%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 128 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q q 1 0 0 1 0 450 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q Q q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.79999924 0 20.79999924 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.3690033 l -90 87.3690033 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 41.42499924 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 413.36099243 41.42499924 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.4109993 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.39700317 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.38300323 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 -0.00000076 cm q 188.3614502 0 0 -41.42535019 0 41.42535019 cm /X2 Do Q Q Q q 1 0 0 1 90 129.91900635 cm /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 0 21.06800079 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 54.8769989 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 40 54.8769989 Tm [(HEPES)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 102.9489975 54.8769989 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 147.125 54.8769989 Tm 0 Tr [(\(1)1(m)-1(o)1(l/L,)1(pH7.2\))] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 285.39801025 54.8769989 Tm 2 Tr [<0005>-4<0006>-4<0007>] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 351.6619873 54.8769989 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 69.80000305 62.40000153 cm /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 0 11.38799953 Tm /GS2 gs 0 g [( )-1( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 10.5 27.25500107 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0008>-4<0009>-4<000A>-4<000B>-4<000C>-4<000D>-3<000E>-4<000F>-4<0010>-4<0011>-4<0012>-4<0013>-4<0014>-4<0015>-4<0012>-4<0016>-3<0017>-4<0018>-4<0019>-4<001A>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 221.33999634 27.25500107 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 109.19999695 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 124.80000305 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0009>-4<000A>-4<001B>-4<001C>-4<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 140.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.04500008 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 32.4109993 11.65499973 Tm [<001E>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 43.02700043 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.39300156 11.65499973 Tm [(4-\(2-Hydroxyethyl\)p)-1(ip)-1(e)1(razin)-1(e)1(-1-ethan)-1(e)1(su)-1(lfo)-1(ni)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.13900757 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.6289978 11.65499973 Tm [(acid)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 268.14099121 11.65499973 Tm [<0013>-11<001F>-11<0020>-11<0021>-11<0022>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 321.2210083 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 326.58700562 11.65499973 Tm [(N-\(2-)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 348.41598511 11.65499973 Tm [<0023>-11<0024>-11<0025>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 380.26400757 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 385.63000488 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 388.81399536 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 394.17999268 11.65499973 Tm [<0026>-11<0027>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 415.4119873 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [(-N')1(-)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.84600067 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 26.09600067 27.25500107 Tm [<002800290013002A002B002C002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 99.59600067 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.84600067 27.25500107 Tm [(C8H18N)1(2O4S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.1499939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 167.3999939 27.25500107 Tm [<0013002A002B002E002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 219.8999939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.1499939 27.25500107 Tm [(238.31)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.41000366 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 259.66000366 27.25500107 Tm [<0013>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 270.16000366 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.41000366 27.25500107 Tm [(CAS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.90899658 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.2829895 27.25500107 Tm [(Number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 329.36700439 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.74099731 27.25500107 Tm [(7365)1(-45-9)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 375.42300415 27.25500107 Tm [<0013002F00300031>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<0032>-8<0033>-8<0034>-9<0035>-8<0012>-8<0036>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 63.51599884 42.85499954 Tm [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.56099701 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 95.89700317 42.85499954 Tm [<0037>-8<0038>-8<0039>-9<003A>-8<003B>-8<002B>-8<003C>-8<0034>-9<003D>-8<003E>-8<003F>-8<0013>-8<0040>-8<0041>-9<0042>-8<0043>-8<0044>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 275.85900879 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.19500732 42.85499954 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.2539978 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 298.58999634 42.85499954 Tm [<0045>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 309.17599487 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.51199341 42.85499954 Tm [(6.8)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 327.89199829 42.85499954 Tm [<0046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 338.47799683 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 343.81399536 42.85499954 Tm [(8.2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.10800171 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 362.44400024 42.85499954 Tm [<0047>-8<0048>-8<0013>-9<0049>-8<004A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [<0045>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 11.96399975 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.6779995 58.45499802 Tm [(pH7.)-1(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 45.49499893 58.45499802 Tm [<0046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 57.45899963 58.45499802 Tm [(7.4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.75299835 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 77.46700287 58.45499802 Tm [<004B>-139<0041>-140<004C>-139<004D>-140<004E>-139<003D>-140<003E>-139<0040>-139<004F>-140<0013>-139<0050>-140<0051>-139<0052>-140<0038>-139<0053>-139<002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 268.89099121 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.60501099 58.45499802 Tm [(10)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 287.7130127 58.45499802 Tm [<0046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 299.67700195 58.45499802 Tm [(50mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 344.97601318 58.45499802 Tm [<0013>-139<0054>-140<0055>-139<0004>-140<0056>-139<0057>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 416.76000977 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.05500031 Tm [(20mm)1(o)-1(l/L)-1(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.87999725 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 76.20899963 74.05500031 Tm [<001E>-8<0058>-7<0059>-8<005A>-7<004C>-8<004D>-7<004E>-8<003D>-7<003E>-8<0040>-7<004F>-8<0036>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 203.15699768 74.05500031 Tm [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.20199585 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 235.53100586 74.05500031 Tm [<005B>-8<005C>-7<0037>-8<0045>-7<005D>-8<005E>-7<002C>-8<0054>-7<0055>-8<005F>-7<0030>-8<0031>-7<0060>-8<0061>-7<0062>-8<0040>-7<0063>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.65499878 Tm [<0064004C00650066>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 42 89.65499878 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.25 89.65499878 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.30899811 89.65499878 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 64.55899811 89.65499878 Tm [<00670036>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 85.55899811 89.65499878 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 234 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 249.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.04500008 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 32.29499817 11.65499973 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 53.29499817 11.65499973 Tm [(\(1mol)-1(/L,pH7.)-1(2)1(\))] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 117.76100159 11.65499973 Tm [<00370038003900680012000300040013>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 201.76100159 11.65499973 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.82000732 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 219.07000732 11.65499973 Tm [<0067002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 240.07000732 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.32000732 11.65499973 Tm [(7.2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 258.61401367 11.65499973 Tm [<00130069006A006B006C006D006E006F00130070007100720073005A0054>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<00550025001F001E00580036>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 63 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 280.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 296.3999939 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0009>-4<000A>-4<0074>-4<0075>-4<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 312 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 327.6000061 cm q 0.25 0.5 m 126.55000305 0.5 l 126.55000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 39.9280014 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0009>-4<000A>-4<0021>-4<0022>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 76.0719986 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 126.80000305 0 cm 0.25 0.5 m 78.5 0.5 l 78.5 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 24.93899918 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0076>-4<0077>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 43.01100159 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 205.55000305 0 cm 0.25 0.5 m 76.25 0.5 l 76.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 14.77799988 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0078>-4<0079>-4<007A>-4<007B>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 50.92200089 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.89599991 15.00500011 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0005>-4<0006>-4<0007>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 34.00400162 15.00500011 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.546 15.00500011 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0041>-4<0042>-4<007C>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 33.65399933 15.00500011 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 23.89999962 cm q 0.25 0.5 m 126.55000305 0.5 l 126.55000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 8.65600014 14.77600098 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 34.0870018 15.00499916 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 52.0870018 14.77600098 Tm [(\(1mol)-1(/L,pH7.)-1(2)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.34400177 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 126.80000305 0 cm 0.25 0.5 m 78.5 0.5 l 78.5 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 22.72500038 15.00499916 Tm /GS2 gs 0 g [(100ml)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 45.22499847 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 205.55000305 0 cm 0.25 0.5 m 76.25 0.5 l 76.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 28.35000038 15.00499916 Tm /GS2 gs 0 g [(RT)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 37.34999847 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.54399967 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 19.3560009 15.00500011 Tm [<0083>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.3560009 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.19400024 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 19.00600052 15.00500011 Tm [<0084>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.00600052 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 47.79999924 cm q 0.25 0.5 m 126.55000305 0.5 l 126.55000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 1.93799996 14.77600098 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.11899948 14.77600098 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.15399933 14.77600098 Tm [(sol)-1(uti)-1(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.76900101 14.77600098 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.80400085 14.77600098 Tm [(\(1mol)-1(/L,pH7.)-1(2)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.06099701 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 126.80000305 0 cm 0.25 0.5 m 78.5 0.5 l 78.5 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 22.72500038 15.00499916 Tm /GS2 gs 0 g [(100ml)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.22499847 15.00499916 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 205.55000305 0 cm 0.25 0.5 m 76.25 0.5 l 76.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 21.60000038 15.00499916 Tm /GS2 gs 0 g [(-20)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 35.09999847 15.00499916 Tm [<0087>] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 44.09999847 15.00499916 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.54399967 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 19.3560009 15.00500011 Tm [<0083>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.3560009 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.19400024 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 19.00600052 15.00500011 Tm [<0084>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.00600052 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 71.69999695 l S Q q 0.5 w 126.80000305 0.5 m 126.80000305 23.89999962 l S Q q 0.5 w 126.80000305 24.39999962 m 126.80000305 47.79999924 l S Q q 0.5 w 126.80000305 48.29999924 m 126.80000305 71.69999695 l S Q q 0.5 w 205.55000305 0.5 m 205.55000305 23.89999962 l S Q q 0.5 w 205.55000305 24.39999962 m 205.55000305 47.79999924 l S Q q 0.5 w 205.55000305 48.29999924 m 205.55000305 71.69999695 l S Q q 0.5 w 282.04998779 0.5 m 282.04998779 23.89999962 l S Q q 0.5 w 282.04998779 24.39999962 m 282.04998779 47.79999924 l S Q q 0.5 w 282.04998779 48.29999924 m 282.04998779 71.69999695 l S Q q 0.5 w 333.75 0.5 m 333.75 23.89999962 l S Q q 0.5 w 333.75 24.39999962 m 333.75 47.79999924 l S Q q 0.5 w 333.75 48.29999924 m 333.75 71.69999695 l S Q q 0.5 w 384.75 0.5 m 384.75 71.69999695 l S Q q 0.5 w -0.25 0.25 m 385 0.25 l S Q q 0.5 w 0.25 24.14999962 m 384.5 24.14999962 l S Q q 0.5 w 0.25 48.04999924 m 384.5 48.04999924 l S Q q 0.5 w -0.25 71.94999695 m 385 71.94999695 l S Q Q q 1 0 0 1 0 399.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 415.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 431 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0088>-4<0035>-4<0089>-4<008A>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm 0 Tr [(\()] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 45.43899918 11.65499973 Tm 2 Tr [<000B>-4<000C>-4<008B>-4<008C>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 87.60700226 11.65499973 Tm 0 Tr [(\))] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 90.87799835 11.65499973 Tm 2 Tr [<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 101.41999817 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 446.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<008D008E008F004B000D0090009100920093008800350036>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 131.32200623 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 462.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<008D0038005300940035005000510052002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 99.8219986 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.0719986 11.65499973 Tm [(10)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 115.71600342 11.65499973 Tm [<0046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 126.21600342 11.65499973 Tm [(50mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 170.05099487 11.65499973 Tm [<0013009500680012004E00510052002D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 254.05099487 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.30099487 11.65499973 Tm [(10mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 303.13598633 11.65499973 Tm [<0013001E00960097>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 345.13598633 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 350.38598633 11.65499973 Tm [(100)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.35101318 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 371.60101318 11.65499973 Tm [<0098001100120036>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 413.60101318 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 477.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 493.3999939 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0099>-4<009A>-4<009B>-4<009C>-4<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 509 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<008D0099009A0032006D008800350013009D002E009E009F00A000A10036>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 162.82200623 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 524.59997559 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<008D00A200510052>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 47.3219986 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5719986 11.65499973 Tm [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.61699677 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 84.86699677 11.65499973 Tm [<002F00A300A40030003100580040004100380066003300340036>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 221.36700439 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 540.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(3)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<008D002D00A500A6004E00A700A800A900AA00AB001300AC00AD0090009100AE00AF00B0003800B1003400B200B3008800350036>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 278.32199097 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 555.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 571.40002441 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<00B4>-4<00B5>-4<0009>-4<000A>-4<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 587 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 602.59997559 cm q 0.25 0.5 m 359.75 0.5 l 359.75 16.14999962 l 0.25 16.14999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.67999935 Tm /GS2 gs 0 g [<00B600B700B80030003100B900BA00BB003F00BC>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 105 11.41299915 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.14999962 cm q 0.25 0.5 m 359.75 0.5 l 359.75 16.14999962 l 0.25 16.14999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.67999935 Tm /GS2 gs 0 g [<00BD00BE002900BF00030004>] TJ ET EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 63 11.67999935 Tm [(\(0.1mol_L,)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 115.5 11.67999935 Tm [<0032006D>] TJ ET EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 136.5 11.67999935 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 141.75 11.41299915 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 32.29999924 l S Q q 0.5 w 360 0.5 m 360 32.29999924 l S Q q 0.5 w -0.25 0.25 m 360.25 0.25 l S Q q 0.5 w 0.25 16.39999962 m 359.75 16.39999962 l S Q q 0.5 w -0.25 32.54999924 m 360.25 32.54999924 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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