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12.27200031 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.27200031 Tm [(ECD)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 106.43599701 12.27200031 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 158.93600464 12.27200031 Tm [(    )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 179.93600464 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 79.23400116 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Anti-)-1(ECD)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 100.91899872 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 103.29299927 12.27200031 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 128.94299316 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 131.31700134 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 174.87600708 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 177.25 12.27200031 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 215.04600525 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.66799927 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(ec)1(d)-1(y)1(s)-1(oneless)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 119.16600037 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 121.54000092 12.27200031 Tm [(ce)1(l)-1(l)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 136.02400208 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 138.397995 12.27200031 Tm [(cy)1(cl)-1(e)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 159.66499329 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 162.03900146 12.27200031 Tm [(re)1(gul)-1(ator;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 204.34700012 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 206.72099304 12.27200031 Tm [(GCR2;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 232.77600098 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 235.1499939 12.27200031 Tm [(SGT)-1(1)1(;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 259.84698486 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 262.2210083 12.27200031 Tm [(HS)-1(G)1(T)-1(1)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 290.6499939 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 144.102005 cm /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 176.53599548 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0015000D>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.27200031 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.27200031 Tm [<0019001A>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.97000122 cm /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001C000D>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 90.69100189 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 241.40400696 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001D000D>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(ECD)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 80.18599701 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.8380127 cm /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 93.99199677 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 306.27200317 cm /P <</Lang (zh-CN) /MCID 69 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <</MCID 70 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 71 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.27200031 Tm [<0023>] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0024000D>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 126 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 338.70599365 cm /P <</Lang (zh-CN) /MCID 78 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 79 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 88.65000153 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 91.02400208 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 134.58299255 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 371.14001465 m 416.75 371.14001465 l 416.75 402.34002686 l -1.45000005 402.34002686 l h f* Q q 1 0 0 1 0 371.14001465 cm /P <</MCID 84 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 85 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 402.33999634 cm /P <</MCID 87 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.00500011 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 427.17401123 cm q /GS2 gs 1 g 0.375 0.75 m 168.2749939 0.75 l 168.2749939 187.94999695 l 0.375 187.94999695 l h f* Q q 0.375 0.75 m 168.2749939 0.75 l 168.2749939 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 88 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 169.0249939 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 169.0249939 187.94999695 l h f* Q q 1 0 0 1 168.6499939 0 cm 0.375 0.75 m 253.7749939 0.75 l 253.7749939 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Regulat)1(or)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 42.16600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 46.66600037 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 55.50799942 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 60.00799942 11.72200012 Tm [(p53)-1(/TP53)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 101.37799835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 105.87799835 11.72200012 Tm [(st)1(ability)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 139.42100525 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 143.92100525 11.72200012 Tm [(and)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 160.19799805 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 164.69799805 11.72200012 Tm [(func)-1(t)1(ion.)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 202.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 207.10499573 11.72200012 Tm [(Inhibit)1(s)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 238.89500427 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(MDM2-mediat)1(e)-1(d)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 74.4960022 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 78.9960022 27.3220005 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 131.77400208 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 136.27400208 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 145.11599731 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 149.61599731 27.3220005 Tm [(p53)-1(/TP53)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 190.98599243 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 195.48599243 27.3220005 Tm [(po)1(ssibly)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 230.58999634 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 235.08999634 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 245.602005 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(cooperat)1(ing)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 52.27299881 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 56.77299881 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 64.71399689 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 69.21399689 42.92200089 Tm [(pa)1(rt)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 86.72599792 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 91.22599792 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 109.62200165 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 114.12200165 42.92200089 Tm [(TXNIP)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 140.55499268 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 145.05499268 42.92200089 Tm [(\(PubMed:)1(1)-1(68)-1(49)-1(563)-1(,)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 231.07400513 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 235.57400513 42.92200089 Tm [(Pu)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(bMed:)1(2)-1(38)-1(80)-1(345)-1(\).)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 74.96600342 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 79.46600342 58.52199936 Tm [(May)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 97.9980011 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 102.4980011 58.52199936 Tm [(be)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 113.35199738 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 117.85199738 58.52199936 Tm [(involved)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 154.22099304 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 158.72099304 58.52199936 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 220.67500305 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 225.17500305 58.52199936 Tm [(regu)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(lat)1(i)-1(o)1(n.)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 26.55200005 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 31.05200005 74.12200165 Tm [(In)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 39.24300003 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 43.74300003 74.12200165 Tm [(vitr)1(o)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 63.3730011 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 67.8730011 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 82.55500031 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 87.05500031 74.12200165 Tm [(intrinsic)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 120.8010025 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 125.3010025 74.12200165 Tm [(tr)1(ansactivat)1(ion)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 188.727005 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 193.227005 74.12200165 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 223.69900513 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 228.19900513 74.12200165 Tm [(en)-1(h)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ance)-1(d)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 25.89699936 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 30.39699936 89.72200012 Tm [(by)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 40.9090004 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 45.4090004 89.72200012 Tm [(EP300)-1(.)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 73.86399841 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 78.36399841 89.72200012 Tm [(May)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 96.89600372 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 101.39600372 89.72200012 Tm [(be)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 112.25 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 116.75 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 121.72499847 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 126.22499847 89.72200012 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 188.17900085 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 192.67900085 89.72200012 Tm [(activat)1(or)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 230.125 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 234.625 89.72200012 Tm [(re)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(quired)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 27.99799919 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 32.4980011 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 44.77600098 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 49.27600098 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 63.27700043 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 67.77700043 105.3219986 Tm [(expression)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 113.73100281 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 118.23100281 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 127.07299805 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 131.57299805 105.3219986 Tm [(glyc)-1(o)1(ly)-1(t)1(ic)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 172.14300537 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 176.64300537 105.3219986 Tm [(gene)-1(s)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 202.32499695 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 206.82499695 105.3219986 Tm [(\(PubMed)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(:19)-1(919)-1(18)-1(1,)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 46.55599976 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 51.05599976 120.92199707 Tm [(PubMed:992)-1(89)-1(32\).)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 131.79699707 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 136.29699707 120.92199707 Tm [(Involved)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 172.91700745 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 177.41700745 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 185.35800171 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 189.85800171 120.92199707 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 234.08900452 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 238.58900452 120.92199707 Tm [(o)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(f)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 3.11999989 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 7.61999989 136.52200317 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 22.03000069 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 26.53000069 136.52200317 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 47.8219986 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 52.3219986 136.52200317 Tm [(pro)1(gression.)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 105.68900299 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 110.18900299 136.52200317 Tm [(Pro)1(posed)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 151.35299683 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 155.85299683 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 164.92799377 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 169.42799377 136.52200317 Tm [(disr)1(u)-1(p)1(t)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 199.82899475 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 204.32899475 136.52200317 Tm [(Rb-)1(E2F)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 234.85299683 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 239.35299683 136.52200317 Tm [(b)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(inding)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 27.39599991 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 31.89599991 152.12199402 Tm [(leading)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 63.82699966 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 68.32700348 152.12199402 Tm [(to)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 77.40200043 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 81.90200043 152.12199402 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 143.85600281 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 148.35600281 152.12199402 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 190.30599976 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 194.80599976 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 203.647995 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 208.147995 152.12199402 Tm [(E2F)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 223.15499878 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 227.65499878 152.12199402 Tm [(pro)1(t)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ein)-1(s)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 17.21299934 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 21.71299934 167.72200012 Tm [(\(PubMed:)1(1)-1(96)-1(40)-1(839)-1(\).)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 110.73699951 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 115.23699951 167.72200012 Tm [(The)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 131.04400635 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 135.54400635 167.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 149.95399475 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 154.45399475 167.72200012 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 175.7460022 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 180.2460022 167.72200012 Tm [(-r)1(e)-1(g)1(u)-1(lat)1(ing)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 228.40600586 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 232.90600586 167.72200012 Tm [(fu)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(nc)-1(t)1(ion)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 27.07500076 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 31.57500076 183.32200623 Tm [(may)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 49.74599838 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 54.24599838 183.32200623 Tm [(depend)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 87.26699829 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 91.76699829 183.32200623 Tm [(on)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 103.03500366 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 107.53500366 183.32200623 Tm [(its)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 117.4489975 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 121.9489975 183.32200623 Tm [(RU)1(V)-1(BL1)-1(-)1(me)-1(d)1(i)-1(a)1(ted)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 200.94900513 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 205.44900513 183.32200623 Tm [(asso)1(c)-1(iat)1(i)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 168.6499939 0.75 m 168.6499939 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 188.32499695 m 423.17498779 188.32499695 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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