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12.27200031 Tm /GS2 gs 0 g [<0009000A000B000C>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.27200031 Tm [<00030004>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84.18499756 12.27200031 Tm [(DUSP11)] TJ ET EMC /P <</Lang (zh-CN) /MCID 9 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 120.89900208 12.27200031 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 10 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.39900208 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 178.64900208 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 79.23400116 cm /P <</Lang (zh-CN) /MCID 12 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000D000A000B000C>] TJ ET EMC /P <</MCID 13 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm [(  )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 55.31000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Anti-)-1(DU)1(S)-1(P1)1(1)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 117.82299805 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 120.1969986 12.27200031 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 145.84700012 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 148.22099304 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 191.77999878 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 194.15400696 12.27200031 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 231.94999695 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.66799927 cm /P <</Lang (zh-CN) /MCID 24 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000E>] TJ ET EMC /P <</MCID 25 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 26 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<000B>] TJ ET EMC /P <</MCID 27 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(PIR1)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 82.09300232 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 144.102005 cm /P <</Lang (zh-CN) /MCID 31 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0010>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001100120013>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.27200031 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.27200031 Tm [<00140015>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 176.53599548 cm /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0016>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(DUSP11)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 97.08899689 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.97000122 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0017>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0018>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 90.69100189 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 241.40400696 cm /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0019001A001B000E>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001C0004>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 273.8380127 cm /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001D001E001F0020>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 93.99199677 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 306.27200317 cm /P <</Lang (zh-CN) /MCID 66 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0021>] TJ ET EMC /P <</MCID 67 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.27200031 Tm [<0022>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0023>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 126 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 338.70599365 cm /P <</Lang (zh-CN) /MCID 76 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<00060007001B0024>] TJ ET EMC /P <</MCID 77 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 88.65000153 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 91.02400208 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 134.58299255 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 371.14001465 m 416.75 371.14001465 l 416.75 402.34002686 l -1.45000005 402.34002686 l h f* Q q 1 0 0 1 0 371.14001465 cm /P <</MCID 83 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 84 >> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAADC 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 402.33999634 cm /P <</MCID 86 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.00500011 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 427.17401123 cm q /GS2 gs 1 g 0.375 0.75 m 155.5249939 0.75 l 155.5249939 187.94999695 l 0.375 187.94999695 l h f* Q q 0.375 0.75 m 155.5249939 0.75 l 155.5249939 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 97.52200317 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 88 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 156.2749939 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 156.2749939 187.94999695 l h f* Q q 1 0 0 1 155.8999939 0 cm 0.375 0.75 m 266.5249939 0.75 l 266.5249939 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 89 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(d)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ual)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 12.91600037 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 17.41600037 27.3220005 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 59.88499832 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 64.38500214 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 95.69200134 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 100.19200134 27.3220005 Tm [(ph)1(osph)1(ata)1(se)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 155.23399353 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 159.73399353 27.3220005 Tm [(subf)1(amily)-1(.)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 203.44200134 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 207.94200134 27.3220005 Tm [(These)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 233.02200317 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 237.52200317 27.3220005 Tm [(ph)1(os)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ph)1(ata)1(se)-1(s)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 38.02999878 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 42.52999878 42.92200089 Tm [(inac)-1(t)1(ivat)1(e)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 83.86499786 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 88.36499786 42.92200089 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 108.19799805 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 112.69799805 42.92200089 Tm [(ta)1(rget)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 138.67799377 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 143.17799377 42.92200089 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 174.43200684 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 178.93200684 42.92200089 Tm [(by)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 189.44400024 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 193.94400024 42.92200089 Tm [(deph)1(osph)1(oryla)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ting)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 17.0510006 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 21.5510006 58.52199936 Tm [(bo)1(th)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 41.91500092 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 46.41500092 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 60.41600037 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 64.91600037 58.52199936 Tm [(ph)1(osph)1(oserin)-1(e/thr)1(e)-1(o)1(n)-1(ine)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 174.45799255 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 178.95799255 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 195.23500061 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 199.73500061 58.52199936 Tm [(ph)1(osph)1(otyros)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ine)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 13.04699993 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 17.54700089 74.12200165 Tm [(residues.)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 55.39300156 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 59.89300156 74.12200165 Tm [(They)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 80.46399689 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 84.96399689 74.12200165 Tm [(ne)-1(g)1(atively)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 129.08500671 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 133.58500671 74.12200165 Tm [(regulat)1(e)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 169.25999451 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 173.75999451 74.12200165 Tm [(members)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 214.19000244 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 218.69000244 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 227.53199768 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 232.03199768 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 246.03300476 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 250.53300476 74.12200165 Tm [(m)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ito)1(gen)-1(-)1(activat)1(e)-1(d)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 70.92299652 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 75.42299652 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 106.73000336 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 111.23000336 89.72200012 Tm [(\(MAP)1(\))] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 137.87399292 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 142.37399292 89.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 169.46200562 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 173.96200562 89.72200012 Tm [(superfa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 224.04600525 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 228.54600525 89.72200012 Tm [(\(MAP)1(K)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(/ERK,)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 22.54800034 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 27.04800034 105.3219986 Tm [(SAPK)1(/)-1(JNK)1(,)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 72.40000153 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 76.90000153 105.3219986 Tm [(p38)-1(\),)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 98.37599945 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 102.87599945 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 127.97299957 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 132.4730072 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 139.03399658 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 143.53399658 105.3219986 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 188.66099548 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 193.16099548 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 211.55700684 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 216.05700684 105.3219986 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 246.81900024 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 251.31900024 105.3219986 Tm [(p)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(rolif)1(e)-1(ra)1(tion)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 47.60200119 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 52.10200119 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 68.3789978 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 72.8789978 120.92199707 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion.)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 136.3710022 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 140.8710022 120.92199707 Tm [(Diff)1(e)-1(r)1(e)-1(nt)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 178.91000366 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 183.41000366 120.92199707 Tm [(members)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 223.83999634 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 228.33999634 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 237.18200684 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 241.68200684 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 255.68299866 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 26.08200073 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 30.58200073 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 39.42399979 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 43.92399979 136.52200317 Tm [(dual)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 62.59600067 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 67.09600067 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 109.56500244 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 114.06500244 136.52200317 Tm [(ph)1(osph)1(ata)1(se)-1(s)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 173.272995 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 177.772995 136.52200317 Tm [(sho)1(w)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 200.30799866 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 204.80799866 136.52200317 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 236.28599548 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 240.78599548 136.52200317 Tm [(sub)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(st)1(rate)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 24.38999939 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 28.88999939 152.12199402 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 78.26300049 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 82.76300049 152.12199402 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 95.04100037 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 99.54100037 152.12199402 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 130.50500488 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 135.00500488 152.12199402 Tm [(MAP)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 155.63699341 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 160.13699341 152.12199402 Tm [(ki)-1(na)1(se)-1(s,)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 193.55700684 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 198.05700684 152.12199402 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 234.99699402 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 239.49699402 152.12199402 Tm [(tiss)1(u)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(e)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 5.10599995 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 9.60599995 167.72200012 Tm [(dist)1(ributio)1(n)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 59.41799927 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 63.91799927 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 80.19499969 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 84.69499969 167.72200012 Tm [(subce)-1(llular)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 130.91700745 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 135.41700745 167.72200012 Tm [(localizat)1(ion,)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 186.39399719 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 190.89399719 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 207.17100525 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 211.67100525 167.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 248.61099243 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(mod)1(e)-1(s)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 29.18400002 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 33.68399811 183.32200623 Tm [(of)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 42.52600098 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 47.02600098 183.32200623 Tm [(induc)-1(ib)1(i)-1(lit)1(y)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 94.22799683 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 98.72799683 183.32200623 Tm [(of)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 107.56999969 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 112.06999969 183.32200623 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 131.90299988 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 136.40299988 183.32200623 Tm [(expression)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 182.35699463 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 186.85699463 183.32200623 Tm [(by)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 197.3690033 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 201.8690033 183.32200623 Tm [(extra)1(c)-1(ellu)-1(la)1(r)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 254.06300354 183.32200623 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.8999939 0.75 m 155.8999939 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 188.32499695 m 423.17498779 188.32499695 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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