%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 132 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.05000305 0 90.05000305 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 94.67199707 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 144.3480072 23.67700005 Tm 0 Tr [(LI)1(LRB3)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 210.18699646 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 320.62701416 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(LIL)-1(RB3)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 117.45800018 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.95799255 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.20799255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(LILRB3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.94200134 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.31600189 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.96600342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.33999634 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.89900208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.272995 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.06900024 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HL9,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.89800262 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.27200317 12.82499981 Tm [(ILT)-1(5,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.38999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.76399994 12.82499981 Tm [(LIR3,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.46700287 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.84100342 12.82499981 Tm [(PIRB)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.94299316 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.31700134 12.82499981 Tm [(CD85A,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.71400452 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.08799744 12.82499981 Tm [(ILT)-1(-5,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.42100525 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.79499817 12.82499981 Tm [(LIR-3,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.71200562 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.08599854 12.82499981 Tm [(LIL)-1(RA)1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.65899658 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(LIL)-1(RB3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.20800018 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 131.92500305 0.75 l 131.92500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 132.92500305 -0.25 l 132.92500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.67500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 132.67500305 172.3500061 l h f* Q q 1 0 0 1 132.30000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3390007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.8390007 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.81399918 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.31400299 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.57800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.07800293 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.91999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.41999817 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.42100525 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.92100525 11.72200012 Tm [(leu)-1(kocy)-1(t)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.32600403 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.82600403 11.72200012 Tm [(immun)-1(o)1(glob)1(u)-1(lin-like)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.09399414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.42200089 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.92200089 27.3220005 Tm [(\(LIR\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.07300186 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.57299805 27.3220005 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.82099915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.32099915 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.41799927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.91799927 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.47900391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.97900391 27.3220005 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.66900635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.16900635 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.11000061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.61000061 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.58500671 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.08500671 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.60099792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.10099792 27.3220005 Tm [(cl)-1(ust)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.61700439 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.11700439 27.3220005 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.44500732 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.94500732 27.3220005 Tm [(chro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(moso)1(mal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.84500122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.34500122 42.92200089 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.30699921 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.80699921 42.92200089 Tm [(19)-1(q)1(1)-1(3.4.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.28600311 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.78600311 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.59300232 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.09300232 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.6000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.1000061 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.40699768 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90699768 42.92200089 Tm [(belongs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.34700012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.84700012 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.92199707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.42199707 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.42300415 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(subf)1(amily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.54199982 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.04199982 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.68899918 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.18899918 58.52199936 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.40399933 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.90399933 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.7460022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.2460022 58.52199936 Tm [(LIR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.38600159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.88600159 58.52199936 Tm [(rec)-1(ept)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.47399902 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.97399902 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.07099915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.57099915 58.52199936 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.61999512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.11999512 58.52199936 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.30099487 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.80099487 58.52199936 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.95899963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.45901489 58.52199936 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.2829895 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(extra)1(c)-1(ellu)-1(la)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.19400024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.69400024 74.12200165 Tm [(immun)-1(o)1(glob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.27200317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.77200317 74.12200165 Tm [(do)1(mains,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.93200684 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.43200684 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.40699768 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.90699768 74.12200165 Tm [(tr)1(ansme)-1(mb)1(rane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.16700745 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.66699219 74.12200165 Tm [(do)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ain,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.08199978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.58200073 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.85900116 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.35900116 89.72200012 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.54000092 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.04000092 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.11499786 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.61499786 89.72200012 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.43900299 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.93900299 89.72200012 Tm [(cy)-1(t)1(oplas)1(mi)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.91600037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.41600037 89.72200012 Tm [(immun)-1(o)1(re)-1(cepto)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.91299438 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.41299438 89.72200012 Tm [(tyro)1(sin)-1(e-b)1(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 105.3219986 Tm [(inhibito)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.65800095 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.15800095 105.3219986 Tm [(mot)1(ifs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.34700012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.84700012 105.3219986 Tm [(\(ITIMs\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.43499756 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.93499756 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.74200439 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24200439 105.3219986 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.66400146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.16400146 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.7250061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.2250061 105.3219986 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.3789978 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.8789978 105.3219986 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.14700317 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.64700317 105.3219986 Tm [(im)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(mune)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.63100052 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.13100052 120.92199707 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.70700073 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.20700073 120.92199707 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.5039978 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.0039978 120.92199707 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.7519989 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.2519989 120.92199707 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.86399841 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.36399841 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.43899536 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.93899536 120.92199707 Tm [(MHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.71400452 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.21400452 120.92199707 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.42900085 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.92900085 120.92199707 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.57499695 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.07499695 120.92199707 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.45799255 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.95799255 120.92199707 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.22599792 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.72601318 120.92199707 Tm [(antig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(en)-1(-)1(presen)-1(t)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.70600128 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.20600128 136.52200317 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.78199768 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.28199768 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.55899811 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.05899811 136.52200317 Tm [(tr)1(ansduc)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.6230011 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.1230011 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.0980072 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.5980072 136.52200317 Tm [(ne)-1(g)1(ative)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.55999756 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.05999756 136.52200317 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.29299927 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.79299927 136.52200317 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.01501465 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.51501465 136.52200317 Tm [(inhi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(bit)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.6619997 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.16200066 152.12199402 Tm [(st)1(i)-1(mulat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.44000244 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.94000244 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.78199768 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.28199768 152.12199402 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.8030014 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.3030014 152.12199402 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.76199341 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.26199341 152.12199402 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.42599487 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.92599487 152.12199402 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.92500305 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.42500305 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.98599243 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.48599243 152.12199402 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.29899597 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.79899597 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.87399292 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.37399292 152.12199402 Tm [(cont)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(rol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.55300045 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.0529995 167.72200012 Tm [(inflammat)1(ory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.59899902 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.09899902 167.72200012 Tm [(responses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.26200104 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.76200104 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.03900146 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.53900146 167.72200012 Tm [(cy)-1(t)1(oto)1(xic)-1(it)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.94700623 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.44700623 167.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.52200317 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.02200317 167.72200012 Tm [(help)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.81300354 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.31300354 167.72200012 Tm [(fo)1(c)-1(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.38000488 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.88000488 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.88101196 167.72200012 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 132.30000305 0.75 m 132.30000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>