%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 143 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 101.5 l -90 101.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 42.54999924 cm q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q q 1 0 0 1 90 144.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 100.09700012 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 149.772995 23.67700005 Tm 0 Tr [(EI)1(F3C)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 204.76199341 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAAAH 22 Tf 1 0 0 -1 315.20199585 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0009000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 65.80999756 12.27200031 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 89.43499756 12.27200031 Tm [(EIF)-1(3C)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 115.57700348 12.27200031 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 168.07699585 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.32699585 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 79.23400116 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000D000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Anti-)-1(EIF3C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.25099945 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.625 12.27200031 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.2749939 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.64900208 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.20799255 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.58200073 12.27200031 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.37800598 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.66799927 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(eukar)1(yoti)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.86100006 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.23500061 12.27200031 Tm [(transl)-1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.48500061 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.85899353 12.27200031 Tm [(in)-1(iti)-1(atio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.13200378 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.5059967 12.27200031 Tm [(factor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.89500427 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.26899719 12.27200031 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.59100342 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.96499634 12.27200031 Tm [(su)-1(bun)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.06500244 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.43899536 12.27200031 Tm [(C;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.84698486 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.2210083 12.27200031 Tm [(EIF)-1(3CL;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.96200562 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.33599854 12.27200031 Tm [(EIF)-1(3S8;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 344.21099854 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 346.58499146 12.27200031 Tm [(eIF3-p110)] TJ ET EMC /P <> BDC BT 1 0 0 -1 389.29800415 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 144.102005 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001100120013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.27200031 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.27200031 Tm [<00140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 176.53599548 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(EIF)-1(3C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.51699829 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.97000122 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 241.40400696 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0019001A001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.27200031 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.27200031 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.8380127 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001D001E001F000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<00200004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 306.27200317 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0021>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.27200031 Tm [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 338.70599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<00060007001F0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 134.58299255 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 371.14001465 m 416.75 371.14001465 l 416.75 402.34002686 l -1.45000005 402.34002686 l h f* Q q 1 0 0 1 0 371.14001465 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAADC 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 402.33999634 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.33899975 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 427.17401123 cm q /GS2 gs 1 g 0.375 0.75 m 158.5249939 0.75 l 158.5249939 187.94999695 l 0.375 187.94999695 l h f* Q q 0.375 0.75 m 158.5249939 0.75 l 158.5249939 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 97.52200317 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.2749939 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 159.2749939 187.94999695 l h f* Q q 1 0 0 1 158.8999939 0 cm 0.375 0.75 m 263.5249939 0.75 l 263.5249939 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Comp)1(one)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.19599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.69599915 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.53800201 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.03800201 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.03900146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.53900146 11.72200012 Tm [(eu)-1(karyot)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.24899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.74899292 11.72200012 Tm [(tr)1(anslatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.61000061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.11000061 11.72200012 Tm [(initiat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.18400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.68400574 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.80299377 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 27.3220005 Tm [(\(eIF)-1(-)1(3)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.49399948 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.99399948 27.3220005 Tm [(complex,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.63999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.13999939 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.23699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.73699951 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.29799652 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.79799652 27.3220005 Tm [(required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.33900452 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.83900452 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.11700439 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.61700439 27.3220005 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.52600098 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.02600098 27.3220005 Tm [(st)1(e)-1(ps)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.56599426 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.06599426 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.00700378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 42.92200089 Tm [(initiat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.57500076 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.07500076 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.91699982 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.41699982 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.72399902 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.22399902 42.92200089 Tm [(synthesis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.42799377 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.92799377 42.92200089 Tm [(\(PubMed:)1(1)-1(75)-1(81)-1(632)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.94700623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.44700623 42.92200089 Tm [(Pu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(bMed:)1(2)-1(58)-1(49)-1(773)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.95999908 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.45999908 58.52199936 Tm [(PubMed:274)-1(62)-1(815)-1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.47900391 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.97900391 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.78599548 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.28599548 58.52199936 Tm [(eIF)-1(-)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.99099731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.49099731 58.52199936 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.97000122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(asso)1(c)-1(iat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.53699875 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.03699875 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.43299866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.93299866 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.93399811 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.43399811 74.12200165 Tm [(40)-1(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.18399811 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.68399811 74.12200165 Tm [(ribo)1(some)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.41299438 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.91299438 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.19000244 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.69000244 74.12200165 Tm [(fa)1(c)-1(ilitat)1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.43600464 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.93600464 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.93699646 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.43699646 74.12200165 Tm [(rec)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(uitment)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.73199844 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.23199844 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.07400131 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.57400131 89.72200012 Tm [(eIF)-1(-)1(1)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.44499969 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.94499969 89.72200012 Tm [(eIF)-1(-)1(1)-1(A)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.14900208 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.64900208 89.72200012 Tm [(eIF)-1(-)1(2)-1(:)1(GTP:meth)1(i)-1(o)1(n)-1(yl-t)1(RNAi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.46699524 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.96699524 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.2440033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(eIF)-1(-)1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.70499992 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.20499992 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.27999878 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.77999878 105.3219986 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.49100113 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.99099731 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.99199677 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.49199677 105.3219986 Tm [(43)-1(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.24199677 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.74199677 105.3219986 Tm [(pre-initia)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.00100708 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.50100708 105.3219986 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.97999573 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.47999573 105.3219986 Tm [(\(43)-1(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.23599243 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.73599243 105.3219986 Tm [(PIC\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.08099365 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 120.92199707 Tm [(eIF)-1(-)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.01200104 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.51200104 120.92199707 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.99099731 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.49099731 120.92199707 Tm [(st)1(i)-1(mulat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.3789978 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.8789978 120.92199707 Tm [(mRNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.83700562 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.33700562 120.92199707 Tm [(rec)-1(ruit)1(me)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.56199646 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.06199646 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.13699341 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.63699341 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.63800049 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(43)-1(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.75 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.25 136.52200317 Tm [(PIC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.42200089 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.92200089 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.19900131 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.69900131 136.52200317 Tm [(scann)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.14199829 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.64199829 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.48400116 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.98400116 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.98500061 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.48500061 136.52200317 Tm [(mRNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.44299316 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.94299316 136.52200317 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.22099304 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.72099304 136.52200317 Tm [(AU)1(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.46600342 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.96600342 136.52200317 Tm [(rec)-1(o)1(gnitio)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.71199989 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.21199989 152.12199402 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.0189991 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.51900101 152.12199402 Tm [(eIF)-1(-)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.22399902 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.72399902 152.12199402 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.20300293 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.70300293 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.26399994 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.76399994 152.12199402 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.02099609 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.52099609 152.12199402 Tm [(required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.06199646 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.56199646 152.12199402 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.83999634 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.33999634 152.12199402 Tm [(disa)1(sse)-1(mb)1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.41099548 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.91099548 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 167.72200012 Tm [(rec)-1(ycl)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.22900009 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.72900009 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.57099915 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.07099915 167.72200012 Tm [(po)1(st-)1(termin)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.21400452 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.71400452 167.72200012 Tm [(ribo)1(somal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.70599365 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.20599365 167.72200012 Tm [(complexe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.95700073 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.45700073 167.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 183.32200623 Tm [(subsequen)-1(t)1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.0019989 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.5019989 183.32200623 Tm [(prevents)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.68900299 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.18900299 183.32200623 Tm [(premat)1(ure)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.33000183 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.83000183 183.32200623 Tm [(joining)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.59399414 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.09399414 183.32200623 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.93600464 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.43600464 183.32200623 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.43699646 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.93699646 183.32200623 Tm [(40)-1(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.68699646 183.32200623 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 158.8999939 0.75 m 158.8999939 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 188.32499695 m 423.17498779 188.32499695 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>