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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 697.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 101.5 l -90 101.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET Q EMC q 1 0 0 1 90 42.54999924 cm q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q q 1 0 0 1 90 144.05000305 cm q 1 0 0 1 88 0 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(TRDM)-1(T1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 133.59399414 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 244.03399658 23.67700005 Tm 0 Tr [(  )] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 266.03399658 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 5 >> BDC BT 1 0 0 -1 -88 43.20500183 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -88 60.30599976 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -35.5 60.30599976 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -25 60.30599976 Tm [<00030004>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -1.375 60.30599976 Tm [(TRD)-1(M)1(T)-1(1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 37.94400024 60.30599976 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 90.44400024 60.30599976 Tm [(  )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 100.94400024 60.30599976 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.46800232 cm /P <</Lang (zh-CN) /MCID 13 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 14 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Anti-)-1(TRDMT1)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 120.42700195 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 122.8010025 12.27200031 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 148.45100403 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 150.82499695 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 194.38400269 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 196.75799561 12.27200031 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 234.55400085 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 112.90200043 cm /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<000F>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0010000D>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(DMNT2;)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 98.46299744 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 100.83699799 12.27200031 Tm [(DNMT2;)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 136.30000305 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 138.67399597 12.27200031 Tm [(PU)1(MET)-1(;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 172.86599731 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 175.24000549 12.27200031 Tm [(RN)1(MT)-1(1;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 209.94400024 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 212.31799316 12.27200031 Tm [(MHSAIIP)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 249.45300293 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 252 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 145.33599854 cm /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0011>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0012000D>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.27200031 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.27200031 Tm [<00160017>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 147 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 177.77000427 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0018>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0019000D>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 90.69100189 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 210.20399475 cm /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0004>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001A000D>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(TRD)-1(M)1(T)-1(1)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 99.69400024 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.63800049 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<001B001C001D0010000D>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001E0004>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 275.07199097 cm /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<001F002000210022000D>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 93.99199677 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 307.50601196 cm /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0023>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.27200031 Tm [<0024>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 72 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0025000D>] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 339.94000244 cm /P <</Lang (zh-CN) /MCID 76 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<00060007001D0026000D>] TJ ET EMC /P <</MCID 77 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 88.65000153 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 91.02400208 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 134.58299255 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 147 12.27200031 Tm [( )] TJ ET EMC Q q 1 g -1.45000005 372.37399292 m 416.75 372.37399292 l 416.75 403.57400513 l -1.45000005 403.57400513 l h f* Q q 1 0 0 1 0 372.37399292 cm /P <</MCID 83 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 84 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 403.57400513 cm /P <</MCID 86 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 428.4079895 cm q 1 g 0.375 0.75 m 178.9750061 0.75 l 178.9750061 125.55000305 l 0.375 125.55000305 l h f* Q q 0.375 0.75 m 178.9750061 0.75 l 178.9750061 125.55000305 l 0.375 125.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 88 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 179.7250061 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 179.7250061 125.55000305 l h f* Q q 1 0 0 1 179.3500061 0 cm 0.375 0.75 m 243.07499695 0.75 l 243.07499695 125.55000305 l 0.375 125.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 89 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(responsib)1(l)-1(e)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 183.01199341 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 187.51199341 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 199.78999329 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 204.28999329 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 218.29100037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 222.79100037 11.72200012 Tm [(m)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ethylat)1(ion)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 43.15000153 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 47.65000153 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 56.49200058 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 60.99200058 27.3220005 Tm [(asp)1(art)1(i)-1(c)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 94.5530014 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 99.0530014 27.3220005 Tm [(acid)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 116.69300079 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 121.19300079 27.3220005 Tm [(tr)1(ansfer)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 154.33200073 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 158.83200073 27.3220005 Tm [(RNA)1(,)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 180.522995 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 185.022995 27.3220005 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 231.50799561 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(at)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 8.32800007 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 12.82800007 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 26.82900047 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 31.32900047 42.92200089 Tm [(cy)-1(t)1(osine)-1(-)1(3)-1(8)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 81.34300232 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 85.84300232 42.92200089 Tm [(residue)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 117.35600281 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 121.85600281 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 129.79699707 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 134.29699707 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 148.29800415 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 152.79800415 42.92200089 Tm [(anticod)1(on)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 196.32600403 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 200.82600403 42.92200089 Tm [(loop)1(.)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 222.57899475 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 227.07899475 42.92200089 Tm [(T)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(his)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 12.10299969 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 16.60300064 58.52199936 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 49.98400116 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 54.48400116 58.52199936 Tm [(also)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 71.74099731 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 76.24099731 58.52199936 Tm [(po)1(sse)-1(s)1(se)-1(s)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 118.7539978 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 123.2539978 58.52199936 Tm [(residual)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 157.02999878 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 161.52999878 58.52199936 Tm [(DNA)1(-\(cy)-1(t)1(osine)-1(-)1(C)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(5\))] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 8.2840004 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 12.7840004 74.12200165 Tm [(methyltr)1(ansferase)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 89.76300049 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 94.26300049 74.12200165 Tm [(activit)1(y)-1(.)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 126.90100098 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 131.40100098 74.12200165 Tm [(Wh)1(il)-1(e)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 155.99699402 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 160.49699402 74.12200165 Tm [(similar)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 188.69200134 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 193.19200134 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 201.13299561 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 205.63299561 74.12200165 Tm [(seque)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(nc)-1(e)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 15.16600037 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 19.66600037 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 35.94300079 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 40.44300079 89.72200012 Tm [(st)1(ruc)-1(ture)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 78.90000153 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 83.40000153 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 92.47499847 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 96.97499847 89.72200012 Tm [(DNA)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 117.48000336 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 121.98000336 89.72200012 Tm [(cy)-1(t)1(osine)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 157.54499817 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 162.04499817 89.72200012 Tm [(methyltr)1(ansferas)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(es,)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 11.43900013 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 15.93900013 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 31.39500046 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 35.89500046 105.3219986 Tm [(gene)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 57.4109993 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 61.9109993 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 68.47200012 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 72.97200012 105.3219986 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 104.44999695 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 108.94999695 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 125.22699738 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 129.727005 105.3219986 Tm [(hig)1(hly)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 156.1210022 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 160.6210022 105.3219986 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 204.69799805 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 209.19799805 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 217.13900757 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 221.63900757 105.3219986 Tm [(its)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 231.55299377 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 35.74100113 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 40.24100113 120.92199707 Tm [(amo)1(n)-1(g)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 70.67299652 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 75.17299652 120.92199707 Tm [(ta)1(xa.)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 95.20300293 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q 1 g 0.375 0.75 m 178.9750061 0.75 l 178.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 178.9750061 0.75 l 178.9750061 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 200 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 201 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 179.7250061 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 179.7250061 16.35000038 l h f* Q q 1 0 0 1 179.3500061 0 cm 0.375 0.75 m 243.07499695 0.75 l 243.07499695 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 202 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ELISA,)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 45.21099854 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q 1 g 0.375 0.75 m 178.9750061 0.75 l 178.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 178.9750061 0.75 l 178.9750061 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 206 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 211 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 179.7250061 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 179.7250061 16.35000038 l h f* Q q 1 0 0 1 179.3500061 0 cm 0.375 0.75 m 243.07499695 0.75 l 243.07499695 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 212 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(TRDMT1)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 37.12099838 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q 1 g 0.375 0.75 m 178.9750061 0.75 l 178.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 178.9750061 0.75 l 178.9750061 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 214 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <</MCID 215 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 179.7250061 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 179.7250061 16.35000038 l h f* Q q 1 0 0 1 179.3500061 0 cm 0.375 0.75 m 243.07499695 0.75 l 243.07499695 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 216 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Syn)-1(t)1(hetic)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 39.76599884 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 44.26599884 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 77.48000336 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 81.98000336 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 90.8219986 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 95.3219986 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 125.36299896 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 129.86300659 11.72200012 Tm [(TRDMT1)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 166.98399353 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 174.6000061 cm q 1 g 0.375 0.75 m 178.9750061 0.75 l 178.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 178.9750061 0.75 l 178.9750061 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 226 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 229 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 179.7250061 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 179.7250061 16.35000038 l h f* Q q 1 0 0 1 179.3500061 0 cm 0.375 0.75 m 243.07499695 0.75 l 243.07499695 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 230 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(tR)1(NA)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 22.87800026 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 27.37800026 11.72200012 Tm [(asp)1(art)1(i)-1(c)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 60.93899918 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 65.43900299 11.72200012 Tm [(acid)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 83.07900238 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 87.57900238 11.72200012 Tm [(methyltr)1(ansferase)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 164.55799866 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 169.05799866 11.72200012 Tm [(1)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 174.33599854 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 190.95002747 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 179.3500061 0.75 m 179.3500061 125.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 179.3500061 126.30000305 m 179.3500061 141.90000916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 179.3500061 142.65000916 m 179.3500061 158.25001526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 179.3500061 159.00001526 m 179.3500061 174.60002136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 179.3500061 175.35002136 m 179.3500061 190.95002747 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 190.95002747 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 174.97502136 m 422.42498779 174.97502136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 191.32502747 m 423.17498779 191.32502747 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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