%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 136 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.05000305 0 90.05000305 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 16 Tf 1 0 0 -1 115.23400116 21.47500038 Tm 2 Tr 0 g 0.45714286 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 16 Tf 1 0 0 -1 151.36199951 21.47500038 Tm 0 Tr [(HMGCLL1)] TJ ET EMC /P <> BDC BT /FAAABB 16 Tf 1 0 0 -1 219.74499512 21.47500038 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 16 Tf 1 0 0 -1 300.06500244 21.47500038 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(HMGCLL)-1(1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 131.14199829 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 183.64199829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(HMG)1(C)-1(LL)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.6499939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.58299255 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.95700073 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.75300598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(3-hydroxymet)1(h)-1(yl-3-met)1(h)-1(ylglu)-1(tar)1(yl-C)-1(oA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.852005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.22599792 12.82499981 Tm [(lyase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.74899292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.12298584 12.82499981 Tm [(li)-1(ke)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.94000244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.31399536 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.44500732 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.81900024 12.82499981 Tm [(er)1(-cHL)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.12399292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.49798584 12.82499981 Tm [(bA418P)1(12.1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.0960083 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HMGCLL)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.89199829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 123.67500305 0.75 l 123.67500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 124.67500305 -0.25 l 124.67500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.42500305 0.75 m 422.42498779 0.75 l 422.42498779 78.75 l 124.42500305 78.75 l h f* Q q 1 0 0 1 124.05000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Non-mit)1(ochondria)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.66100311 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.16100311 11.72200012 Tm [(3-hydro)1(xyme)-1(t)1(hyl)-1(-)1(3)-1(-)1(me)-1(t)1(hylglutar)1(y)-1(l-)1(CoA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.7170105 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.2170105 11.72200012 Tm [(lyase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.62298584 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.22200012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.72200012 27.3220005 Tm [(cata)1(l)-1(yzes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.39400101 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.89399719 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.8690033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.3690033 27.3220005 Tm [(cation-)1(depe)-1(nd)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.79200745 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.29200745 27.3220005 Tm [(cl)-1(eava)1(ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.84300232 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.34300232 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.18499756 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.68499756 27.3220005 Tm [(\(S\)-3-h)1(y)-1(d)1(roxy-3-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(methylgluta)1(ryl)-1(-)1(CoA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.18199921 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.68199921 42.92200089 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.69799805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.19799805 42.92200089 Tm [(ace)-1(t)1(yl)-1(-)1(CoA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.27200317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.77200317 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.04899597 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.54899597 42.92200089 Tm [(ace)-1(t)1(oacetat)1(e)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.76600647 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.26600647 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.24099731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.74099731 42.92200089 Tm [(ke)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.51098633 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.01098633 42.92200089 Tm [(st)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.74800014 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.24800014 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.18899918 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.68899918 58.52199936 Tm [(ke)-1(t)1(ogene)-1(sis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.17900085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.67900085 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.68000031 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.18000031 58.52199936 Tm [(pro)1(duc)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.42100525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.92100525 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.76300049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.26300049 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.36000061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.86000061 58.52199936 Tm [(supp)1(ort)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.57899475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.07899475 58.52199936 Tm [(en)-1(erg)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.79499817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.29501343 58.52199936 Tm [(pro)1(duc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(tio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.01600075 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.51600075 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.45700073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.95700073 74.12200165 Tm [(nonhepat)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.40200043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.90200043 74.12200165 Tm [(animal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.62000275 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.12000275 74.12200165 Tm [(tiss)1(u)-1(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.18499756 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 78.75 cm q /GS2 gs 1 g 0.375 0.75 m 123.67500305 0.75 l 123.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.67500305 -0.25 l 124.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 124.42500305 16.35000038 l h f* Q q 1 0 0 1 124.05000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 123.67500305 0.75 l 123.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.67500305 -0.25 l 124.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 124.42500305 16.35000038 l h f* Q q 1 0 0 1 124.05000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HMGCLL1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.98300171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 111.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 123.67500305 0.75 l 123.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.67500305 -0.25 l 124.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 124.42500305 16.35000038 l h f* Q q 1 0 0 1 124.05000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(HMGCLL1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.32899475 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.80000305 cm q /GS2 gs 1 g 0.375 0.75 m 123.67500305 0.75 l 123.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.67500305 -0.25 l 124.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 124.42500305 16.35000038 l h f* Q q 1 0 0 1 124.05000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(3-hydro)1(xyme)-1(t)1(hyl)-1(-)1(3)-1(-)1(me)-1(t)1(hylglutar)1(y)-1(l-)1(CoA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.55599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.05599976 11.72200012 Tm [(lyase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.46200562 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.96200562 11.72200012 Tm [(lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.75799561 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.25799561 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.53599548 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 123.67500305 0.75 l 123.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.67500305 -0.25 l 124.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 124.42500305 16.35000038 l h f* Q q 1 0 0 1 124.05000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(er-cH)-1(L;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.69599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.19599915 11.72200012 Tm [(bA)1(4)-1(18)-1(P)1(1)-1(2.1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.61599731 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 160.5 cm q /GS2 gs 1 g 0.375 0.75 m 123.67500305 0.75 l 123.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 124.67500305 -0.25 l 124.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 124.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 124.42500305 16.35000038 l h f* Q q 1 0 0 1 124.05000305 0 cm -0.625 -0.25 m 299.375 -0.25 l 299.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8T)-1(B92)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.97399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 176.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.05000305 0.75 m 124.05000305 78.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.05000305 79.5 m 124.05000305 95.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.05000305 95.84999847 m 124.05000305 111.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.05000305 112.19999695 m 124.05000305 127.79999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.05000305 128.54998779 m 124.05000305 144.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.05000305 144.8999939 m 124.05000305 160.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.05000305 161.25 m 124.05000305 176.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 176.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.125 m 422.42498779 79.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 95.47499847 m 422.42498779 95.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.82499695 m 422.42498779 111.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.17498779 m 422.42498779 128.17498779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 144.5249939 m 422.42498779 144.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.875 m 422.42498779 160.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 177.2250061 m 423.17498779 177.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream 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