%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 138 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 101.5 l -90 101.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 42.54999924 cm q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q q 1 0 0 1 90 144.05000305 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 126 40.51100159 Tm 2 Tr /GS2 gs 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABI 22 Tf 1 0 0 -1 175.67599487 40.51100159 Tm 0 Tr [(DUSP16)] TJ ET EMC /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 253.81500244 40.51100159 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABI 22 Tf 1 0 0 -1 364.25500488 40.51100159 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 375.25500488 40.51100159 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 63.63399887 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 63 12.27200031 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.27200031 Tm [(DUSP16)] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 123.33899689 12.27200031 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.83900452 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.08900452 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 96.06800079 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Anti-)-1(DU)1(S)-1(P1)1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.82299805 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.1969986 12.27200031 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.84700012 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.22099304 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.77999878 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.15400696 12.27200031 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.94999695 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 128.5019989 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(MKP)1(7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.98799896 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.36199951 12.27200031 Tm [(MKP)1(-7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.75499725 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 160.93600464 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 193.36999512 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.27200031 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 108.35800171 12.27200031 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 225.80400085 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 258.23800659 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(DUSP16)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.08899689 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 290.67199707 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 323.10598755 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 15.75 12.27200031 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 355.54000854 cm /P <> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 387.97399902 m 416.75 387.97399902 l 416.75 419.17401123 l -1.45000005 419.17401123 l h f* Q q 1 0 0 1 0 387.97399902 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 419.17401123 cm q /GS2 gs 1 g 0.375 0.75 m 161.5249939 0.75 l 161.5249939 125.55000305 l 0.375 125.55000305 l h f* Q q 0.375 0.75 m 161.5249939 0.75 l 161.5249939 125.55000305 l 0.375 125.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.2749939 0.75 m 422.375 0.75 l 422.375 125.55000305 l 162.2749939 125.55000305 l h f* Q q 1 0 0 1 161.8999939 0 cm 0.375 0.75 m 260.4750061 0.75 l 260.4750061 125.55000305 l 0.375 125.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(mito)1(gen)-1(-)1(activat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.02600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.52600098 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.83299255 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.33299255 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.42100525 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ph)1(osph)1(ata)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.04199982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.54199982 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.76399994 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.26399994 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.82499695 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.32499695 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.30000305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.80000305 27.3220005 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.06399536 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.56399536 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.40600586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.90600586 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.90699768 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.40699768 27.3220005 Tm [(dual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.07899475 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.57899475 27.3220005 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.04800415 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.54800415 27.3220005 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(rot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.55900002 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.05900002 42.92200089 Tm [(ph)1(osph)1(ata)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.10099792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.60099792 42.92200089 Tm [(subf)1(amily)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.30900574 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.80900574 42.92200089 Tm [(These)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.88900757 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.38900757 42.92200089 Tm [(ph)1(osph)1(ata)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.59700012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.09700012 42.92200089 Tm [(inac)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ivat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.5529995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.0529995 58.52199936 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.88600159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.38600159 58.52199936 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.36599731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.86599731 58.52199936 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.12000275 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.62000275 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.13200378 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.63200378 58.52199936 Tm [(deph)1(osph)1(orylating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.30400085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.80400085 58.52199936 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.16799927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.66799927 58.52199936 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(ph)1(osph)1(oserin)-1(e/thr)1(e)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.14800262 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.64800262 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.92500305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.42500305 74.12200165 Tm [(ph)1(osph)1(otyros)1(i)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.102005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.602005 74.12200165 Tm [(residue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.83300018 89.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.63999939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.13999939 89.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.64700317 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.14700317 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.45400238 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.95400238 89.72200012 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.43899536 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.93899536 89.72200012 Tm [(regulat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.77999878 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.27999878 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.28100586 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.78100586 89.72200012 Tm [(c-Jun)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.84300232 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(amino-)1(termin)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.60399628 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.10399628 105.3219986 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.19200134 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.69200134 105.3219986 Tm [(\(JNK\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.29699707 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.79699707 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.07400513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.57400513 105.3219986 Tm [(extra)1(c)-1(ellu)-1(la)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.76800537 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.26800537 105.3219986 Tm [(signal-)1(re)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ulated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.13199997 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.63199997 120.92199707 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.72000122 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.22000122 120.92199707 Tm [(\(ERK)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.76799774 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.26799774 120.92199707 Tm [(pa)1(thw)1(ays.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.06199646 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 161.5249939 0.75 l 161.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 161.5249939 0.75 l 161.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.2749939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 162.2749939 16.35000038 l h f* Q q 1 0 0 1 161.8999939 0 cm 0.375 0.75 m 260.4750061 0.75 l 260.4750061 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 161.5249939 0.75 l 161.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 161.5249939 0.75 l 161.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.2749939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 162.2749939 16.35000038 l h f* Q q 1 0 0 1 161.8999939 0 cm 0.375 0.75 m 260.4750061 0.75 l 260.4750061 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(DU)1(SP1)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.83100128 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q /GS2 gs 1 g 0.375 0.75 m 161.5249939 0.75 l 161.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 161.5249939 0.75 l 161.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.2749939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 162.2749939 16.35000038 l h f* Q q 1 0 0 1 161.8999939 0 cm 0.375 0.75 m 260.4750061 0.75 l 260.4750061 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hetic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.26599884 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48000336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98000336 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.8219986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.3219986 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.36299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86300659 11.72200012 Tm [(DU)1(SP1)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.69400024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 174.6000061 cm q /GS2 gs 1 g 0.375 0.75 m 161.5249939 0.75 l 161.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 161.5249939 0.75 l 161.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.2749939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 162.2749939 16.35000038 l h f* Q q 1 0 0 1 161.8999939 0 cm 0.375 0.75 m 260.4750061 0.75 l 260.4750061 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(dual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.67200089 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.17200089 11.72200012 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.64099884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.14099884 11.72200012 Tm [(ph)1(osph)1(ata)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.18299866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.68299866 11.72200012 Tm [(16)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.23899841 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 190.95002747 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.8999939 0.75 m 161.8999939 125.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.8999939 126.30000305 m 161.8999939 141.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.8999939 142.65000916 m 161.8999939 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.8999939 159.00001526 m 161.8999939 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.8999939 175.35002136 m 161.8999939 190.95002747 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.75 0.75 m 422.75 190.95002747 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.125 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.375 125.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.375 142.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.375 158.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 174.97502136 m 422.375 174.97502136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 191.32502747 m 423.125 191.32502747 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> 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