%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 128 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q q 1 0 0 1 0 450 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q Q q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.79999924 0 20.79999924 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.3690033 l -90 87.3690033 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 41.42499924 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 413.36099243 41.42499924 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.4109993 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.39700317 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.38300323 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 -0.00000076 cm q 188.3614502 0 0 -41.42535019 0 41.42535019 cm /X2 Do Q Q Q q 1 0 0 1 90 129.91900635 cm /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 0 21.06800079 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 54.8769989 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 56 54.8769989 Tm [(HEPES)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 118.9489975 54.8769989 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 163.125 54.8769989 Tm 0 Tr [(\(1)1(m)-1(o)1(l/L,)1(pH7.5\))] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 301.39801025 54.8769989 Tm 2 Tr [<0005>-4<0006>-4<0007>] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 367.6619873 54.8769989 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 69.80000305 62.40000153 cm /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 0 11.38799953 Tm /GS2 gs 0 g [( )-1( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.5 27.25500107 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 21 27.25500107 Tm 2 Tr 0.30000001 w [<0008>-4<0009>-4<000A>-4<000B>-4<000C>-4<000D>-3<000E>-4<000F>-4<0010>-4<0011>-4<0012>-4<0013>-4<0014>-4<0015>-4<0012>-4<0016>-3<0017>-4<0018>-4<0019>-4<001A>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 231.83999634 27.25500107 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 109.19999695 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 124.80000305 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0009>-4<000A>-4<001B>-4<001C>-4<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 140.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 30.10099983 11.65499973 Tm [<001E>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 43.6570015 11.65499973 Tm [(4-\(2-Hydroxyethyl\)p)-1(ip)-1(e)1(razin)-1(e)1(-1-ethan)-1(e)1(su)-1(lfo)-1(ni)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.40299988 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.20799255 11.65499973 Tm [(acid)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 264.03500366 11.65499973 Tm [<0013>-41<001F>-41<0020>-41<0021>-41<0022>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 318.69000244 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.3710022 11.65499973 Tm [(N-\(2-)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 346.51501465 11.65499973 Tm [<0023>-41<0024>-41<0025>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 379.30801392 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 384.98901367 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 388.17300415 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 393.85400391 11.65499973 Tm [<0026>-41<0027>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 415.71600342 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [(-N')1(-)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.84600067 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 26.09600067 27.25500107 Tm [<002800290013002A002B002C002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 99.59600067 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.84600067 27.25500107 Tm [(C8H18N)1(2O4S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.1499939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 167.3999939 27.25500107 Tm [<0013002A002B002E002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 219.8999939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.1499939 27.25500107 Tm [(238.31)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.41000366 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 259.66000366 27.25500107 Tm [<0013>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 270.16000366 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.41000366 27.25500107 Tm [(CAS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.90899658 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.2829895 27.25500107 Tm [(Number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 329.36700439 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.74099731 27.25500107 Tm [(7365)1(-45-9)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 375.42300415 27.25500107 Tm [<0013002F00300031>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<0032>-59<0033>-59<0034>-59<0035>-58<0012>-59<0013>-59<0036>-59<0037>-59<0038>-59<0039>-59<003A>-58<002B>-59<003B>-59<0034>-59<003C>-59<003D>-59<003E>-59<0013>-58<003F>-59<0040>-59<0041>-59<0042>-59<0043>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 255.71400452 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.58200073 42.85499954 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.64099121 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 279.50900269 42.85499954 Tm [<0044>-59<0045>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 301.74499512 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.61300659 42.85499954 Tm [(6.8)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 321.5249939 42.85499954 Tm [<0046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 332.64300537 42.85499954 Tm [(8.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 340.61499023 42.85499954 Tm [(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 349.17999268 42.85499954 Tm [<0047>-59<0048>-59<0013>-59<0049>-58<004A>-59<0045>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 415.88800049 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [(pH7.)-1(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 25.70499992 58.45499802 Tm [<0046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 36.55699921 58.45499802 Tm [(7.4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.85100174 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 55.45299911 58.45499802 Tm [<004B>-34<0040>-33<004C>-34<004D>-33<004E>-34<003C>-33<003D>-34<003F>-33<004F>-34<0013>-33<0050>-34<0051>-33<0052>-34<0037>-33<0053>-34<002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 229.08500671 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.68699646 58.45499802 Tm [(10)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 245.68299866 58.45499802 Tm [<0046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 256.53500366 58.45499802 Tm [(50mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 300.72198486 58.45499802 Tm [<0013>-34<0054>-33<0055>-34<0004>-33<0056>-34<0057>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 365.83401489 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 371.43600464 58.45499802 Tm [(20mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.27099609 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.05500031 Tm [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.04500008 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 32.29499817 74.05500031 Tm [<001E00580059005A004C004D004E003C003D003F004F0013005B005C00360045005D005E002C00540055005F00300031006000610062003F00630064004C00650066>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 378.79501343 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 384.04501343 74.05500031 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 396.10400391 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 401.35400391 74.05500031 Tm [<00440067>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 422.35400391 74.05500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 218.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 234 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 29.72800064 11.65499973 Tm [<0003>-6<0004>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 50.84400177 11.65499973 Tm [(\(1mol)-1(/L,pH7.)-1(5)1(\))] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 115.36799622 11.65499973 Tm [<0036>-6<0037>-5<0038>-6<0068>-5<0012>-6<0003>-5<0004>-6<0013>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 199.83200073 11.65499973 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.89100647 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 217.19900513 11.65499973 Tm [<0044>-6<0069>-5<002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 248.8730011 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.18099976 11.65499973 Tm [(7.5)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 267.5329895 11.65499973 Tm [<0013>-6<006A>-5<006B>-6<006C>-5<006D>-6<006E>-5<006F>-6<0070>-5<0013>-6<0071>-5<0072>-6<0073>-5<0074>-6<005A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<005400550025001F001E0058006700750076003E000B001200160077000F0078007900130014007A00120016001700180019001A005F004A007B0012007C0067>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 336 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 265.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 280.79998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0009>-4<000A>-4<007D>-4<007E>-4<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 296.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 312 cm q 0.25 0.5 m 126.55000305 0.5 l 126.55000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 39.9280014 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0009>-4<000A>-4<0021>-4<0022>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 76.0719986 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 126.80000305 0 cm 0.25 0.5 m 78.5 0.5 l 78.5 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 24.93899918 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<007F>-4<0080>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 43.01100159 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 205.55000305 0 cm 0.25 0.5 m 76.25 0.5 l 76.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 14.77799988 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0081>-4<0082>-4<0083>-4<0084>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 50.92200089 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.89599991 15.00500011 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0005>-4<0006>-4<0007>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 34.00400162 15.00500011 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.546 15.00500011 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0040>-4<0041>-4<0085>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 33.65399933 15.00500011 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 23.89999962 cm q 0.25 0.5 m 126.55000305 0.5 l 126.55000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 8.65600014 14.77600098 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 34.0870018 15.00499916 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 52.0870018 14.77600098 Tm [(\(1mol)-1(/L,pH7.)-1(5)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.34400177 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 126.80000305 0 cm 0.25 0.5 m 78.5 0.5 l 78.5 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 22.72500038 15.00499916 Tm /GS2 gs 0 g [(100ml)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 45.22499847 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 205.55000305 0 cm 0.25 0.5 m 76.25 0.5 l 76.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 28.35000038 15.00499916 Tm /GS2 gs 0 g [(RT)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 37.34999847 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.54399967 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 19.3560009 15.00500011 Tm [<008C>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.3560009 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.19400024 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 19.00600052 15.00500011 Tm [<008D>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.00600052 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 47.79999924 cm q 0.25 0.5 m 126.55000305 0.5 l 126.55000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 1.63100004 14.77600098 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.81200027 14.77600098 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.84700012 14.77600098 Tm [(So)-1(lu)-1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.07699966 14.77600098 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.11199951 14.77600098 Tm [(\(1mol)-1(/L,pH7.)-1(5)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.3690033 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 126.80000305 0 cm 0.25 0.5 m 78.5 0.5 l 78.5 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 22.72500038 15.00499916 Tm /GS2 gs 0 g [(100ml)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.22499847 15.00499916 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 205.55000305 0 cm 0.25 0.5 m 76.25 0.5 l 76.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 21.60000038 15.00499916 Tm /GS2 gs 0 g [(-20)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 35.09999847 15.00499916 Tm [<0090>] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 44.09999847 15.00499916 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.54399967 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 19.3560009 15.00500011 Tm [<008C>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.3560009 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.19400024 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 19.00600052 15.00500011 Tm [<008D>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.00600052 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 71.69999695 l S Q q 0.5 w 126.80000305 0.5 m 126.80000305 23.89999962 l S Q q 0.5 w 126.80000305 24.39999962 m 126.80000305 47.79999924 l S Q q 0.5 w 126.80000305 48.29999924 m 126.80000305 71.69999695 l S Q q 0.5 w 205.55000305 0.5 m 205.55000305 23.89999962 l S Q q 0.5 w 205.55000305 24.39999962 m 205.55000305 47.79999924 l S Q q 0.5 w 205.55000305 48.29999924 m 205.55000305 71.69999695 l S Q q 0.5 w 282.04998779 0.5 m 282.04998779 23.89999962 l S Q q 0.5 w 282.04998779 24.39999962 m 282.04998779 47.79999924 l S Q q 0.5 w 282.04998779 48.29999924 m 282.04998779 71.69999695 l S Q q 0.5 w 333.75 0.5 m 333.75 23.89999962 l S Q q 0.5 w 333.75 24.39999962 m 333.75 47.79999924 l S Q q 0.5 w 333.75 48.29999924 m 333.75 71.69999695 l S Q q 0.5 w 384.75 0.5 m 384.75 71.69999695 l S Q q 0.5 w -0.25 0.25 m 385 0.25 l S Q q 0.5 w 0.25 24.14999962 m 384.5 24.14999962 l S Q q 0.5 w 0.25 48.04999924 m 384.5 48.04999924 l S Q q 0.5 w -0.25 71.94999695 m 385 71.94999695 l S Q Q q 1 0 0 1 0 384.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 399.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 415.3999939 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0091>-4<0035>-4<0092>-4<0093>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm 0 Tr [(\()] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 45.43899918 11.65499973 Tm 2 Tr [<000B>-4<000C>-4<0094>-4<0095>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 87.60700226 11.65499973 Tm 0 Tr [(\))] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 90.87799835 11.65499973 Tm 2 Tr [<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 101.41999817 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 431 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<009600970098004B000D0099009A009B009C009100350067>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 131.32200623 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 446.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<009600370053009D0035005000510052002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 99.8219986 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.0719986 11.65499973 Tm [(10)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 115.71600342 11.65499973 Tm [<0046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 126.21600342 11.65499973 Tm [(50mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 170.05099487 11.65499973 Tm [<0013009E00680012004E00510052002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 254.05099487 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.30099487 11.65499973 Tm [(10mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 303.13598633 11.65499973 Tm [<0013001E009F00A0>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 345.13598633 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 350.38598633 11.65499973 Tm [(100)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.35101318 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 371.60101318 11.65499973 Tm [<00A1001100120067>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 413.60101318 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 462.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 477.79998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<00A2>-4<00A3>-4<00A4>-4<00A5>-4<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 493.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<009600A200A30032006E00910035001300A6002E00A700A800A900AA0067>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 162.82200623 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 509 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<009600AB00510052>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 47.3219986 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5719986 11.65499973 Tm [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.61699677 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 84.86699677 11.65499973 Tm [<002F00AC00AD003000310058003F004000370066003300340067>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 221.36700439 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 524.59997559 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(3)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<0096002D00AE00AF004E00B000B100B200B300B4001300B500B60099009A00B700B800B9003700BA003400BB00BC009100350067>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 278.32199097 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 540.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 555.79998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<00BD>-4<00BE>-4<0009>-4<000A>-4<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 571.40002441 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 587 cm q 0.25 0.5 m 379.75 0.5 l 379.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(PEG6000-NaCl)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 65.625 11.65499973 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 86.625 11.65499973 Tm [(\(20%,)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 112.875 11.65499973 Tm [<0032006E>] TJ ET EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 133.875 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 139.125 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.10000038 cm q 0.25 0.5 m 379.75 0.5 l 379.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(PEG4000)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 39.375 11.65499973 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 60.375 11.65499973 Tm [(\(50%,)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 86.625 11.65499973 Tm [<0032006E>] TJ ET EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 107.625 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 112.875 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.20000076 cm q 0.25 0.5 m 379.75 0.5 l 379.75 16.10000038 l 0.25 16.10000038 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(PEG1500)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 39.375 11.65499973 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 60.375 11.65499973 Tm [(\(50%,)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 86.625 11.65499973 Tm [<0032006E>] TJ ET EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 107.625 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 112.875 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 48.30000305 l S Q q 0.5 w 380 0.5 m 380 48.30000305 l S Q q 0.5 w -0.25 0.25 m 380.25 0.25 l S Q q 0.5 w 0.25 16.35000038 m 379.75 16.35000038 l S Q q 0.5 w 0.25 32.45000076 m 379.75 32.45000076 l S Q q 0.5 w -0.25 48.55000305 m 380.25 48.55000305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>