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/FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.27200031 Tm [(ECT)-1(2)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 110.41400146 12.27200031 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 162.91400146 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 168.16400146 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 79.23400116 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Anti-)-1(ECT2)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 104.89700317 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 107.27100372 12.27200031 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 132.92100525 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 135.29499817 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 178.85400391 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 181.22799683 12.27200031 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 219.02400208 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.66799927 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(ARHG)1(E)-1(F31)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 108.53800201 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 144.102005 cm /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 29 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 30 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 176.53599548 cm /P <</Lang (zh-CN) /MCID 32 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0014>] TJ ET EMC /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0015000D>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.27200031 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.27200031 Tm [<0019001A>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.97000122 cm /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<001B>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001C000D>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 90.69100189 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 241.40400696 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0004>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001D000D>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(ECT)-1(2)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 84.16400146 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.8380127 cm /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 96.61199951 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 98.98600006 12.27200031 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 128.3480072 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 306.27200317 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0022>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.27200031 Tm [<0023>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0024000D>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 126 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 338.70599365 cm /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 371.14001465 m 416.75 371.14001465 l 416.75 402.34002686 l -1.45000005 402.34002686 l h f* Q q 1 0 0 1 0 371.14001465 cm /P <</MCID 72 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 402.33999634 cm /P <</MCID 75 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 427.17401123 cm q 1 g 0.375 0.75 m 166.0249939 0.75 l 166.0249939 187.94999695 l 0.375 187.94999695 l h f* Q q 0.375 0.75 m 166.0249939 0.75 l 166.0249939 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 76 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 77 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 166.7749939 0.75 m 422.375 0.75 l 422.375 187.94999695 l 166.7749939 187.94999695 l h f* Q q 1 0 0 1 166.3999939 0 cm 0.375 0.75 m 255.9750061 0.75 l 255.9750061 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 78 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(guanine)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 214.51199341 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 219.01199341 11.72200012 Tm [(nuc)-1(leo)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(tid)1(e)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 16.61100006 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 21.11100006 27.3220005 Tm [(exc)-1(h)1(ange)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 62.21699905 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 66.71700287 27.3220005 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 91.83599854 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 96.33599854 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 112.61299896 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 117.11299896 27.3220005 Tm [(tr)1(ansfor)1(m)-1(ing)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 172.9980011 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 177.4980011 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 208.80499268 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 213.30499268 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 230.5269928 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 235.0269928 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 241.58799744 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(related)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 30.12899971 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 34.62900162 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 43.70399857 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 48.20399857 42.92200089 Tm [(Rho)1(-sp)1(e)-1(cific)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 101.19300079 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 105.69300079 42.92200089 Tm [(exc)-1(h)1(ange)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 146.79899597 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 151.29899597 42.92200089 Tm [(fa)1(c)-1(t)1(ors)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 180.58399963 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 185.08399963 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 201.36099243 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 205.86099243 42.92200089 Tm [(ye)-1(a)1(st)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 228.2250061 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 232.7250061 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 247.13499451 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 21.29199982 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 25.79199982 58.52199936 Tm [(regulat)1(ors.)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 71.85099792 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 76.35099792 58.52199936 Tm [(The)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 92.15799713 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 96.65799713 58.52199936 Tm [(expression)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 142.61199951 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 147.11199951 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 155.95399475 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 160.45399475 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 175.91000366 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 180.41000366 58.52199936 Tm [(gene)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 201.92599487 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 206.42599487 58.52199936 Tm [(is)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 212.98699951 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 217.48699951 58.52199936 Tm [(ele)-1(vat)1(e)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(d)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 5.75699997 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 10.25699997 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 28.65299988 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 33.15299988 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 47.15399933 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 51.65399933 74.12200165 Tm [(onset)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 75.54699707 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 80.04699707 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 88.88899994 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 93.38899994 74.12200165 Tm [(DNA)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 113.89399719 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 118.39399719 74.12200165 Tm [(synthesis)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 157.5980072 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 162.0980072 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 178.375 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 182.875 74.12200165 Tm [(remains)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 216.93299866 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 221.43299866 74.12200165 Tm [(ele)-1(vat)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ed)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 10.86299992 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 15.36299992 89.72200012 Tm [(during)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 43.79999924 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 48.29999924 89.72200012 Tm [(G2)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 60.27099991 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 64.77100372 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 81.04799652 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 85.54799652 89.72200012 Tm [(M)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 94.34100342 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 98.84100342 89.72200012 Tm [(ph)1(ases.)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 130.71000671 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 135.21000671 89.72200012 Tm [(In)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 143.40100098 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 147.90100098 89.72200012 Tm [(situ)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 163.36099243 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 167.86099243 89.72200012 Tm [(hybrid)1(izat)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 224.31300354 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 228.81300354 89.72200012 Tm [(anal)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ysis)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 15.49100018 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 19.99099922 105.3219986 Tm [(sho)1(wed)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 53.38899994 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 57.88899994 105.3219986 Tm [(th)1(at)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 75.11100006 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 79.61100006 105.3219986 Tm [(expression)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 125.56500244 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 130.06500244 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 136.62600708 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 141.12600708 105.3219986 Tm [(at)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 149.45399475 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 153.95399475 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 158.92900085 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 163.42900085 105.3219986 Tm [(hig)1(h)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 182.66400146 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 187.16400146 105.3219986 Tm [(leve)-1(l)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 206.89100647 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 211.39100647 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 219.33200073 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 223.83200073 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 242.40800476 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(undergoing)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 50.56800079 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 55.06800079 120.92199707 Tm [(mito)1(sis)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 85.69799805 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 90.19799805 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 98.13899994 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 102.63899994 120.92199707 Tm [(regene)-1(ra)1(ting)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 158.16000366 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 162.66000366 120.92199707 Tm [(live)-1(r)1(.)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 182.88400269 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 187.38400269 120.92199707 Tm [(Thus,)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 209.96299744 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 214.46299744 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 229.91900635 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 234.41900635 120.92199707 Tm [(pr)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 22.12199974 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 26.62199974 136.52200317 Tm [(is)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 33.18299866 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 37.68299866 136.52200317 Tm [(expressed)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 80.83699799 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 85.33699799 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 93.27799988 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 97.77799988 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 102.75299835 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 107.25299835 136.52200317 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 121.66300201 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 126.16300201 136.52200317 Tm [(cy)-1(cle)-1(-)1(depen)-1(d)1(e)-1(nt)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 198.37399292 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 202.87399292 136.52200317 Tm [(manne)-1(r)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 235.91600037 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 240.41600037 136.52200317 Tm [(d)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(uring)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 22.68000031 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 27.18000031 152.12199402 Tm [(live)-1(r)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 45.23699951 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 49.73699951 152.12199402 Tm [(regene)-1(ra)1(tion,)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 107.38899994 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 111.88899994 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 128.16600037 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 132.66600037 152.12199402 Tm [(is)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 139.227005 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 143.727005 152.12199402 Tm [(th)1(ought)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 178.53999329 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 183.03999329 152.12199402 Tm [(to)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 192.11500549 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 196.61500549 152.12199402 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 216.96200562 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 221.46200562 152.12199402 Tm [(an)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 231.98300171 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 236.48300171 152.12199402 Tm [(im)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(po)1(rtant)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 32.13299942 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 36.63299942 167.72200012 Tm [(role)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 53.29299927 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 57.79299927 167.72200012 Tm [(in)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 65.73400116 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 70.23400116 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 84.23500061 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 88.73500061 167.72200012 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 132.96600342 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 137.46600342 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 146.30799866 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 150.80799866 167.72200012 Tm [(cy)-1(t)1(oki)-1(nesis.)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 200 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 204.5 167.72200012 Tm [(Se)-1(v)1(e)-1(ra)1(l)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 235.43800354 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 239.93800354 167.72200012 Tm [(tr)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(anscript)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 34.13199997 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 38.63199997 183.32200623 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 72.20200348 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 76.70200348 183.32200623 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 117.04399872 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 121.54399872 183.32200623 Tm [(tw)1(o)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 137.7250061 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 142.2250061 183.32200623 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 179.16499329 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 183.66499329 183.32200623 Tm [(isof)1(orms)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 220.82499695 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 225.32499695 183.32200623 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 245.67199707 183.32200623 Tm [( )] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.3999939 0.75 m 166.3999939 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.75 0.75 m 422.75 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.125 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 188.32499695 m 423.125 188.32499695 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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