%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 132 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 101.5 l -90 101.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 42.54999924 cm q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q q 1 0 0 1 90 144.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 76.42700195 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 126.10299683 23.67700005 Tm 0 Tr [(CD)-1(C42B)1(PA)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 228.43299866 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 338.87298584 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.27200031 Tm [(CDC)-1(4)1(2BPA)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.76199341 12.27200031 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 187.26199341 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.76199341 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 79.23400116 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Anti-)-1(CDC42BP)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.24499512 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.6190033 12.27200031 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.26899719 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.64300537 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.20199585 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.57600403 12.27200031 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.37199402 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.66799927 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(MRCK;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.54199982 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.91600037 12.27200031 Tm [(MRCKA)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.53300476 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.90699768 12.27200031 Tm [(PK)1(428)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.7519989 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 144.102005 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 176.53599548 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.27200031 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.27200031 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.27200031 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.97000122 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 241.40400696 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(CDC)-1(4)1(2BPA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.51200104 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.8380127 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 306.27200317 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.27200031 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 338.70599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 371.14001465 m 416.75 371.14001465 l 416.75 402.34002686 l -1.45000005 402.34002686 l h f* Q q 1 0 0 1 0 371.14001465 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 402.33999634 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.00500011 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 427.17401123 cm q /GS2 gs 1 g 0.375 0.75 m 171.2749939 0.75 l 171.2749939 187.94999695 l 0.375 187.94999695 l h f* Q q 0.375 0.75 m 171.2749939 0.75 l 171.2749939 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 172.0249939 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 172.0249939 187.94999695 l h f* Q q 1 0 0 1 171.6499939 0 cm 0.375 0.75 m 250.7749939 0.75 l 250.7749939 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(Se)-1(r)1(in)-1(e/T)-1(h)1(re)-1(o)1(ni)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.79399872 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.29399872 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.60099792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.10099792 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.18899536 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.68899536 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.93699646 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.43699646 27.3220005 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.69900513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.19900513 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.28700256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.21500015 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.71500015 42.92200089 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.08699799 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.58699799 42.92200089 Tm [(func)-1(t)1(ional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.6969986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.19700623 42.92200089 Tm [(do)1(mains.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.35699463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.85699463 42.92200089 Tm [(Its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.02200317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.52200317 42.92200089 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.61000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.11000061 42.92200089 Tm [(do)1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.00200081 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.50200081 58.52199936 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.89599991 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.39599991 58.52199936 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.59100342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.09100342 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.16600037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.66600037 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.88800049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.38800049 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.22999573 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.72999573 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.73100281 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.23100281 58.52199936 Tm [(myoto)1(n)-1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.67799377 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.17799377 58.52199936 Tm [(dyst)1(roph)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.42900085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 74.12200165 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.89500046 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.39499664 74.12200165 Tm [(\(DMPK)1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.44100189 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.94100189 74.12200165 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.20300293 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.70300293 74.12200165 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.79100037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.29100037 74.12200165 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.54800415 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.04800415 74.12200165 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.26300049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.76300049 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.73800659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.23800659 74.12200165 Tm [(Ra)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.51300001 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.01299953 89.72200012 Tm [(interactive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.91600037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.41600037 89.72200012 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.55999756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.05999756 89.72200012 Tm [(\(CRIB\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.26000214 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.76000214 89.72200012 Tm [(do)1(main,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.7539978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.2539978 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.53100586 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.03100586 89.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.71299744 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.21299744 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.72000122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.22000122 89.72200012 Tm [(sh)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ow)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.37400055 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.87400055 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.9489994 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.44900131 105.3219986 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.89500046 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.39500046 105.3219986 Tm [(CDC42.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.01399994 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.51399994 105.3219986 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.51300049 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.01300049 105.3219986 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.18399811 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.68400574 105.3219986 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.42500305 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.92500305 105.3219986 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.06599426 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.56599426 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.54100037 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.04100037 105.3219986 Tm [(CDC42)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.49299622 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.99299622 105.3219986 Tm [(do)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(wnst)1(ream)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.12200165 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.62200165 120.92199707 Tm [(effec)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.09999847 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.59999847 120.92199707 Tm [(mediat)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.31700134 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.81700134 120.92199707 Tm [(CDC42)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.26899719 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.76899719 120.92199707 Tm [(induc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.38900757 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.88900757 120.92199707 Tm [(periph)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.36999989 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.86999989 136.52200317 Tm [(actin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65200043 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.15200043 136.52200317 Tm [(fo)1(rmatio)1(n)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.01999664 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.51999664 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.79699707 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.29699707 136.52200317 Tm [(pro)1(moting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.40899658 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.90899658 136.52200317 Tm [(cy)-1(t)1(oske)-1(letal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.65699768 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.15699768 136.52200317 Tm [(reorg)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(nizat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.52299881 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.02299881 152.12199402 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.75499725 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.25499725 152.12199402 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.77799988 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.27799988 152.12199402 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.35899353 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.85899353 152.12199402 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.78100586 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.28100586 152.12199402 Tm [(var)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(nts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.06499958 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.56500053 167.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.91199875 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.41199875 167.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.91899872 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.41899872 167.72200012 Tm [(described,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.57099915 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.07099915 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.3480072 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.8480072 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.84899902 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.34899902 167.72200012 Tm [(full-length)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.39700317 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.89700317 167.72200012 Tm [(nature)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.85899353 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.84200001 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.34200001 183.32200623 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.52300072 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.02299881 183.32200623 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.86500168 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.36500168 183.32200623 Tm [(th)1(e)-1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.7990036 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.2990036 183.32200623 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.98100281 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.48100281 183.32200623 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.98799896 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.48799896 183.32200623 Tm [(repor)1(ted.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.32000732 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 171.6499939 0.75 m 171.6499939 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 188.32499695 m 423.17498779 188.32499695 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj 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