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-1 0 12.27200031 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 68.25 12.27200031 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 91.875 12.27200031 Tm [(COPS3)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 122.6210022 12.27200031 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.1210022 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 79.23400116 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 65.37400055 12.27200031 Tm [(Anti-)-1(COPS3)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 114.22899628 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 116.60299683 12.27200031 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 142.25300598 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 144.6269989 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 188.18600464 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 190.55999756 12.27200031 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 228.35600281 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.66799927 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 47.25 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(COP9)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 86.29699707 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 88.67099762 12.27200031 Tm [(si)-1(g)1(n)-1(alo)-1(some)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 141.8789978 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 144.25300598 12.27200031 Tm [(su)-1(bun)-1(it)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 176.35299683 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 178.727005 12.27200031 Tm [(3;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 186.85800171 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 189.23199463 12.27200031 Tm [(CS)-1(N)1(3;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 214.56399536 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 216.93800354 12.27200031 Tm [(SGN3)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 240.48599243 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 144.102005 cm /P <</Lang (zh-CN) /MCID 37 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <</MCID 38 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [<0011000D>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 47.25 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.27200031 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.27200031 Tm [<00150016>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 176.53599548 cm /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [<0017000D>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 47.25 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(COPS3)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 91.1210022 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.97000122 cm /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0018>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [<0019000D>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 47.25 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 90.69100189 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 241.40400696 cm /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001A001B001C001D000D>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 96.61199951 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 98.98600006 12.27200031 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 130.96800232 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 133.34199524 12.27200031 Tm [(Rat)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 147.58999634 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.8380127 cm /P <</Lang (zh-CN) /MCID 66 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001E001F0020000F000D>] TJ ET EMC /P <</MCID 67 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<00210004>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 306.27200317 cm /P <</Lang (zh-CN) /MCID 71 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.27200031 Tm [<0023>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0024000D>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 126 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 338.70599365 cm /P <</Lang (zh-CN) /MCID 80 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0006000700200025000D>] TJ ET EMC /P <</MCID 81 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 88.65000153 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 91.02400208 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 134.58299255 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 371.14001465 m 416.75 371.14001465 l 416.75 402.34002686 l -1.45000005 402.34002686 l h f* Q q 1 0 0 1 0 371.14001465 cm /P <</MCID 86 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 87 >> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 88 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 402.33999634 cm /P <</MCID 89 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.00500011 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 427.17401123 cm q /GS2 gs 1 g 0.375 0.75 m 176.5249939 0.75 l 176.5249939 125.55000305 l 0.375 125.55000305 l h f* Q q 0.375 0.75 m 176.5249939 0.75 l 176.5249939 125.55000305 l 0.375 125.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 91 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 177.2749939 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 177.2749939 125.55000305 l h f* Q q 1 0 0 1 176.8999939 0 cm 0.375 0.75 m 245.5249939 0.75 l 245.5249939 125.55000305 l 0.375 125.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 92 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(po)1(sse)-1(s)1(se)-1(s)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 201.61799622 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 206.11799622 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 233.20599365 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 30.47200012 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 34.97200012 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 52.19400024 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 56.69400024 27.3220005 Tm [(ph)1(osph)1(orylates)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 123.07800293 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 127.57800293 27.3220005 Tm [(regulat)1(ors)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 171.47099304 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 175.97099304 27.3220005 Tm [(involved)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 212.33999634 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 216.83999634 27.3220005 Tm [(in)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 224.78100586 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 229.28100586 27.3220005 Tm [(si)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(gnal)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 18.67200089 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 23.17200089 42.92200089 Tm [(tr)1(ansduc)-1(t)1(ion.)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 79.64600372 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 84.14600372 42.92200089 Tm [(It)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 90.14499664 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 94.64499664 42.92200089 Tm [(ph)1(osph)1(orylates)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 161.02900696 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 165.52900696 42.92200089 Tm [(I)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 168.17500305 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 172.67500305 42.92200089 Tm [(kappa)1(-Balpha)1(,)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 234.36099243 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(p10)-1(5,)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 23.74799919 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 28.24799919 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 44.52500153 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 49.02500153 58.52199936 Tm [(c-Jun)-1(.)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 74.2539978 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 78.7539978 58.52199936 Tm [(It)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 84.75299835 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 89.25299835 58.52199936 Tm [(acts)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 106.26000214 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 110.76000214 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 119.90100098 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 124.40100098 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 129.37600708 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 133.87600708 58.52199936 Tm [(do)1(c)-1(kin)-1(g)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 168.46499634 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 172.96499634 58.52199936 Tm [(site)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 187.98599243 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 192.48599243 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 204.76400757 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 209.26400757 58.52199936 Tm [(compl)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ex-mediat)1(e)-1(d)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 54.44400024 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 58.94400024 74.12200165 Tm [(ph)1(osph)1(orylation.)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 131.88400269 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 136.38400269 74.12200165 Tm [(The)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 152.19099426 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 156.69099426 74.12200165 Tm [(gene)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 178.20700073 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 182.70700073 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 189.26800537 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 193.76800537 74.12200165 Tm [(located)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 225.58900452 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 230.08900452 74.12200165 Tm [(w)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ith)1(i)-1(n)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 19.22999954 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 23.72999954 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 37.73099899 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 42.23099899 89.72200012 Tm [(Smith-)1(Magenis)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 107.77999878 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 112.27999878 89.72200012 Tm [(syndrome)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 155.21000671 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 159.71000671 89.72200012 Tm [(region)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 187.67199707 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 192.17199707 89.72200012 Tm [(on)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 203.44000244 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 207.94000244 89.72200012 Tm [(chrom)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(oso)1(me)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 29.14900017 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 33.64899826 105.3219986 Tm [(17)-1(.)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 46.37099838 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 50.87099838 105.3219986 Tm [(Se)-1(v)1(e)-1(ra)1(l)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 81.80899811 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 86.30899811 105.3219986 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 127.23100281 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 131.73100281 105.3219986 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 165.30099487 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 169.80099487 105.3219986 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 210.14300537 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 214.64300537 105.3219986 Tm [(dif)1(fe)-1(r)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(en)-1(t)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 14.00500011 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 18.50499916 120.92199707 Tm [(isof)1(orms)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 55.66500092 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 60.16500092 120.92199707 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 80.51200104 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 85.01200104 120.92199707 Tm [(been)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 106.51899719 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 111.01899719 120.92199707 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 136.70899963 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 141.20899963 120.92199707 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 153.48699951 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 157.98699951 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 173.44299316 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 177.94299316 120.92199707 Tm [(gene)-1(.)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 201.625 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 176.5249939 0.75 l 176.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 176.5249939 0.75 l 176.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 209 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 210 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 177.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 177.2749939 16.35000038 l h f* Q q 1 0 0 1 176.8999939 0 cm 0.375 0.75 m 245.5249939 0.75 l 245.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 211 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 176.5249939 0.75 l 176.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 176.5249939 0.75 l 176.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 217 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 222 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 177.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 177.2749939 16.35000038 l h f* Q q 1 0 0 1 176.8999939 0 cm 0.375 0.75 m 245.5249939 0.75 l 245.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 223 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(COPS3)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 29.33300018 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q /GS2 gs 1 g 0.375 0.75 m 176.5249939 0.75 l 176.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 176.5249939 0.75 l 176.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 225 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <</MCID 226 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 177.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 177.2749939 16.35000038 l h f* Q q 1 0 0 1 176.8999939 0 cm 0.375 0.75 m 245.5249939 0.75 l 245.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 227 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(COPS3)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 145.67900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 174.6000061 cm q /GS2 gs 1 g 0.375 0.75 m 176.5249939 0.75 l 176.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 176.5249939 0.75 l 176.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 237 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 240 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 177.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 177.2749939 16.35000038 l h f* Q q 1 0 0 1 176.8999939 0 cm 0.375 0.75 m 245.5249939 0.75 l 245.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 241 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(COP9)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 24.13899994 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 28.63899994 11.72200012 Tm [(signalo)1(some)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 83.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 87.52100372 11.72200012 Tm [(subunit)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 119.82099915 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 124.32099915 11.72200012 Tm [(3)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 129.59899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 190.95002747 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.8999939 0.75 m 176.8999939 125.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.8999939 126.30000305 m 176.8999939 141.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.8999939 142.65000916 m 176.8999939 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.8999939 159.00001526 m 176.8999939 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.8999939 175.35002136 m 176.8999939 190.95002747 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 190.95002747 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 174.97502136 m 422.42498779 174.97502136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 191.32502747 m 423.17498779 191.32502747 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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