%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 79 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 154.77600098 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 182.36399841 23.67700005 Tm 0 Tr [(IgG\()1(H+L\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.52398682 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.33699799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.71099854 12.82499981 Tm [(\(H+L)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.26399994 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.63800049 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00090005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.57800293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.95200348 12.82499981 Tm [(\(H+L)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.50500488 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.21199799 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000F0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001000110012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(2-8)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00130014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.10800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 180.95599365 m 416.75 180.95599365 l 416.75 212.1559906 l -1.45000005 212.1559906 l h f* Q q 1 0 0 1 0 180.95599365 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 240.09500122 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 113.92500305 156.75 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 309.875 -0.25 l 309.875 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.1289978 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40600586 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08099365 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.49899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.99899292 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.94000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.68799973 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.18799973 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.58399963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.08399963 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.59100342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.09100342 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.98400116 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48400116 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.55599976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.05599976 27.3220005 Tm [(8-17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.78300476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.28300476 27.3220005 Tm [(mg/mL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.36999512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.86999512 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.81100464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.31100464 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.33599854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.83599854 27.3220005 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.3460083 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.8460083 27.3220005 Tm [(Ig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.69299984 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.19299984 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.75399971 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.25399971 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.21499634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.71499634 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.99299622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.49299622 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.1969986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.6969986 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.60499573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.10499573 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.27099609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.77099609 42.92200089 Tm [(mic)-1(r)1(oorg)1(anisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.86599731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.36599731 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.64300537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.14300537 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.14401245 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.64401245 42.92200089 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(olec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.95000076 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.45000076 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.9679985 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.4679985 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.0530014 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.5530014 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.06500244 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.56500244 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.21199799 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.71200562 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.21699524 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.71699524 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.85800171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.35800171 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.33299255 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.83299255 58.52199936 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.34500122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.84500122 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.68699646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.18699646 58.52199936 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.89099121 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.39099121 58.52199936 Tm [(ad)1(apt)1(iv)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.06499863 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.56499863 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.72899628 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.22899628 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.03600311 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.53600311 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.6309967 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.1309967 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.3480072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.8480072 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.52999878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.02999878 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.21099854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.71099854 74.12200165 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.57699585 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.07699585 74.12200165 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.66699982 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.74199963 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.24200058 89.72200012 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.68799973 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.18799973 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.26300049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.76300049 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.76399994 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.26399994 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.01200104 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.51200104 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.73399353 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.23399353 89.72200012 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.25500488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.75500488 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.7559967 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.2559967 89.72200012 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.25300598 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.75300598 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.02999878 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.52999878 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.60501099 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.10501099 89.72200012 Tm [(rec)-1(rui)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.35299993 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.85300016 105.3219986 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.01199913 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.51200104 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.08800125 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.58800125 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.86499786 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.36499786 105.3219986 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.7480011 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.2480011 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.32299805 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.82299805 105.3219986 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.1269989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.6269989 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.62800598 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.12800598 105.3219986 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97200012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.47200012 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.27900696 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.77900696 105.3219986 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.33401489 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.84200001 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.34200001 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.34300041 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.84300041 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.93799973 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.43799973 120.92199707 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.02400208 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.52400208 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.08499908 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.58499908 120.92199707 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.72799683 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.22799683 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.74000549 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.24000549 120.92199707 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.79699707 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.29699707 120.92199707 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.18699646 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.68699646 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.96398926 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.46398926 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.46499634 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.96499634 120.92199707 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(umber)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.27000046 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.77000046 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.61199951 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.11199951 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.48500061 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.98500061 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.9260025 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.4260025 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.9469986 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.4469986 136.52200317 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.33099365 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.83099365 136.52200317 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.15899658 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.65899658 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.63400269 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.13400269 136.52200317 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.66200256 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.16200256 136.52200317 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.44999695 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.94999695 136.52200317 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.71398926 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.21398926 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.7749939 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.2749939 136.52200317 Tm [(esti)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(mat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.62400055 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.12400055 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.19900131 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.69900131 152.12199402 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.5530014 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.0530014 152.12199402 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.16400146 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.66400146 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.40000153 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 113.92500305 31.95000076 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 309.875 -0.25 l 309.875 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Opt)1(imal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.63299942 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.13299942 11.72200012 Tm [(test)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.97499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.47499847 11.72200012 Tm [(ap)1(plic)-1(at)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.40499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.90499878 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.18200684 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.68200684 11.72200012 Tm [(wo)1(rk)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.54400635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.04400635 11.72200012 Tm [(dilutions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.31799316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.81799316 11.72200012 Tm [(must)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.31599426 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.81599426 11.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.67001343 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.17001343 11.72200012 Tm [(determ)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.80400085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.30400085 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.81600189 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.31600189 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.31700134 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.81700134 27.3220005 Tm [(en)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.22599792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.72599792 27.3220005 Tm [(user.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.14700317 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 0.75 m 113.55000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 157.5 m 113.55000305 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07499695 m 423.17498779 189.07499695 l S Q Q q 1 0 0 1 0 429.54501343 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 457.48400879 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 485.42300415 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 513.36199951 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 541.30102539 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 569.23999023 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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