%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 153 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 101.5 l -90 101.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 42.54999924 cm q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q q 1 0 0 1 90 144.05000305 cm q 1 0 0 1 88 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(TPM4)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 108.15599823 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 218.59599304 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 251.59599304 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -88 43.20500183 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -88 60.30599976 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -35.5 60.30599976 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -25 60.30599976 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -1.375 60.30599976 Tm [(TPM4)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.08999634 60.30599976 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 78.58999634 60.30599976 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.33999634 60.30599976 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.46800232 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Anti-)-1(TPM)1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.57299805 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.9469986 12.27200031 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.59700012 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.97099304 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.52999878 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.90400696 12.27200031 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.69999695 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 112.90200043 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(HEL)-1(-S-)-1(1)1(08)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.30200195 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 145.33599854 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(TPM4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.83999634 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 177.77000427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<001100120013000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<00140004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 210.20399475 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.27200031 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.27200031 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.63800049 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 275.07199097 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.27200031 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.27200031 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 307.50601196 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.27200031 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 339.94000244 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm 0 g [<0006000700130025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 372.37399292 m 416.75 372.37399292 l 416.75 403.57400513 l -1.45000005 403.57400513 l h f* Q q 1 0 0 1 0 372.37399292 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 403.57400513 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.00500011 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 428.4079895 cm q 1 g 0.375 0.75 m 166.2250061 0.75 l 166.2250061 187.94999695 l 0.375 187.94999695 l h f* Q q 0.375 0.75 m 166.2250061 0.75 l 166.2250061 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 166.9750061 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 166.9750061 187.94999695 l h f* Q q 1 0 0 1 166.6000061 0 cm 0.375 0.75 m 255.82499695 0.75 l 255.82499695 187.94999695 l 0.375 187.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(tr)1(opomyos)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.28300476 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.78300476 11.72200012 Tm [(fa)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.5539999 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0539999 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.89599991 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.39599991 27.3220005 Tm [(actin-b)1(in)-1(d)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.21499634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.71499634 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.18800354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.68800354 27.3220005 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.05700684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.55700684 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.4980011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.9980011 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.99899292 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.49899292 27.3220005 Tm [(contractile)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.80700684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(system)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.98800087 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.48799896 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33000183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.83000183 42.92200089 Tm [(st)1(riated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.37200165 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.87200165 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.14900208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.64900208 42.92200089 Tm [(smoo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.58599854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.08599854 42.92200089 Tm [(musc)-1(les)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.41200256 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.91200256 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.18899536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.68899536 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.69000244 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.19000244 42.92200089 Tm [(cy)-1(t)1(osk)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ele)-1(t)1(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.22900009 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.72900009 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.57099915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.07099915 58.52199936 Tm [(non-muscle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.93800354 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.43800354 58.52199936 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.18000031 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.68000031 58.52199936 Tm [(Trop)1(omy)-1(o)1(sins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.65899658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.15899658 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.67700195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.17700195 58.52199936 Tm [(dimers)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.47099304 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.97099304 58.52199936 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.11999989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.61999989 74.12200165 Tm [(coile)-1(d)1(-c)-1(o)1(il)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.42699814 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.92699814 74.12200165 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.40000153 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.90000153 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.12200165 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.62200165 74.12200165 Tm [(po)1(l)-1(ymerize)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.15299988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.65299988 74.12200165 Tm [(en)-1(d)1(-t)1(o-end)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.33299255 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.83299255 74.12200165 Tm [(alon)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.25799942 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.75799942 89.72200012 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.72800064 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.22800064 89.72200012 Tm [(gr)1(oove)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.69499969 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.19499969 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.13600159 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.63600159 89.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.30999756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.80999756 89.72200012 Tm [(actin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.59199524 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.09199524 89.72200012 Tm [(filaments.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.7480011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.2480011 89.72200012 Tm [(They)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.81900024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.31900024 89.72200012 Tm [(pro)1(v)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.25800037 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.75799942 105.3219986 Tm [(st)1(ability)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.30099869 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.80099869 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.87599945 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.37599945 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.3769989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.8769989 105.3219986 Tm [(filaments)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.36599731 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.86599731 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.14300537 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.64300537 105.3219986 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.31799316 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.81799316 105.3219986 Tm [(acc)-1(ess)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.25700378 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.75700378 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.59899902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.09899902 105.3219986 Tm [(ot)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.08399963 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.58399963 120.92199707 Tm [(actin-b)1(in)-1(d)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.40299988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.90299988 120.92199707 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.54199982 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.04199982 120.92199707 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.23300171 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.73300171 120.92199707 Tm [(musc)-1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.89300537 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.39300537 120.92199707 Tm [(ce)-1(lls,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.13499451 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.63499451 120.92199707 Tm [(th)1(e)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.3999939 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.8999939 120.92199707 Tm [(regula)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.45899963 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.95899963 136.52200317 Tm [(musc)-1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.11899948 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.61899948 136.52200317 Tm [(contractio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.69300079 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.19300079 136.52200317 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.70500183 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.20500183 136.52200317 Tm [(controlling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.98500061 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.48500061 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.48599243 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.98599243 136.52200317 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.13000488 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.63000488 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.47200012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.97200012 136.52200317 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(yosin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.59199905 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.09199905 152.12199402 Tm [(head)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.63700104 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.13700104 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.21199799 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.71199799 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.71299744 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.21299744 152.12199402 Tm [(actin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.99500275 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.49500275 152.12199402 Tm [(filament.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.98500061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.48500061 152.12199402 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.21699524 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.71699524 152.12199402 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.63900757 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.13900757 152.12199402 Tm [(v)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(aria)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.84600067 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.34600067 167.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.68800354 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.18800354 167.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.12799835 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.62799835 167.72200012 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.78799438 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.28799438 167.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.63499451 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.13499451 167.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.64199829 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.14199829 167.72200012 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.83200073 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.33200073 167.72200012 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.15799999 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.65799999 183.32200623 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.11400032 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.61399841 183.32200623 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.29600143 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 166.6000061 0.75 m 166.6000061 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.80001831 0.75 m 422.80001831 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17501831 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 188.32499695 m 423.17501831 188.32499695 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>