%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 79 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 178.69900513 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 206.28700256 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.60099792 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.33699799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.71099854 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00090005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Pig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.77600098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.15000153 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<00110008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.85800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 180.95599365 m 416.75 180.95599365 l 416.75 212.1559906 l -1.45000005 212.1559906 l h f* Q q 1 0 0 1 0 180.95599365 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 240.09500122 cm q /GS2 gs 1 g 0.375 0.75 m 98.17500305 0.75 l 98.17500305 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 99.17500305 -0.25 l 99.17500305 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.92500305 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 98.92500305 141.1499939 l h f* Q q 1 0 0 1 98.55000305 0 cm -0.625 -0.25 m 324.875 -0.25 l 324.875 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.1289978 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40600586 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08099365 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.49899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.99899292 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.94000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.44000244 11.72200012 Tm [(ser)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(um)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.97900009 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.47900009 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.875 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.375 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.88200378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.38200378 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.27500153 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.77500153 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.84700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.34700012 27.3220005 Tm [(9.5)-1(-)1(1)-1(2.5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.96299744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.46299744 27.3220005 Tm [(mg/ml)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.32600403 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.82600403 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.76699829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.26699829 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.29200745 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.79199219 27.3220005 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.30200195 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.80200195 27.3220005 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.89700317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.39700317 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.95800781 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.96099854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.46099854 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.73899841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.23899841 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.94300079 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.44300079 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.35099792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.85099792 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.01699829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.51699829 42.92200089 Tm [(mic)-1(r)1(oorg)1(anisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.61199951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.11199951 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.38900757 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.88900757 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.89001465 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.39001465 42.92200089 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77301025 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.51799965 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.01799965 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.60300064 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.10299683 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.61499786 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.11499786 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.76200104 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.26200104 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.76699829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.26699829 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.40800476 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.90800476 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.88299561 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.38299561 58.52199936 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.89500427 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.39500427 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.23699951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.73699951 58.52199936 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.44099426 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.94099426 58.52199936 Tm [(ad)1(apt)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.97399902 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.47399902 58.52199936 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.93301392 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.43301392 58.52199936 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(spo)1(n)-1(s)1(e)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.62099838 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.12099838 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.9280014 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.4280014 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.52300262 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.02300262 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.23999786 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.73999786 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.42199707 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.92199707 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.10299683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.60299683 74.12200165 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.46899414 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.96899414 74.12200165 Tm [(func)-1(t)1(ions;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.04200745 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.54200745 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.61700439 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.11700439 74.12200165 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.56298828 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.06298828 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.13800049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.63800049 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.63900757 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.7480011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.2480011 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.47000122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.97000122 89.72200012 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.99099731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.49099731 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.49199677 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.99199677 89.72200012 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.98899841 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.48899841 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.76600647 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.26600647 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.34100342 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.84100342 89.72200012 Tm [(rec)-1(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.62800598 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.12800598 89.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.28700256 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.7869873 89.72200012 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.36300659 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.86300659 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.14001465 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.64001465 89.72200012 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(olec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.95000076 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.45000076 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.52500153 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.02500153 105.3219986 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.32900238 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.82900238 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.83000183 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.33000183 105.3219986 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.17399597 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.67399597 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.48100281 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.98100281 105.3219986 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.53599548 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.03599548 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.87800598 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.37800598 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.3789978 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.8789978 105.3219986 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.97399902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.47399902 105.3219986 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.05999756 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.55999756 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.1210022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.6210022 105.3219986 Tm [(ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ne)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.27999878 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.77999878 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.29199982 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.79199982 120.92199707 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.34899902 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.84899902 120.92199707 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.73899841 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.23899841 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.51600647 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.01600647 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.01699829 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.51699829 120.92199707 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.33299255 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.83299255 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.67500305 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.17500305 120.92199707 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.54800415 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.04800415 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.98901367 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.52099991 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.02099991 136.52200317 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.90499878 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.40499878 136.52200317 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.73300171 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.23300171 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.20800018 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.70800018 136.52200317 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.23600006 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.73600006 136.52200317 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.02400208 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.52400208 136.52200317 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.28799438 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.78799438 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.34899902 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.84899902 136.52200317 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.4940033 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.9940033 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.06900024 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.56900024 136.52200317 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.42300415 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.92300415 136.52200317 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.03399658 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.53399658 136.52200317 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.26998901 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 98.17500305 0.75 l 98.17500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 99.17500305 -0.25 l 99.17500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 98.92500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 98.92500305 31.95000076 l h f* Q q 1 0 0 1 98.55000305 0 cm -0.625 -0.25 m 324.875 -0.25 l 324.875 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Opt)1(imal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.63299942 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.13299942 11.72200012 Tm [(test)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.97499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.47499847 11.72200012 Tm [(ap)1(plic)-1(at)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.40499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.90499878 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.18200684 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.68200684 11.72200012 Tm [(wo)1(rk)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.54400635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.04400635 11.72200012 Tm [(dilutions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.31799316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.81799316 11.72200012 Tm [(must)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.31599426 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.81599426 11.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.67001343 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.17001343 11.72200012 Tm [(determine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.7689991 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.2689991 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.27000046 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.77000046 27.3220005 Tm [(en)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.17900085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.67900085 27.3220005 Tm [(user.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.09999847 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.09999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 98.55000305 0.75 m 98.55000305 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 98.55000305 141.8999939 m 98.55000305 173.09999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.09999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.47499084 m 423.17498779 173.47499084 l S Q Q q 1 0 0 1 0 413.94500732 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 441.88400269 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 469.82299805 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 497.76199341 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 525.70098877 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 553.64001465 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>