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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 101.5 l -90 101.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 42.54999924 cm q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q q 1 0 0 1 90 144.05000305 cm q 1 0 0 1 99 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(CSNK1)1(G)-1(1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 140.06100464 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 250.50100708 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.27200031 Tm [(CS)-1(N)1(K1G)1(1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 129.17399597 12.27200031 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 181.67399597 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.92399597 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 79.23400116 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Anti-)-1(CSNK)1(1G1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.65699768 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.03099823 12.27200031 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.68099976 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.05499268 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.61399841 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.98800659 12.27200031 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.78399658 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.66799927 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(casein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.72699738 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.10099792 12.27200031 Tm [(kinas)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.16100311 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.53500366 12.27200031 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.85700226 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.23100281 12.27200031 Tm [(gamm)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.00799561 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.38200378 12.27200031 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.70399475 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.07800293 12.27200031 Tm [(CK1g)1(amma1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.55200195 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 144.102005 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 176.53599548 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.27200031 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.27200031 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.97000122 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 241.40400696 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(CS)-1(N)1(K1G)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.9240036 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.8380127 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.27200031 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.27200031 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 306.27200317 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.27200031 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 338.70599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 371.14001465 m 416.75 371.14001465 l 416.75 402.34002686 l -1.45000005 402.34002686 l h f* Q q 1 0 0 1 0 371.14001465 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 402.33999634 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 427.17401123 cm q 1 g 0.375 0.75 m 150.2749939 0.75 l 150.2749939 109.94999695 l 0.375 109.94999695 l h f* Q q 0.375 0.75 m 150.2749939 0.75 l 150.2749939 109.94999695 l 0.375 109.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 58.52199936 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 151.0249939 0.75 m 422.375 0.75 l 422.375 109.94999695 l 151.0249939 109.94999695 l h f* Q q 1 0 0 1 150.6499939 0 cm 0.375 0.75 m 271.7250061 0.75 l 271.7250061 109.94999695 l 0.375 109.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(casei)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.97799683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.47799683 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.56599426 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.06599426 11.72200012 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.71200562 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.21200562 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.72799683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.24799919 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.7480011 27.3220005 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.00999832 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.50999832 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.59200287 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.09200287 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.65299988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.15299988 27.3220005 Tm [(comprised)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.42999268 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.92999268 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.77200317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.27200317 27.3220005 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.62600708 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.12600708 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.88800049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.38800049 42.92200089 Tm [(ph)1(osph)1(orylate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.60600281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.10600281 42.92200089 Tm [(acidic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.65399933 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.15399933 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.6269989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.1269989 42.92200089 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.89399719 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.39399719 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.53500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.03500366 42.92200089 Tm [(casei)-1(ns.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.06900024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.56900024 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.37600708 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.50699997 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.00699997 58.52199936 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.09500122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.59500122 58.52199936 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.64199829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.14199829 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.11699677 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.61699677 58.52199936 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.27700043 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.7769928 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.71800232 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.21800232 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.62800598 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.12800598 58.52199936 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.41999817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.91999817 58.52199936 Tm [(che)-1(ckpoint)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.25799561 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.75799561 58.52199936 Tm [(arr)1(e)-1(st)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.23098755 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 74.12200165 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.43799973 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.93799973 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.01300049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.51300049 74.12200165 Tm [(st)1(alle)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66000366 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.16000366 74.12200165 Tm [(replic)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.7440033 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.2440033 74.12200165 Tm [(fo)1(rk)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.58799744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.08799744 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.6000061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.1000061 74.12200165 Tm [(ph)1(osph)1(orylating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.90899658 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(Clasp)1(in)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.41199875 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.91199875 89.72200012 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.24499893 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.74499893 89.72200012 Tm [(mutat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.06700134 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.56700134 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.50800323 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.00800323 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.46399689 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.96399689 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.47999573 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.97999573 89.72200012 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.15100098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.65100098 89.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.50500488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.00500488 89.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.13200378 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.63200378 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.02801514 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(non-syndro)1(mi)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.43900299 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.93900299 105.3219986 Tm [(early-onset)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.40200043 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.90200043 105.3219986 Tm [(epile)-1(p)1(sy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.33099365 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.83099365 105.3219986 Tm [(\(NSEOE\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.75100708 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q 1 g 0.375 0.75 m 150.2749939 0.75 l 150.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 150.2749939 0.75 l 150.2749939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 151.0249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 151.0249939 16.35000038 l h f* Q q 1 0 0 1 150.6499939 0 cm 0.375 0.75 m 271.7250061 0.75 l 271.7250061 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q 1 g 0.375 0.75 m 150.2749939 0.75 l 150.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 150.2749939 0.75 l 150.2749939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 151.0249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 151.0249939 16.35000038 l h f* Q q 1 0 0 1 150.6499939 0 cm 0.375 0.75 m 271.7250061 0.75 l 271.7250061 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(CSNK1G1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.49300003 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q 1 g 0.375 0.75 m 150.2749939 0.75 l 150.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 150.2749939 0.75 l 150.2749939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 151.0249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 151.0249939 16.35000038 l h f* Q q 1 0 0 1 150.6499939 0 cm 0.375 0.75 m 271.7250061 0.75 l 271.7250061 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Syn)-1(t)1(hetic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.26599884 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48000336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98000336 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.8219986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.3219986 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.36299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86300659 11.72200012 Tm [(CSNK1G1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.35600281 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159 cm q 1 g 0.375 0.75 m 150.2749939 0.75 l 150.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 150.2749939 0.75 l 150.2749939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 151.0249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 151.0249939 16.35000038 l h f* Q q 1 0 0 1 150.6499939 0 cm 0.375 0.75 m 271.7250061 0.75 l 271.7250061 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(casei)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.70100021 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.20100021 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.28900146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.78900146 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.06700134 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.56700134 11.72200012 Tm [(ga)1(mma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.13899994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.63899994 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.91699982 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 175.3500061 cm q 1 g 0.375 0.75 m 150.2749939 0.75 l 150.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 150.2749939 0.75 l 150.2749939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 151.0249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 151.0249939 16.35000038 l h f* Q q 1 0 0 1 150.6499939 0 cm 0.375 0.75 m 271.7250061 0.75 l 271.7250061 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(CK1gamma)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.86100006 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 191.70001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 150.6499939 0.75 m 150.6499939 109.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 150.6499939 110.69999695 m 150.6499939 126.29999542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 150.6499939 127.04999542 m 150.6499939 142.6499939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 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