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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 178.69900513 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 206.28700256 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.60099792 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.33699799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.71099854 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00090005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Do)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.93900299 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.31300354 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.52500153 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<00110008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 180.95599365 m 416.75 180.95599365 l 416.75 212.1559906 l -1.45000005 212.1559906 l h f* Q q 1 0 0 1 0 180.95599365 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 240.09500122 cm q /GS2 gs 1 g 0.375 0.75 m 125.92500305 0.75 l 125.92500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 126.92500305 -0.25 l 126.92500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 126.67500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 126.67500305 156.75 l h f* Q q 1 0 0 1 126.30000305 0 cm -0.625 -0.25 m 297.125 -0.25 l 297.125 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.1289978 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40600586 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08099365 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.49899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 27.3220005 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.12900162 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.62900162 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.02500153 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.52500153 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.03199768 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.53199768 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.42500305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.92500305 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.99699402 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.49699402 27.3220005 Tm [(8-17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.22399902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.72399902 27.3220005 Tm [(mg/mL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.81100464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.31100464 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.2519989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.7519989 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.77700806 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.27700806 27.3220005 Tm [(blo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(od)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.64500046 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.14500046 42.92200089 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.24000168 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.74000168 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.30099869 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.80099869 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.76200104 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.26200104 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.54000092 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.04000092 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.7440033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.2440033 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.1519928 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.6519928 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.81799316 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.31799316 42.92200089 Tm [(mic)-1(r)1(oorg)1(anisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.41299438 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.91299438 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.80400085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.30400085 58.52199936 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.68699646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.18699646 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.70500183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.20500183 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.78999329 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.28999329 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.80200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.30200195 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.94900513 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.44900513 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.95399475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.45399475 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.59500122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.09500122 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.07000732 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.57000732 58.52199936 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.08200073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.58200073 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.42401123 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.70400047 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.20400047 74.12200165 Tm [(ad)1(apt)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.23699951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.73699951 74.12200165 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.19599915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.69599915 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.86000061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.36000061 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.16700745 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.66700745 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.76199341 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.26199341 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.47900391 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.97900391 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.66099548 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.16099548 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.3420105 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.8420105 74.12200165 Tm [(sep)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ara)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.84499931 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.34499931 89.72200012 Tm [(func)-1(t)1(ions,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.41799927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.91799927 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.99299622 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.49299622 89.72200012 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.93900299 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.43900299 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51399994 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.01399994 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.01499939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.51499939 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.26300049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.76300049 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.98500061 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.48500061 89.72200012 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.5059967 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.0059967 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.00698853 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.50698853 89.72200012 Tm [(respo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.81799984 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.31800079 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.59500122 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.09500122 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.16999817 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.66999817 105.3219986 Tm [(rec)-1(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.45700073 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.95700073 105.3219986 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.11599731 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.61599731 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.19200134 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.69200134 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.96899414 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.46899414 105.3219986 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.852005 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.352005 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.42700195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.92700195 105.3219986 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.23100281 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.73100281 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.73199463 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.23199463 105.3219986 Tm [(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(igen.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.97100067 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.47100067 120.92199707 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.27799988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.77799988 120.92199707 Tm [(var)1(i)-1(a)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.33300018 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.83300018 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.67500305 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.17500305 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.1760025 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.6760025 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.77099609 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.27099609 120.92199707 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.85699463 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.35699463 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.91799927 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.41799927 120.92199707 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.56100464 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.06100464 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.57299805 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.07299805 120.92199707 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.63000488 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.13000488 120.92199707 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(combinatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.34700012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.84700012 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.12400055 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.62400055 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.625 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.125 136.52200317 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.94099426 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.44099426 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.28300476 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.78300476 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.15600586 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.65600586 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.59700012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.09700012 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.61799622 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.11799622 136.52200317 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.00201416 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.50201416 136.52200317 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.82998657 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.9749999 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.47500038 152.12199402 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.00299835 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.50299835 152.12199402 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.79100037 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.29100037 152.12199402 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.05500031 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.55500031 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.11599731 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.61599731 152.12199402 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.26100159 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.76100159 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.83599854 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.33599854 152.12199402 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.19000244 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.69000244 152.12199402 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.80099487 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.30099487 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.03700256 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 125.92500305 0.75 l 125.92500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 126.92500305 -0.25 l 126.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 126.67500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 126.67500305 31.95000076 l h f* Q q 1 0 0 1 126.30000305 0 cm -0.625 -0.25 m 297.125 -0.25 l 297.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Opt)1(imal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.63299942 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.13299942 11.72200012 Tm [(test)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.97499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.47499847 11.72200012 Tm [(ap)1(plic)-1(at)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.40499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.90499878 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.18200684 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.68200684 11.72200012 Tm [(wo)1(rk)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.54400635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.04400635 11.72200012 Tm [(dilutions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.31799316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.81799316 11.72200012 Tm [(must)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.31599426 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.81599426 11.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.67001343 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.17001343 11.72200012 Tm [(det)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ermin)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.77999878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.27999878 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.79199982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.29199982 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.29299927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.79299927 27.3220005 Tm [(en)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.20200348 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.70200348 27.3220005 Tm [(user.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.1230011 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 126.30000305 0.75 m 126.30000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 126.30000305 157.5 m 126.30000305 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 188.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07499695 m 423.17498779 189.07499695 l S Q Q q 1 0 0 1 0 429.54501343 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 457.48400879 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 485.42300415 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 513.36199951 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 541.30102539 cm Q Q 1 0 0 -1 0 841.90002441 cm
endstream
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