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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 101.5 l -90 101.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 42.54999924 cm q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q q 1 0 0 1 90 144.05000305 cm q 1 0 0 1 99 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(CUL1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 101.63600159 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 212.07600403 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0009000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.27200031 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84.18499756 12.27200031 Tm [(CUL1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.88200378 12.27200031 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 161.38200378 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.63200378 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 79.23400116 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<000D000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.31000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Anti-)-1(CU)1(L)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.80500031 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.17900085 12.27200031 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.82899475 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.20300293 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.76199341 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.13600159 12.27200031 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.93200684 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.66799927 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(CUL1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.0719986 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 144.102005 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001100120013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.27200031 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.27200031 Tm [<00140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 176.53599548 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 208.97000122 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<00180019001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.27200031 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 241.40400696 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<00200004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.8380127 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0021>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.27200031 Tm [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 306.27200317 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<00060007001E0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 134.58299255 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 338.70599365 m 416.75 338.70599365 l 416.75 369.90600586 l -1.45000005 369.90600586 l h f* Q q 1 0 0 1 0 338.70599365 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 369.90600586 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 394.73999023 cm q 1 g 0.375 0.75 m 158.92500305 0.75 l 158.92500305 219.1499939 l 0.375 219.1499939 l h f* Q q 0.375 0.75 m 158.92500305 0.75 l 158.92500305 219.1499939 l 0.375 219.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 113.12200165 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 113.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 159.67500305 0.75 m 422.42498779 0.75 l 422.42498779 219.1499939 l 159.67500305 219.1499939 l h f* Q q 1 0 0 1 159.30000305 0 cm 0.375 0.75 m 263.125 0.75 l 263.125 219.1499939 l 0.375 219.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Core)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.28499985 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.78499985 11.72200012 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.47399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.97399902 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.81600189 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.31600189 11.72200012 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.68800354 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.18800354 11.72200012 Tm [(cu)-1(llin-RING)1(-ba)1(se)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.04800415 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.54800415 11.72200012 Tm [(SCF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.54400635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.04400635 11.72200012 Tm [(\(SKP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(1-CUL1-F-b)1(ox)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.4070015 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.90699768 27.3220005 Tm [(pro)1(tein)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.21900177 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.71900177 27.3220005 Tm [(E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.94499969 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.44499969 27.3220005 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.32600403 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.82600403 27.3220005 Tm [(ligas)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.61999512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.11999512 27.3220005 Tm [(compl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(exe)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.10700035 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.60700035 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.70399857 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.20399857 42.92200089 Tm [(mediat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.32900238 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.82900238 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.83000183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.33000183 42.92200089 Tm [(ubiquitinat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.00100708 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.50100708 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.34300232 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.84300232 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.31599426 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.81599426 42.92200089 Tm [(invol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.58699989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.08699989 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.02799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.52799988 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.93799973 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.43799973 58.52199936 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.73000336 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.23000336 58.52199936 Tm [(pro)1(gression,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.59700012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.09700012 58.52199936 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.33000183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.83000183 58.52199936 Tm [(tr)1(ansduc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.13800049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.63800049 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.91499329 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.41499329 58.52199936 Tm [(tr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(anscript)1(i)-1(o)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.96099854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.46099854 74.12200165 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.65200043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.15200043 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.15299988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.65299988 74.12200165 Tm [(SCF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.64900208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.14900208 74.12200165 Tm [(complex,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.79499817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.29499817 74.12200165 Tm [(serves)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.00100708 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.50100708 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.64199829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.14199829 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.11700439 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.61700439 74.12200165 Tm [(rigid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.35699463 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.85699463 74.12200165 Tm [(scaff)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.47900009 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.97900009 89.72200012 Tm [(org)1(anizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.50700378 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.00700378 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.00800323 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.50800323 89.72200012 Tm [(SKP1-F-b)1(ox)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.79899597 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.29899597 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.60600281 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.10600281 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.38299561 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.88299561 89.72200012 Tm [(RBX1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.48800659 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.98800659 89.72200012 Tm [(subu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nits.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.62599945 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.12599945 105.3219986 Tm [(May)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.65800095 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.15800095 105.3219986 Tm [(contribut)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.8769989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.3769989 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.45200348 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.95200348 105.3219986 Tm [(cata)1(l)-1(ysis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.65299988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.15299988 105.3219986 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.05000305 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.55000305 105.3219986 Tm [(po)1(sitioning)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.29400635 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.79400635 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.63600159 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 120.92199707 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.35100174 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.85100174 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.12799835 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.62799835 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.6289978 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.1289978 120.92199707 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.21600342 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.71600342 120.92199707 Tm [(en)-1(z)1(y)-1(me.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.26300049 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.76300049 120.92199707 Tm [(Th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 136.52200317 Tm [(E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.83200073 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.33200073 136.52200317 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.21299744 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.71299744 136.52200317 Tm [(ligase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.50700378 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.00700378 136.52200317 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.47900391 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.97900391 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.82099915 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.32099915 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.32200623 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82200623 136.52200317 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.30099487 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.80099487 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.36199951 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(dependen)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.02600098 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.52600098 152.12199402 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.79399872 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.29399872 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.29499817 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.79499817 152.12199402 Tm [(ne)-1(d)1(dylatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.11000061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.61000061 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.45199585 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.95199585 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.95300293 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.45300293 152.12199402 Tm [(cu)-1(llin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.24299622 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.74299622 152.12199402 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.04299927 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.54299927 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.82000732 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(exc)-1(h)1(ange)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.10599899 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.60599899 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.44800186 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.94800186 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.9489975 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.4489975 167.72200012 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.2990036 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.7990036 167.72200012 Tm [(rec)-1(o)1(gnition)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.28999329 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.78999329 167.72200012 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.47900391 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.97900391 167.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.53999329 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.03999329 167.72200012 Tm [(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(dia)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.34300041 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.84300041 183.32200623 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.35499954 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.85499954 183.32200623 Tm [(TIP12)-1(0A/CAND)1(1)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.14700317 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.64700317 183.32200623 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.45399475 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.95399475 183.32200623 Tm [(func)-1(t)1(ional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.06399536 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.56399536 183.32200623 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.03300476 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.53300476 183.32200623 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.375 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 198.92199707 Tm [(SCF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.49700165 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.99700165 198.92199707 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.47599792 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.97599792 198.92199707 Tm [(depends)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.16300201 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.66300201 198.92199707 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.93099976 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.43099976 198.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.43200684 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.93200684 198.92199707 Tm [(F-bo)1(x)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.63800049 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.13800049 198.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.44500732 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.94500732 198.92199707 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.08599854 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.58599854 198.92199707 Tm [(subs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 214.52200317 Tm [(tr)1(ate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.22400093 214.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.72400093 214.52200317 Tm [(rec)-1(o)1(gnition)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.21499634 214.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.71499634 214.52200317 Tm [(component.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.57000732 214.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.07000732 214.52200317 Tm [(SCF\(B)-1(TRC\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.77999878 214.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.27999878 214.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.55700684 214.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.05700684 214.52200317 Tm [(SCF\(F)-1(BXW1)] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 219.1499939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.30000305 0.75 m 159.30000305 219.1499939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 219.1499939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 219.5249939 m 423.17498779 219.5249939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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