%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 131 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 101.5 l -90 101.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 42.54999924 cm q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q q 1 0 0 1 90 144.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.52200317 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 138.19799805 23.67700005 Tm 0 Tr [(DUSP14)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 216.33700562 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 326.77700806 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.27200031 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.27200031 Tm [(DUSP14)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 112.83899689 12.27200031 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 165.33900452 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.58900452 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 79.23400116 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Anti-)-1(DU)1(S)-1(P1)1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.82299805 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.1969986 12.27200031 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.84700012 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.22099304 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.77999878 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.15400696 12.27200031 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.94999695 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.66799927 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.27200031 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.27200031 Tm /GS2 gs 0 g [(MKP)1(6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.98799896 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.36199951 12.27200031 Tm [(MKP)1(-L)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.84799957 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 144.102005 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.27200031 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(DUSP14)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.08899689 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 176.53599548 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.27200031 Tm [<0012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.27200031 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.27200031 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.97000122 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.27200031 Tm [<0019000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 241.40400696 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001A001B001C000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001D0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 273.8380127 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.27200031 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 306.27200317 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 338.70599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<00060007001C0025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 371.14001465 m 416.75 371.14001465 l 416.75 402.34002686 l -1.45000005 402.34002686 l h f* Q q 1 0 0 1 0 371.14001465 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 402.33999634 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.00500011 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 427.17401123 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 156.75 l 0.375 156.75 l h f* Q q 0.375 0.75 m 154.7749939 0.75 l 154.7749939 156.75 l 0.375 156.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 155.5249939 156.75 l h f* Q q 1 0 0 1 155.1499939 0 cm 0.375 0.75 m 267.2749939 0.75 l 267.2749939 156.75 l 0.375 156.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Dual-)1(spec)-1(ificity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.13300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.63300323 11.72200012 Tm [(ph)1(osph)1(ata)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.84100342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.34100342 11.72200012 Tm [(\(DU)1(SPs\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.79400635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.29400635 11.72200012 Tm [(constitut)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.34700012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.84700012 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.82200623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.32200623 11.72200012 Tm [(larg)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.99099731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(heterog)1(e)-1(neous)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.21499634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.71499634 27.3220005 Tm [(subg)1(roup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.38400269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.88400269 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.72599792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.22599792 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.227005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.727005 27.3220005 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.69799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.19799805 27.3220005 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.84399414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.34399414 27.3220005 Tm [(cy)-1(st)1(e)-1(ine-ba)1(se)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.93899536 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.43899536 27.3220005 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ot)1(e)-1(in-t)1(yrosine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.50400162 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.0039978 42.92200089 Tm [(ph)1(osph)1(ata)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.04599762 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.54599762 42.92200089 Tm [(superfa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.79699707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.29699707 42.92200089 Tm [(DU)1(SPs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.73800659 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.23800659 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.7559967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.2559967 42.92200089 Tm [(chara)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(cterized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.0929985 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.5929985 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.10499954 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.60499954 58.52199936 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.43800354 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.93800354 58.52199936 Tm [(ab)1(i)-1(lit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.96199799 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.46199799 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.53700256 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.03700256 58.52199936 Tm [(deph)1(osph)1(orylate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.11799622 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.61799622 58.52199936 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.98199463 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.48199463 58.52199936 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.97000122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 74.12200165 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.1309967 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.6309967 74.12200165 Tm [(residues.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.477005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.977005 74.12200165 Tm [(They)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.54800415 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.04800415 74.12200165 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.39500427 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.89500427 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.4019928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.9019928 74.12200165 Tm [(implicated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.97198486 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.14099979 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.64099979 89.72200012 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.61100006 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.11100006 89.72200012 Tm [(mod)1(u)-1(la)1(tors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.61499786 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.11499786 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.95700073 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.45700073 89.72200012 Tm [(critic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43299866 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.93299866 89.72200012 Tm [(signaling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.86399841 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.36399841 89.72200012 Tm [(pa)1(thw)1(ays.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.15800476 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.65800476 89.72200012 Tm [(DU)1(SP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(14)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.55599976 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.05599976 105.3219986 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.27099991 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.77099991 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.77200317 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.27200317 105.3219986 Tm [(conse)-1(nsus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.74900055 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.24900055 105.3219986 Tm [(DU)1(SP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.52400208 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.02400208 105.3219986 Tm [(C-t)1(e)-1(r)1(min)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.57800293 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.07800293 105.3219986 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.31300354 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.81300354 105.3219986 Tm [(do)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.34900093 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.84900093 120.92199707 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.49599838 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.99599838 120.92199707 Tm [(lack)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.94499969 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.44499969 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.44599915 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.94599915 120.92199707 Tm [(N-t)1(e)-1(r)1(mi)-1(na)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.79600525 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.29600525 120.92199707 Tm [(CH2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.55499268 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.05499268 120.92199707 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.88200378 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.38200378 120.92199707 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.07200623 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.57200623 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.51300049 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.01300049 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.01400757 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(MKP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.01300049 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.51300049 136.52200317 Tm [(\(mito)1(gen)-1(-)1(activat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.875 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.375 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.68200684 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.18200684 136.52200317 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.27000427 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.77000427 136.52200317 Tm [(ph)1(osph)1(ata)1(se)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.81700134 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.31700134 136.52200317 Tm [(cl)-1(a)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.50799942 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.00799942 152.12199402 Tm [(DU)1(SPs.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.61600113 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 154.7749939 0.75 l 154.7749939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.5249939 16.35000038 l h f* Q q 1 0 0 1 155.1499939 0 cm 0.375 0.75 m 267.2749939 0.75 l 267.2749939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 173.1000061 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 154.7749939 0.75 l 154.7749939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.5249939 16.35000038 l h f* Q q 1 0 0 1 155.1499939 0 cm 0.375 0.75 m 267.2749939 0.75 l 267.2749939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(DU)1(SP1)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.83100128 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 189.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 0.75 m 155.1499939 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 157.5 m 155.1499939 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 173.8500061 m 155.1499939 189.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 189.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 173.4750061 m 422.42498779 173.4750061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.82501221 m 423.17498779 189.82501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>