>-4<000E>-4<001F>-4<0020>-4<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 140.3999939 cm /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<001200220023002400250026002700280029002A002B002C002D002E002F00300031>] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.5 11.65499973 Tm [<0017>] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.51600647 11.65499973 Tm [<003200330034003500360037002D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.01599121 11.65499973 Tm [<0038>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 270.03201294 11.65499973 Tm [(DE)-1(A)1(E-)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 296.03601074 11.65499973 Tm [<0039003A003B00360037002D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 359.03601074 11.65499973 Tm [<0038>] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.05200195 11.65499973 Tm [<003C003D0011002D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 410.05200195 11.65499973 Tm [<0038>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<003E>-56<003F>-56<0040>-57<002D>-56<0038>-56<0041>-56<0042>-56<0043>-57<0044>-56<002D>-56<0045>-56<0046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 133.08000183 27.25500107 Tm [(2)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 138.99200439 27.25500107 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 150.08200073 27.25500107 Tm [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.1269989 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 182.96699524 27.25500107 Tm [<0003>-56<0004>-56<0005>-57<0006>-56<0007>-56<0047>-56<0048>-56<0016>-57<001A>-56<0033>-56<0034>-56<0035>-56<0036>-56<0037>-57<0017>-56<0049>-56<0047>-56<0048>-56<004A>-57<004B>-56<004C>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 415.85699463 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [(HEPES)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 27.77300072 42.85499954 Tm [<0017>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 39.00099945 42.85499954 Tm [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.04599762 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 72.02400208 42.85499954 Tm [<004D>-69<004E>-70<0031>-69<004F>-69<0050>-70<0051>-69<0052>-69<0053>-70<0003>-69<0004>-69<0054>-70<0017>-69<0055>-69<002E>-70<0056>-69<0057>-69<0058>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 262.8999939 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.87799072 42.85499954 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.93701172 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 286.91500854 42.85499954 Tm [<0059>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 298.14300537 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.1210022 42.85499954 Tm [(6.8)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 318.14300537 42.85499954 Tm [<005A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 329.3710022 42.85499954 Tm [(8.2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 342.66500854 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 348.64300537 42.85499954 Tm [<005B>-69<005C>-70<0017>-69<005D>-69<0049>-70<0059>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 416.01098633 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [(pH7.)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.35300064 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 31.71699905 58.45499802 Tm [<005A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 43.33100128 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.69499969 58.45499802 Tm [(7.4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.98899841 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 69.35299683 58.45499802 Tm [<005E>-106<002E>-106<005F>-106<0060>-106<002B>-106<0003>-107<0004>-106<0055>-106<0061>-106<0017>-106<0062>-106<0063>-106<0064>-106<004E>-106<0065>-106<004C>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 255.17700195 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.54098511 58.45499802 Tm [(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.18499756 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 278.54901123 58.45499802 Tm [<005A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 290.16299438 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.52700806 58.45499802 Tm [(50mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT 1 0 0 -1 340.36199951 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 346.72601318 58.45499802 Tm [<0017>-106<0066>-106<0067>-106<0007>-106<0068>-106<0069>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 416.41000366 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.05500031 Tm [(20mm)1(o)-1(l/L)-1(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.87999725 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 76.12999725 74.05500031 Tm [<006A006B006C006D005F0060002B00030004005500610046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 202.13000488 74.05500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 218.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 234 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.04500008 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 32.34500122 11.65499973 Tm [<0003>-5<0004>-5<0005>-4<0006>-5<0007>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 85.09500122 11.65499973 Tm [(\(2)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 93.65100098 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 104.2009964 11.65499973 Tm [(HeBS\))] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 129.73699951 11.65499973 Tm [<004D>-5<004E>-5<0031>-4<006E>-5<0016>-5<002B>-5<0029>-4<002A>-5<0036>-5<0037>-5<0006>-4<0007>-5<0017>-5<0047>-5<0048>-4<006F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 298.5369873 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.83700562 11.65499973 Tm [(HEPES)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 330.93200684 11.65499973 Tm [<0038>-5<0070>-5<0071>-4<0072>-5<0038>-5<0033>-5<0034>-4<0005>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<00450073004A0017004900740075>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 73.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.75 27.25500107 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.80899811 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 96.05899811 27.25500107 Tm [<0076004C>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 117.05899811 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.30899811 27.25500107 Tm [(6.7)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 135.60299683 27.25500107 Tm [<0017007700780079007A007B007C007D0046007E007F0033003400350036003700560080002B0024008100470048002E008200830084>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 419.10299683 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.31299973 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 24.61100006 42.85499954 Tm [<0069>-5<0085>-4<0038>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 56.25500107 42.85499954 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.56800079 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 80.86599731 42.85499954 Tm [<0059>-5<0029>-4<002A>-5<0086>-4<0087>-5<0088>-4<002B>-5<0089>-5<008A>-4<0038>-5<008B>-4<008C>-5<0089>-4<008A>-5<0046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 239.08599854 42.85499954 Tm [(2)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 244.45599365 42.85499954 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 255.0039978 42.85499954 Tm [(HeBS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.30599976 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 282.60400391 42.85499954 Tm [<0048>-5<008D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 306.32501221 42.85499954 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.63800049 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 330.93600464 42.85499954 Tm [<0063>-5<0064>-4<0059>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 362.57998657 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 367.87799072 42.85499954 Tm [(10)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 378.57000732 42.85499954 Tm [<005A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 389.11801147 42.85499954 Tm [(50)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 399.80999756 42.85499954 Tm [<008E>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 410.35800171 42.85499954 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29998779 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 0 58.45499802 Tm [<004C>-26<008F>-27<0017>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 32.33399963 58.45499802 Tm [(Hela)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 51.81800079 58.45499802 Tm [<0038>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 62.59600067 58.45499802 Tm [(BALB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.50900269 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 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[(DMS)-1(O)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29501343 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 0 74.05500031 Tm [<009700980099008B008C007C007D0093009A009B00360037005600800046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 157.5 74.05500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 312 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.6000061 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000D>-4<000E>-4<0073>-4<004A>-4<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 343.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 358.79998779 cm q 0.25 0.5 m 148.8999939 0.5 l 148.8999939 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 51.10300064 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<000D>-4<000E>-4<009C>-4<009D>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 87.24700165 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 149.1499939 0 cm 0.25 0.5 m 56.15000153 0.5 l 56.15000153 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 13.76399994 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<009E>-4<009F>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 31.83600044 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 205.55000305 0 cm 0.25 0.5 m 76.25 0.5 l 76.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 14.77799988 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<00A0>-4<00A1>-4<00A2>-4<00A3>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 50.92200089 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.89599991 15.00500011 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0009>-4<000A>-4<000B>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 34.00400162 15.00500011 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.546 15.00500011 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<002E>-4<0056>-4<00A4>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 33.65399933 15.00500011 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 23.89999962 cm q 0.25 0.5 m 148.8999939 0.5 l 148.8999939 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 2.90300012 14.77600098 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 28.33399963 15.00499916 Tm [<00030004000500060007>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 73.33399963 14.77600098 Tm [(\(2)] TJ ET EMC /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 80.625 15.00499916 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 89.625 14.77600098 Tm [(HeBS,pH6.7\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.44700623 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 149.1499939 0 cm 0.25 0.5 m 56.15000153 0.5 l 56.15000153 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 11.55000019 15.00499916 Tm /GS2 gs 0 g [(100ml)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 34.04999924 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 205.55000305 0 cm 0.25 0.5 m 76.25 0.5 l 76.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 28.35000038 15.00499916 Tm /GS2 gs 0 g [(RT)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 37.34999847 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.54399967 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 19.3560009 15.00500011 Tm [<00AB>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.3560009 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.19400024 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 19.00600052 15.00500011 Tm [<00AC>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.00600052 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 47.79999924 l S Q q 0.5 w 149.1499939 0.5 m 149.1499939 23.89999962 l S Q q 0.5 w 149.1499939 24.39999962 m 149.1499939 47.79999924 l S Q q 0.5 w 205.54998779 0.5 m 205.54998779 23.89999962 l S Q q 0.5 w 205.54998779 24.39999962 m 205.54998779 47.79999924 l S Q q 0.5 w 282.04998779 0.5 m 282.04998779 23.89999962 l S Q q 0.5 w 282.04998779 24.39999962 m 282.04998779 47.79999924 l S Q q 0.5 w 333.75 0.5 m 333.75 23.89999962 l S Q q 0.5 w 333.75 24.39999962 m 333.75 47.79999924 l S Q q 0.5 w 384.75 0.5 m 384.75 47.79999924 l S Q q 0.5 w -0.25 0.25 m 385 0.25 l S Q q 0.5 w 0.25 24.14999962 m 384.5 24.14999962 l S Q q 0.5 w -0.25 48.04999924 m 385 48.04999924 l S Q Q q 1 0 0 1 0 407.1000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 422.70001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 438.29998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<00AD>-4<00AE>-4<00AF>-4<00B0>-4<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 453.8999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<003800B100B200B300B400B500710007>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 89.3219986 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 469.5 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<0038>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 15.82199955 11.65499973 Tm [(PBS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.78199959 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 485.1000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(3)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<003800B6007B00B7>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 47.3219986 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 500.70001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(4)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<0038>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 15.82199955 11.65499973 Tm [(CaCl)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.77999878 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 45.02999878 11.65499973 Tm [<00060007>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 66.02999878 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 516.29998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(5)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<00380095009600B8>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 47.3219986 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5719986 11.65499973 Tm [(DMS)-1(O)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.78600311 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 531.90002441 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(6)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<003800B900BA00BB00BC>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 57.8219986 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 547.5 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 563.09997559 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<00BD>-4<00BE>-4<00BF>-4<00C0>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm 0 Tr [(\()] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 45.43899918 11.65499973 Tm 2 Tr [<000F>-4<0010>-4<00C1>-4<00C2>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 87.60700226 11.65499973 Tm 0 Tr [(\))] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 90.87799835 11.65499973 Tm 2 Tr [<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 101.41999817 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 578.70001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<003800590036003700C3>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 57.8219986 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.0719986 11.65499973 Tm [(24h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.23200226 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 84.48200226 11.65499973 Tm [<001600B200B300B400B50071006600670029002A001700C40075008500C500A40029002A003600C600C700C8002B0066006700C900CA0084001700150029002A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 420.48199463 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 594.29998779 cm /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<005900360037008900CB00CC00CD00CE00CF00600046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 115.5 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 609.90002441 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<0038005900D00026>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 47.3219986 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5719986 11.65499973 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.88500214 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 77.13500214 11.65499973 Tm [<00D100C3>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 98.13500214 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.38500214 11.65499973 Tm [(2)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 108.70700073 11.65499973 Tm [<005A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 119.20700073 11.65499973 Tm [(4h)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 130.04499817 11.65499973 Tm [<001700D2>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 151.04499817 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.29499817 11.65499973 Tm [(9ml/10cm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.94099426 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 205.19099426 11.65499973 Tm [<0066006700CA002B00D300D400D0002600D500D600660067000700170091001A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 373.19100952 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.44100952 11.65499973 Tm [(37)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 389.08499146 11.65499973 Tm [<00D7>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 399.58499146 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 404.83499146 11.65499973 Tm [(5%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 417.66299438 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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