%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 158 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 101.5 l -90 101.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 42.54999924 cm q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q q 1 0 0 1 90 144.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 82.74299622 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 132.41900635 23.67700005 Tm 0 Tr [(CSNK2)1(A2)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 222.11599731 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 332.55599976 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.27200031 Tm [(CS)-1(N)1(K2A)1(2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 128.625 12.27200031 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 181.125 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.875 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 79.23400116 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Anti-)-1(CSNK)1(2A2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.10800171 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.48200226 12.27200031 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.13200378 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.5059967 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.06500244 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.43899536 12.27200031 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.23500061 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.66799927 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(casein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.72699738 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.10099792 12.27200031 Tm [(kinas)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.16100311 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.53500366 12.27200031 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.85700226 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.23100281 12.27200031 Tm [(alp)-1(ha)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.73300171 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.10699463 12.27200031 Tm [(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.23800659 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.61199951 12.27200031 Tm [(CK2A)1(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.19400024 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.56799316 12.27200031 Tm [(CS)-1(N)1(K2A)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.75300598 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.1269989 12.27200031 Tm [(CK2alph)-1(a')] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.32199097 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 144.102005 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 176.53599548 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.27200031 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.27200031 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.97000122 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 241.40400696 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(CS)-1(N)1(K2A)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.375 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.8380127 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.27200031 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 306.27200317 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.27200031 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 338.70599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 371.14001465 m 416.75 371.14001465 l 416.75 402.34002686 l -1.45000005 402.34002686 l h f* Q q 1 0 0 1 0 371.14001465 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 402.33999634 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.00500011 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 427.17401123 cm q /GS2 gs 1 g 0.375 0.75 m 147.2749939 0.75 l 147.2749939 187.94999695 l 0.375 187.94999695 l h f* Q q 0.375 0.75 m 147.2749939 0.75 l 147.2749939 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 97.52200317 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.0249939 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 148.0249939 187.94999695 l h f* Q q 1 0 0 1 147.6499939 0 cm 0.375 0.75 m 274.7749939 0.75 l 274.7749939 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.19599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.69599915 11.72200012 Tm [(alph)1(a',)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.80299377 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.30299377 11.72200012 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.46099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.96099854 11.72200012 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.59500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.09500122 11.72200012 Tm [(2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.53900146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.03900146 11.72200012 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.27400208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.77400208 11.72200012 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.07400513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.84200001 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.34200001 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.34300041 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.84300041 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.15000153 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.65000153 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.73799896 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.23799896 27.3220005 Tm [(en)-1(z)1(y)-1(me,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.78500366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.28500366 27.3220005 Tm [(casei)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.98599243 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.48599243 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.57400513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.07400513 27.3220005 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.352005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.852005 27.3220005 Tm [(\(CK2\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.04100037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.54100037 27.3220005 Tm [(Casei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 42.92200089 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.13399887 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.63399887 42.92200089 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.91199875 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.41199875 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.97299957 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.47299957 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.44799805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.94799805 42.92200089 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.30200195 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.80200195 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.10899353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.60899353 42.92200089 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.69700623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.19700623 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.41900635 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.91900635 42.92200089 Tm [(ph)1(osp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ho)1(ry)-1(la)1(tes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.45800018 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.95800018 58.52199936 Tm [(acidic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.5059967 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.0059967 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.47899628 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.97899628 58.52199936 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.7460022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.2460022 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.38699341 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.88699341 58.52199936 Tm [(casei)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.75500488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.25500488 58.52199936 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.2539978 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.7539978 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.31500244 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.81500244 58.52199936 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.18400574 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.68400574 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.625 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.125 58.52199936 Tm [(v)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ario)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.23999977 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.73999977 74.12200165 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.5019989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.0019989 74.12200165 Tm [(pro)1(c)-1(esses,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.2990036 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.7990036 74.12200165 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.64900208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.14900208 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.55900574 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.05900574 74.12200165 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.35099792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.85099792 74.12200165 Tm [(control,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.70500183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.20500183 74.12200165 Tm [(ap)1(opt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(osis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.61499977 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.11499977 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.39199829 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.89199829 89.72200012 Tm [(ci)-1(r)1(c)-1(ad)1(ian)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.39700317 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.89700317 89.72200012 Tm [(rhyt)1(hms.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.2990036 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.79899597 89.72200012 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.06100464 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.56100464 89.72200012 Tm [(heterot)1(e)-1(t)1(rameric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.93499756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.43499756 89.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.522995 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.02301025 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(cl)-1(ud)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.4829998 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.9829998 105.3219986 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.16400146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.66400146 105.3219986 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.89900208 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.39900208 105.3219986 Tm [(subunits,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.03100586 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.53100586 105.3219986 Tm [(either)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.47000122 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.97000122 105.3219986 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.60400391 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.10400391 105.3219986 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.26199341 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.76199341 105.3219986 Tm [(alph)1(a',)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.8690033 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.3690033 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.64599609 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.14599609 105.3219986 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(wo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.82800007 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.32799911 120.92199707 Tm [(regulat)1(ory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.81800079 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.31800079 120.92199707 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.5 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90 120.92199707 Tm [(subunits.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.63200378 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.13200378 120.92199707 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.93899536 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.43899536 120.92199707 Tm [(cl)-1(o)1(se)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.5 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187 120.92199707 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.1289978 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.6289978 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.14500427 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.64500427 120.92199707 Tm [(pa)1(ra)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(log)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.8739996 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.37400055 136.52200317 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.7159996 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.2159996 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.21700287 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.71700287 136.52200317 Tm [(alph)1(a,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.51699829 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.01699829 136.52200317 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.17500305 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.67500305 136.52200317 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.30900574 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.80900574 136.52200317 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.08700562 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.58700562 136.52200317 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.88699341 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.38699341 136.52200317 Tm [(\(CSNK2A1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.69200134 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.19200134 136.52200317 Tm [(Ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.65200043 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.15200043 152.12199402 Tm [(ID:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.81900024 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.31900024 152.12199402 Tm [(14)-1(57)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.43600082 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.93600082 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.49700165 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.99700165 152.12199402 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.68699646 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.18699646 152.12199402 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.45500183 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.95500183 152.12199402 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.75 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.25 152.12199402 Tm [(20)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.97200012 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.47200012 152.12199402 Tm [(An)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.3500061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.8500061 152.12199402 Tm [(intro)1(n)-1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.7559967 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.2559967 152.12199402 Tm [(var)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.8739996 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.37400055 167.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.31500053 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.81500053 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.27099991 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.77099991 167.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.28700256 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.78700256 167.72200012 Tm [(\(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.42700195 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.92700195 167.72200012 Tm [(2\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.21099854 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.71099854 167.72200012 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.88200378 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.38200378 167.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.23599243 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.73599243 167.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.86300659 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.36300659 167.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.75900269 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.25900269 167.72200012 Tm [(leu)-1(kocy)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 183.32200623 Tm [(telomere)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.26499939 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.76499939 183.32200623 Tm [(len)-1(g)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.46399689 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.96399689 183.32200623 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.90499878 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.40499878 183.32200623 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.37999725 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.87999725 183.32200623 Tm [(South)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.23599243 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.73599243 183.32200623 Tm [(Asia)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.1499939 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.6499939 183.32200623 Tm [(po)1(pulation.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.96499634 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.46499634 183.32200623 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.79800415 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.29800415 183.32200623 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.42700195 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.92700195 183.32200623 Tm [(t)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 147.6499939 0.75 m 147.6499939 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 188.32499695 m 423.17498779 188.32499695 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>