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1 0 0 -1 0 841.90002441 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q q 1 0 0 1 0 450 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q Q q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.79999924 0 20.79999924 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.3690033 l -90 87.3690033 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 41.42499924 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 413.36099243 41.42499924 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.4109993 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.39700317 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.38300323 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 -0.00000076 cm q 188.3614502 0 0 -41.42535019 0 41.42535019 cm /X2 Do Q Q Q q 1 0 0 1 90 129.91900635 cm /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 0 21.06800079 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 54.8769989 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 40 54.8769989 Tm [(HEPES)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 102.9489975 54.8769989 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 147.125 54.8769989 Tm 0 Tr [(\(1)1(m)-1(o)1(l/L,)1(Fr)-1(ee)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.75201416 54.8769989 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.72601318 54.8769989 Tm [(Acid\))] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 316.32598877 54.8769989 Tm 2 Tr [<0005>-4<0006>-4<0007>] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 382.58999634 54.8769989 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 69.80000305 62.40000153 cm /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 0 11.38799953 Tm /GS2 gs 0 g [( )-1( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 10.5 27.25500107 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0008>-4<0009>-4<000A>-4<000B>-4<000C>-4<000D>-3<000E>-4<000F>-4<0010>-4<0011>-4<0012>-4<0013>-4<0014>-4<0015>-4<0012>-4<0016>-3<0017>-4<0018>-4<0019>-4<001A>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 221.33999634 27.25500107 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 109.19999695 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 124.80000305 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0009>-4<000A>-4<001B>-4<001C>-4<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 140.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 30.10099983 11.65499973 Tm [<001E>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 43.6570015 11.65499973 Tm [(4-\(2-Hydroxyethyl\)p)-1(ip)-1(e)1(razin)-1(e)1(-1-ethan)-1(e)1(su)-1(lfo)-1(ni)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.40299988 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.20799255 11.65499973 Tm [(acid)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 264.03500366 11.65499973 Tm [<0013>-41<001F>-41<0020>-41<0021>-41<0022>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 318.69000244 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.3710022 11.65499973 Tm [(N-\(2-)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 346.51501465 11.65499973 Tm [<0023>-41<0024>-41<0025>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 379.30801392 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 384.98901367 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 388.17300415 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 393.85400391 11.65499973 Tm [<0026>-41<0027>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 415.71600342 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [(-N')1(-)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.84600067 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 26.09600067 27.25500107 Tm [<002800290013002A002B002C002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 99.59600067 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.84600067 27.25500107 Tm [(C8H18N)1(2O4S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.1499939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 167.3999939 27.25500107 Tm [<0013002A002B002E002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 219.8999939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.1499939 27.25500107 Tm [(238.31)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.41000366 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 259.66000366 27.25500107 Tm [<0013>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 270.16000366 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.41000366 27.25500107 Tm [(CAS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.90899658 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.2829895 27.25500107 Tm [(Number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 329.36700439 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.74099731 27.25500107 Tm [(7365)1(-45-9)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 375.42300415 27.25500107 Tm [<0013002F00300031>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<0032>-59<0033>-59<0034>-59<0035>-58<0012>-59<0013>-59<0036>-59<0037>-59<0038>-59<0039>-59<003A>-58<002B>-59<003B>-59<0034>-59<003C>-59<003D>-59<0004>-59<0013>-58<003E>-59<003F>-59<0040>-59<0041>-59<0042>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 255.71400452 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.58200073 42.85499954 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.64099121 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 279.50900269 42.85499954 Tm [<0043>-59<0044>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 301.74499512 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.61300659 42.85499954 Tm [(6.8)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 321.5249939 42.85499954 Tm [<0045>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 332.64300537 42.85499954 Tm [(8.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 340.61499023 42.85499954 Tm [(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 349.17999268 42.85499954 Tm [<0046>-59<0047>-59<0013>-59<0048>-58<0049>-59<0044>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 415.88800049 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [(pH7.)-1(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 25.70499992 58.45499802 Tm [<0045>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 36.55699921 58.45499802 Tm [(7.4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.85100174 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 55.45299911 58.45499802 Tm [<004A>-34<003F>-33<004B>-34<004C>-33<004D>-34<003C>-33<003D>-34<003E>-33<004E>-34<0013>-33<004F>-34<0050>-33<0051>-34<0037>-33<0052>-34<002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 229.08500671 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.68699646 58.45499802 Tm [(10)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 245.68299866 58.45499802 Tm [<0045>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 256.53500366 58.45499802 Tm [(50mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 300.72198486 58.45499802 Tm [<0013>-34<0053>-33<0054>-34<0055>-33<0056>-34<0057>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 365.83401489 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 371.43600464 58.45499802 Tm [(20mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.27099609 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.05500031 Tm [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.04500008 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 32.29499817 74.05500031 Tm [<001E00580059005A004B004C004D003C003D003E004E0013005B005C00360044005D005E002C00530054005F00300031006000610062003E00630064004B00650066>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 378.79501343 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 384.04501343 74.05500031 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 396.10400391 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 401.35400391 74.05500031 Tm [<00430067>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 422.35400391 74.05500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 218.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 234 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.04500008 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 32.29499817 11.65499973 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 53.29499817 11.65499973 Tm [(\(1mol)-1(/L,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.22499847 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.59899902 11.65499973 Tm [(Free)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.53299713 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.90699768 11.65499973 Tm [(Ac)1(i)-1(d\))] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 134.53199768 11.65499973 Tm [<00360037003800680012003C003D006900550003006A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.03199768 11.65499973 Tm [<0013>] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.85400391 11.65499973 Tm [<006B006C006D0029>] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.85400391 11.65499973 Tm [<0067>] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.67599487 11.65499973 Tm [<006E006F0004000B001200160070000F00710072>] TJ ET EMC /P <> BDC BT 1 0 0 -1 412.67599487 11.65499973 Tm [<0013>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<0014007300120016001700180019001A005F00490074001200750067>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 147 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.25 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 265.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 280.79998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0009>-4<000A>-4<0076>-4<0077>-4<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 296.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 312 cm q 0.25 0.5 m 137 0.5 l 137 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 45.15299988 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0009>-4<000A>-4<0021>-4<0022>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 81.29699707 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 137.25 0 cm 0.25 0.5 m 61.25 0.5 l 61.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 16.31399918 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0078>-4<0079>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 34.38600159 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 198.75 0 cm 0.25 0.5 m 73.69999695 0.5 l 73.69999695 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 13.50300026 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<007A>-4<007B>-4<007C>-4<007D>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 49.64699936 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 272.70001221 0 cm 0.25 0.5 m 49.75 0.5 l 49.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.046 15.00500011 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0005>-4<0006>-4<0007>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 33.15399933 15.00500011 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 322.70001221 0 cm 0.25 0.5 m 49.04999924 0.5 l 49.04999924 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 5.6960001 15.00500011 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<003F>-4<0040>-4<007E>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 32.80400085 15.00500011 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 23.89999962 cm q 0.25 0.5 m 137 0.5 l 137 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 7.71099997 14.77600098 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 33.14199829 15.00499916 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 51.14199829 14.77600098 Tm [(\(1mol)-1(/L,Free)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.16799927 14.77600098 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.20300293 14.77600098 Tm [(Ac)1(i)-1(d\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.73899841 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 137.25 0 cm 0.25 0.5 m 61.25 0.5 l 61.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 14.10000038 15.00499916 Tm /GS2 gs 0 g [(100ml)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 36.59999847 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 198.75 0 cm 0.25 0.5 m 73.69999695 0.5 l 73.69999695 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 27.07500076 15.00499916 Tm /GS2 gs 0 g [(RT)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 36.07500076 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 272.70001221 0 cm 0.25 0.5 m 49.75 0.5 l 49.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 11.69400024 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 18.50600052 15.00500011 Tm [<0085>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 27.50600052 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 322.70001221 0 cm 0.25 0.5 m 49.04999924 0.5 l 49.04999924 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 11.34399986 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 18.15600014 15.00500011 Tm [<0086>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 27.15600014 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 47.79999924 cm q 0.25 0.5 m 137 0.5 l 137 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 0.69700003 14.77600098 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.87800026 14.77600098 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.91300011 14.77600098 Tm [(Powder)1(\()-1(1)1(mo)-1(l/L)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.88300323 14.77600098 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.91799927 14.77600098 Tm [(Free)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.14700317 14.77600098 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.18199921 14.77600098 Tm [(Ac)1(i)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.98899841 14.77600098 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.02400208 14.77600098 Tm [(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.75299835 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 137.25 0 cm 0.25 0.5 m 61.25 0.5 l 61.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 14.10000038 15.00499916 Tm /GS2 gs 0 g [(100ml)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.59999847 15.00499916 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 198.75 0 cm 0.25 0.5 m 73.69999695 0.5 l 73.69999695 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 27.07500076 15.00499916 Tm /GS2 gs 0 g [(RT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.07500076 15.00499916 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 272.70001221 0 cm 0.25 0.5 m 49.75 0.5 l 49.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 11.69400024 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 18.50600052 15.00500011 Tm [<0085>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 27.50600052 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 322.70001221 0 cm 0.25 0.5 m 49.04999924 0.5 l 49.04999924 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 11.34399986 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 18.15600014 15.00500011 Tm [<0086>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 27.15600014 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 71.69999695 l S Q q 0.5 w 137.25 0.5 m 137.25 23.89999962 l S Q q 0.5 w 137.25 24.39999962 m 137.25 47.79999924 l S Q q 0.5 w 137.25 48.29999924 m 137.25 71.69999695 l S Q q 0.5 w 198.75 0.5 m 198.75 23.89999962 l S Q q 0.5 w 198.75 24.39999962 m 198.75 47.79999924 l S Q q 0.5 w 198.75 48.29999924 m 198.75 71.69999695 l S Q q 0.5 w 272.70001221 0.5 m 272.70001221 23.89999962 l S Q q 0.5 w 272.70001221 24.39999962 m 272.70001221 47.79999924 l S Q q 0.5 w 272.70001221 48.29999924 m 272.70001221 71.69999695 l S Q q 0.5 w 322.70001221 0.5 m 322.70001221 23.89999962 l S Q q 0.5 w 322.70001221 24.39999962 m 322.70001221 47.79999924 l S Q q 0.5 w 322.70001221 48.29999924 m 322.70001221 71.69999695 l S Q q 0.5 w 372 0.5 m 372 71.69999695 l S Q q 0.5 w -0.25 0.25 m 372.25 0.25 l S Q q 0.5 w 0.25 24.14999962 m 371.75 24.14999962 l S Q q 0.5 w 0.25 48.04999924 m 371.75 48.04999924 l S Q q 0.5 w -0.25 71.94999695 m 372.25 71.94999695 l S Q Q q 1 0 0 1 0 384.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 399.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 415.3999939 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0087>-4<0035>-4<0088>-4<0089>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm 0 Tr [(\()] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 45.43899918 11.65499973 Tm 2 Tr [<000B>-4<000C>-4<008A>-4<008B>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 87.60700226 11.65499973 Tm 0 Tr [(\))] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 90.87799835 11.65499973 Tm 2 Tr [<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 101.41999817 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 431 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 6.77600002 11.65499973 Tm [<008C>-138<008D>-139<0003>-138<006A>-139<0069>-138<008E>-139<0016>-138<008F>-139<0013>-138<0090>-139<008F>-138<0091>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 150.22399902 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.92799377 11.65499973 Tm [(100m)1(l)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 185.14500427 11.65499973 Tm [<0013>-138<001E>-139<0092>-138<0042>-139<0077>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 244.91499329 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.6190033 11.65499973 Tm [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.66400146 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.49200439 11.65499973 Tm [(Powder)1(\()-1(1)1(mo)-1(l/L)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 351.29098511 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 355.11898804 11.65499973 Tm [(Free)] TJ ET EMC /P <> BDC BT 1 0 0 -1 374.05300903 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 377.88101196 11.65499973 Tm [(Ac)1(i)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 396.32299805 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 400.15100098 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 404.78900146 11.65499973 Tm [<0067>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 415.28900146 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 27.25500107 Tm [<008C>] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.98799992 27.25500107 Tm [<0037005200930035004F00500051002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 98.98799896 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.23799896 27.25500107 Tm [(10)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 114.88200378 27.25500107 Tm [<0045>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 125.38200378 27.25500107 Tm [(50mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 169.21699524 27.25500107 Tm [<0013>] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.88299561 27.25500107 Tm [<009400680012004D00500051002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 252.38299561 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.63299561 27.25500107 Tm [(10mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 301.46798706 27.25500107 Tm [<0067>] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.13400269 27.25500107 Tm [<0095009600320097>] TJ ET EMC /P <> BDC BT 1 0 0 -1 353.13400269 27.25500107 Tm [<0013>] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.79998779 27.25500107 Tm [<005800980099009A0097>] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29998779 27.25500107 Tm [<0067>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 420.54998779 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 462.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 477.79998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<009B>-4<009C>-4<009D>-4<009E>-4<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 493.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<008C009B009C00320097008700350013009F002E00A000A100A200A30067>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 162.82200623 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 509 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<008C>] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.82199955 11.65499973 Tm [<00A400500051>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 49.9469986 11.65499973 Tm [(HEPES)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 79.61699677 11.65499973 Tm [<002F00A500A6003000310058003E003F00370066003300340067>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 216.11700439 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 524.59997559 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(3)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<008C002D00A700A8004D00A900AA00AB00AC00AD001300AE00AF00B000B100B200B300B4003700B5003400B600B7008700350067>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 278.32199097 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 540.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 555.79998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<00B8>-4<00B9>-4<0009>-4<000A>-4<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 571.40002441 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 587 cm q 0.25 0.5 m 354.75 0.5 l 354.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<003200BA0030003100BB00BC0055>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 73.5 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.10000038 cm q 0.25 0.5 m 354.75 0.5 l 354.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<0032009700BD003A002B008F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 63 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.20000076 cm q 0.25 0.5 m 354.75 0.5 l 354.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<00BE00120030003100BF007B0055>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 73.5 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 48.30000305 l S Q q 0.5 w 355 0.5 m 355 48.30000305 l S Q q 0.5 w -0.25 0.25 m 355.25 0.25 l S Q q 0.5 w 0.25 16.35000038 m 354.75 16.35000038 l S Q q 0.5 w 0.25 32.45000076 m 354.75 32.45000076 l S Q q 0.5 w -0.25 48.55000305 m 355.25 48.55000305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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