%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 118 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q q 1 0 0 1 0 450 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q Q q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.79999924 0 20.79999924 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.3690033 l -90 87.3690033 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 41.42499924 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 413.36099243 41.42499924 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.4109993 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.39700317 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.38300323 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 -0.00000076 cm q 188.3614502 0 0 -41.42535019 0 41.42535019 cm /X2 Do Q Q Q q 1 0 0 1 90 129.91900635 cm /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 0 21.06800079 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 54.8769989 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 56 54.8769989 Tm [(HEPES)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 118.9489975 54.8769989 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 185.21299744 54.8769989 Tm 0 Tr [(\(1)] TJ ET EMC /P <> BDC BT /FAAACB 22 Tf 1 0 0 -1 203.21699524 54.8769989 Tm 2 Tr [(?] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 225.30499268 54.8769989 Tm 0 Tr [(,)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 230.977005 54.8769989 Tm 2 Tr [<0007>-4<0008>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 297.24099731 54.8769989 Tm 0 Tr [(\))] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 304.09500122 54.8769989 Tm 2 Tr [<000A>-4<000B>-4<000C>] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 370.35900879 54.8769989 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 69.80000305 62.40000153 cm /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 0 11.38799953 Tm /GS2 gs 0 g [( )-1( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.5 27.25500107 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 21 27.25500107 Tm 2 Tr 0.30000001 w [<000D>-4<000E>-4<000F>-4<0010>-4<0011>-4<0012>-3<0013>-4<0014>-4<0015>-4<0016>-4<0017>-4<0018>-4<0019>-4<001A>-4<0017>-4<001B>-3<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 231.83999634 27.25500107 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 109.19999695 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 124.80000305 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000E>-4<000F>-4<0020>-4<0021>-4<0022>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 140.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.04500008 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 32.61899948 11.65499973 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 43.44300079 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.01699829 11.65499973 Tm [(4-\(2-Hydroxyethyl\)p)-1(ip)-1(e)1(razin)-1(e)1(-1-ethan)-1(e)1(su)-1(lfo)-1(ni)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.76300049 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.46099854 11.65499973 Tm [(acid)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 269.18099976 11.65499973 Tm [<0018>-31<0018>-31<0024>-31<0025>-30<0026>-31<0027>-31<0028>-31<0029>-31<002A>-31<0017>-31<002B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 388.24499512 11.65499973 Tm [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29000854 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 0 27.25500107 Tm [<002C002D002E002F0030003100320029000300040033001800340035003600370038>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 178.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.75 27.25500107 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.80900574 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 201.05900574 27.25500107 Tm [<0039>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 211.55900574 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.80900574 27.25500107 Tm [(6.8)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 230.10299683 27.25500107 Tm [<003A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 240.60299683 27.25500107 Tm [(8.2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.89700317 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 259.14700317 27.25500107 Tm [<003B003C0018003D003E0039>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 322.14700317 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 327.39700317 27.25500107 Tm [(pH7.)-1(2)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 352.75 27.25500107 Tm [<003A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 363.25 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.5 27.25500107 Tm [(7.4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 381.79400635 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 387.04400635 27.25500107 Tm [<003F00350040>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<0041>-12<0042>-12<0003>-12<0004>-12<0034>-12<0043>-13<0018>-12<0044>-12<0045>-12<0046>-12<002D>-12<0047>-12<0048>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 138.15100098 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.52799988 42.85499954 Tm [(10)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 154.29899597 42.85499954 Tm [<003A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 164.92599487 42.85499954 Tm [(50mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 208.88800049 42.85499954 Tm [<0018>-12<0049>-12<004A>-12<0005>-12<004B>-12<0007>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 272.6499939 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.02700806 42.85499954 Tm [(20mm)1(o)-1(l/L)-1(HEPES)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 351.65899658 42.85499954 Tm [<0023>-12<004C>-12<004D>-12<004E>-12<0040>-12<0041>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [<00420003000400340043002B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 63 58.45499802 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 202.80000305 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 218.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.04500008 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 32.29499817 11.65499973 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 63.79499817 11.65499973 Tm [(\(1)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 72.3010025 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 82.8010025 11.65499973 Tm [(,)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 85.42099762 11.65499973 Tm [<000700080009>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 116.92099762 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 120.10500336 11.65499973 Tm [<002C002D002E00250026>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 172.60499573 11.65499973 Tm [(-)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 175.82000732 11.65499973 Tm [<00250026004F005000510052005300540017005500050018>] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.82000732 11.65499973 Tm [<005600570058>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 335.94500732 11.65499973 Tm [(HEPES)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 362.98999023 11.65499973 Tm [<0059005A005B005C0059>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<005A>-8<005B>-9<005D>-8<0059>-8<005E>-8<005F>-9<0060>-8<0059>-8<0061>-9<0062>-8<0063>-8<0064>-8<0065>-9<0066>-8<0018>-8<0067>-9<0007>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 179.97900391 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.31599426 27.25500107 Tm [(Ca2+)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 206.58200073 27.25500107 Tm [<0059>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 217.16900635 27.25500107 Tm [(Mg2+)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 241.727005 27.25500107 Tm [<0018>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 252.31399536 27.25500107 Tm [(pH7.)-1(4)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 277.7539978 27.25500107 Tm [<0018>-8<0068>-9<0069>-8<006A>-8<006B>-8<006C>-9<006D>-8<006E>-8<002B>-9<0054>-8<0017>-8<001B>-8<006F>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<0070007100720049004A0069007300530074007500650076007700250026>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 157.5 42.85499954 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 160.68400574 42.85499954 Tm [<003D003E002C0078007900250026>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 234.18400574 42.85499954 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 237.36799622 42.85499954 Tm [<0018>] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.58399963 42.85499954 Tm [<007A007B007C007D0025002600420008004F007E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 352.58401489 42.85499954 Tm [<0018>] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.79998779 42.85499954 Tm [<007F0080001900810082>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [<0025002600710072004200830066002B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 84 58.45499802 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 280.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 296.3999939 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000E>-4<000F>-4<0065>-4<0066>-4<0022>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 312 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 327.6000061 cm q 0.25 0.5 m 126.55000305 0.5 l 126.55000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 39.9280014 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<000E>-4<000F>-4<0084>-4<0085>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 76.0719986 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 126.80000305 0 cm 0.25 0.5 m 78.5 0.5 l 78.5 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 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1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.546 15.00500011 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0035>-4<0036>-4<0070>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 33.65399933 15.00500011 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 23.89999962 cm q 0.25 0.5 m 126.55000305 0.5 l 126.55000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 7.65100002 14.77600098 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 33.08200073 15.00499916 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 60.08200073 14.77600098 Tm [(\(1)] TJ ET EMC /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 67.3730011 15.00499916 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 76.3730011 14.77600098 Tm [(,)] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 78.6190033 15.00499916 Tm [<000700080009>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 105.6190033 14.77600098 Tm [(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.34799957 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 126.80000305 0 cm 0.25 0.5 m 78.5 0.5 l 78.5 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 22.72500038 15.00499916 Tm /GS2 gs 0 g [(500ml)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 45.22499847 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 205.55000305 0 cm 0.25 0.5 m 76.25 0.5 l 76.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACH 9 Tf 1 0 0 -1 28.35000038 15.00499916 Tm /GS2 gs 0 g [(RT)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 37.34999847 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.54399967 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 19.3560009 15.00500011 Tm [<0091>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.3560009 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 7.69399977 15.00500011 Tm /GS2 gs 0 g [(3)] TJ ET EMC /P <> BDC BT /FAAACD 9 Tf 1 0 0 -1 14.50599957 15.00500011 Tm [<00920093>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 32.50600052 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 47.79999924 l S Q q 0.5 w 126.80000305 0.5 m 126.80000305 23.89999962 l S Q q 0.5 w 126.80000305 24.39999962 m 126.80000305 47.79999924 l S Q q 0.5 w 205.55000305 0.5 m 205.55000305 23.89999962 l S Q q 0.5 w 205.55000305 24.39999962 m 205.55000305 47.79999924 l S Q q 0.5 w 282.04998779 0.5 m 282.04998779 23.89999962 l S Q q 0.5 w 282.04998779 24.39999962 m 282.04998779 47.79999924 l S Q q 0.5 w 333.75 0.5 m 333.75 23.89999962 l S Q q 0.5 w 333.75 24.39999962 m 333.75 47.79999924 l S Q q 0.5 w 384.75 0.5 m 384.75 47.79999924 l S Q q 0.5 w -0.25 0.25 m 385 0.25 l S Q q 0.5 w 0.25 24.14999962 m 384.5 24.14999962 l S Q q 0.5 w -0.25 48.04999924 m 385 48.04999924 l S Q Q q 1 0 0 1 0 375.8999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 391.5 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 407.1000061 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0094>-4<002A>-4<0095>-4<0096>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm 0 Tr [(\()] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 45.43899918 11.65499973 Tm 2 Tr [<0010>-4<0011>-4<0097>-4<0098>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 87.60700226 11.65499973 Tm 0 Tr [(\))] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 90.87799835 11.65499973 Tm 2 Tr [<0022>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 101.41999817 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 422.70001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<0059005600570017001B00740075002500260018002A00170099009A001B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 162.82200623 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.07200623 11.65499973 Tm [(PBS)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 184.03199768 11.65499973 Tm [<0018009B009C00160017002B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 247.03199768 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 438.29998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.43499994 11.65499973 Tm [<0059>-11<009D>-11<0048>-10<0025>-11<0026>-11<0018>-11<009B>-10<009C>-11<0074>-11<0075>-11<0023>-10<004C>-11<002B>-11<009D>-11<0048>-10<0065>-11<0076>-11<0018>-11<009E>-10<009F>-11<00A0>-11<0065>-11<0076>-11<0018>-10<00A1>-11<001B>-11<00A2>-11<00A3>-10<0042>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 313.21200562 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 318.57501221 11.65499973 Tm [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 345.61999512 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 350.98300171 11.65499973 Tm [<0003>-11<0004>-11<0005>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 382.82199097 11.65499973 Tm [(\(1)] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 391.44100952 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 402.0539856 11.65499973 Tm [(,)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 404.7869873 11.65499973 Tm [<0007>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<00080009>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 21 27.25500107 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 24.18400002 27.25500107 Tm [<005300180067009F006600A400A50018007A00A600A400A7004200030004000500A8007200650076001800A900AA00AB>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 276.18399048 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.43399048 27.25500107 Tm [(BSA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.04501343 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 303.29501343 27.25500107 Tm [<00AC00AD004100420049004A00AE00530018001700AF>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<00B000B100650076009F00B2001800B300B400B500B6002500260049004A006400510052002B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 199.5 42.85499954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 485.1000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 500.70001221 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<00B7>-4<00B8>-4<00B9>-4<00BA>-4<0022>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 516.29998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<005900B700B80027006C0094002A001800BB00A700BC00BD00BE00BF002B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 162.82200623 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 531.90002441 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<0059004800C000C1004200C200C300C400C500C6001800C700C80051005200C9006700CA002D00CB002900CC00CD0094002A002B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 278.32199097 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 547.5 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 563.09997559 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<00CE>-4<00CF>-4<000E>-4<000F>-4<0022>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 578.70001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 594.29998779 cm q 0.25 0.5 m 373.75 0.5 l 373.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<00D000D100D200D3>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 42 11.65499973 Tm [(-EDTA)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 70.875 11.65499973 Tm [<00550005>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 91.875 11.65499973 Tm [(\(0.25%_0.02%,)] TJ ET EMC /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 160.125 11.65499973 Tm [<000700DD00DE>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 191.625 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 196.875 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.10000038 cm q 0.25 0.5 m 373.75 0.5 l 373.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACD 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<00D000D100D200D300550005>] TJ ET EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 63 11.65499973 Tm [(\(0.25%\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 99.75 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 32.20000076 l S Q q 0.5 w 374 0.5 m 374 32.20000076 l S Q q 0.5 w -0.25 0.25 m 374.25 0.25 l S Q q 0.5 w 0.25 16.35000038 m 373.75 16.35000038 l S Q q 0.5 w -0.25 32.45000076 m 374.25 32.45000076 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>