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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 112.43499756 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 272.55099487 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.86499023 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<0003000400050006000700080009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 139.125 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.33700562 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.71099854 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Bio)-1(tin)-1(-conj)-1(ugate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.06900024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.44299316 12.82499981 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.41000366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.78399658 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.9960022 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010001100120013000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.21199799 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0007>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0004000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Bio)-1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.10199738 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.37400055 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.37399292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 273.63400269 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 144.67500305 172.3500061 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\),is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.35600281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.85600281 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.22999573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.72999573 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.57200623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.07200623 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.07299805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.57299805 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.74699402 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.19200134 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.69200134 11.72200012 Tm [(pro)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.10700035 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60700035 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.54800034 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.04800034 27.3220005 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.73600006 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.23600006 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.63200378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.13200378 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.63899994 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.13899994 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.03199768 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.53199768 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.60400391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.10400391 27.3220005 Tm [(9.5)-1(-)1(1)-1(2.5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.72000122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.22000122 27.3220005 Tm [(mg/ml)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.08300781 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.58300781 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.52398682 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.02499962 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.52499962 42.92200089 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.03499985 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.53499985 42.92200089 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.62999725 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.12999725 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.69100189 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.19100189 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.1519928 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.6519928 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.92999268 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.42999268 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.13400269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.63400269 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.54200745 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.04200745 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.20799255 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.70799255 42.92200089 Tm [(mic)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(oo)1(rganisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.31700134 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.81700134 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.09400177 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.59400177 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.59500122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.09500122 58.52199936 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.47799683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.97799683 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.4960022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.9960022 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.58099365 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.08099365 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.59300232 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.09300232 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.74000549 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.24000549 58.52199936 Tm [(lymphoc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.38899994 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.88899994 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.03000069 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.52999878 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.50500107 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.00500107 74.12200165 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.51699829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.01699829 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.85900116 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.35900116 74.12200165 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.06300354 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.56300354 74.12200165 Tm [(ad)1(apt)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.59599304 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.09599304 74.12200165 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.55499268 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.05499268 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.21899414 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.71899414 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.52600098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.02600098 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.1210022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.21699905 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.71699905 89.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.39899826 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.89899826 89.72200012 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.08000183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.58000183 89.72200012 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.44599915 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.94599915 89.72200012 Tm [(func)-1(t)1(ions;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.01899719 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.51899719 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.59399414 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.09399414 89.72200012 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.53999329 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.03999329 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.11500549 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.61500549 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.61599731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.11599731 89.72200012 Tm [(pa)1(tho)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.4090004 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.9090004 105.3219986 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.13100052 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.63100052 105.3219986 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.65200043 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.15200043 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.15299988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.65299988 105.3219986 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.6499939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.1499939 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.42700195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.92700195 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.0019989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.5019989 105.3219986 Tm [(rec)-1(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.28900146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.78900146 105.3219986 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.94799805 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.44799805 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.02400208 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.52398682 105.3219986 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 120.92199707 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.63999939 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.13999939 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.21499634 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.71499634 120.92199707 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.01899719 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.51899719 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.51999664 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.01999664 120.92199707 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.86399841 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.36399841 120.92199707 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.17100525 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.67100525 120.92199707 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.22599792 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.72599792 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.56799316 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.06799316 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.06900024 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.56900024 120.92199707 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(gG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44999981 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.95000076 136.52200317 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.5359993 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.0359993 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.59700012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.09700012 136.52200317 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.23999786 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.73999786 136.52200317 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.2519989 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.7519989 136.52200317 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.30900574 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.80900574 136.52200317 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.69900513 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.19900513 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.47599792 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.97599792 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.977005 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.47698975 136.52200317 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(umber)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.27000046 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.77000046 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.61199951 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.11199951 152.12199402 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.48500061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.98500061 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.9260025 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.4260025 152.12199402 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.9469986 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.4469986 152.12199402 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.33099365 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.83099365 152.12199402 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.15899658 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.65899658 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.63400269 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.13400269 152.12199402 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.66200256 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.16200256 152.12199402 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.44999695 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.94999695 152.12199402 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.71398926 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.56099987 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.06099987 167.72200012 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.70600128 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.20600128 167.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.28099823 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.78099823 167.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.63500214 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.13500214 167.72200012 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.2460022 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.7460022 167.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.48199463 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 172.3500061 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 144.67500305 31.95000076 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(50)-1(0-500)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.96099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.46099854 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.73899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.23899841 11.72200012 Tm [(ELISA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.97799683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.47799683 11.72200012 Tm [(1/)-1(50)-1(0-500)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.43899536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.93899536 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.21699524 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.71699524 11.72200012 Tm [(West)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.58999634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.08999634 11.72200012 Tm [(blot)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.35899353 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.85899353 11.72200012 Tm [(1/)-1(50)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(0-50)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28300095 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.78300095 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.06100082 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.56100082 27.3220005 Tm [(Immunohist)1(oc)-1(h)1(e)-1(mist)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.77200317 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 0.75 m 144.30000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 173.1000061 m 144.30000305 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 172.7250061 m 422.42498779 172.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 204.67500305 m 423.17498779 204.67500305 l S Q Q q 1 0 0 1 0 478.68399048 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 506.62298584 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 534.56201172 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 562.50097656 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 590.44000244 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm
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