%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 136 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 101.5 l -90 101.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 42.54999924 cm q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q q 1 0 0 1 90 144.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 94.91899872 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 144.59500122 23.67700005 Tm 0 Tr [(CD)-1(K2)1(0)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 209.94000244 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 320.38000488 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 60 12.82299995 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 87 12.82299995 Tm [(CDK20)] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 122.18000031 12.82299995 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 182.17999268 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.17999268 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 79.23400116 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 60 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(Anti-)-1(CDK2)1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.875 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.58799744 12.82299995 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.9019928 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.61500549 12.82299995 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.39599609 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.10899353 12.82299995 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.30400085 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.66799927 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 12 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 36 12.82299995 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 60 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(cy)1(cl)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.39299774 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.10600281 12.82299995 Tm [(depend)-1(e)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.56100464 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.27400208 12.82299995 Tm [(kinas)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.19999695 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.91299438 12.82299995 Tm [(20;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.28799438 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.00100708 12.82299995 Tm [(P4)1(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.57499695 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.28799438 12.82299995 Tm [(CCRK;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.04600525 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.75900269 12.82299995 Tm [(CDC)-1(H;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.62600708 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.33898926 12.82299995 Tm [(PN)1(QALRE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.72198486 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 144.102005 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 60 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 87 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82299995 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 176.53599548 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 12 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 30 12.82299995 Tm [<0014000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 54 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(CDK20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.18000031 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.97000122 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 12 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 30 12.82299995 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 54 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 99 12.82299995 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 114.83799744 12.82299995 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 138.83799744 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 241.40400696 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 12 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 30 12.82299995 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 54 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.64600372 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82299995 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 273.8380127 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 60 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.41400146 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.1269989 12.82299995 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.67799377 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.39100647 12.82299995 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.67399597 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 306.27200317 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 12 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 18 12.82299995 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 30 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 36 12.82299995 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 60 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.27300262 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82299995 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 338.70599365 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 60 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.31400299 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.02700043 12.82299995 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.80799866 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 371.14001465 m 416.75 371.14001465 l 416.75 402.34002686 l -1.45000005 402.34002686 l h f* Q q 1 0 0 1 0 371.14001465 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 402.33999634 cm /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 0 12.51799965 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 427.17401123 cm q /GS2 gs 1 g 0.375 0.75 m 164.5249939 0.75 l 164.5249939 94.34999847 l 0.375 94.34999847 l h f* Q q 0.375 0.75 m 164.5249939 0.75 l 164.5249939 94.34999847 l 0.375 94.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 165.2749939 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 165.2749939 94.34999847 l h f* Q q 1 0 0 1 164.8999939 0 cm 0.375 0.75 m 257.5249939 0.75 l 257.5249939 94.34999847 l 0.375 94.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.32000732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.82000732 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.79499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.29499817 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.38299561 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.88299561 11.72200012 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(oma)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.06999969 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.56999969 27.3220005 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.24399948 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.74399948 27.3220005 Tm [(cl)-1(o)1(se)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.80500031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.30500031 27.3220005 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.43399811 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.93399811 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.00900269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.50900269 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.50999451 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.00999451 27.3220005 Tm [(cy)-1(clin)-1(-)1(depen)-1(d)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.05499268 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.55499268 27.3220005 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.12199974 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.62199974 42.92200089 Tm [(ki)-1(na)1(se)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.04199982 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.54199982 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.34899902 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.84899902 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.35600281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.85600281 42.92200089 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.94400024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.44400024 42.92200089 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.61500549 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.11500549 42.92200089 Tm [(activat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.50900269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.00900269 42.92200089 Tm [(cy)-1(clin)-1(-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(dependen)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.02600098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.52600098 58.52199936 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.61399841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.11399841 58.52199936 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.39199829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.89199829 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.16899872 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.66899872 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.23000336 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.73000336 58.52199936 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.09899902 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.59899902 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.53999329 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.03999329 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.44999695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.94999695 58.52199936 Tm [(gr)1(owt)1(h.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.03199768 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.53199768 58.52199936 Tm [(Alt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ernatively)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.80099869 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.30099869 74.12200165 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.38200378 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.88200378 74.12200165 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.80400085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.30400085 74.12200165 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.87399292 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.37399292 74.12200165 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.71600342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.21600342 74.12200165 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.69400024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.19400024 74.12200165 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(sof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.76499939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.26499939 89.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.61199951 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.11199951 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.6190033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.1190033 89.72200012 Tm [(repor)1(ted.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.95100403 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 94.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 164.5249939 0.75 l 164.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 164.5249939 0.75 l 164.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 165.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 165.2749939 16.35000038 l h f* Q q 1 0 0 1 164.8999939 0 cm 0.375 0.75 m 257.5249939 0.75 l 257.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 110.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 164.5249939 0.75 l 164.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 164.5249939 0.75 l 164.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 165.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 165.2749939 16.35000038 l h f* Q q 1 0 0 1 164.8999939 0 cm 0.375 0.75 m 257.5249939 0.75 l 257.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CDK)1(2)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.14500046 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 164.5249939 0.75 l 164.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 164.5249939 0.75 l 164.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 165.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 165.2749939 16.35000038 l h f* Q q 1 0 0 1 164.8999939 0 cm 0.375 0.75 m 257.5249939 0.75 l 257.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hetic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.26599884 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48000336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98000336 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.8219986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.3219986 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.36299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86300659 11.72200012 Tm [(CDK)1(2)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.00799561 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 143.3999939 cm q /GS2 gs 1 g 0.375 0.75 m 164.5249939 0.75 l 164.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 164.5249939 0.75 l 164.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 165.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 165.2749939 16.35000038 l h f* Q q 1 0 0 1 164.8999939 0 cm 0.375 0.75 m 257.5249939 0.75 l 257.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(cy)-1(clin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.12599945 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.62599945 11.72200012 Tm [(dependen)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.65200043 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.15200043 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.23999786 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.73999786 11.72200012 Tm [(20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.29599762 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159.75 cm q /GS2 gs 1 g 0.375 0.75 m 164.5249939 0.75 l 164.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 164.5249939 0.75 l 164.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 165.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 165.2749939 16.35000038 l h f* Q q 1 0 0 1 164.8999939 0 cm 0.375 0.75 m 257.5249939 0.75 l 257.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P42)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.22900009 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.72900009 11.72200012 Tm [(CCRK)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.52500153 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.02500153 11.72200012 Tm [(CDCH;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.0490036 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.5490036 11.72200012 Tm [(PNQA)1(L)-1(R)1(E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.48200226 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 176.1000061 cm q /GS2 gs 1 g 0.375 0.75 m 164.5249939 0.75 l 164.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 164.5249939 0.75 l 164.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 165.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 165.2749939 16.35000038 l h f* Q q 1 0 0 1 164.8999939 0 cm 0.375 0.75 m 257.5249939 0.75 l 257.5249939 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8IZL)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.73500061 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 192.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.8999939 0.75 m 164.8999939 94.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.8999939 95.09999847 m 164.8999939 110.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.8999939 111.44999695 m 164.8999939 127.04999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.8999939 127.79999542 m 164.8999939 143.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.8999939 144.1499939 m 164.8999939 159.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.8999939 160.5 m 164.8999939 176.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.8999939 176.8500061 m 164.8999939 192.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 192.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 94.72499847 m 422.42498779 94.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.07499695 m 422.42498779 111.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 127.42499542 m 422.42498779 127.42499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.7749939 m 422.42498779 143.7749939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.125 m 422.42498779 160.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 176.4750061 m 422.42498779 176.4750061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 192.82501221 m 423.17498779 192.82501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>