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[<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 361.28900146 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT 1 0 0 -1 52.5 12.27200031 Tm [<00030004>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.27200031 Tm [(GA)1(B2\(Ab-)-1(6)1(23\))] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 136.99699402 12.27200031 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 142.24699402 12.27200031 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 194.74699402 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 79.23400116 cm /P <</Lang (zh-CN) /MCID 13 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 14 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Anti-)-1(G)1(AB2\(Ab-623\))] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 144.60600281 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 146.97999573 12.27200031 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 172.63000488 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 175.0039978 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 218.56300354 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 220.93699646 12.27200031 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 258.73300171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.66799927 cm /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 21 12.27200031 Tm [<000B000D>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(KI)1(AA05)1(71)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 104.53900146 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 144.102005 cm /P <</Lang (zh-CN) /MCID 29 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 30 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 31 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 176.53599548 cm /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 21 12.27200031 Tm [<0014000D>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(GA)1(B2\(Ab-)-1(6)1(23\))] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 123.87200165 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.97000122 cm /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 21 12.27200031 Tm [<0016000D>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.27200031 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 108.35800171 12.27200031 Tm [<001A001B>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.27200031 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 134.60800171 12.27200031 Tm [<001C001D>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 241.40400696 cm /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001E>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 21 12.27200031 Tm [<001F000D>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 90.69100189 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 273.8380127 cm /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 93.99199677 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 306.27200317 cm /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 126 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 338.70599365 cm /P <</Lang (zh-CN) /MCID 66 >> BDC BT /FAAACA 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <</MCID 67 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 88.65000153 12.27200031 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 91.02400208 12.27200031 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 134.58299255 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 371.14001465 m 416.75 371.14001465 l 416.75 402.34002686 l -1.45000005 402.34002686 l h f* Q q 1 0 0 1 0 371.14001465 cm /P <</MCID 72 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 402.33999634 cm /P <</MCID 75 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.00500011 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 427.17401123 cm q /GS2 gs 1 g 0.375 0.75 m 156.67500305 0.75 l 156.67500305 125.55000305 l 0.375 125.55000305 l h f* Q q 0.375 0.75 m 156.67500305 0.75 l 156.67500305 125.55000305 l 0.375 125.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 76 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 77 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.42500305 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 157.42500305 125.55000305 l h f* Q q 1 0 0 1 157.05000305 0 cm 0.375 0.75 m 265.375 0.75 l 265.375 125.55000305 l 0.375 125.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 78 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Ad)1(apt)1(e)-1(r)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 34.70800018 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 39.20800018 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 70.51499939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 75.01499939 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 100.11199951 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 104.61199951 11.72200012 Tm [(acts)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 121.6190033 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 126.1190033 11.72200012 Tm [(do)1(wnstr)1(e)-1(am)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 179.71899414 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 184.21899414 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 193.06100464 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 197.56100464 11.72200012 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 227.47000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 231.97000122 11.72200012 Tm [(mem)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(bra)1(ne)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 24.81200027 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 29.31200027 27.3220005 Tm [(rec)-1(ept)1(ors)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 69.90000153 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 74.40000153 27.3220005 Tm [(inc)-1(luding)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 114.25 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 118.75 27.3220005 Tm [(cy)-1(t)1(oki)-1(ne,)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 157.21499634 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 161.71499634 27.3220005 Tm [(antig)1(e)-1(n,)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 196.55900574 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 201.05900574 27.3220005 Tm [(ho)1(rmone)-1(,)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 242.73199463 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 247.23199463 27.3220005 Tm [(ce)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ll)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 4.78999996 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 9.28999996 42.92200089 Tm [(mat)1(rix)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 36.44400024 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 40.94400024 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 57.22100067 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 61.72100067 42.92200089 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 92.63700104 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 97.13700104 42.92200089 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 122.2559967 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 126.7559967 42.92200089 Tm [(rec)-1(ept)1(ors)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 167.34399414 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 171.84399414 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 180.91900635 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 185.41900635 42.92200089 Tm [(regulat)1(e)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 221.09399414 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 225.59399414 42.92200089 Tm [(multipl)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(e)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 5.10599995 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 9.60599995 58.52199936 Tm [(signaling)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 48.53699875 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 53.03699875 58.52199936 Tm [(pa)1(thw)1(ays.)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 95.83100128 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 100.33100128 58.52199936 Tm [(Regulat)1(e)-1(s)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 142.61099243 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 147.11099243 58.52199936 Tm [(ost)1(e)-1(o)1(c)-1(last)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 190.58200073 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 195.08200073 58.52199936 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 256.4079895 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(mediat)1(i)-1(ng)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 43.71699905 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 48.21699905 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 62.2179985 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 66.71800232 74.12200165 Tm [(TNFRSF)-1(11)-1(A)1(/RANK)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 145.79800415 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 150.29800415 74.12200165 Tm [(signaling.)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 191.39599609 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 195.89599609 74.12200165 Tm [(In)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 204.08700562 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 208.58700562 74.12200165 Tm [(allergic)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 239.55999756 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 244.05999756 74.12200165 Tm [(res)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(po)1(n)-1(se,)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 28.45499992 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 32.95500183 89.72200012 Tm [(it)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 38.70299911 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 43.20299911 89.72200012 Tm [(plays)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 65.25 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 69.75 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 74.72499847 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 79.22499847 89.72200012 Tm [(role)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 95.88500214 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 100.38500214 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 108.3259964 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 112.8259964 89.72200012 Tm [(mast)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 133.75300598 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 138.25300598 89.72200012 Tm [(ce)-1(lls)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 156.82899475 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 161.32899475 89.72200012 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 203.27900696 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 207.77900696 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 224.05599976 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 228.55599976 89.72200012 Tm [(degra)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nul)-1(a)1(tion)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 35.47700119 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 39.97700119 105.3219986 Tm [(th)1(rough)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 74.87400055 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 79.37400055 105.3219986 Tm [(PI-)1(3)-1(-)1(k)-1(inase)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 127.67900085 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 132.17900085 105.3219986 Tm [(regulat)1(i)-1(o)1(n)-1(.)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 178.57600403 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 183.07600403 105.3219986 Tm [(Also)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 201.69099426 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 206.19099426 105.3219986 Tm [(involved)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 242.55999756 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 247.05999756 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 255.00100708 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 14.0010004 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 18.50099945 120.92199707 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 62.73199844 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 67.23200226 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 76.0739975 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 80.5739975 120.92199707 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 94.98400116 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 99.48400116 120.92199707 Tm [(pro)1(life)-1(r)1(ation)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 152.83399963 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 157.33399963 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 173.61099243 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 178.11099243 120.92199707 Tm [(hemat)1(opoiesis.)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 243.10600281 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 156.67500305 0.75 l 156.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 156.67500305 0.75 l 156.67500305 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 197 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 198 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 157.42500305 16.35000038 l h f* Q q 1 0 0 1 157.05000305 0 cm 0.375 0.75 m 265.375 0.75 l 265.375 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 199 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 156.67500305 0.75 l 156.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 156.67500305 0.75 l 156.67500305 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 201 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 206 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 157.42500305 16.35000038 l h f* Q q 1 0 0 1 157.05000305 0 cm 0.375 0.75 m 265.375 0.75 l 265.375 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 207 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(GA)1(B)-1(2\(Ab)1(-62)-1(3\))] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 61.77000046 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q /GS2 gs 1 g 0.375 0.75 m 156.67500305 0.75 l 156.67500305 31.95000076 l 0.375 31.95000076 l h f* Q q 0.375 0.75 m 156.67500305 0.75 l 156.67500305 31.95000076 l 0.375 31.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 209 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <</MCID 210 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.42500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 157.42500305 31.95000076 l h f* Q q 1 0 0 1 157.05000305 0 cm 0.375 0.75 m 265.375 0.75 l 265.375 31.95000076 l 0.375 31.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 211 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hesized)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 51.35400009 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 55.85400009 11.72200012 Tm [(non-p)1(hosp)1(hopept)1(ide)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 147.96299744 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 152.46299744 11.72200012 Tm [(derived)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 184.74499512 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 189.24499512 11.72200012 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 209.95599365 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 214.45599365 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 244.49699402 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 248.99699402 11.72200012 Tm [(G)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ab)1(2)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 16 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 20.5 27.3220005 Tm [(aro)1(u)-1(nd)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 51.48099899 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 55.98099899 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 69.98200226 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 74.48200226 27.3220005 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 145.2559967 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 149.7559967 27.3220005 Tm [(site)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 164.7769928 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 169.2769928 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 178.1190033 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 182.6190033 27.3220005 Tm [(serine)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 208.375 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 212.875 27.3220005 Tm [(62)-1(3)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 228.70799255 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 233.20799255 27.3220005 Tm [(\(P-)1(S)-1(-)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 190.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 157.05000305 0.75 m 157.05000305 125.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 157.05000305 126.30000305 m 157.05000305 141.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 157.05000305 142.65000916 m 157.05000305 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 157.05000305 159.00001526 m 157.05000305 190.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 190.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 190.57501221 m 423.17498779 190.57501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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