%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 152 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 101.5 l -90 101.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 42.54999924 cm q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q q 1 0 0 1 90 144.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 95.36000061 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 145.03599548 23.67700005 Tm 0 Tr [(CD)-1(20)1(7)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 209.5 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 319.94000244 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 60 12.82299995 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 87 12.82299995 Tm [(CD207)] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 122.02700043 12.82299995 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 182.0269928 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.0269928 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 79.23400116 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 60 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(Anti-)-1(CD207)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.72299957 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.43599701 12.82299995 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.75 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.46299744 12.82299995 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.2440033 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.95700073 12.82299995 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.1519928 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.66799927 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 12 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 24 12.82299995 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 48 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(CL)-1(EC4K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.01799774 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 144.102005 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 12 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 24 12.82299995 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 48 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(CD207)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.02700043 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 176.53599548 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 12 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 24 12.82299995 Tm [<0012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 48 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 99 12.82299995 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 114.83799744 12.82299995 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 138.83799744 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.97000122 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 12 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 24 12.82299995 Tm [<0019000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 48 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.64600372 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82299995 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 241.40400696 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<001A001B001C000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 60 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [<001D0004>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 87 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82299995 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 273.8380127 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 60 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.41400146 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.1269989 12.82299995 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.68400574 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 306.27200317 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 48 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.27300262 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82299995 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 338.70599365 cm /P <> BDC BT /FAAABJ 12 Tf 1 0 0 -1 0 12.82299995 Tm /GS2 gs 0 g [<00060007001C0025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 12 Tf 1 0 0 -1 60 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82299995 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.31400299 12.82299995 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.02700043 12.82299995 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.80799866 12.82299995 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 371.14001465 m 416.75 371.14001465 l 416.75 402.34002686 l -1.45000005 402.34002686 l h f* Q q 1 0 0 1 0 371.14001465 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 402.33999634 cm /P <> BDC BT 1 0 0 -1 0 12.51799965 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 427.17401123 cm q /GS2 gs 1 g 0.375 0.75 m 173.5249939 0.75 l 173.5249939 187.94999695 l 0.375 187.94999695 l h f* Q q 0.375 0.75 m 173.5249939 0.75 l 173.5249939 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 174.2749939 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 174.2749939 187.94999695 l h f* Q q 1 0 0 1 173.8999939 0 cm 0.375 0.75 m 248.5249939 0.75 l 248.5249939 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.32000732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.82000732 11.72200012 Tm [(only)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.2460022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 27.3220005 Tm [(Langerha)1(n)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.10800171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.60800171 27.3220005 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.18399811 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.68399811 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.78099823 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.28099823 27.3220005 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.79899597 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.29899597 27.3220005 Tm [(immat)1(u)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.977005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.477005 27.3220005 Tm [(dendrit)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.73599243 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.23599243 27.3220005 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.50799942 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.00799942 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.00899887 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.50899887 42.92200089 Tm [(epidermis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.05200195 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.55200195 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.82900238 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.32900238 42.92200089 Tm [(muc)-1(o)1(sa.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.8500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.3500061 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.34899902 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.84899902 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.41000366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.91000366 42.92200089 Tm [(localized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.59300232 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.09300232 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.03399658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.53399658 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.53500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(Bi)-1(r)1(bec)-1(k)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.74600029 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.24599838 58.52199936 Tm [(gr)1(anu)-1(les,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.33999634 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.83999634 58.52199936 Tm [(org)1(ane)-1(lles)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.44400024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.94400024 58.52199936 Tm [(present)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.40600586 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.90600586 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.84700012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.34700012 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.3480072 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.8480072 58.52199936 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.91600037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.84200001 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.34200001 74.12200165 Tm [(Langerha)1(n)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.00899887 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50900269 74.12200165 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.08499908 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.58499908 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.86199951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.36199951 74.12200165 Tm [(consisting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.92100525 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.42100525 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.26300049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.76300049 74.12200165 Tm [(superimpos)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.09300232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 89.72200012 Tm [(zip)1(pe)-1(r)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.5 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 89.72200012 Tm [(membranes.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.11699677 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.61699677 89.72200012 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.61599731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.11599731 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.67700195 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.17700195 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.1519928 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.6519928 89.72200012 Tm [(C-t)1(ype)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.53700256 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.03700256 89.72200012 Tm [(lec)-1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.34599304 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.84599304 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.24200439 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(mannose)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.49399948 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.99399948 105.3219986 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.13800049 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.63800049 105.3219986 Tm [(speci)-1(f)1(ic)-1(it)1(y)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.27300262 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.772995 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.05000305 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.55000305 105.3219986 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.29800415 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.79800415 105.3219986 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.47999573 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.97999573 105.3219986 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.48699951 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.98699951 105.3219986 Tm [(pro)1(pos)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 120.92199707 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.58499908 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.08499908 120.92199707 Tm [(mannose)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.57900238 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.07900238 120.92199707 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.22299957 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.72299957 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.23500061 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.73500061 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.19099426 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.69099426 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.9980011 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.4980011 120.92199707 Tm [(leads)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.89700317 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.39700317 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.47200012 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.97200012 120.92199707 Tm [(int)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ernalizat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.26900101 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.76900101 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.61100006 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.11100006 136.52200317 Tm [(antig)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.78900146 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.28900146 136.52200317 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.30500031 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.80500031 136.52200317 Tm [(Bi)-1(r)1(bec)-1(k)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.55099487 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.05099487 136.52200317 Tm [(gr)1(anu)-1(les)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.97799683 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.47799683 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.75500488 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.25500488 136.52200317 Tm [(pro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(viding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.5739994 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.0739994 152.12199402 Tm [(acc)-1(ess)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.51300049 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.01300049 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.08799744 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.58799744 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.56300354 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.06300354 152.12199402 Tm [(nonc)-1(la)1(ssic)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.3690033 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.8690033 152.12199402 Tm [(antig)1(e)-1(n-)1(proce)-1(s)1(sin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.9960022 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.4960022 152.12199402 Tm [(pa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(th)1(way.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.90500069 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.40499878 167.72200012 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.2539978 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.7539978 167.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.69499969 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.19499969 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.65100098 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.15100098 167.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.66700745 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.16700745 167.72200012 Tm [(result)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.16999817 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.66999817 167.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.61099243 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.11099243 167.72200012 Tm [(Bi)-1(r)1(bec)-1(k)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.85699463 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.35699463 167.72200012 Tm [(gr)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(ule)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.21299934 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.71299934 183.32200623 Tm [(deficie)-1(ncy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.92900085 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.42900085 183.32200623 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.58699799 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.08699799 183.32200623 Tm [(loss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.53600311 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.03600311 183.32200623 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.87799835 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.37799835 183.32200623 Tm [(suga)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.25799561 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.75799561 183.32200623 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.9019928 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.4019928 183.32200623 Tm [(activit)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.03999329 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 173.8999939 0.75 m 173.8999939 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 188.32499695 m 423.17498779 188.32499695 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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