%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 109 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q q 1 0 0 1 0 450 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q Q q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.79999924 0 20.79999924 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.3690033 l -90 87.3690033 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 41.42499924 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 413.36099243 41.42499924 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.4109993 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.39700317 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.38300323 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 -0.00000076 cm q 188.3614502 0 0 -41.42535019 0 41.42535019 cm /X2 Do Q Q Q q 1 0 0 1 90 129.91900635 cm /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 0 23.11899948 Tm 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22 23.11899948 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 54.8769989 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 22 54.8769989 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABD 22 Tf 1 0 0 -1 154.52799988 54.8769989 Tm 0 Tr [(\(4)1(%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.57000732 54.8769989 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.54400635 54.8769989 Tm [(PFA,RNa)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.94198608 54.8769989 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.91598511 54.8769989 Tm [(fr)-1(ee)-1(\))] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 340.70098877 54.8769989 Tm 2 Tr [<0009>-4<000A>-4<000B>] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 406.96499634 54.8769989 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 69.80000305 62.40000153 cm /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 0 11.38799953 Tm /GS2 gs 0 g [( )-1( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.5 27.25500107 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 26.25 27.25500107 Tm 2 Tr 0.30000001 w [<000C>-4<000D>-4<000E>-4<000F>-4<0010>-4<0011>-3<0012>-4<0013>-4<0014>-4<0015>-4<0016>-4<0017>-4<0018>-4<0019>-4<0016>-4<001A>-3<001B>-4<001C>-4<001D>-4<001E>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 237.08999634 27.25500107 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 109.19999695 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 124.80000305 cm /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 140.3999939 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000D>-4<000E>-4<001F>-4<0020>-4<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 156 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<002200230024002500240026001A002700280029002A002B002C002D0024002E002F0030003100320033>] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.5 11.65499973 Tm [<0017>] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.30000305 11.65499973 Tm [<00220023003400350036003700380039003A0007003B0011003B003C003D003E002C002D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<002B0029002A0024003D0007>] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 27.25500107 Tm [<003F>] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.01300049 27.25500107 Tm [<0040004100290042002B00430042002400440045>] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.01300049 27.25500107 Tm [<0046>] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.02600098 27.25500107 Tm [<0022002300080047004800060049002200230008>] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.02600098 27.25500107 Tm [<003F>] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.03900146 27.25500107 Tm [<004A0049002200230008>] TJ ET EMC /P <> BDC BT 1 0 0 -1 349.53900146 27.25500107 Tm [<003F>] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.55200195 27.25500107 Tm [<004B0049002200230008>] TJ ET EMC /P <> BDC BT 1 0 0 -1 410.05200195 27.25500107 Tm [<003F>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<004C004D00340049002200230008003F004E004F005000510049002200230008005200170053004800540016002400550006004900560024005700580059005A003F004B004900560024005B004B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 409.5 42.85499954 Tm [<0046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 415.29998779 42.85499954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 202.80000305 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 218.3999939 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<0003>-23<0004>-23<0005>-23<0006>-22<0007>-23<0008>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 64.44000244 11.65499973 Tm [(\(4%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.4509964 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.06500244 11.65499973 Tm [(PFA,)1(RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.84899902 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.46299744 11.65499973 Tm [(fre)1(e\))] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 152.20100403 11.65499973 Tm [<005C>-23<005D>-23<005E>-23<005F>-22<0060>-23<0003>-23<0004>-23<0005>-23<0006>-23<003F>-23<0061>-22<0050>-23<0051>-23<003F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 302.56100464 11.65499973 Tm [(DE)-1(P)1(C)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 328.03601074 11.65499973 Tm [<0062>-23<0063>-23<0064>-23<0052>-22<002C>-23<0065>-23<0017>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 403.21600342 11.65499973 Tm [(pH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.2749939 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 27.25500107 Tm [<00660067>-1<0048>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 31.51499939 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.77000046 27.25500107 Tm [(7.4)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 50.06900024 27.25500107 Tm [<00170068>-1<0069001A>-1<006A006B>-1<0003006C>-1<002C002D>-1<002B0029>-1<002A0024>-1<00220023>-1<0017006D>-1<006E0068>-1<0016001A006F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 291.68399048 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.93899536 27.25500107 Tm [(RN)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.49301147 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 320.74798584 27.25500107 Tm [<002F0070>-1<00710072>-1<00170073>-1<00350053>-1<0074>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<0024>-7<0027>-8<0075>-7<002C>-8<002D>-7<002B>-8<0029>-7<002A>-7<0024>-8<0030>-7<0031>-8<0032>-7<0033>-8<0076>-7<0077>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 158.66999817 42.85499954 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.9980011 42.85499954 Tm [(RN)1(A)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 182.63000488 42.85499954 Tm [<0046>-7<0078>-8<0079>-7<0034>-8<000F>-7<0016>-8<001A>-7<007A>-7<0013>-8<007B>-7<007C>-8<0017>-7<0018>-8<0068>-7<0016>-7<001A>-8<001B>-7<001C>-8<001D>-7<001E>-8<007D>-7<006E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [<007E0016007F0046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 42 58.45499802 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.25 58.45499802 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 280.79998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 296.3999939 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<000D>-4<000E>-4<002C>-4<0065>-4<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 312 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 327.6000061 cm q 0.25 0.5 m 138.94999695 0.5 l 138.94999695 24.25 l 0.25 24.25 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 46.12799835 15.17999935 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<000D>-4<000E>-4<0080>-4<0081>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 82.27200317 14.95100021 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 139.19999695 0 cm 0.25 0.5 m 74.80000305 0.5 l 74.80000305 24.25 l 0.25 24.25 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 23.0890007 15.17999935 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0082>-4<0083>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 41.1609993 14.95100021 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 214.25 0 cm 0.25 0.5 m 79.44999695 0.5 l 79.44999695 24.25 l 0.25 24.25 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 16.37800026 15.17999935 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0027>-4<0028>-4<0084>-4<0085>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 52.52199936 14.95100021 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 293.95001221 0 cm 0.25 0.5 m 53.65000153 0.5 l 53.65000153 24.25 l 0.25 24.25 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 7.99599981 15.18000031 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0009>-4<000A>-4<000B>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 35.10400009 15.18000031 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 347.8500061 0 cm 0.25 0.5 m 52.90000153 0.5 l 52.90000153 24.25 l 0.25 24.25 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 7.62099981 15.18000031 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<002F>-4<0086>-4<0087>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 34.72900009 15.18000031 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 24.25 cm q 1 0 0 1 139.19999695 0 cm 0.25 0.5 m 74.80000305 0.5 l 74.80000305 32 l 0.25 32 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0.625 19.05500031 Tm /GS2 gs 0 g [(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.625 19.05500031 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.625 19.05500031 Tm [(10ml/100ml)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 63.625 18.82600021 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 214.25 0 cm 0.25 0.5 m 79.44999695 0.5 l 79.44999695 32 l 0.25 32 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.95000076 19.05500031 Tm /GS2 gs 0 g [(RT)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 38.95000076 18.82600021 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 293.95001221 0 cm 0.25 0.5 m 53.65000153 0.5 l 53.65000153 32 l 0.25 32 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 13.64400005 19.05500031 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 20.45599937 19.05500031 Tm [<0090>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 29.45599937 19.05500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 347.8500061 0 cm 0.25 0.5 m 52.90000153 0.5 l 52.90000153 32 l 0.25 32 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 13.26900005 19.05500031 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 20.08099937 19.05500031 Tm [<0091>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 29.08099937 19.05500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 56.25 cm q 1 0 0 1 0 -32 cm 0.25 0.5 m 138.94999695 0.5 l 138.94999695 64.5 l 0.25 64.5 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 0 35.30500031 Tm /GS2 gs 0 g [<000300040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 54 35.07600021 Tm [(\(4%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.72399902 35.07600021 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.75900269 35.07600021 Tm [(PFA,)1(RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.0019989 35.07600021 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.03700256 35.07600021 Tm [(fre)1(e\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60600281 35.07600021 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 139.19999695 0 cm 0.25 0.5 m 74.80000305 0.5 l 74.80000305 32.5 l 0.25 32.5 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0.625 19.30500031 Tm /GS2 gs 0 g [(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.625 19.30500031 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.625 19.30500031 Tm [(30ml/500ml)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.625 19.30500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 214.25 0 cm 0.25 0.5 m 79.44999695 0.5 l 79.44999695 32.5 l 0.25 32.5 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 29.95000076 19.30500031 Tm /GS2 gs 0 g [(RT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.95000076 19.30500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 293.95001221 0 cm 0.25 0.5 m 53.65000153 0.5 l 53.65000153 32.5 l 0.25 32.5 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 13.64400005 19.30500031 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 20.45599937 19.30500031 Tm [<0090>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 29.45599937 19.30500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 347.8500061 0 cm 0.25 0.5 m 52.90000153 0.5 l 52.90000153 32.5 l 0.25 32.5 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 13.26900005 19.30500031 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 20.08099937 19.30500031 Tm [<0091>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 29.08099937 19.30500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 88.75 l S Q q 0.5 w 139.19999695 0.5 m 139.19999695 24.25 l S Q q 0.5 w 139.19999695 24.75 m 139.19999695 88.75 l S Q q 0.5 w 214.25 0.5 m 214.25 24.25 l S Q q 0.5 w 214.25 24.75 m 214.25 56.25 l S Q q 0.5 w 214.25 56.75 m 214.25 88.75 l S Q q 0.5 w 293.95001221 0.5 m 293.95001221 24.25 l S Q q 0.5 w 293.95001221 24.75 m 293.95001221 56.25 l S Q q 0.5 w 293.95001221 56.75 m 293.95001221 88.75 l S Q q 0.5 w 347.8500061 0.5 m 347.8500061 24.25 l S Q q 0.5 w 347.8500061 24.75 m 347.8500061 56.25 l S Q q 0.5 w 347.8500061 56.75 m 347.8500061 88.75 l S Q q 0.5 w 401 0.5 m 401 88.75 l S Q q 0.5 w -0.25 0.25 m 401.25 0.25 l S Q q 0.5 w 0.25 24.5 m 400.75 24.5 l S Q q 0.5 w 139.44999695 56.5 m 400.75 56.5 l S Q q 0.5 w -0.25 89 m 401.25 89 l S Q Q q 1 0 0 1 0 416.8500061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 432.45001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 448.04998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0094>-4<0095>-4<0096>-4<0097>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm 0 Tr [(\()] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 45.43899918 11.65499973 Tm 2 Tr [<000F>-4<0010>-4<0098>-4<0099>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 87.60700226 11.65499973 Tm 0 Tr [(\))] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 90.87799835 11.65499973 Tm 2 Tr [<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 101.41999817 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 463.6499939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<003F009A009B002C002D00220023009C009D009E00410026>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 131.32200623 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.57200623 11.65499973 Tm [(4)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 141.89399719 11.65499973 Tm [<009F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 152.39399719 11.65499973 Tm [(12h)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 168.55400085 11.65499973 Tm [<0017006B00A0000C00A1006800A200A3004500220023009C009D001700A400A50029002A007D0029002A00A600A7>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 410.0539856 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 479.25 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<00220023009C009D009E00410026>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 73.5 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.75 11.65499973 Tm [(10)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 89.39399719 11.65499973 Tm [<009F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 99.89399719 11.65499973 Tm [(15min)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 126.85199738 11.65499973 Tm [<001700A800A900AA00AB00AC00120046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 210.852005 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 494.8500061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<003F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 15.82199955 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.0720005 11.65499973 Tm [(10)] TJ ET EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 31.7159996 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 42.2159996 11.65499973 Tm [(10m)1(l)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 63.6570015 11.65499973 Tm [<003F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 74.15699768 11.65499973 Tm [(10)] TJ ET EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 84.8010025 11.65499973 Tm [(?] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 95.3010025 11.65499973 Tm [(30m)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.74199677 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 121.99199677 11.65499973 Tm [<008200830024000D000E001700AD0022002300AE00AF00B000B100B20079003400B30017>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 310.99200439 11.65499973 Tm [(4)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 316.31399536 11.65499973 Tm [<00B400450087002700280046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 379.31399536 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 510.45001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 526.04998779 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<00B5>-4<00B6>-4<00B7>-4<00B8>-4<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 541.65002441 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<003F007800220023000800B900BA00BB00BC00BD0042001700BE007600B900BA00BF00C000C100C20024>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 225.82200623 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.07200623 11.65499973 Tm [(RN)1(as)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.9119873 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.28601074 11.65499973 Tm [(fre)1(e)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 277.6000061 11.65499973 Tm [<001700940095009C00C300B500B60078002900C40046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 393.1000061 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 27.25500107 Tm [<003F>] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.96800041 27.25500107 Tm [<000300040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 77.96800232 27.25500107 Tm [(\(4%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.97899628 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.35299683 27.25500107 Tm [(PFA,)1(RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.13699341 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.51100159 27.25500107 Tm [(fre)1(e\))] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 165.00900269 27.25500107 Tm [<002F009A002300C500C6003A002B00C700C8003A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.00900269 27.25500107 Tm [<0017>] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.65499878 27.25500107 Tm [<009A00C900CA00CB>] TJ ET EMC /P <> BDC BT 1 0 0 -1 321.65499878 27.25500107 Tm [<0017>] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.30099487 27.25500107 Tm [<00CC002800CD00CE00220023008600CF>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<00D000D100D20046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 42 42.85499954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 588.45001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(3)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.33400011 11.65499973 Tm [<003F>-1<00D3>-1<00D4>-1<00CD>-2<00D5>-1<00A3>-1<0045>-1<0022>-1<0023>-1<009C>-1<009D>-2<0017>-1<00D6>-1<00D7>-1<00D8>-1<00D9>-1<0044>-1<00DA>-2<006B>-1<0047>-1<00DB>-1<00CD>-1<00D5>-1<00DC>-1<00DD>-2<00DE>-1<00DF>-1<00E0>-1<00E1>-1<00D5>-1<0018>-1<00E2>-2<0017>-1<0022>-1<0023>-1<009C>-1<009D>-1<00E3>-1<0018>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<00E20046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 21 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 619.65002441 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(4)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<003F002200230008002400E400E500A100E600E70017009A009B002200230008006F002C002D00E80024001100E900EA00EB00A1006B001A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 299.32199097 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.57199097 11.65499973 Tm [(10)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 315.21600342 11.65499973 Tm [<0021>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 325.71600342 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 331.03799438 11.65499973 Tm [<0046>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 341.53799438 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>