%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 135 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q q 1 0 0 1 0 450 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q Q q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.79999924 0 20.79999924 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.3690033 l -90 87.3690033 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 41.42499924 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 413.36099243 41.42499924 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.4109993 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.39700317 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.38300323 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 -0.00000076 cm q 188.3614502 0 0 -41.42535019 0 41.42535019 cm /X2 Do Q Q Q q 1 0 0 1 90 129.91900635 cm /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 0 21.06800079 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 0 54.8769989 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 65.04599762 54.8769989 Tm 2 Tr 0.62857145 w 0 G [<0003>-99<0004>] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 113.41600037 54.8769989 Tm 0 Tr [(\(1)1(m)-1(o)1(l/L,)1(pH6.8-8.0,)] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 287.51699829 54.8769989 Tm 2 Tr [<0005>-99<0006>-100<0007>] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 360.07199097 54.8769989 Tm 0 Tr [(\))] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 369.02301025 54.8769989 Tm 2 Tr [<0008>-99<0009>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 86.07700348 Tm [<000A>] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 22.08799934 86.07700348 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 69.80000305 93.59999847 cm /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [( )-1( )] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 42 11.65499973 Tm 2 Tr 0.30000001 w [<000B>-4<000C>-4<000D>-4<000E>-4<000F>-4<0010>-3<0011>-4<0012>-4<0013>-4<0014>-4<0015>-4<0016>-4<0017>-4<0018>-4<0015>-4<0019>-3<001A>-4<001B>-4<001C>-4<001D>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 252.83999634 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 109.19999695 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 124.80000305 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 140.3999939 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000C>-4<000D>-4<001E>-4<001F>-4<0020>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 156 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.04500008 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 32.4109993 11.65499973 Tm [<0021>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 43.02700043 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.39300156 11.65499973 Tm [(4-\(2-Hydroxyethyl\)p)-1(ip)-1(e)1(razin)-1(e)1(-1-ethan)-1(e)1(su)-1(lfo)-1(ni)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.13900757 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.6289978 11.65499973 Tm [(acid)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 268.14099121 11.65499973 Tm [<0016>-11<0022>-11<0023>-11<0024>-11<0025>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 321.2210083 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 326.58700562 11.65499973 Tm [(N-\(2-)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 348.41598511 11.65499973 Tm [<0026>-11<0027>-11<0028>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 380.26400757 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 385.63000488 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 388.81399536 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 394.17999268 11.65499973 Tm [<0029>-11<002A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 415.4119873 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [(-N')1(-)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.84600067 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 26.09600067 27.25500107 Tm [<002B002C0016002D002E002F0030>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 99.59600067 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.84600067 27.25500107 Tm [(C8H18N)1(2O4S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.1499939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 167.3999939 27.25500107 Tm [<0016002D002E00310030>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 219.8999939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.1499939 27.25500107 Tm [(238.31)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.41000366 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 259.66000366 27.25500107 Tm [<0016>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 270.16000366 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.41000366 27.25500107 Tm [(CAS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.90899658 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.2829895 27.25500107 Tm [(Number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 329.36700439 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.74099731 27.25500107 Tm [(7365)1(-45-9)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 375.42300415 27.25500107 Tm [<0016003200330034>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<0006>-8<0035>-8<0036>-9<0037>-8<0015>-8<0038>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 63.51599884 42.85499954 Tm [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.56099701 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 95.89700317 42.85499954 Tm [<0039>-8<003A>-8<003B>-9<0005>-8<003C>-8<002E>-8<003D>-8<0036>-9<003E>-8<003F>-8<0040>-8<0016>-8<0041>-8<0042>-9<0043>-8<0044>-8<0045>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 275.85900879 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.19500732 42.85499954 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.2539978 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 298.58999634 42.85499954 Tm [<0046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 309.17599487 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.51199341 42.85499954 Tm [(6.8)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 327.89199829 42.85499954 Tm [<0047>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 338.47799683 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 343.81399536 42.85499954 Tm [(8.2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.10800171 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 362.44400024 42.85499954 Tm [<0048>-8<0049>-8<0016>-9<004A>-8<004B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [<0046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 11.96399975 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.6779995 58.45499802 Tm [(pH7.)-1(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 45.49499893 58.45499802 Tm [<0047>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 57.45899963 58.45499802 Tm [(7.4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.75299835 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 77.46700287 58.45499802 Tm [<004C>-139<0042>-140<004D>-139<004E>-140<004F>-139<003E>-140<003F>-139<0041>-139<0050>-140<0016>-139<0051>-140<0052>-139<0053>-140<003A>-139<0054>-139<0030>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 268.89099121 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.60501099 58.45499802 Tm [(10)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 287.7130127 58.45499802 Tm [<0047>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 299.67700195 58.45499802 Tm [(50mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 344.97601318 58.45499802 Tm [<0016>-139<0055>-140<0056>-139<0004>-140<0057>-139<0058>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 416.76000977 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.05500031 Tm [(20mm)1(o)-1(l/L)-1(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.87999725 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 76.20899963 74.05500031 Tm [<0021>-8<0059>-7<005A>-8<005B>-7<004D>-8<004E>-7<004F>-8<003E>-7<003F>-8<0041>-7<0050>-8<0038>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 203.15699768 74.05500031 Tm [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.20199585 74.05500031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 235.53100586 74.05500031 Tm [<005C>-8<005D>-7<0039>-8<0046>-7<005E>-8<005F>-7<002F>-8<0055>-7<0056>-8<0060>-7<0033>-8<0034>-7<0061>-8<0062>-7<0063>-8<0041>-7<0064>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.65499878 Tm [<0065004D00660067>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 42 89.65499878 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.25 89.65499878 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.30899811 89.65499878 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 64.55899811 89.65499878 Tm [<00680038>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 85.55899811 89.65499878 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 249.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.04500008 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 32.29499817 11.65499973 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 53.29499817 11.65499973 Tm [(\(1mol)-1(/L,pH6.)-1(8)1(-)-1(8)1(.)-1(0)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 131.08599854 11.65499973 Tm [<0016000500060007>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 173.08599854 11.65499973 Tm [(\))] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 176.27000427 11.65499973 Tm [<0039003A003B00690015003E003F000300040016>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 281.26998901 11.65499973 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.32901001 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 298.57901001 11.65499973 Tm [<0068006A006B006C006D006E006F0070007100720073>] TJ ET EMC /P <> BDC BT 1 0 0 -1 414.07901001 11.65499973 Tm [<0016>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<0074007500760077007800070079007A001600170059007B007C007D007E005B0055005600280022002100590038>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 241.5 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 296.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 312 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000C>-4<000D>-4<007F>-4<0080>-4<0020>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 327.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 343.20001221 cm q 0.25 0.5 m 150.69999695 0.5 l 150.69999695 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 52.00299835 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<000C>-4<000D>-4<0024>-4<0025>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 88.14700317 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 150.94999695 0 cm 0.25 0.5 m 64.55000305 0.5 l 64.55000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 17.9640007 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0081>-4<0082>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 36.0359993 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 215.75 0 cm 0.25 0.5 m 66.05000305 0.5 l 66.05000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 9.67800045 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0083>-4<0084>-4<0085>-4<0086>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 45.8219986 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.89599991 15.00500011 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 34.00400162 15.00500011 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.546 15.00500011 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0042>-4<0043>-4<0087>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 33.65399933 15.00500011 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 23.89999962 cm q 0.25 0.5 m 150.69999695 0.5 l 150.69999695 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 0 14.77600098 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 25.43099976 15.00499916 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 43.43099976 14.77600098 Tm [(\(1mol)-1(/L,pH6.)-1(8)1(-)-1(8)1(.)-1(0,)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 112.35500336 15.00499916 Tm [<000500060007>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 139.35499573 14.77600098 Tm [(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.08399963 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 150.94999695 0 cm 0.25 0.5 m 64.55000305 0.5 l 64.55000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 2.25 15.00499916 Tm /GS2 gs 0 g [(500ml/100ml)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 51.75 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 215.75 0 cm 0.25 0.5 m 66.05000305 0.5 l 66.05000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.25 15.00499916 Tm /GS2 gs 0 g [(RT)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 32.25 14.77600098 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.54399967 15.00500011 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 19.3560009 15.00500011 Tm [<0090>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.3560009 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 7.69399977 15.00500011 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 14.50599957 15.00500011 Tm [<00910092>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 32.50600052 15.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 47.79999924 cm q 0.25 0.5 m 150.69999695 0.5 l 150.69999695 31.70000076 l 0.25 31.70000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 2.68000007 10.8760004 Tm /GS2 gs 0 g [(HEPES)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.86100006 10.8760004 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.89599991 10.8760004 Tm [(sol)-1(uti)-1(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.51100159 10.8760004 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.54600143 10.8760004 Tm [(\(1mol)-1(/L,pH6.)-1(8)1(-)-1(8)1(.)-1(0,)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 128.47000122 11.10499954 Tm [<0006>] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.20999908 26.70499992 Tm [<0007>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 73.20999908 26.47600174 Tm [(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.93900299 26.47600174 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 150.94999695 0 cm 0.25 0.5 m 64.55000305 0.5 l 64.55000305 31.70000076 l 0.25 31.70000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 2.25 18.90499878 Tm /GS2 gs 0 g [(500ml/100ml)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.75 18.90499878 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 215.75 0 cm 0.25 0.5 m 66.05000305 0.5 l 66.05000305 31.70000076 l 0.25 31.70000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 23.25 18.90499878 Tm /GS2 gs 0 g [(RT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.25 18.90499878 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 31.70000076 l 0.25 31.70000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.54399967 18.90500069 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 19.3560009 18.90500069 Tm [<0090>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.3560009 18.90500069 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 31.70000076 l 0.25 31.70000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 7.69399977 18.90500069 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 14.50599957 18.90500069 Tm [<00910092>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 32.50600052 18.90500069 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 79.5 l S Q q 0.5 w 150.94999695 0.5 m 150.94999695 23.89999962 l S Q q 0.5 w 150.94999695 24.39999962 m 150.94999695 47.79999924 l S Q q 0.5 w 150.94999695 48.29999924 m 150.94999695 79.5 l S Q q 0.5 w 215.75 0.5 m 215.75 23.89999962 l S Q q 0.5 w 215.75 24.39999962 m 215.75 47.79999924 l S Q q 0.5 w 215.75 48.29999924 m 215.75 79.5 l S Q q 0.5 w 282.04998779 0.5 m 282.04998779 23.89999962 l S Q q 0.5 w 282.04998779 24.39999962 m 282.04998779 47.79999924 l S Q q 0.5 w 282.04998779 48.29999924 m 282.04998779 79.5 l S Q q 0.5 w 333.75 0.5 m 333.75 23.89999962 l S Q q 0.5 w 333.75 24.39999962 m 333.75 47.79999924 l S Q q 0.5 w 333.75 48.29999924 m 333.75 79.5 l S Q q 0.5 w 384.75 0.5 m 384.75 79.5 l S Q q 0.5 w -0.25 0.25 m 385 0.25 l S Q q 0.5 w 0.25 24.14999962 m 384.5 24.14999962 l S Q q 0.5 w 0.25 48.04999924 m 384.5 48.04999924 l S Q q 0.5 w -0.25 79.75 m 385 79.75 l S Q Q q 1 0 0 1 0 423.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 438.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 454.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 470 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 485.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 501.20001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 516.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 532.40002441 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 548 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 563.59997559 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 579.20001221 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0093>-4<0037>-4<0094>-4<0095>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm 0 Tr [(\()] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 45.43899918 11.65499973 Tm 2 Tr [<000E>-4<000F>-4<0096>-4<0097>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 87.60700226 11.65499973 Tm 0 Tr [(\))] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 90.87799835 11.65499973 Tm 2 Tr [<0020>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 101.41999817 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 594.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 6.66900015 11.65499973 Tm [<0098>-128<006A>-129<006B>-128<004C>-128<0010>-128<0099>-129<009A>-128<006F>-128<009B>-129<0093>-128<0037>-128<0016>-128<003A>-129<0054>-128<009C>-128<0037>-129<0051>-128<0052>-128<0053>-128<0030>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 243.60899353 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.20599365 11.65499973 Tm [(10)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 262.19699097 11.65499973 Tm [<0047>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 274.04400635 11.65499973 Tm [(50mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 319.22601318 11.65499973 Tm [<0016>] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.07299805 11.65499973 Tm [<009D>-128<0069>-129<0015>-128<004F>-128<0052>-128<0053>-129<0030>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 27.25500107 Tm [(10mm)1(o)-1(l/L)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 43.83499908 27.25500107 Tm [<00160021009E009F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 85.83499908 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.08499908 27.25500107 Tm [(100)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.05000305 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 112.30000305 27.25500107 Tm [<00A0001400150038>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 154.30000305 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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