%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 67 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 135.40299988 23.67700005 Tm 0 g [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 22 Tf 1 0 0 -1 162.90299988 23.67700005 Tm [(IgY\(IgG\)\(H+L)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.89599609 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.75 12.82499981 Tm [(IgY\(IgG\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.03399658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.40799713 12.82499981 Tm [(\(H+L)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.96099854 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.33500671 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00090005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Ch)-1(icke)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.47899628 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.85299683 12.82499981 Tm [(IgY\(IgG\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.13699341 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.51100159 12.82499981 Tm [(\(H+L)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.06399536 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.21199799 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000F0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001000110012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00130014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.10800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 180.95599365 m 416.75 180.95599365 l 416.75 212.1559906 l -1.45000005 212.1559906 l h f* Q q 1 0 0 1 0 180.95599365 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACC 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 240.09500122 cm q /GS2 gs 1 g 0.375 0.75 m 122.92500305 0.75 l 122.92500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 123.92500305 -0.25 l 123.92500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACC 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 54.72100067 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.67500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 123.67500305 156.75 l h f* Q q 1 0 0 1 123.30000305 0 cm -0.625 -0.25 m 300.125 -0.25 l 300.125 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.1289978 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40600586 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08099365 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.49899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.99899292 11.72200012 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 27.3220005 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.73400116 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.23400116 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.63000107 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.12999725 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.63700104 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.13700104 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.02999878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.52999878 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.602005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.102005 27.3220005 Tm [(8-17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.82899475 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.32899475 27.3220005 Tm [(mg/mL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.41600037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.91600037 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.85699463 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.35699463 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.38198853 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.88198853 27.3220005 Tm [(bloo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.92299986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.42300034 42.92200089 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.51799965 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.01800156 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.57899857 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.07899857 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.04000092 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.54000092 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.81800079 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.31800079 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.02200317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.52200317 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.42999268 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.92999268 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.09599304 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.59599304 42.92200089 Tm [(mic)-1(r)1(oorg)1(anisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.69100952 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.19100952 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.46798706 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 58.52199936 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.88399887 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.38400269 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.90200043 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.40200043 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.98699951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.48699951 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.99899292 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.49899292 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.14599609 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.64599609 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.15100098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.65100098 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.79200745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.29200745 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.26699829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.76699829 58.52199936 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.27900696 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.7789917 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.6210022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.1210022 58.52199936 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.82501221 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ad)1(apt)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.03300095 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.53300095 74.12200165 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.99199677 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.49199677 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.65599823 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.15599823 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.96299744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.46299744 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.55799866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.05799866 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.2749939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.7749939 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.45700073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.95700073 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.13800049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.63800049 74.12200165 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.5039978 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(func)-1(t)1(ions,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.07300186 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.57300186 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.64799881 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.14799881 89.72200012 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.59400177 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.09400177 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16899872 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66899872 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.66999817 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.16999817 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.91799927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.41799927 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.63999939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.13999939 89.72200012 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.16099548 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.66099548 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.66200256 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.16200256 89.72200012 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.15899658 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.65899658 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.87800026 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.37800026 105.3219986 Tm [(rec)-1(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.16500092 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66500092 105.3219986 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.8239975 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.3239975 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.90000153 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.40000153 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.67700195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.17700195 105.3219986 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.55999756 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.05999756 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.13499451 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.63499451 105.3219986 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.93899536 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.43899536 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.44000244 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.94000244 105.3219986 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.78399658 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 120.92199707 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.86199951 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.36199951 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.20400238 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.70400238 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.70500183 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.20500183 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.30000305 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.80000305 120.92199707 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.38600159 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.88600159 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.44700623 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.94700623 120.92199707 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.08999634 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.58999634 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.102005 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.602005 120.92199707 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.15899658 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.65899658 120.92199707 Tm [(rec)-1(o)1(mbi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(natio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.5359993 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.0359993 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.31299973 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.81299973 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.81400299 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.31400299 136.52200317 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.12999725 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.62999725 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.47200012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.97200012 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.34500122 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.84500122 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.78599548 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.28599548 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.80700684 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.30700684 136.52200317 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.19099426 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.69099426 136.52200317 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.01901245 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.51901245 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.49398804 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.99398804 136.52200317 Tm [(give)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 152.12199402 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.33399963 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.83399963 152.12199402 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.59799957 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.09799957 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.65899658 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.15899658 152.12199402 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.80400085 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.30400085 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3789978 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.8789978 152.12199402 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.73300171 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.23300171 152.12199402 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.34399414 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.84399414 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.58000183 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 122.92500305 0.75 l 122.92500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 123.92500305 -0.25 l 123.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACC 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 56.50899887 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.67500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 123.67500305 31.95000076 l h f* Q q 1 0 0 1 123.30000305 0 cm -0.625 -0.25 m 300.125 -0.25 l 300.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Opt)1(imal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.63299942 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.13299942 11.72200012 Tm [(test)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.97499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.47499847 11.72200012 Tm [(ap)1(plic)-1(at)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.40499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.90499878 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.18200684 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.68200684 11.72200012 Tm [(wo)1(rk)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.54400635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.04400635 11.72200012 Tm [(dilutions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.31799316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.81799316 11.72200012 Tm [(must)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.31599426 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.81599426 11.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.67001343 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.17001343 11.72200012 Tm [(dete)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(rmine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.67399979 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.17399979 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.68600082 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.18600082 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.18699646 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.68699646 27.3220005 Tm [(en)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.09600067 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.59600067 27.3220005 Tm [(user.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.01699829 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 123.30000305 0.75 m 123.30000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 123.30000305 157.5 m 123.30000305 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07499695 m 423.17498779 189.07499695 l S Q Q q 1 0 0 1 0 429.54501343 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 457.48400879 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 485.42300415 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 513.36199951 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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