%PDF-1.7 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 128 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 101.5 l -90 101.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET Q EMC q 1 0 0 1 90 42.54999924 cm q 1 0 0 1 9 1 cm q 270.25 0 0 -90.25 0 90.25 cm /X1 Do Q Q Q q 1 0 0 1 90 144.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 42.79700089 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 114.56099701 23.67700005 Tm 0 Tr [(NFKB)1(IA\()1(N-ter)-1(m\))] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 262.06201172 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 372.50201416 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.27200031 Tm [(NFKB)1(IA\(N-te)1(rm\))] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 165.76499939 12.27200031 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 218.26499939 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.76499939 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 79.23400116 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Anti-)-1(N)1(F)-1(K)1(BIA\(N)1(-)-1(t)1(erm)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.3730011 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.74699402 12.27200031 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.51899719 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.89300537 12.27200031 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.21400452 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.58799744 12.27200031 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.38400269 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.66799927 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(NFKB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.76899719 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.14299774 12.27200031 Tm [(in)-1(hi)-1(bi)-1(tor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.63700104 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.01100159 12.27200031 Tm [(alp)-1(ha;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.32299805 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.69700623 12.27200031 Tm [(IK)1(BA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.39399719 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.76800537 12.27200031 Tm [(MAD-3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.6269989 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.00100708 12.27200031 Tm [(NFKB)1(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.41499329 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 144.102005 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 176.53599548 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.27200031 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.27200031 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 208.97000122 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 241.40400696 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(NFKB)1(IA\(N-te)1(rm\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.63999939 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 273.8380127 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.27200031 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 306.27200317 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.27200031 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.27200031 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.27200031 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 338.70599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.27200031 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.27200031 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.27200031 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.73600006 12.27200031 Tm [(Mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.64700317 12.27200031 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 371.14001465 m 416.75 371.14001465 l 416.75 402.34002686 l -1.45000005 402.34002686 l h f* Q q 1 0 0 1 0 371.14001465 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 402.33999634 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.00500011 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 427.17401123 cm q /GS2 gs 1 g 0.375 0.75 m 172.42500305 0.75 l 172.42500305 156.75 l 0.375 156.75 l h f* Q q 0.375 0.75 m 172.42500305 0.75 l 172.42500305 156.75 l 0.375 156.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 173.17500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 173.17500305 156.75 l h f* Q q 1 0 0 1 172.80000305 0 cm 0.375 0.75 m 249.625 0.75 l 249.625 156.75 l 0.375 156.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(NF-kapp)1(a-B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.15400696 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.65400696 11.72200012 Tm [(inh)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ibit)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.04899979 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.54899979 27.3220005 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.79700089 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.29700089 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.39399719 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.89399719 27.3220005 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.94300079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.44300079 27.3220005 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.81500244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.31500244 27.3220005 Tm [(ankrin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.11300659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.61300659 27.3220005 Tm [(repeat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.33799744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.83799744 27.3220005 Tm [(do)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(mains.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.68099976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.18099976 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.98799896 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.48799896 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.99500275 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.49500275 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.80200195 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30200195 42.92200089 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.14599609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.64599609 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.04200745 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.54200745 42.92200089 Tm [(REL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.98399353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.48399353 42.92200089 Tm [(dimer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.74099922 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.24099922 58.52199936 Tm [(inhibit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.61500168 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.11500168 58.52199936 Tm [(NF-kapp)1(a-B/REL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.27999878 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.77999878 58.52199936 Tm [(complexe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.53100586 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.03100586 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.12800598 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.62800598 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.14599609 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.64599609 58.52199936 Tm [(inv)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(olved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.70400047 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.20400047 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.14500046 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.64500046 74.12200165 Tm [(inflammat)1(ory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.19100189 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.69100189 74.12200165 Tm [(responses.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.02099609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.52099609 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.32800293 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.82800293 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.33500671 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.83500671 74.12200165 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 89.72200012 Tm [(moves)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.1969986 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.6969986 89.72200012 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.76899719 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.26899719 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.26999664 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.76999664 89.72200012 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83799744 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.33799744 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.61500549 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.11500549 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.11599731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.61599731 89.72200012 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.43400574 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.93400574 89.72200012 Tm [(via)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.02799988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.9749999 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.47500038 105.3219986 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.99300003 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.49300003 105.3219986 Tm [(localizat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.3030014 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.8030014 105.3219986 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.03600311 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.53599548 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.81300354 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.31300354 105.3219986 Tm [(CRM1-mediat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.05599976 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.55599976 105.3219986 Tm [(nuc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.91300011 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.41300011 120.92199707 Tm [(expor)1(t.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.50699997 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.00699997 120.92199707 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.85600281 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.35600281 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.29699707 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.79699707 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.25300598 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.75300598 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.26899719 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.76899719 120.92199707 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.11599731 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.61599731 120.92199707 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.1230011 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.6230011 120.92199707 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.31300354 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 136.52200317 Tm [(ec)-1(t)1(odermal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.23799896 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.73799896 136.52200317 Tm [(dyspla)1(sia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.07800293 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.57800293 136.52200317 Tm [(anhid)1(rotic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.21099854 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.71099854 136.52200317 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.10699463 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.60699463 136.52200317 Tm [(T-ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.06900024 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.56900024 136.52200317 Tm [(immun)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(od)1(e)-1(f)1(i)-1(cie)-1(ncy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.93799973 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.43799973 152.12199402 Tm [(auto)1(somal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.72399902 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.22399902 152.12199402 Tm [(do)1(mi)-1(na)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.94999695 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.44999695 152.12199402 Tm [(disease.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.28799438 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 172.42500305 0.75 l 172.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 172.42500305 0.75 l 172.42500305 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 173.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 173.17500305 16.35000038 l h f* Q q 1 0 0 1 172.80000305 0 cm 0.375 0.75 m 249.625 0.75 l 249.625 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 173.1000061 cm q /GS2 gs 1 g 0.375 0.75 m 172.42500305 0.75 l 172.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q 0.375 0.75 m 172.42500305 0.75 l 172.42500305 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 173.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 173.17500305 16.35000038 l h f* Q q 1 0 0 1 172.80000305 0 cm 0.375 0.75 m 249.625 0.75 l 249.625 16.35000038 l 0.375 16.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NFKBIA\(N-t)1(e)-1(r)1(m\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.98699951 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 189.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 172.80000305 0.75 m 172.80000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 172.80000305 157.5 m 172.80000305 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 172.80000305 173.8500061 m 172.80000305 189.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 189.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 173.4750061 m 422.42498779 173.4750061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.82501221 m 423.17498779 189.82501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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