%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 100 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q q 1 0 0 1 0 450 cm q 1 g 0 0 m 600 0 l 600 450 l 0 450 l h f* Q Q q 1 0 0 1 65.65000153 94.18599701 cm q 474.8500061 0 0 -20.79999924 0 20.79999924 cm /X1 Do Q Q /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 87.3690033 l -90 87.3690033 l h W n BT /FAAAAI 9 Tf 1 0 0 -1 0 9.56900024 Tm 0 g [( )-1( )-1( )-1( )] TJ /GS1 gs 0 g [-11231( )] TJ ET q 1 0 0 1 0 11.98600006 cm BT 1 0 0 -1 0 41.42499924 Tm /GS2 gs 0 g [( )-1( )-1( )-1( )-1( )] TJ 1 0 0 -1 413.36099243 41.42499924 Tm /GS1 gs 0 g [( )] TJ ET Q q 1 0 0 1 0 53.4109993 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )-1( )-1( )] TJ /GS1 gs 0 g [-9040( )] TJ ET Q q 1 0 0 1 0 64.39700317 cm BT 1 0 0 -1 0 8.56900024 Tm [( )] TJ ET Q q 1 0 0 1 0 75.38300323 cm BT 1 0 0 -1 0 8.56900024 Tm /GS2 gs 0 g [( )] TJ /FAAABD 9 Tf [-548( )] TJ ET Q Q EMC q 1 0 0 1 90 54.5359993 cm q 1 0 0 1 225 -0.00000076 cm q 188.3614502 0 0 -41.42535019 0 41.42535019 cm /X2 Do Q Q Q q 1 0 0 1 90 129.91900635 cm /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 0 21.06800079 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 52.67500305 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABH 16 Tf 1 0 0 -1 56 52.67500305 Tm 2 Tr 0.45714286 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-3<0009>-4<000A>-4<000B>] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 200.57600403 52.67500305 Tm 0 Tr [(\(1)1(0%,RNa)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.45098877 52.67500305 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.06799316 52.67500305 Tm [(fr)-1(ee)-1(\))] TJ ET EMC /P <> BDC BT /FAAABH 16 Tf 1 0 0 -1 314.9119873 52.67500305 Tm 2 Tr [<000C>-4<000D>-4<000E>] TJ ET EMC /P <> BDC BT /FAAABD 16 Tf 1 0 0 -1 363.10400391 52.67500305 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 69.80000305 62.40000153 cm /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 0 11.38799953 Tm /GS2 gs 0 g [( )-1( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.38799953 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.5 27.25500107 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 21 27.25500107 Tm 2 Tr 0.30000001 w [<000F>-4<0010>-4<0011>-4<0012>-4<0013>-4<0014>-3<0015>-4<0016>-4<0017>-4<0018>-4<0019>-4<001A>-4<001B>-4<001C>-4<0019>-4<001D>-3<001E>-4<001F>-4<0020>-4<0021>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 231.83999634 27.25500107 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 93.59999847 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 109.19999695 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 124.80000305 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0010>-4<0011>-4<0022>-4<0023>-4<0024>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 140.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 156 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<0009000A0025002600250027001D00280029002A002B002C002D002E0025002F00300031003200330034>] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.5 11.65499973 Tm [<001A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.30000305 11.65499973 Tm [<0009000A00350036003700380039003A0004003B003C0014003C003D003E003F002D002E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<002C002A002B0025003E003B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 27.25500107 Tm [<0040>] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.93399811 27.25500107 Tm [<00410042002A0043002C00440043002500450046>] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.93400574 27.25500107 Tm [<001A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.86799622 27.25500107 Tm [<0009000A00350047004800490009>] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.36801147 27.25500107 Tm [<0040>] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.30200195 27.25500107 Tm [<0045004A004B004C004D004E004F0050001800510052005300390054>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<003300340055004500560057>] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 42.85499954 Tm [<001A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.93399811 42.85499954 Tm [<005800590018003C005A005B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.93400574 42.85499954 Tm [<001A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.86799622 42.85499954 Tm [<0009000A0035003D002A002B005C002A002B0015004A005D00550045004F005E00560057>] TJ ET EMC /P <> BDC BT 1 0 0 -1 332.86801147 42.85499954 Tm [<005F>] TJ ET EMC /P <> BDC BT 1 0 0 -1 341.80200195 42.85499954 Tm [<0009000A000B00600061005D0062>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.45499802 Tm [<006300640009000A000B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 58.45499802 Tm [<0040>] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.06000137 58.45499802 Tm [<006500640009000A000B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.55999756 58.45499802 Tm [<0040>] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.12000275 58.45499802 Tm [<006600640009000A000B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.61999512 58.45499802 Tm [<0040>] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.17999268 58.45499802 Tm [<0067004D003500640009000A000B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.67999268 58.45499802 Tm [<0040>] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.23999023 58.45499802 Tm [<00680069006A006B00640009000A000B0050>] TJ ET EMC /P <> BDC BT 1 0 0 -1 363.73999023 58.45499802 Tm [<001A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 373.29998779 58.45499802 Tm [<006C0062006D0019>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.05500031 Tm [<0025006E0063006400030025000500060007000800400066006400030025006F0066005F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 189 74.05500031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 234 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 249.6000061 cm /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [<0003000400050006000700080009000A000B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 94.5 11.65499973 Tm [(\(10%,)1(RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.29299927 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.66700745 11.65499973 Tm [(fre)1(e\))] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 168.16499329 11.65499973 Tm [<00600061007000710063>] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.66499329 11.65499973 Tm [<0040>] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.66000366 11.65499973 Tm [<0072006A006B>] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.16000366 11.65499973 Tm [<0040>] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.15499878 11.65499973 Tm [<00730074007500760050002D004A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 345.65499878 11.65499973 Tm [<001A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 355.6499939 11.65499973 Tm [<0077>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 368.7749939 11.65499973 Tm [(RN)1(as)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 395.61499023 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 397.98901367 11.65499973 Tm [(fre)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.30300903 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 0 27.25500107 Tm [<0078005E001A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 31.5 27.25500107 Tm [(pH)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 46.18399811 27.25500107 Tm [<00790062>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 67.18399811 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.43399811 27.25500107 Tm [(7.2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 85.72799683 27.25500107 Tm [<007A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 96.22799683 27.25500107 Tm [(7.4)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 109.52200317 27.25500107 Tm [<001A007B0009000A000B007C004E001D007D007E007F0080002D002E00250009000A001A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.52200317 27.25500107 Tm [<00810082007C0019001D0083>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 364.14700317 27.25500107 Tm [(RN)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 382.70098877 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 387.95098877 27.25500107 Tm [<003000840025>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.85499954 Tm [<008500860087000F00250009000A005F007B0088003500120019001D00890016008A008B001A001B007C0019001D001E001F00200021008C0082008D0019008E005F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 346.5 42.85499954 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 296.3999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 312 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<0010>-4<0011>-4<002D>-4<004A>-4<0024>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 327.6000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 343.20001221 cm q 0.25 0.5 m 126.55000305 0.5 l 126.55000305 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 39.9280014 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0010>-4<0011>-4<008F>-4<0090>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 76.0719986 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 126.80000305 0 cm 0.25 0.5 m 78.5 0.5 l 78.5 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 24.93899918 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0091>-4<0092>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 43.01100159 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 205.55000305 0 cm 0.25 0.5 m 76.25 0.5 l 76.25 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 14.77799988 15.00499916 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0028>-4<0029>-4<0093>-4<0094>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 50.92200089 14.77600098 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.89599991 15.00500011 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<000C>-4<000D>-4<000E>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 34.00400162 15.00500011 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 23.89999962 l 0.25 23.89999962 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAABH 9 Tf 1 0 0 -1 6.546 15.00500011 Tm 2 Tr /GS2 gs 0 g 0.25714287 w [<0030>-4<0095>-4<0096>] TJ ET EMC /P <> BDC BT /FAAABD 9 Tf 1 0 0 -1 33.65399933 15.00500011 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 23.89999962 cm q 0.25 0.5 m 126.55000305 0.5 l 126.55000305 31.70000076 l 0.25 31.70000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 17.5 11.10499954 Tm /GS2 gs 0 g [<0003000400050006000700080009000A000B>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 26.42900085 26.47600174 Tm [(\(10%,)1(RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.96600342 26.47600174 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.00099945 26.47600174 Tm [(fre)1(e\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.56999969 26.47600174 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 126.80000305 0 cm 0.25 0.5 m 78.5 0.5 l 78.5 31.70000076 l 0.25 31.70000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 22.72500038 18.90499878 Tm /GS2 gs 0 g [(500ml)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 45.22499847 18.6760006 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 205.55000305 0 cm 0.25 0.5 m 76.25 0.5 l 76.25 31.70000076 l 0.25 31.70000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 28.35000038 18.90499878 Tm /GS2 gs 0 g [(RT)] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 37.34999847 18.6760006 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 282.04998779 0 cm 0.25 0.5 m 51.45000076 0.5 l 51.45000076 31.70000076 l 0.25 31.70000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.54399967 18.90500069 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 19.3560009 18.90500069 Tm [<009D>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.3560009 18.90500069 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 333.75 0 cm 0.25 0.5 m 50.75 0.5 l 50.75 31.70000076 l 0.25 31.70000076 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 12.19400024 18.90500069 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 9 Tf 1 0 0 -1 19.00600052 18.90500069 Tm [<009E>] TJ ET EMC /P <> BDC BT /FAAAAI 9 Tf 1 0 0 -1 28.00600052 18.90500069 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 55.59999847 l S Q q 0.5 w 126.80000305 0.5 m 126.80000305 23.89999962 l S Q q 0.5 w 126.80000305 24.39999962 m 126.80000305 55.59999847 l S Q q 0.5 w 205.55000305 0.5 m 205.55000305 23.89999962 l S Q q 0.5 w 205.55000305 24.39999962 m 205.55000305 55.59999847 l S Q q 0.5 w 282.04998779 0.5 m 282.04998779 23.89999962 l S Q q 0.5 w 282.04998779 24.39999962 m 282.04998779 55.59999847 l S Q q 0.5 w 333.75 0.5 m 333.75 23.89999962 l S Q q 0.5 w 333.75 24.39999962 m 333.75 55.59999847 l S Q q 0.5 w 384.75 0.5 m 384.75 55.59999847 l S Q q 0.5 w -0.25 0.25 m 385 0.25 l S Q q 0.5 w 0.25 24.14999962 m 384.5 24.14999962 l S Q q 0.5 w -0.25 55.84999847 m 385 55.84999847 l S Q Q q 1 0 0 1 0 399.29998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 11.38799953 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 414.8999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 430.5 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<009F>-4<00A0>-4<00A1>-4<00A2>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 42.16799927 11.65499973 Tm 0 Tr [(\()] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 45.43899918 11.65499973 Tm 2 Tr [<0012>-4<0013>-4<00A3>-4<00A4>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 87.60700226 11.65499973 Tm 0 Tr [(\))] TJ ET EMC /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 90.87799835 11.65499973 Tm 2 Tr [<0024>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 101.41999817 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 446.1000061 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<004000A50085008600A60014006100A7009F00A0005F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 120.8219986 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 461.70001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<004000A800A900AA000F0009000A00AB00AC00AD00420027>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 131.32200623 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.57200623 11.65499973 Tm [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 141.89399719 11.65499973 Tm [<007A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 152.39399719 11.65499973 Tm [(4h/mm)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 184.06300354 11.65499973 Tm [<001A007E00AA000F00AE007C00AF00B000460009000A00AB00AC005F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 331.06298828 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 477.29998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(3)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<00400009000A00B10025002D002E001A00B200270003000400050006000700080009000A000B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 204.82200623 11.65499973 Tm [(\(10%,)1(RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.61500549 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.98901367 11.65499973 Tm [(fre)1(e\))] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 278.48699951 11.65499973 Tm [<008C>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 291.61199951 11.65499973 Tm [(70%)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 309.76098633 11.65499973 Tm [<006F006600030046009600280029005F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 393.76098633 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 492.8999939 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.38799953 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 508.5 cm /P <> BDC BT /FAAABH 10.5 Tf 1 0 0 -1 0 11.65499973 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<00B3>-4<00B4>-4<00B5>-4<00B6>-4<0024>] TJ ET EMC /P <> BDC BT /FAAABD 10.5 Tf 1 0 0 -1 52.70999908 11.65499973 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 524.09997559 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 7.94700003 11.65499973 Tm [<0003000400050006000700080009000A000B>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 102.4469986 11.65499973 Tm [(\(10%,)1(RNase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.24000549 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.61399841 11.65499973 Tm [(fre)1(e\))] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 176.11199951 11.65499973 Tm [<003000A8000A00B700B80004002C00B900BA0004>] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.11199951 11.65499973 Tm [<001A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.29998779 11.65499973 Tm [<00BB0027004700BC006C00B1002500BD00BE00BF00C000C1>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<009F00A0001A00C200C300C400C5005F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 84 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 555.29998779 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<0040002D002E00C600C7002500C800C9001B00CA001A0009000A00AB00AC00CB001B00CA00CC006D0091005B00CD002D002E00CE006C007C004E002500C800C90062>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 351.82199097 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.07199097 11.65499973 Tm [(2)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 362.39401245 11.65499973 Tm [<007A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 372.89401245 11.65499973 Tm [(4mm)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 394.99099731 11.65499973 Tm [<001A00A8>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<00A9001B00CF0048>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 42 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.25 27.25500107 Tm [(6mm)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 69.34700012 27.25500107 Tm [<001A003D002D002E00D000AF002500D100C7003000D2001D0009000A000B002500D300D4005F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 268.84698486 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 586.5 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(3)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<00400009000A000B002500D500D600AE00D700D8001A00A800A90009000A000B0083002D002E00D90025001400DA00CE00DB00AE007E001D>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 299.32199097 11.65499973 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.57199097 11.65499973 Tm [(10:)1(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 323.34698486 11.65499973 Tm [<00CC00DC00DD00D500DA001B00D8007E001A>] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.25500107 Tm [<00B200DE00270009000A009600AC00DF00E0>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 94.5 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.75 27.25500107 Tm [(1)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 105.0719986 27.25500107 Tm [<007A>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 115.5719986 27.25500107 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.89399719 27.25500107 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 126.14399719 27.25500107 Tm [<00E10009000A000B005F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 178.64399719 27.25500107 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 617.70001221 cm /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 0 11.65499973 Tm /GS2 gs 0 g [(4)] TJ ET EMC /P <> BDC BT /FAAACB 10.5 Tf 1 0 0 -1 5.32200003 11.65499973 Tm [<004000E200C9003D0009000A002500E300E400E5000D00E6001A00E700E800E200C900B200DE004C00E90009000A00A00019001A00EA00E200C9001B00EB004800E8005F>] TJ ET EMC /P <> BDC BT /FAAAAI 10.5 Tf 1 0 0 -1 362.32199097 11.65499973 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ÿ??ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> 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