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Tf 1 0 0 -1 0 12.82299995 Tm 0 g [<0009000A000B000C>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 48 12.82299995 Tm [(:)] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 51.21099854 12.82299995 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 69.21099854 12.82299995 Tm [<00030004>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 96.21099854 12.82299995 Tm [(CDKL1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 9 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 130.35400391 12.82299995 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 10 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 190.35400391 12.82299995 Tm [(    )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 214.35400391 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 79.23400116 cm /P <</Lang (zh-CN) /MCID 12 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm 0 g [<000D000A000B000C>] TJ ET EMC /P <</MCID 13 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 48 12.82299995 Tm [(:)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 51.21099854 12.82299995 Tm [(  )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 63.21099854 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 84 12.82299995 Tm /GS2 gs 0 g [(Anti-)-1(CDKL1)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 138.83799744 12.82299995 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 141.55099487 12.82299995 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 170.86500549 12.82299995 Tm [( )] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 173.57800293 12.82299995 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 223.35899353 12.82299995 Tm [( )] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 226.07200623 12.82299995 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 269.26699829 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.66799927 cm /P <</Lang (zh-CN) /MCID 24 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm 0 g [<000E>] TJ ET EMC /P <</MCID 25 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 12 12.82299995 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 26 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 36 12.82299995 Tm [<000B>] TJ ET EMC /P <</MCID 27 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 48 12.82299995 Tm [(:)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 51.21099854 12.82299995 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 53.92399979 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(P4)1(2;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 84.5739975 12.82299995 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 87.28700256 12.82299995 Tm [(KK)1(IALRE)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 127.14199829 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 144.102005 cm /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm 0 g [<0004>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 12 12.82299995 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 30 12.82299995 Tm [<000F>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 42 12.82299995 Tm [(:)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 45.21099854 12.82299995 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 47.92399979 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(CDKL1)] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 94.14299774 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 176.53599548 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm 0 g [<0010>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 12 12.82299995 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 30 12.82299995 Tm [<0011>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 42 12.82299995 Tm [(:)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 45.21099854 12.82299995 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 47.92399979 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 99 12.82299995 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 114.83799744 12.82299995 Tm [<00150016>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 138.83799744 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.97000122 cm /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm 0 g [<0017>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 12 12.82299995 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 30 12.82299995 Tm [<0018>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 42 12.82299995 Tm [(:)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 45.21099854 12.82299995 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 47.92399979 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 94.64600372 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 105 12.82299995 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 241.40400696 cm /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm 0 g [<0019001A001B001C>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 48 12.82299995 Tm [(:)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 51.21099854 12.82299995 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 53.92399979 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 98.41999817 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.8380127 cm /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm 0 g [<001D001E001F000E>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 48 12.82299995 Tm [(:)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 51.21099854 12.82299995 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 53.92399979 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 71 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [<00200004>] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 87 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 306.27200317 cm /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm 0 g [<0021>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 12 12.82299995 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 18 12.82299995 Tm [<0022>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 30 12.82299995 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 36 12.82299995 Tm [<0023>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 48 12.82299995 Tm [(:)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 51.21099854 12.82299995 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 53.92399979 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 125.27300262 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 126 12.82299995 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 338.70599365 cm /P <</Lang (zh-CN) /MCID 84 >> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm 0 g [<00060007001F0024>] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAAAH 12 Tf 1 0 0 -1 48 12.82299995 Tm [(:)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 51.21099854 12.82299995 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 53.92399979 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 92.31400299 12.82299995 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 95.02700043 12.82299995 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 91 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 144.80799866 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 371.14001465 cm /P <</MCID 92 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 93 >> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 94 >> BDC BT /FAAADC 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 410.33999634 cm /P <</MCID 95 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 12.33899975 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 435.17401123 cm q 1 g 0.375 0.75 m 162.2749939 0.75 l 162.2749939 187.94999695 l 0.375 187.94999695 l h f* Q q 0.375 0.75 m 162.2749939 0.75 l 162.2749939 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 96 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 97.52200317 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 97 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 163.0249939 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 163.0249939 187.94999695 l h f* Q q 1 0 0 1 162.6499939 0 cm 0.375 0.75 m 259.7749939 0.75 l 259.7749939 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 98 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 62.25699997 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 66.75700378 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 75.59899902 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 80.09899902 11.72200012 Tm [(signal)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 105.33200073 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 109.83200073 11.72200012 Tm [(tr)1(ansduc)-1(t)1(ion)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 164.13999939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 168.63999939 11.72200012 Tm [(pa)1(thw)1(ays)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 209.26699829 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 213.76699829 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 224.27900696 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 228.77900696 11.72200012 Tm [(gr)1(ow)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(th)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 8.89500046 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 13.39500046 27.3220005 Tm [(fa)1(c)-1(t)1(ors,)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 44.84700012 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 49.34700012 27.3220005 Tm [(ho)1(rmone)-1(s)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 93.01999664 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 97.51999664 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 113.79699707 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 118.29699707 27.3220005 Tm [(ne)-1(uro)1(transmit)1(ters)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 195.3730011 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 199.8730011 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 206.43400574 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 210.93400574 27.3220005 Tm [(mediat)1(e)-1(d)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 251.81599426 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(by)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 10.51200008 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 15.01200008 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 29.01300049 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 33.51300049 42.92200089 Tm [(MAP)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 54.14500046 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 58.64500046 42.92200089 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 89.89900208 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 94.39900208 42.92200089 Tm [(ERK)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 110.93599701 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 115.43599701 42.92200089 Tm [(1)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 120.71399689 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 125.21399689 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 141.49099731 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 145.99099731 42.92200089 Tm [(ERK)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 162.52799988 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 167.02799988 42.92200089 Tm [(2.)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 174.47200012 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 178.97200012 42.92200089 Tm [(ERK)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 195.50900269 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 200.00900269 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 235.48199463 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 239.98199463 42.92200089 Tm [(ar)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(e)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 5.10599995 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 9.60599995 58.52199936 Tm [(regulat)1(e)-1(d)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 51.0379982 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 55.5379982 58.52199936 Tm [(by)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 66.05000305 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 70.55000305 58.52199936 Tm [(dual)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 89.22200012 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 93.72200012 58.52199936 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 164.4960022 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 168.9960022 58.52199936 Tm [(at)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 177.32400513 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 181.82400513 58.52199936 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 213.78100586 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 218.28100586 58.52199936 Tm [(tyro)1(sin)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 25.88299942 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 30.38299942 74.12200165 Tm [(th)1(re)-1(o)1(ni)-1(ne)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 72.13500214 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 76.63500214 74.12200165 Tm [(sites)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 95.8219986 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 100.3219986 74.12200165 Tm [(map)1(ping)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 138.92399597 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 143.42399597 74.12200165 Tm [(wit)1(hin)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 169.75999451 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 174.25999451 74.12200165 Tm [(a)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 179.23500061 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 183.73500061 74.12200165 Tm [(chara)1(c)-1(terist)1(ic)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 240.40699768 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 244.90699768 74.12200165 Tm [(T)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(hr-)1(Glu-Tyr)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 44.75799942 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 49.25799942 89.72200012 Tm [(mot)1(if.)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 74.4469986 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 78.9469986 89.72200012 Tm [(The)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 94.7539978 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 99.2539978 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 130.56100464 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 135.06100464 89.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 162.14900208 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 166.64900208 89.72200012 Tm [(p56)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 182.95300293 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 187.45300293 89.72200012 Tm [(KKI)1(AMRE)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 227.47399902 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 231.97399902 89.72200012 Tm [(is)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 238.53500366 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 243.03500366 89.72200012 Tm [(di)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(st)1(antly)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 28.5510006 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 33.05099869 105.3219986 Tm [(related)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 63.18000031 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 67.68000031 105.3219986 Tm [(to)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 76.75499725 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 81.25499725 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 95.2559967 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 99.7559967 105.3219986 Tm [(MAP)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 120.38800049 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 124.88800049 105.3219986 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 151.97599792 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 156.47599792 105.3219986 Tm [(gr)1(oup)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 182.68499756 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 187.18499756 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 196.0269928 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 200.5269928 105.3219986 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 236 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 240.5 105.3219986 Tm [(an)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(d)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 5.75699997 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 10.25699997 120.92199707 Tm [(is)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 16.81800079 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 21.31800079 120.92199707 Tm [(cl)-1(o)1(se)-1(ly)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 50.37900162 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 54.87900162 120.92199707 Tm [(related)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 85.00800323 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 89.50800323 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 98.58300018 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 103.08300018 120.92199707 Tm [(p42)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 119.38700104 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 123.88700104 120.92199707 Tm [(KKI)1(ALRE.)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 161.8999939 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 166.3999939 120.92199707 Tm [(KKI)1(AMRE)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 206.42100525 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 210.92100525 120.92199707 Tm [(is)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 217.48199463 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 221.98199463 120.92199707 Tm [(predo)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(minantly)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 37.40599823 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 41.90599823 136.52200317 Tm [(expressed)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 85.05999756 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 89.55999756 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 97.50099945 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 102.00099945 136.52200317 Tm [(test)1(i)-1(s)1(,)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 126.70700073 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 131.20700073 136.52200317 Tm [(ki)-1(d)1(ne)-1(y,)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 161.84100342 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 166.34100342 136.52200317 Tm [(bra)1(in)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 188.44099426 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 192.94099426 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 209.21800232 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 213.71800232 136.52200317 Tm [(lun)-1(g)1(.)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 235.12800598 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 239.62800598 136.52200317 Tm [(KK)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(IAMR)1(E)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 28.59499931 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 33.09500122 152.12199402 Tm [(contains)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 69.30999756 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 73.80999756 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 87.81099701 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 92.31099701 152.12199402 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 136.38800049 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 140.88800049 152.12199402 Tm [(MAP)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 161.52000427 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 166.02000427 152.12199402 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 193.10800171 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 197.60800171 152.12199402 Tm [(dual)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 216.27999878 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 220.77999878 152.12199402 Tm [(ph)1(osp)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ho)1(ry)-1(la)1(tion)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 43.84899902 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 48.34899902 167.72200012 Tm [(mot)1(if)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 71.37200165 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 75.87200165 167.72200012 Tm [(in)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 83.81300354 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 88.31300354 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 102.31400299 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 106.81400299 167.72200012 Tm [(seque)-1(nce)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 147.66099548 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 152.16099548 167.72200012 Tm [(Thr-)1(Asp-)1(Ty)-1(r)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 203.69099426 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 208.19099426 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 224.46800232 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 228.96800232 167.72200012 Tm [(is)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 235.52900696 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 240.02900696 167.72200012 Tm [(ac)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(tiva)1(ted)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 29.66300011 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 34.1629982 183.32200623 Tm [(by)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 44.67499924 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 49.17499924 183.32200623 Tm [(tr)1(e)-1(at)1(men)-1(t)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 91.83699799 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 96.33699799 183.32200623 Tm [(of)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 105.17900085 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 109.67900085 183.32200623 Tm [(ce)-1(lls)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 128.25500488 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 132.75500488 183.32200623 Tm [(by)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 143.26699829 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 147.76699829 183.32200623 Tm [(EG)1(F)-1(.)] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 166.35600281 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 170.85600281 183.32200623 Tm [(However,)] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 211.18499756 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 215.68499756 183.32200623 Tm [(unl)-1(ike)] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 241.57299805 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 246.07299805 183.32200623 Tm [(o)] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 162.6499939 0.75 m 162.6499939 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 188.32499695 m 423.17498779 188.32499695 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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